Thyroid (non-cancer) | 0049 | ECE2017 | 19th European Congress of Endocrinology

Background-aim: Tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). Our aim was to examine the prevalence of thyroid autoimmunity in BTM.Method: Eighty six adults with BTM and 93 age and gender matched controls were included in the study. The two groups were compared cross-sectionally in terms of anti-thyroid antibodies (anti-TG and anti-TPO) and thyroid hormones. Patients with known autoimmune disorders oth...

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ea0049ep1229 | Thyroid (non-cancer) | ECE2017

Thyroid disorders and type 1 diabetes

Taieb Ach , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: Type 1 Diabetes is an auto-immune disease caused by a disturbance of the immune system, damaging the Beta-cells. The association with other auto-immune diseases was frequently described, and dysthyroidism represents an important part of these associations. In type 1 diabetes, the hormonal profile can be disturbed regardless of auto-immunity. The goal of our study the thyroid hormonal profile in type 1 diabetes, as well as the prevalence of auto-immune dysthyroidi...

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ea0049ep1230 | Thyroid (non-cancer) | ECE2017

Keep calm and put on the emergency list: total thyroidectomy for refractory thyrotoxicosis

Al-Sharefi Ahmed , Ashraff Suhel , Elasaify Wael , Mukhtar Rasha

The standard management for Graves thyrotoxicosis includes the use anti-thyroid drugs, surgery and radioactive iodine treatment. In certain situations,alternative methods including bile acid sequestrants and therapeutic plasma exchange (TPE) have proven effective especially when other treatment modalities fail. We describe a case where conventional and alternative non-invasive measures failed to restore an euthyroid state and resorted to emergency thyroidectomy. A 49 yea...

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ea0049ep1231 | Thyroid (non-cancer) | ECE2017

Screening with TSH and anti-TPO antibodies of patients with vitiligo

Chiriac Anca E , Chiriac Anca , Azoicai Doina

Aim: The aim of the study was to evaluate the relation of vitiligo with thyroid autoimmunity.Materials and methods: A cross sectional study was done on 75 patients clinically diagnosed (old and new) with different types of vitiligo. Patients with known thyroid disease were excluded from the study. Serum TSH and anti-TPO antibodies were measured in all patients.Results: The prevalence of anti-TPO antibody positivity was found in 23 ...

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ea0049ep1232 | Thyroid (non-cancer) | ECE2017

Clinical aspects of cardiothyreosis in patients with Graves’ disease

Belaid Rym , Oueslati Ibtissem , Mimita Wafa , Mchirgui Nadia , Khiari Karima , Abdallah Nejib Ben

Introduction: Cardiothyreosis (CT) is the most frequent and dangerous complication of hyperthyroidism (HT). It is defined as an association of HT with severe heart abnormalities such as: rhythmic troubles, heart and/or coronary insufficiency. The aim of our study was to describe the frequency and the clinical characteristics of CT in Graves disease (GD).Methods: Patients with GD were enrolled into a retrospective study. The prevalence and the clini...

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ea0049ep1233 | Thyroid (non-cancer) | ECE2017

Risk factors associated with the severity of Graves’ ophthalmopathy

Belaid Rym , Oueslati Ibtissem , Mimita Wafa , Khiari Karima , Mchirgui Nadia , Abdallah Nejib Ben

Introduction: Graves ophthalmopathy (GO) is an autoimmune disorder affecting the retro-orbital tissues. It represents the main extra- thyroidal expression of Graves disease (GD). Its onset and progression are influenced by several factors that are potentially modifiable. The aim of this study was to identify risk factors for severe GO.Methods: Patients with GD were enrolled into a retrospective study. We compared possible risk factors and var...

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ea0049ep1234 | Thyroid (non-cancer) | ECE2017

Determination of plasma cortisol levels in women with dysthyroidism

Akdader-Oudahmane Samira , Hamouli-Said Zohra , Hadj-Bekkouche Fatma

Activation of the corticotropic axis seems to affect the thyroid axis at the central level and/or by a direct effect on the thyroid gland. The aim of this study is to investigate a possible disruption of the adrenal cortical function that would cause dysthyroidism in a population of women by assaying plasma cortisol. The study was carried out in a human population divided into three subpopulations according to plasma levels in TSH, FT4 and FT3: the subpopulation with euthyroid...

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ea0049ep1235 | Thyroid (non-cancer) | ECE2017

Therapeutic plasma exchange in the treatment of hyperthyroidism

Piskinpasa Hamide , Mert Meral , Dural Ahmet Cem , Karakaya Pinar , Kursat Firuze Midi , Okuturlar Yildiz , Ozdemir Bahar

Preoperative preparation of the hyperthyroid patient for thyroidectomy is imperative to avoid perioperative complications due to severe thyrotoxicosis. 24-years old woman was admitted at our clinic for uncontrolled Graves disease. In our case, agranulocytosis introduced by propylthiouracil. Therefore, surgery was the only chance of an effective therapy. In cases when the patient is unresponsive to medical therapy or when such therapy is contraindicated, therapeutic plasm...

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ea0049ep1236 | Thyroid (non-cancer) | ECE2017

Adult outcome of congenital hypothyroidism

Lassoued Najoua , Ouannes Selmane , Soua Hbib , Hammouda Hachmi Ben , Sfar Mohamed Taher

Introduction: It is because of the heavy somatic and especially intellectual impact of congenital hypothyroidism that its systematic screening from birth has been proved to be essential. Numerous publications have already reported the considerable improvement in the prognosis of this condition but still few relate to adults. This preliminary work proposes to report the adult outcome in a cohort of 12 patients followed for congenital hypothyroidism.Patien...

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ea0049ep1237 | Thyroid (non-cancer) | ECE2017

Asymptomatic riedel thyroiditis presented in a patient with thyroid storm and polyglandular autoimmune disease

Garcia Maria Laura , Artola Yamila Martinez , Endelman Marta , Mayoni Sabrina , Garcia Daniel Santiago , Rella Noelia

Riedel Thyroiditis is a rare form of infiltrative and fibrotic disease of the thyroid that is characterized by compressive symptoms resulting from a rapidly enlarging goiter. The association with Graves Thyroiditis and autoimmune diseases is very rare. The aim of this presentation is to report a patient with asymptomatic Riedel Thyroiditis associated with Thyroid Storm and Polyglandular Autoimmune Disease. A 54-year-old female patient with recent diagnosis of Graves Dise...

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ea0049ep1238 | Thyroid (non-cancer) | ECE2017

Congenital hypothyroidism in children with down syndrome

Lassoued Najoua , Ouannes Salmane , Ghanmi Sobhi , Hammouda Hachmi Ben , Soua Hbib , Sfar Mohamed Taher

Introduction: Congenital hypothyroidism is 30 times more frequent in newborns with Down syndrome (DS) than in the population of healthy children. Mild isolated TSH elevation with normal thyroxine (T4) levels is the most commonly seen pattern of thyroid dysfunction in these children.Patients and methods: A retrospective study was carried out on eleven patients with DS in the pediatric department of Mahdia who were followed for congenital hypothyroidism.</...

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ea0049ep1239 | Thyroid (non-cancer) | ECE2017

Retrospective audit: To investigate the long-term outcome of fixed dose 300 MBq of radioiodine (131-I) treatment for Autonomous Toxic Thyroid Nodule

Lal Vikram , Quinton Richard

Introduction: Radioiodine (131-I) treatment for benign thyroid disease has a 70 year history. Among the radioactive isotopes, (131-I) can be used successfully. The intention of radioiodine treatment is primarily to induce a euthyroid or hypothyroid state, but in the case of large multinodular goitres, shrinkage represents a secondary aim of therapy. The optimal method for determining iodine-131 treatment doses for Toxic Thyroid nodule is unknown, and techniques have varied fro...

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ea0049ep1240 | Thyroid (non-cancer) | ECE2017

Assessment of thyroid functions, thyroid autoimmunity and insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease

Assem Maha , Fawzi May , Ibrahim Alhosaeyn , Saif Aasem

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a common cause of impaired liver functions. It is associated with hepatic and adipose tissue insulin resistance (IR) as well as decreased whole-body insulin sensitivity. Thyroid hormones are important for the intrahepatic metabolism of lipids. Thyroid disorders have been associated with IR due to various mechanisms such as altered insulin secretion and lipid levels.Aim: The aim of our study was t...

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ea0049ep1241 | Thyroid (non-cancer) | ECE2017

Two pseudomalabsorbtion cases successfully treated with parenteral levothyroxine

Altuntaş Seher Cetinkaya , Evran Mehtap , Sert Murat , Tetiker Tamer

Hypothyroidism is a common endocrine disorder which is easily treatable by an appropriate thyroid hormone replacement therapy in the majority of patients. In some patients, hypothyroidism is refractory to oral levothyroxine substitution. Common causes of lack of response to levothyroxine replacement comprise non-compliance and impaired absorption. We report a case of pseudomalabsorption of levothyroxine. Here, we report two female patients with hypothyroidism who had multinod&...

