Endocrine Abstracts

The leptin-melanocortin signaling pathway plays a pivotal role in the regulation of body weight within the hypothalamus. Leptin, secreted by the adipose tissue, activates the leptin receptor at the arcuate nucleus, which in turn leads to the production of proopiomelanocortin (POMC) derived peptides as melanocyte stimulating hormone (MSH). MSH activates the melanocortin 4 receptor (MC4R), regulating thereby satiety and energy expenditure. Mutations within this pathway are leadi...

A complex interaction between environmental and genetic/epigenetic factors is driving the escalating obesity and diabetes epidemics together with a multitude of associated comorbidities. In the past decades the role of gastrointestinal signals in energy homeostasis and glucose control has made tangible progress mainly due to the findings derived from bariatric/metabolic surgery. In particular, incretin-based approaches in relation with glucagon-like peptide 1 and amylin have f...

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