Endocrine Abstracts

Male fertility is controlled by complex interactions among the hypothalamus, pituitary, and testis. The major functions of the testis include production of spermatozoa (male gametes) and synthesis of testosterone. Testosterone is produced by the testicular Leydig cells and is responsible for the development of gonad, the attainment of puberty, and the maintenance of secondary sexual characteristics. It is also involved in the maintenance of of spermatogenesis and thus ensuring...

Estrogen receptors (ER) are expressed in the majority of breast cancers, are key drivers of breast cancer development and progression and hence therapies to inhibit their activities are a mainstay of treatment for breast cancer. A large proportion of patients develop resistance to these therapies, so determining the mechanisms of ER action is important for improving patient management and for identifying new therapies. In defining the mechanisms by which ER regulates gene expr...

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