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ea0049ep1242 | Thyroid (non-cancer) | ECE2017

Follow-up observations on nodular goiter in Japanese – Progression and related factors

Kunori Takao , Nemoto Noriko , Fujikawa Nanako , Shiraso Satoru , Yoshida Hiroshi , Hashimoto Akihiko , Kawaguchi Shinya , Shinya Fumiaki

Nodular goiter (ND) is increasingly found by image analysis. The long-term course of ND, however, is not necessarily clear and may differ in locality. The present study analyzed the changes of ND in Japanese, taking iodine-rich foods, during follow-up periods.Patients and methods: Patients (n=4,229) were followed up to 28 years (3.4±5.8 years). Volume of nodules (VOL) by ultrasonography (US) and laboratory data, including thyroid hormones (...

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ea0049ep1243 | Thyroid (non-cancer) | ECE2017

Aggravation of thyroid dysfunction in a case of thyroid hormone resistance after near total thyroidectomy for multinodular goiter

Kartal Ilkay , Tamer Gonca

Introduction: Resistance to thyroid hormone (RTH), a syndrome reduced end-organ responsiveness to thyroid hormone.Case report: A 42 year old woman underwent near total thyroidectomy due to her enlarged thyroid with multiple nodules. At that time she had sligthly elevated values of plasma FT4, FT3 and normal TSH values and had no sign and symptoms of thyrotoxicosis or hypothyroidism. After thyroidectomy she recieved L-T4 treatment but her TSH levels remai...

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ea0049ep1244 | Thyroid (non-cancer) | ECE2017

Thyroid function and weight loss after Roux-en-Y gastric bypass: observational study

Amaral de Carvalho Gisah , Mesa Cleo , Strobel Rodrigo , Granzotto Paula Carolina Dambros

Background: TSH seems to be positively related to the degree of obesity and weight loss seems to induce a reduction in the TSH levels and T3Total. TSH is the first regulatory mechanism of total energy expenditure and T3 regulates energy metabolism and thermogenesis (1)Objective: The aim of this study was to investigate the association between thyroid function and body mass index (BMI) in obese population. And evaluate the influence of weight reduction af...

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ea0049ep1245 | Thyroid (non-cancer) | ECE2017

Correlation between serum nitrite (NO2) levels, TQ7 and GHQ12 questionnaire scores in treatment-naïve hypothyroid patients

Gluvić Zoran , Samardzić Vladimir , Jevtić Jelena Tica , Vujović Marina , Lačković Milena , Popović-Radinović Vesna , Radenković Saša , Mladenović Violeta , Sudar-Milovanović Emina , Obradović Milan , Isenović Esma R

Introduction: Primary hypothyroidism, as a clinical syndrome caused by insufficiency or inefficacy of thyroid hormones, significantly influences on patients quality of life (QoL). Accelerated atherosclerosis induces increased cardiovascular morbidity and mortality rates in hypothyroid patients. Serum NO2 levels, the stable NO metabolites, are among well-known markers for endothelial dysfunction and atherosclerosis in hypothyroidism. We examined the correlation between se...

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ea0049ep1246 | Thyroid (non-cancer) | ECE2017

Vitamin D levels in Graves’ disease (GD) are lower than in general population but do not correlate with laboratory and clinical parameters in GD or SNPs associated with GD

Planck Tereza , Shahida Bushra , Malm Johan , Manjer Jonas

Introduction: The role of vitamin D in GD is poorly understood. The aim was to compare vitamin D levels in newly diagnosed patients with GD with the general population and to correlate vitamin D levels at diagnosis with laboratory and clinical parameters in GD. Moreover, we examined genetic variation in genes involved in the vitamin D metabolism and their association with GD.Material and methods: Levels of vitamin D were compared in 292 patients with new...

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ea0049ep1247 | Thyroid (non-cancer) | ECE2017

Action of several bioavailable antioxidants in orbital fibroblasts from patients with Graves’ Orbitopathy (GO): a new frontier in GO treatment?

Dottore Giovanna Rotondo , Casini Giamberto , Franceschini Stefano Sellari , Nardi Marco , Vitti Paolo , Marcocci Claudio , Marino Michele

Oxidative stress plays a crucial role in the pathogenesis of Graves Orbitopathy (GO), supporting the use of antioxidants in GO patients. Selenium has a beneficial effect, but other antioxidants have not been investigated. Here we evaluated several antioxidants in primary cultures of orbital fibroblasts from GO patients and control subjects. The following substances were tested: Vitamin C (Vit-C), N-Acetyl-l-Cysteine (NAC), melatonin (Mel), retinol (Ret), beta-carotene (b...

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ea0049ep1248 | Thyroid (non-cancer) | ECE2017

Intrathyroidal and peripheral venous blood lymphocyte subset patterns in patients with Graves disease

Dudina Margarita , Sergey Dogadin , Andrey Savchenko , Vladimir Mankovsky , Alexander Borisov

Graves disease (GD) is an autoimmune disease with genetic predisposition. The link with the major histocompatibility complex determines the complexity of the excess thyroid hormones molecular action on immune system that may cause the divergence of autoimmune process in GD, functioning not only in peripheral immune cells, but also in the thyroid. Objective: to study the phenotypic composition of T- and B-lymphocyte subset patterns in peripheral blood and thyroid tissue i...

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ea0049ep1249 | Thyroid (non-cancer) | ECE2017

No impact of subclinical hypothyroidism on cognitive functions among the elderly

Kaur Harleen , Malhotra Nitin , Jacob Jubbin

Background: Most recent cross sectional and longitudinal studies have failed to find an association between cognitive dysfunction and subclinical hypothyroidism. A recent paper from our country however suggested a significant association.Objectives: This study was undertaken to determine the prevelance of cognitive impairement among educated, elderly Indian patients (>60 years) with and without subclinical hypothyroidism.Materi...

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ea0049ep1250 | Thyroid (non-cancer) | ECE2017

Prolonged iodine excess due to hysterosalpingography in a pregnant woman

Ali Tam Abbas , Faki Sevgul , Ozdemir Didem , Aydin Cevdet , Ersoy Reyhan , Cakir Bekir

Introduction: Hysterosalphingography (HSG) is the radiographic examination of uterine cavity and fallopian tubes. It is generally used during evaluation of infertility and radioopaque contrast is injected through cervical duct during the procedure. Lipiodol which is the most commonly used contrast media in HSG is a fatsoluble iodinated contrast media. This iodine is progressively cleared from the body in a period ranging from a few weeks to a few months. Here, we present a 6 w...

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ea0049ep1251 | Thyroid (non-cancer) | ECE2017

The challenge of diagnosing thyroid storm: a comparison of the Japanese Thyroid Association Criteria to de Burch Wartofsky Point Scale

Garcia Maria Laura , Szuman Gabriela , Scoscia Maria Florencia , Bacigaluppi Susana , Panebianco Maria Victoria , Rella Noelia

Thyroid storm (TS) is a rare and life threatening condition that requires a prompt recognition and treatment. The clinical features may overlap with other acute medical conditions. Currently both Akamizu Criteria (JTA) and Burch and Wartofsky Scale (BW) are helpful diagnostics tools.Objective: To evaluate TS patients according to currently available criteria and to identify the clinical features and outcomes.Methods: A single cente...

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ea0049ep1252 | Thyroid (non-cancer) | ECE2017

The role of FNDC5 gene expression in irisin level changes accompanying thyroid pathologies

Zybek-Kocik Ariadna , Sawicka-Gutaj Nadia , Andrusiewicz Miroslaw , Waligorska-Stachura Joanna , Bialas Piotr , Skrobisz Jerzy , Ruchala Marek

Irisin is a recently reported, widely discussed new adipo-myokin secreted mainly by muscle tissue. It is a cleaved and secreted part of fibronectin type III domain containing 5, encoded by the FNDC5 gene. Some of the previously published studies claim that alterations of irisin levels in patients affected by thyroid diseases may be connected mainly with accompanying myopathy. However, to date it has not been evaluated, whether the changes in expression of FNDC5</e...

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ea0049ep1253 | Thyroid (non-cancer) | ECE2017

Long term effects of the less than total thyroidectomy: The experience of a tertiary care center

Boutzios Georgios , Garoufalia Zoe , Alexandraki Krystallenia , Kaltsas Gregory , Kouraklis Grigorios , Tsourouflis Gerasimos

Background and aims: Less than total thyroidectomy (lobectomy, partial or subtotal thyroidectomy) is used mainly to treat thyroid nodules, and/or hyperthyroidism. The aim of the study was to investigate the long term effects of less extensive surgical procedures. such as re-appearance of nodules and the need of thyroxin supplementation, or re-operation.Material and methods: Retrospective study in a tertiary Academic medical center. The study population c...

