Endocrine Abstracts (2017) 49 EP1262 | DOI: 10.1530/endoabs.49.EP1262

Congenital disorders in children of the mothers with thyroid malfunctioning at pregnancy

Saba Akbar1, Rubina Mansoor2 & Muhammad Irfan1

1Department of Zoology, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan; 2Chemical Pathology, Rawalpindi Medical College, Rawalpindi, Pakistan.

: In the present study we hypothesized that maternal thyroid disorders may be associated with maternal and foetal morbidity and mortality. The present study included 136 pregnant women selected randomly in first trimester and observed throughout the pregnancy till birth. The assessment of thyroid hormones showed a total of 33.08% (n=45) pregnant ladies were having thyroid disorders; 17.65% (n=24) with hypothyroidism and 15.44% (n=21) with hyperthyroidism. The mothers with hypothyroidism were significantly (P<0.05) heavier than normal mothers while the mother with hyperthyroidism were significantly (P<0.05) lighter than normal and those with hypothyroidism. The hyperthyroidism increased the odds (OR: 6.80; 95% CI: 1.65–28.09) of miscarriages significantly (P<0.05). Maternal hypothyroidism increased the gestational period significantly (P<0.05) and hyperthyroidism decreased the gestational age significantly (P<0.05). Maternal hypothyroidism may lead to significantly (P<0.05) increased birth weight and maternal hyperthyroidism may decreased the birth weight significantly (P<0.05). The maternal hypothyroidism may lead to a statistically significant (P<0.05) decrease in the size of skull and brain weight in neonates. Furthermore, the hypothyroidism and hyperthyroidism increased the odds of webbed neck neonates (OR: 5.87; 95% CI: 1.22–28.30 & OR: 11.73 95% CI: 2.64–52.06, respectively. The data exhibited that the maternal hyperthyroidism increased the odds (OR: 10.47; 95% CI: 1.78–61.78) of eyes defects in neonates. The maternal hypothyroidism increased the risk (OR: 18.00; 95% CI: 1.91–169.10) of neonatal congenital heart defects.

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