Endocrine Abstracts

Background: It is generally reported that female fertility is not affected by high-dose RAI treatment. AMH has been considered a reliable and accurate index of ovarian reserve. There are few data on AMH values in thyroid diseases. Recently, in DTC women who had undergone RAI ablation treatment, Acibucu et al. (2016) reported low AMH levels without significant impairment of fertility.Aim: The aim of this single-center study was to evaluate AMH le...

Oxidative stress generated in the process of iodide metabolism and thyroid hormone synthesis may play a role in thyroid tumorigenesis and progression of thyroid cancer. The transcription factor Nrf2 is the most important regulator of antioxidant responses. It has been shown that Nrf2 expression is upregulated in papillary thyroid cancer. In response to oxidative stress, nuclear Nrf2 activates antioxidant-responsive elements and induces the expression of stress-responsive genes...

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype.Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNM) and distant metastases.Material and Methods: Mutation analysis was performed in 437 tissue samples from 204...

Background: In Belgium, lower thyroid cancer incidence – most pronounced for microcancers (T1a) – is present in the North compared to the South. This variation is paralleled by differences in clinical practice: in the North less thyroid surgery is performed, more surgery is preceded by fine needle aspiration (FNA), and more patients with a final cancer diagnosis (2004–2006) underwent a presurgical FNA or a lymph node dissection (LND) at fist surgery.<p class...

Background: Unlike excellent prognosis of classical papillary thyroid carcinoma (cPTC), certain pathological subtypes of aggressive variants of PTC (AV-PTC) are considered to have poor clinical outcome. However, the evidence of unfavorable outcome of AV-PTC is not clear because previous studies did not control other confounding factors contributed to clinical outcomes.Methods: This retrospective cohort study initially included 4339 patients with cPTC and...