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ea0049ep1254 | Thyroid (non-cancer) | ECE2017

Severe hyperthyroidism imposes large amounts of antithyroid compounds

Mazilu Adina , Spiroiu Cristina , Ranetti A E

We present three cases of females with low body weight that needed large amounts of anti-thyroid drugs 45 mg/kg Thiamazole and 50 mg/kg of Propylthiouracil. First patient, aged 32, weight 45 kg, had Gravess disease evolving for more than five years. She has been proposed surgery and needed 1200 mg/day of Propylthiouracil. She delayed surgery for 2 weeks, then the dosage required for euthyroidism was 1800 mg/day for three weeks. The goitre had 1.2 kg, from ma...

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ea0049ep1255 | Thyroid (non-cancer) | ECE2017

Postpartum thyrotoxicosis – a diagnosis, sometimes, postponed

Araujo Alexandra Novais , Marcalo Jose , Costa Cristiana , Wessling Ana , Bugalho Maria Joao

Postpartum thyroid dysfunction occurs in 510% of women in the general population within one year of delivery. The prevalence of postpartum Graves disease is estimated at 0.54%. Postpartum thyroiditis is much more common. Differential diagnosis is essential for an adequate treatment. Radioactive iodine uptake can be useful to establish the etiologic diagnosis, but is contraindicated during lactation. Elevated titers of antithyrotropin receptor antibodies (TRAbs) are...

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ea0049ep1256 | Thyroid (non-cancer) | ECE2017

Clinical characteristics of painless thyroiditis

Kim Yonghyun , Choi Jeonga , Shin Donghyun

Background: There are a lot of painless thyroiditis cases without symptoms diagnosed on health check up or thyroid hormone screening, but there is a few data about it compared to much data about painful subacute thyroiditis. So, we collected data about diagnostic routes, laboratory and clinical characteristics of painless thyroiditis.Method: Painless thyroiditis patients diagnosed between 2010 and 2016 were reviewed. We defined painless thyroiditis as di...

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ea0049ep1257 | Thyroid (non-cancer) | ECE2017

The effectiveness of parathyroidectomy in children with primary hyperparathyroidism

Rikhsieva Nazira

Objective: To Evaluate the effectiveness of parathyroidectomy in children with primary hyperparathyroidism.Materials and methods: Under our observation in the period 20142015, were 46 patients with primary hyperparathyroidism at the age of 1116 years. To assess the effectiveness of parathyroidectomy a questionnaire was used and table PAS (Parathyreoidectomy Assessment of symptoms- table of symptoms in primary hyperparathyroidism to assess the...

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ea0049ep1258 | Thyroid (non-cancer) | ECE2017

Fluctuating thyroid hormones in Graves disease: a case series of brittle Graves

Cuneyt Bilginer Muhammet , Faki Sevgul , Aydin Cevdet , Ozdemir Didem , Ali Tam Abbas , Ersoy Reyhan , Cakir Bekir

Introduction: Brittle hypertyroidism is a term used for the clinical situation characterized by hypo-hyperthyroidism with antithyroid drugs, despite good compliance and follow-up. Here, we presented five patients suggested to have Brittle Graves.Case-1: Thyrotoxicosis was observed in a 57-year-old female patient and Graves was diagnosed after laboratory and imaging examinations 25 months after initiation of propylthiouracil 50 mg/day, she developed hypot...

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ea0049ep1259 | Thyroid (non-cancer) | ECE2017

The role of an ultra-sensitive fourth-generation TSH assay in the management of subclinical hyperthyroidism

Austin Emily , Peacey Steve , Bates Andrew

: The management of endogenous subclinical hyperthyroidism is largely guided by perceived risk, including the presence of cardiovascular disease, atrial fibrillation or osteoporosis. We have utilised a fourth-generation TSH assay, providing a 10-fold increase in sensitivity compared to third-generation assays, to determine whether patients with subclinical hyperthyroidism can be differentiated from those with overt hyperthyroidism, based on their now measurable TSH levels. Two...

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ea0049ep1260 | Thyroid (non-cancer) | ECE2017

Non-thyroidal illness syndrome in chronic renal failure and oxidative stress: preliminary data on triiodothyronine relationships with extracellular superoxide-dismutase

Mancini Antonio , Panocchia Nicola , Martino Giuseppe , Bruno Carmine , Silvestri Sonia , Orlando Patrick , Marcheggiani Fabio , Tazza Luigi , Tiano Luca , Gambaro Giovanni , Pontecorvi Alfredo

: Non-thyroidal-illness syndrome (NTIS) is present in chronic renal failure and considered an adaptive mechanism. However oxidative stress is linked to NTIS in a vicious circle, due to deiodinases alteration and negative effect on antioxidant levels or activity. One key antioxidant, protective toward ROS-mediated tissue damage, is extracellular superoxide-dismutase (ec-SOD), present in extracellular matrix and with a role in mediating nitric oxide-induced signaling. ec-SOD is ...

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ea0049ep1261 | Thyroid (non-cancer) | ECE2017

Therapeutic options in severe thyrotoxicosis with malabsorption

Stojkovic Mirjana , Savic Slavica , Nedeljkovic-Beleslin Biljana , Ciric Jasmina , Nisic Tanja , Zarkovic Milos

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohns disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

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ea0049ep1262 | Thyroid (non-cancer) | ECE2017

Congenital disorders in children of the mothers with thyroid malfunctioning at pregnancy

Akbar Saba , Mansoor Rubina , Irfan Muhammad

: In the present study we hypothesized that maternal thyroid disorders may be associated with maternal and foetal morbidity and mortality. The present study included 136 pregnant women selected randomly in first trimester and observed throughout the pregnancy till birth. The assessment of thyroid hormones showed a total of 33.08% (n=45) pregnant ladies were having thyroid disorders; 17.65% (n=24) with hypothyroidism and 15.44% (n=21) with hyperthyroi...

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ea0049ep1263 | Thyroid (non-cancer) | ECE2017

Psychometric evaluation of the newly developed hypoparathyroidism symptom diary

Coles Theresa , Chen Kristina , Nelson Lauren , Harris Nimanee I , Vera-Llonch Montserrat , Martin Susan

Objective: The purpose of this study was to evaluate the psychometric properties of a novel, patient-reported outcome (PRO) measure, the Hypoparathyroidism (HPT) Symptom Diary (HPT-SD), using data collected during a cross-sectional, noninterventional, observational study. The HPT-SD, developed according to the US Food and Drug Administration PRO guidance, addresses the severity of key symptoms (muscle cramping, tingling and muscle spasms/twitching, fatigue, cognition, emotions...

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ea0049ep1264 | Thyroid (non-cancer) | ECE2017

Early diagnosis of primary biliary cirrhosis during follow-up for Graves’ disease

Faki Sevgul , Bilginer Muhammet Cuneyt , Aydin Cevdet , Ozdemir Didem , Baser Husniye , Ersoy Osman , Ersoy Reyhan , Cakir Bekir

Introduction: Hepatic dysfunction in hyperthyroidism may occur due to high thyroid hormones, medications or associated autoimmune liver disease. Autoimmune hepatitis or primary biliary cirrhosis (PBC) has rarely been reported in Graves disease. We report a patient presenting with pruritus and diagnosed as accompanying PBC and Graves disease.Case: A 50 years old female patient applied with progressive pruritus for at least 4 months. Laboratory...

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ea0049ep1265 | Thyroid (non-cancer) | ECE2017

Survey on the management of hypothyroidism during pregnancy by general practitioners, endocrinologists and obstetricians in Australia and New Zealand

Dravec Danijela , Champion Bernard , Wall Jack , Hibbert Emily

Background: Optimal management of hypothyroidism prior to and after conception is associated with improved pregnancy outcomes. Compliance with existing management guidelines in Australia and New Zealand is unknown.Methods: A validated electronic survey was distributed to endocrinologists, obstetricians and general practitioners via their specialty professional bodies and results were analysed.Results: There were 394 survey responde...

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ea0049ep1266 | Thyroid (non-cancer) | ECE2017

Analysis of cardiovascular changes in Graves disease and their dynamic during the treatment

Frolova Arina , Rodionova Tatiana , Orlova Marina , Chuvashova Marina

Objectives: Estimate the prevalence of of cardiovascular symptoms, to identify the main changes in echocardiography at Graves disease (GD) and their dynamic during treatment.Methods: Investigated 86 patients with GD. The functional class (FC) chronic heart failure (CHF) was determined according to the New York Heart Association (NYHA). All patients underwent echocardiography before treatment and after 3 months of euthyroid state.Re...

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ea0049ep1267 | Thyroid (non-cancer) | ECE2017

Prevalence of the thyroiditis in childbearing age women

Amani Mohammed El Amine , Chentli Farida

Background and aims: It has been demonstrated that the thyroid autoimmunity, during pregnancy, adversely affects the course of the pregnancy. The anomalies may be prior to the conception, hence the interest of studying the women during the genital activity period. Our objective was to determine the prevalence of the thyroiditis in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical exam...

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ea0049ep1268 | Thyroid (non-cancer) | ECE2017

Prevalence and etiology of the hypothyroidy in childbearing age women

Amani Mohammed El Amine , Chentli Farida

Background and aims: The hypothyroidism may be prior to the conception, hence the interest of studying women during the genital activity period. Our objective was to determine the prevalence and the etiologies of the hypothyroidism in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical examination, urinary iodine, thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid antib...

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ea0049ep1269 | Thyroid (non-cancer) | ECE2017

Effectiveness of radioiodine treatment for autonomous toxic node

Osorio Ana Sofia , Martins Ana Filipa , Gomes Vania , de Castro Raquel Vaz , Nobre Ema , Ferreira Mickael Antoine , Cantinho Guilhermina , Bugalho Maria Joao

Objective: The aim of this study was to evaluate the treatment outcomes in patients with autonomous toxic nodule (ATN) that received a radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size and iodine activity.Methods: We performed a retrospective study of all RAIT done for hyperthyroidism (n=149) in our hospital during 2014 and 2015. Patients with ATN submitted to RAIT were selected to analysis. We studied 58 pa...

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ea0049ep1270 | Thyroid (non-cancer) | ECE2017

Endemic goiter in Xinjiang, Northwestern China

Izumi Yoichi , Kasamaki Yuji , Ozawa Yukio , Kawamura Hirosi

Background: Endemic goiter occurs frequently in iodine deficient areas. Our past medical survey revealed that goiter was endemic in Xinjiang, Northwestern China, because, several elderly Uygur subjects had goiter. In the present study, several medical parameters were compared between subjects with and those without goiter.Methods: Elderly Uygur (age, 6570 years n=99) and very old Uygur subjects (age, >90 years n=111) were hosp...

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ea0049ep1271 | Thyroid (non-cancer) | ECE2017

How does overt and subclinical hypothyroidism due to thyroiditis of Hashimoto affect lipid parameters

Tosheva Gergana , Siderova Mira , Hristozov Kiril , Bocheva Yana , Kostova Mila

Aim: The aim of this retrospective study is to assess the lipid disturbances in patients with autoimmune thyroiditis.Methods: 1380 patients with autoimmune thyroiditis, hospitalized in Endocrinology department of St. Marina Hospital, Varna for the period of 20042015 year, participated in the study. After excluding conditions influencing lipid profile, 771 patients remained for analysis (36 men and 735 women, mean age 49.81±13.98 ye...

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ea0049ep1272 | Thyroid (non-cancer) | ECE2017

Primary hypothyreosis in cobalt intoxication

Langova Dagmar

Most common causes of primary hypothyreosis are destruction of thyroidal parenchyma by the autoimmune antibodies, interventions on the gland (surgery, radioiodine treatment) and external actinotherapy (hematologic and ENT malignancies). Drug induced thyroidal impairment is well-known too (amiodarone, lithium, interferon). Our case demostrates the primary hypothyreosis caused by cobalt. The source was Co-Cr hip prostehis after its rupture (PHACT). A 55 old man was reffered to e...

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ea0049ep1273 | Thyroid (non-cancer) | ECE2017

Evaluation of circulating irisin levels in patients with never treated overt hyperthyrodisim

Gokcay Canpolat Asena , Sahin Mustafa , Corapcioglu Demet , Emral Rıfat , Rıza Uysal Ali

Aims: Because of an increased metabolic activity and thermogenesis in hyperthyroidism, we aimed to evaluate the association of serum irisin with thyroid hormones.Methods: A total of 25 hyperthyroid patients and 24 age- and gender-matched healthy controls were enrolled. Serum irisin levels, thyroid hormones and body compositions were analyzed.Results: Serum irisin levels were significantly higher in hyperthyroid group (P&#6...

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ea0049ep1274 | Thyroid (non-cancer) | ECE2017

Is there a correlation between serum selenium level and the severity of Graves’ orbitopathy?

Palyga Iwona , Gasior-Perczak Danuta , Gadawska-Juszczyk Klaudia , Mikina Estera , Piwowar Monika , Szymonek Monika , Trybek Tomasz , Walczyk Agnieszka , Mezyk Ryszard , Majewska Urszula , Kowalska Aldona

Introduction: Selenium (Se) deficiency is a known risk factor for autoimmune thyroid diseases including Graves orbitopathy (GO).Objective: To determine the concentration of Se in serum and to determine the dependency of Se concentration on known markers of disease severity: the TRAB levels and the CAS (clinical activity score) in patients with GO.Material: 64 patients (50 women, 14 men; average age- 54.5 years) with active, m...

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ea0049ep1275 | Thyroid (non-cancer) | ECE2017

Nicotinamide phosphoribosyltransferase expression in thyroid glands of patients with Graves’ disease

Sawicka-Gutaj Nadia , Andrusiewicz Miroslaw , Czarnywojtek Agata , Waligorska-Stachura Joanna , Biczysko Maciej , Skrobisz Jerzy , Sowinski Jerzy , Ruchala Marek

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent th...

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ea0049ep1276 | Thyroid (non-cancer) | ECE2017

Associations between thyroid and kidney functions

Zabuliene Lina , Petraviciute Modesta , Pauliukiene Birute , Urboniene Jurgita

: Two-way interactions between thyroid and kidney functions are known. Chronic kidney disease (CKD) is accompanied by changes in synthesis, secretion, metabolism, and elimination of thyroid hormones, increased risk of hypothyroidism, rarely subclinical hyperthyroidism, whereas thyroid dysfunction affects physiology of the kidney, renal blood flow, glomerular filtration rate (GFR), tubular function, metabolism of water and electrolytes, and kidney structure. The aim of the stud...

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ea0049ep1277 | Thyroid (non-cancer) | ECE2017

Hypothyroidism – once a week treatment option in young- and middle-aged adults

Chander Wasoori Satish , Naik Manoj , Pande Deepak G , Bhardwaj Chetan

Objective: To evaluate the effectiveness and compliance to L-thyroxine in the treatment of Hypothyroidism in a weekly dose of 7 times of normal dose as an alternative to daily dosing in young and middle aged adults.Methods: A randomized prospective observational study on 180 patients (female:male) ratio of 5:1 aged between 18 and 55 years with an established diagnosis of Hypothyroidism were assigned a weekly dose of seven times of normal dose. The patien...

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ea0049ep1278 | Thyroid (non-cancer) | ECE2017

Effect of subclinical hypothyroidism and autoimmunity on adverse pregnancy and neonatal outcome in our population

Lopez-Tinoco Cristina , Sanchez-Lechuga Begona , Lara Almudena , Barcala Julia , Larran Laura , Medina Daniel , Aguilar-Diosdado Manuel

The effect of subclinical hypothyroidism (SH) and thyroid autoimmunity on adverse pregnancy and neonatal outcome, are still subject of interest and controversy. Nowadays, guidelines recommend establishing reference values of local thyroid hormones that allow definition of the SH in a specific population. The objective of this study was to assess the effect of SH and autoimmunity in early pregnancy on adverse pregnancy and neonatal outcome in our population. The reference range...

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ea0049ep1279 | Thyroid (non-cancer) | ECE2017

Metastatic differentiated thyroid carcinoma: cumulative doses of adjunct 131i-iodide therapy

Gouveia Patricia , Pereira Teresa , Amado Ana , Teixeira Ricardo , Costa Antonio , Carvalho Andre , Freitas Claudia , Borges Fatima

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

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ea0049ep1280 | Thyroid (non-cancer) | ECE2017

Autoimmune thyroid disease may affect prognosis of breast cancer

Yalcin Selim , Cosar Ramazan , Cifci Aydin , Gungunes Askin , Durmaz Senay Arikan

Aim and objective: The aims of this study were to determine the incidence of breast cancer molecular subgroups, to investigate the relationship between autoimmune thyroid disease and prognostic and predictive factors in patients who were diagnosed with breast cancer.Materials and methods: One hundred one patients who were followed up with the diagnosis of breast cancer at our Endocrinology and Medical Oncology Departments were included. Patients are divi...

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ea0049ep1281 | Thyroid (non-cancer) | ECE2017

Subacute Thyroiditis with an atypical clinical course and thyroid ^99mTc uptake

Sema Deniz , Celikmen Maktav , Ozdemir Ali

Background: Subacute thyroiditis (SAT) is a transient inflammatory, probably viral disease of the thyroid gland. It is clinically characterized by pain, fever, increased erythyrocyte sedimentation rate (ESR) or other markers of inflammation, transient thyrotoxicosis, and has a tendency to recur. In most cases, in addition to the clinical features, scintigraphy and ultrasound may support the diagnosis of SAT. However, in the present case, SAT with an atypical thyroid 99m</...

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ea0049ep1282 | Thyroid (non-cancer) | ECE2017

Weak numeracy is common problem in patients with thyroid diseases

Wawak Ewa , Basinski Pawel , Gasiorek Malgorzata , Marczewski Krzysztof

Introduction: In modern medicine, we expect from patients numeracy skills. Starting with the correct dosage of drugs up to understand the principles of risk assessment of alternative treatments. These skills, however, are probably rarely checked. Just as the skills of reading, where we entrust signature read and understood. That is why we want to introduce our observation.Method: Subsequent patient, outpatient endocrinological clinic, we have...

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ea0049ep1283 | Thyroid (non-cancer) | ECE2017

A case of levothyroxine tablet malabsorption associated with gastric neuroendocrine tumour corrected with gel capsule formulation

Boskovic Olivera , Lazovic Ranko , Smolovic Brigita , Hasanbegovic Mirha

Multiple dose adjustments can sometimes be inefficient in reaching eumetabolic state in patients with hypothyroidism treated by levothyroxine sodium tablets. We report a case of 44-year-old female who has been on levothyroxine sodium tablet replacement therapy since 2004 without ever reaching eumetabolic state, presented as outpatient one year ago. As sellar MRI ruled out pituitary adenoma, investigation targeting malabsorption was initiated. Antibodies to gliadin and transglu...

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ea0049ep1284 | Thyroid (non-cancer) | ECE2017

Percutaneous ablation of benign thyroid nodules: specific simulators for practicing enolization and laser procedures

Jimenez Teresa , Vidal-Rios Pablo , Rodriguez Antonio , Villas Laura , Vidal-Rios Sebastian

Ethanol and laser ablation of benign thyroid nodules is bursting rapidly in clinical practice because of its efficacy, safety and economy. However, these techniques require some manual operator training. In order to facilitate this hands-on training, we propose two homemade, cheap and specific simulators to practice these clinical procedures.Material and methodsTwo models were optimized: Gel-Phantom Coruna VR16 (gelatine a...

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ea0049ep1285 | Thyroid (non-cancer) | ECE2017

Improved diagnostics with increased treatment of hypothyroidism during pregnancy – a 10 year study of Finnish pregnant women

Turunen Suvi , Mannisto Tuija , Hartikainen Anna-Liisa , Gissler Mika , Lahesmaa-Korpinen Anna-Maria , Vaarasmaki Marja , Suvanto Eila

Thyroid diseases affect up to 4% of all pregnancies. Several evidence-based recommendations have been created to observe and treat thyroid diseases in pregnant women. We studied whether the diagnostics and treatment of hypothyroidism among pregnant women have improved in the course of time. Data consisted of all singleton pregnancies (N=571785) during 20042013 in Finland, collected from the Finnish Medical Birth Register (MBR). Data on maternal thyroid diseases ...

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ea0049ep1286 | Thyroid (non-cancer) | ECE2017

Radiofrequency ablation for benign thyroid nodules: 450 patients - three years follow-up

Solovov Viacheslav , Makhonin Aleksandr , Vozdvizhenskiy Mikhail , Orlov Andrew

Purpose: The objective of this study was to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating of benign thyroid nodules.Material and methods: The retrospective analysis included the results of treatment of 450 patients with benign tumors of the thyroid gland in the Samara Oncology Center. 91 (20.2%) patients had autonomously functioning thyroid nodules and 359 (79.8%) had symptomatic ones. The mean volu...

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ea0049ep1287 | Thyroid (non-cancer) | ECE2017

Coexistence of Graves’ disease and unilateral benign struma ovarii: A case report

Marquez-Pardo Rosa , Garcia-Garcia-Doncel Lourdes , Baena-Nieto Mgloria , Cayon-Blanco Manuel , Lopez-Velasco Rosario , Torres-Barea Isabel

Introduction: Struma ovarii (SO) is a rare ovarian teratoma composed predominantly (more than 50%) or entirely of thyroid tissue. It constitutes 2% to 4% of ovarian teratomas. This tumor is often asymptomatic and discovered incidentally. Only 8% of patients present clinical hyperthyroidism.Case report: A 42-year-old woman presented palpitations, anxiety, sweating, emotional lability and weight loss for several months. Physical examination revealed goitre...

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ea0049ep1288 | Thyroid (non-cancer) | ECE2017

Clinical characteristics and outcomes of patients with myxedema coma: a 15-years experience of a tertiary care center in Thailand

Pitchaiprasert Suwanna , Buranasupkajorn Patinut , Suwanwalaikorn Sompongse , Sunthornyothin Sarat , Khovidhunkit Weerapan , Snabboon Thiti

Background: Myxedema coma is an uncommon but life-threatening condition of severe and decompensated hypothyroidism requiring early recognition and prompt treatment. The aim of this study is to describe the clinical features and identify factors associated with mortality of our patients diagnosed myxedema coma over the past 15 years.Materials and methods: Retrospective chart review of patients diagnosed and treated at King Chulalongkorn Memorial Hospital ...

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ea0049ep1289 | Thyroid (non-cancer) | ECE2017

Evaluation of interrelationships between thyroid function, autoimmunity, insulin resistance and lipid profile in Graves’ disease

Carujo Antonio , Neves Celestino , Sergio Neves Joao , Castro Oliveira Sofia , Sokhatska Oksana , Esteves Cesar , Pereira Miguel , Luis Medina Jose , Delgado Luis , Carvalho Davide

Background: Thyroid hormones modulate the lipoprotein and glucose metabolisms. In hyperthyroidism, insulin resistance is a frequent finding.Aim: To assess interrelationships between thyroid function, autoimmunity, lipid profile, glucose metabolism and other cardiovascular risk factors in patients with Graves disease.Methods: We recorded free T3 (FT3), free T4 (FT4), TSH, TSH receptor antibodies (TRAB), parameters of the lipid...

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ea0049ep1290 | Thyroid (non-cancer) | ECE2017

Successful radioiodine treatment of Graves disease for a patient with a history of «iodide allergy»

Cheikhrouhou Nesrine , Elbez Intidhar , Limem Kaouthar , Mhiri Aida , Ltaeif Bechir , Ben Slimene Faouzi

Introduction: Gravess disease is the most common cause of hyperthyroidism. There are three current therapeutic options: anti-thyroid medication, surgery, and radioactive iodine (I 131). There are few data in the literature regarding the effects of radioiodine therapy.Case report: We describe a 47-year-old patient who had Graves disease resistant to anti thyroid medication. Radioactive iodine was indicated. The patient was reluctant because sh...

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ea0049ep1291 | Thyroid (non-cancer) | ECE2017

Trans-axillary endoscopic thyroidectomy – technique

Vilaca Jaime , Graca Susana , Mendes Paula

Introduction: Trans-axillary surgery is an emerging technique for cervical approach with fantastic cosmetic result. With more than 50 cases treated by our group, we developed our technique with specific safe methodologies.Aims: To present step-by-step technique of trans-axillary endoscopic thyroidectomy.Material and methods: This is a video surgery that uses three trocars and a harmonic scalpel for dissection and ligation. Incision...

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ea0049ep1292 | Thyroid (non-cancer) | ECE2017

Trans-axillary endoscopic thyroidectomy – scarless surgery of the neck: our experience

Vilaca Jaime , Graca Susana , Mendes Paula

Introduction: Endoscopic techniques are uprising in the cervical field mainly because of the exceptional cosmetic results. These surgeries are frequent in the far east Asia but still rare in Europe. We started these approach on November 2014. This paper is a review of our experience.Aims: To present a series of trans-axillary endoscopic thyroidectomy.Material and methods: This is a cohort study of 50 consecutive patients treated by...

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ea0049ep1293 | Thyroid (non-cancer) | ECE2017

TSH oscillations in young patients with type 1 diabetes may be due to glycemic variability

Bellastella Giuseppe , Casciano Ofelia , Scappaticcio Lorenzo , Giugliano Dario , Ida Maiorino Maria , Esposito Katherine

: A link between thyroid dysfunction and diabetes mellitus exist. Uncertainties on the role of glycemic variability on thyroid hormones and TSH concentrations still persist. We want to evaluate the influence of glycemic variability on thyroid hormones and TSH concentrations in patients with type 1 diabetes (T1DM). 77 patients with T1DM on insulin therapy without thyroid dysfunction and 100 healthy controls were evaluated for basal glucose concentrations, HbA1c, thyroid hormone...

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ea0049ep1294 | Thyroid (non-cancer) | ECE2017

May erythrovirus (parvovirus) B19 trigger autoimmune thyroid diseases?

Ucgun Serdar , Onbasi Kevser , Kasifoglu Nilgun

: Erythrovirus (EVB19) can recognize auto-antigens by using molecular mimicry mechanisms. EVB 19 is accused in the pathogenesis of many autoimmune diseases. Especially EVB19 is very important in the pathogenesis of autoimmune thyroid diseases. Thus in some case presentations; it was shown that EVB19 might be related with Hashimotos thyroiditis. Although etiopathogenesis of Graves disease and Hashimotos thyroiditis is not known exactly; they are thought to occ...

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ea0049ep1295 | Thyroid (non-cancer) | ECE2017

Treatment of toxic multinodular goiter with 131 radioactive iodine – effects in volume reduction, thyroid function and autoimmunity

Roque Catarina , Sousa Santos Francisco , Pilli Tania , Pacini Furio

Abstract: Radioiodine is a definite treatment option for toxic goiter. We have evaluated volume reduction, function and autoimmunity outcomes with a 15 mCi fixed regimen. Patients with at least one US evaluation before and after Iodine-131 therapy and with at least one year of follow-up were included. TSH, free-T4, antibodies and goiter volume before and yearly after Iodine-131 treatment were analysed for the length of the entire follow-up. The total 151 patients, 72.6% female...

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ea0049ep1296 | Thyroid (non-cancer) | ECE2017

Four out of five patients with acute kidney injury have thyroid dysfunction

Choulia Manpreet , Das Jasmine , Ghosh Maria , Jacob Jubbin

Objectives: This study was undertaken to ascertain the prevalence of thyroid dysfunction(TD) in patients with Acute Kidney Injury(AKI) and assess the prognostic implications of TD in AKI patients.Materials and methods: Consecutive adult patients (>18 years) admitted with AKI to the departments of Nephrology & Medicine were recruited if they met AKIN classification criteria for AKI after 48 h of admission (1). Patients were screened for thyroid dy...

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ea0049ep1297 | Thyroid (non-cancer) | ECE2017

The assessment of influence vitamin D deficiency on the Hashimoto’s thyroiditis activity

Lizis-Kolus Katarzyna , Hubalewska-Dydejczyk Alicja , Sowa-Staszczak Anna , Skalniak Anna , Kowalska Aldona , Lizis Pawel

: The observed increase in the incidence of Hashimotos thyroiditis (HT) requires research on factors that may affect its development. One of them may be vitamin D deficiency which is an epidemiological problem all over the world.Aim: The assessment of influence vitamin D deficiency on the HT activity.Material and methods: 310 people were enrolled in the study: 155 patients with HT (a-TPO and/or a-TG positivity)-144 women (93%...

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ea0049ep1298 | Thyroid (non-cancer) | ECE2017

The role of 99mTc-sestamibi in amiodarone-induced thyrotoxicosis – Case report

Victor Margarida , Ferreira Ana Goncalves , Carmona Susana , Luiz Henrique Vara , Cordeiro Maria Carlos , Portugal Jorge , Santos Ana Isabel

Introduction: Amiodarone is an antiarrhythmic iodine-rich drug, known to induce thyroid dysfunction both due to its high iodine content and through amiodarone-induced thyrotoxicosis (AIT), being this latter process classified into three different types. Type 1 is associated with increased thyroid hormone synthesis; type 2 is a destructive process with thyroid hormone release and type 3 is thought to be a mixture of the former two. Since treatment options are different, there h...

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ea0049ep1299 | Thyroid (non-cancer) | ECE2017

Effect of vitamin D supplementation on patients with Graves disease

Maher Maram , Sheriba Nermin , Elewa Abeer , Eldin Ahmed Mohamed Bahaa , Ibrahim Nesma Ali , Marawan Dina

Multiple factors contribute to the etiology of Graves disease(GD), including genetic and environmental factors.vitamin D is well known in calcium metabolism and has also been shown to be a modulator in innate and adaptive immunity. There is a well-established link between vitamin D deficiency and various autoimmune diseases. The prevalence of vitamin D deficiency was reported to be common in patients with GD. Whether vitamin D deficiency has a causal relationship with GD remai...

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ea0049ep1300 | Thyroid (non-cancer) | ECE2017

Primary hyperparathyroidism coexisting with Graves’ disease in a patient with vitamin D deficiency

Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia , Pantazi Eleni

Primary hyperparathyroidism is known to coexist with thyroid cancer and breast cancer. However, primary hyperparathyroidism coexisting with Graves disease is extremely rare. The aim was to describe the case of a patient with Graves disease causing severe hyperthyroidism who in the course of the disease developed vitamin D deficiency and primary hyperparathyroidism. A patient, female, aged 49 years, presented with severe hyperthyroidism causing tachycardia, palpitat...

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ea0049ep1301 | Thyroid (non-cancer) | ECE2017

Primary underdosed hypothyroidism – parodontal implications in adults

Circo Razvan , Ibadula Seila , Circo Eduard

Introduction: Dento-maxillary system changes associated to thyroid disorders are constantly present. Differentiated impairment, depending on the period of evolution of the disease, explains the high percentage of over 60% of cases with parodonthopathy.Aim of the study: Evaluating the oro-maxillo-facial changes in patients with underdose treated hypothyroidism.Methods: The study group comprised 154 patients with hypothyroidism, 132 ...

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ea0049ep1302 | Thyroid (non-cancer) | ECE2017

Assessment of the degree of depression in patients with chronic autoimmune thyroiditis depending on the serum autoantibodies and thyroid hormone levels

Ibadula Seila , Scinic Olesea , Circo Eduard

Introduction: The incidence of depressive type psychoaffective disorders is significantly increased in patients with chronic autoimmune thyroiditis.Objectives: The study of thyroid autoimmunity correlated with serum levels of TSH, FT4 and depression degree.Methods: The study comprised 70 patients (64 women and 6 men), aged between 18 and 66 years, divided in 4 groups. All study groups were analyzed according to the degree of depres...

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ea0049ep1303 | Thyroid (non-cancer) | ECE2017

Frequency and prognostic factors of non-diagnostic cytology in ultrasound guided thyroid fine needle aspiration biopsy: a 2-year single centre experience

Chambidis Vasileios , Siolos Athanasios , Efstathiadou Zoe , Sykja Albana , Georgiou Thomas , Chambidou Eleni , Panagiotou Athanasios , Adamidou Fotini , Kita Marina

Aim: Ultrasound-guided Fine Needle Aspiration Biopsy (USg-FNAB) is the most accurate modality for distinguishing malignant or possibly malignant from benign thyroid nodules. However, a certain amount of specimens turn out to be non-diagnostic or inadequate. Several factors contribute to this outcome such as the examiners experience, characteristics of the nodule and patients compliance. Understanding these factors could contribute to reduction of non-diagnostic res...

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ea0049ep1304 | Thyroid (non-cancer) | ECE2017

Juvenile hypothyroidism-particularities in the development of the dento-maxilary system

Circo Razvan , Ibadula Seila , Circo Eduard

Introduction: Juvenile hypothyiroidism shows various complications depending on the correctitude of substitutive treatment.Aims of the study: To identify the massive facial changes with occlusive disorders, dental malpositions, altered chronology of dental eruption, periodontal changes in terms of absence of thyroid replacement therapy or drug sub-dosing.Methods: The study group comprised 24 children, 15 girls and 8 boys; 4 cases o...

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ea0049ep1305 | Thyroid (non-cancer) | ECE2017

Thyrotoxic periodic paralysis

Kaya Ahmet , Kulaksizoglu Mustafa

Thyrotoxic periodic paralysis (TPP) is due to a fall in potassium levels and threat life if it effects respiratory muscles. Men are more effected than women, and lower extremeties are more prone to involvement. Serum potassium in hyperthroidism is usually normal, but Na+/K+ ATPase sensitivity is increased and extracellular potassium rapidly passes to the intracellular space. Beta blockers, small dose potassium replacement and hyperthyroidism treatme...

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ea0049ep1306 | Thyroid (non-cancer) | ECE2017

Audit of utility of radio-isotope scan in the investigation of thyrotoxicosis or subclinical hyperthyroidism and timing of anti-thyroid medication

Artham Satish , MacFarlane Heather , Ali Nishwa , James Andy

Thyrotoxicosis is one of the most common clinical problems in patients referred to endocrine clinic. TRAb is specific for graves disease (GD) and radioisotope scan (RIS) is useful diagnostic test in the investigation of thyrotoxicosis. RIS is commonly used when TRAb is borderline or negative to exclude thyroiditis.Aims and methods: To look at the use of RIS in the investigation of thyrotoxicosis and sub-clinical hyperthyroidism (SCH), and use of anti-thy...

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ea0049ep1307 | Thyroid (non-cancer) | ECE2017

Thyroid autoimmunity and frequency of malignant or suspicious for malignancy thyroid nodule cytology

Siolos Athanasios , Chambidis Vasileios , Efstathiadou Zoe , Georgiou Thomas , Panagiotou Athanasios , Adamidou Fotini , Kita Marina

Introduction: Thyroid autoimmunity has been associated with the diagnosis of differentiated thyroid (DTC) cancer in surgical series. However, this finding has not been consistent in Fine Needle Aspiration Biopsy (FNAB) cytology series.Aim: We aimed to investigate the association between thyroid autoimmunity and DTC in patients who underwent ultrasound-guided FNAB.Methods: A retrospective analysis of patients who had undergone ultra...

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ea0049ep1308 | Thyroid (non-cancer) | ECE2017

Clinical experience with glucocorticoid therapy in patients with endocrine ophthalmopathy

Bourko Irina , Korolenko Halina , Bourko Olga , Dudich Oksana , Krasilnikova Viktoria

Objective: To evaluate the efficacy, safety and to determine the criteria for the glucocorticoid therapy scheme: intravenous pulse therapy followed by tablet form in prolonged regime in the treatment of active phase of endocrine ophthalmopathy (EOP).Materials and methods: 28 patients of both sexes (52 eyes) with endocrine ophthalmopathy in the active phase were included in the study. The average age 43.4±10.6 years. The duration of the diseas...

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ea0049ep1309 | Thyroid (non-cancer) | ECE2017

Thyroid storm presenting in the context of recent influenza vaccination and untreated Graves disease

Kelly Neil , Sharma Dushyant , Zaidi Reza

Introduction: Thyroid Storm is a life-threatening but rare (incidence 0.2 per 100 000) disease state which presents as an extreme form of thyrotoxicosis. A hyper-metabolic state resulting from excessive thyroid hormone release which can be precipitated by both thyroidal and non-thyroidal illness.Case: In this case we discuss a 72 year old female with previously treated Graves disease who presented in thyroid storm one week after annual flu vaccination. O...

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ea0049ep1310 | Thyroid (non-cancer) | ECE2017

Relapsing Graves’ hyperthyroidism in a male patient with central hypothyroidism after surgery of craniopharyngioma: case report

Bumbu Anisoara , Abouleka Yawa , Potier Louis , Roussel Ronan , Marre Michel

Introduction: Graves disease is an autoimmune thyroiditis, less common in men but with relapse of hyperthyroidism significantly more frequent in men than in women after anti-thyroid medications withdrawal. Craniopharyngioma is a rare brain tumor which arises in the pituitary stalk and project into the hypothalamus. The distribution by age is bimodal with a slight male predominance and a poor survival rate for older than 65 years. The association of these pathologie...

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ea0049ep1311 | Thyroid (non-cancer) | ECE2017

TSH normalization and negative anti-TSH receptor antibodies – Predictive value for remission in Graves’ disease

Roque Catarina , Santos Francisco Sousa , Capitao Ricardo , Bello Carlos , Ferrinho Catia , Vasconcelos Carlos

Graves disease is the most common cause of hyperthyroidism in non-endemic areas and antithyroid drugs are the preferred first-line therapy in many centers. The aim of this retrospective investigation was to verify the association of remission with the achievement of normal TSH and free-T4 during the first 18 months of treatment and to compare it with negative anti-TSH-receptor antibodies at 18 months, a marker with known prognostic value. All patients diagnosed with Grav...

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ea0049ep1312 | Thyroid (non-cancer) | ECE2017

Treatment choice and patient satisfaction in thyrotoxicosis

Conaglen Helen , Tamatea Jade , Swarbrick Mark , Conaglen John , Elston Marianne

Background: Thyrotoxicosis may be associated with considerable patient morbidity. Graves disease (GD) and toxic multinodular goitre (TMNG) are the most common causes of thyrotoxicosis. Therapeutic options include anti-thyroid medication or definitive treatment by radioiodine or surgery. Efficacy, quality of life and cost-effectiveness are among the outcomes that have been compared between these two therapies. However, there is still no clear consensus as to which treatme...

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ea0049ep1313 | Thyroid (non-cancer) | ECE2017

Management of relapsing Graves: a clinical survey among endocrinologists in Israel

Koren Shlomit , Shteinshnaider Miriam , Or Karen , Cantrell Dror , Benbassat Carlos A , Koren Ronit

Background: The management of relapsing Graves disease is controversial. Previous surveys from different regions in the world demonstrated variations in the clinical practices of patients with Graves disease relapse.Methods: To determine management pattern among endocrinologists in Israel an electronic questionnaire was e-mailed to all members of the Israeli Endocrine Society. Questionnaires included demographic data and clinical scenarios wi...

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ea0049ep1314 | Thyroid (non-cancer) | ECE2017

Case report: identification and characterization of interference by IgM anti-streptavidin antibody in a patient with spurious thyroid function tests

Lam Leo , Bagg Warwick , Lim Julie , Middleditch Martin , Kyle Campbell

Introduction: Falsely high FT4 and FT3 with concurrent falsely low TSH have been reported in patients taking biotin and in a few case reports of patients with IgG anti-streptavidin antibody. However, other isotypes and effects on other immunoassays have not been reported.Case: A 77 year female presented with worsening fatigue with a background of hyperthyroidism on carbimazole. Clinically she appeared hypothyroid. Her results on Roche Cobas platform were...

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ea0049ep1315 | Thyroid (non-cancer) | ECE2017

Severe Grave’s dermopathy and acropachy discording with moderate ophtalmopathy: (a case report)

Bellarbi Dhiyaeddine , Youcef Hafsa Si , Fedala Noura Soumeya

Introduction: Pretibial Myxedema(PM) and acropachy(AP) are rare extrathyroidal manifestations of Graves disease observed only in 0.54% of all cases. These extrathyroidal manifestations are generally associated to severe ophtalmopathy. Only few cases of severe thyroid dermopathy and achropachy occurring with moderate ophtalmopathy were reported.Observation: We present a 60years old female patient who developed graves disease on a pre-exi...

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ea0049ep1316 | Thyroid (non-cancer) | ECE2017

The importance of the study of several immunoregulatory cytokines in the manifest hypothyroidism

Orlova Marina , Frolova Arina , Rodionova Tatiana , Badak Irina , Baitman Tatiana

The research goal was to study serum concentration of immunoregulatory cytokines (IL-1ß, IL-6ß, IL-8ß, IL-10ß) in 80 patients with manifest hypothyroidism at the age of 2150. 48 patients suffering from chronic autoimmune hypothyroidism and 32 patients with postoperative hypothyroidism were examined. It was revealed that autoimmune hypothyroidism effects balance disturbance of cytokine-producing activity Th1 and Th2 types, this plays an important role ...

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ea0049ep1317 | Thyroid (non-cancer) | ECE2017

The position of immunoglobuline G4 positive in Hashimoto’s thyroiditis

Cetin Zeynep , Can Bulent , Catak Merve , Baser Ozden Ozdemir , Berker Dilek , Guler Serdar

Aim: There are studies showing that Hashimotos thyroiditis (HT) progresses more rapidly, thyroid echogenicity is lower and thyroid autoantibodies are higher titer positive in immunoglobulin G4 (IGg4) positive patients.But a small number of studies that do not support this data have also been published.We planned this study to evaluate the findings of IgG4 (+) Hashimotos thyroiditis cases.Materials and methods: New diagnosis without treatment ...

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ea0049ep1318 | Thyroid (non-cancer) | ECE2017

TRAB positive thyroid dysfunction associated with Alemtuzumab treatment for MS: A case series

Garrahy Aoife , Ali Sulaiman , McQuaid Siobhan , Byrne Maria M

Alemtuzumab is a monoclonal antibody directed against CD52 licenced for the treatment of relapsing remitting multiple sclerosis (MS). Thyroid dysfunction occurs in one third of patients, likely secondary to lymphocyte reconstitution.Case 1: A 36 year old female, treated with alemtuzumab 15 months prior, presented to antenatal clinic at 12 weeks gestation with symptoms of thyrotoxicosis. fT4 was 83.7 pmol/l (RR 12-22), TSH suppressed, TRAB positive. She w...

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ea0049ep1319 | Thyroid (non-cancer) | ECE2017

Serum levels of insulin-like growth factor 1 in patients with hyperthyroidism or euthyroidism

Tseng Fen-Yu , Chen Yen-Ting , Chi Yu-Chao , Chen Pei-Lung , Yang Wei-Shiung

Background: Insulin-like growth factor 1 (IGF1) has molecular structure similar to insulin. As an important mediator of growth hormone, IGF-1 plays roles in growth of children and anabolic effects of adults. We evaluate serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism.Subjects and methods: In this study, 30 patients with hyperthyroidism (HY group) and 30 euthyroid individuals (EU group) were recruited. The patients of HY group were ...

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ea0049ep1320 | Thyroid (non-cancer) | ECE2017

Evaluation of oxidative stres by means of thiol-disulphide homeostasis in patients with euthyroid Hashimoto’s thyroiditis

Dirikoc Merve , Topaloglu Oya , Aydin Cevdet , Dirikoc Ahmet , Polat Sefika Burcak , Erel Ozcan , Ersoy Reyhan , Cakir Bekir

Aim: In this study we aimed to evaluate the oxidative stress via evaluating changes in dynamic thiol-disulphide status in euthyroid patients with Hashimotos thyroiditis (HT).Methods: Fifty euthyroid patients with HT and 50 healthy individuals were enrolled in this study. Thyroid function tests (free triiodothyronine (fT3), free thyroxine (fT4), thyrotropin (TSH)), acute phase reactants (C-reactive protein (CRP), high sensitive CRP (hs-CRP)) and thi...

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ea0049ep1321 | Thyroid (non-cancer) | ECE2017

Hashimoto Encephalopathy with polymorphic neuropsychiatric signs: a case report

Simoniene Diana , Klimaite Raimonda , Mikelaityte Greta , Danyte Evalda

Hashimoto encephalopathy (HE) is a rare and steroid responsive encephalopathy associated with autoimmune thyroiditis (1). Patients with Hashimoto encephalopathy may present with a variety of neuropsychiatric signs (2). 68-year old woman was admitted to the Neurology Department, of Hospital of Lithuanian University of Health Sciences, Kauno klinikos (HLUHS KK), due to disorder of consciousness of uncertain aetiology in August 2016. The signs of motor dysfunction, generalized ri...

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ea0049ep1322 | Thyroid (non-cancer) | ECE2017

Cardiothyreosis: prevalence and risk factors

Yazidi Meriem , Chihaoui Melika , Oueslati Hiba , Rejeb Ons , Ouali Sana , Rejaibi Salsabil , Chaker Fatma , Slimane Hedia

Background: Cardiothyreosis (CT) or thyrotoxic heart is associated with higher morbidity and mortality than the other forms of hyperthyroidism. Its risk factors have been investigated in a limited number of studies. The aim of our study was to identify risk factors of CT in patients with hyperthyroidism.Methods: We identified 538 patients with a hospital discharge diagnosis of hyperthyroidism from January 2000 to December 2015. Thirty five patients were ...

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ea0049ep1323 | Thyroid (non-cancer) | ECE2017

Takotsubo cardiomyopathy associated with thyrotoxicosis

Vitorino Helena , Costa Joana , Moleiro Filipa , Jesus Claudia , Afonso Ana , Monteiro Nadine , Santos Sofia , Comenda Eduarda , Cantante Helena

Background: Takotsubo cardiomyopathy is a rare, acute, nonischemic cardiomyopathy causing transient systolic disfunction of the apical and/or mid segments of left ventricle and is commonly associated with emotional and physical stress. Thyrotoxicosis is a rare cause of this condition, resulting from direct and indirect action of thyroid hormones on the cardiovascular system.Case presentation: A 43-year-old woman presented at emergency room with chest pai...

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ea0049ep1324 | Thyroid (non-cancer) | ECE2017

Therapeutic and evolutionary characteristics of subclinical hypothyroidism

Yazidi Meriem , Mezghani Imed , Chaker Fatma , Rejeb Ons , Chihaoui Melika , Slimane Hedia

Subclinical hypothyroidism (SCH) is a common disorder and indications of treatment are still being debated. The aim of our study was to describe the therapeutic and evolutionary characteristics of SCH.Methods: We undertook a longitudinal retrospective study in 110 patients with SCH biologically defined by increased serum thyroid-stimulating hormone (TSH) levels (>4 mIU/l) and normal FT4. Pregnancy, age less than 18 years, personal history of partial ...

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ea0049ep1325 | Thyroid (non-cancer) | ECE2017

The manner of performing the thyroid ultrasound examination and the reliability of assessment of the thyroid size in school-aged children

Zygmunt Arkadiusz , Adamczewski Zbigniew , Karbownik-Lewinska Malgorzata , Lewinski Andrzej

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

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ea0049ep1326 | Thyroid (non-cancer) | ECE2017

Which cytologic or architectural characteristics are associated with malignancy in AUS/FLUS cytologies according to subgroups?

Topaloglu Oya , Altinboga Aysegul , Cuhaci Fatma Neslihan , Aydin Cevdet , Baser Husniye , Yazicioglu Omer , Alkan Afra , Ersoy Reyhan , Cakir Bekir

Aim: Atypia/follicular lesion of undetermined significance(AUS/FLUS) is a category of thyroid cytology with features that are neither definitely benign or malignant. We aimed to determine whether specific cytologic or architectural features are associated with malignancy in AUS/FLUS category of Bethesda system according to subgroups.Methods: The specimens of patients who underwent surgery with preoperative thyroid fine neeedle aspiration (FNA) biopsies o...

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ea0049ep1327 | Thyroid (non-cancer) | ECE2017

Relationship between thyroid volume and baseline vitamin D levels in new-onset graves disease

Yalin Gulsah Y , Cenik Fuat , Celik Huseyin , Kumbasar Abdulbaki

Introduction: Serum 25(OH) vitamin D levels are shown to be significantly lower and associated with lower remission rates in Graves disease. In this study we aimed to investigate the impact of baseline vitamin D levels on thyroid volume in patients with new-onset Graves disease.Materials and methods: This is a monocenter cross sectional study with a total of 61 new-onset Graves disease patients (n:61, F: 40, M:21) who were divided into two groups accordi...

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ea0049ep1328 | Thyroid (non-cancer) | ECE2017

A novel mutation in thyroid hormone receptor-beta gene causing resitance to thyroid hormone in a tunisian female

Rejeb Ons , Chihaoui Melika , Yazidi Meriem , Oueslati Ibtissem , Chaker Fatma , Slimane Hedia

Introduction: The syndrome of resistance to thyroid hormone is a rare inherited disorder characterized by elevated circulating thyroid hormones, failure to suppress pituitary thyroid stimulating hormone (TSH) and variable tissue target hyposensitivity to thyroid hormone action. We reported the case of a RTH syndrome with a novel mutation.Case report: A 15-year-old girl was investigated for visual hallucinations and behavior disorders. Her medical history...

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ea0049ep1329 | Thyroid (non-cancer) | ECE2017

Succesfull treatment of hyperthyroidism with plasmapheresis

Baser Ozden Ozdemir , Koseoglu Derya , Catak Merve , Cetin Zeynep , Berker Dilek

Introduction: Hyperthyroidism is the condition that occurs due to excessive release of thyroid hormone by the thyroid gland. Anti-thyroid drugs are usually the first choice of the treatment but surgery and radioactive iodine can also be used in treatment of hyperthyroidism. Plasmapheresis is a rapid and effective treatment option in cases where immediate euthyroidism is needed to be obtained due to complications of thyrotoxicosis and major side effects of antithyroid drugs.</p...

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ea0049ep1330 | Thyroid (non-cancer) | ECE2017

Measurement of anti-thyroglobulin antibodies, a matter of equipment?

Capitao Ricardo , Prazeres Susana , Font Ana , Godinho Conceicao , Rodrigues Isaura , Cerveira Frederico , Belo Graca , Viana Joao , Madureira Deolinda

Introduction: The presence of anti-thyroglobulin antibodies (ATG) can induce falsely lower thyroglobulin (Tg) values. The methods characteristics used for ATG measurement vary according to the equipment/reagent used. ATG at our centre is measured by Unicap.Objective: To assess if patients with negative ATG by Unicap® have different results with other equipment.Methods: A cross-sectional retrospective study was condu...

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ea0049ep1331 | Thyroid (non-cancer) | ECE2017

Reference range determination of TSH during the first trimester of pregnancy and the impact of its future implantation in the South area of Seville

Gordillo Guillermo Martinez de Pinillos , Marin Carmen Carretero , Porcel Jose Alvaro Romero , Viloria Maria del Mar , Hidalgo Maria Dolores , Carrasco Rufina , Bobillo Joaquin , Fernandez-Ladreda Mariana Tome , Leon Maria Victoria Cozar

Objectives: Different scientific societies recommend performing screening for clinical primary hypothyroidism during the first trimester of pregnancy using local normality ranges of TSH and just in the lack of these, should the American population reference levels be used. Our objective is to determinate the reference range of TSH during the 1st trimester of pregnancy in our healthcare area and the impact of its implantation.Material and metho...

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ea0049ep1332 | Thyroid (non-cancer) | ECE2017

Iodine content of iodized salt in Spain

Arosa Vanessa , Goitia Maider Sanchez , Espada Mercedes , Irigoyen Luis , Maldonado Gonzalo , Arrizabalaga Juan Jose , Santiago Piedad , Orosia Maria , Menendez Edelmiro , Vila Lluis , Wengrowicz Silvia , Donnay Sergio

Introduction: Optimization of iodine intake aims to prevent the irreversible damage that iodine deficiency (ID) can cause in the central nervous system during its development, as well as thyroid disorders that can be induced by both ID and excessive micronutrient intake. The Spanish legal regulation stipulates that iodized salt (IS) must contain 60 mg of iodine per kg of salt (60 ppm), allowing a tolerance of ±15%. The aim of this study is to address the iodine content of...

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ea0049ep1333 | Thyroid (non-cancer) | ECE2017

Low DHEAS levels predict rheumatism in primary hypothyroidism: preliminary data from tertiary hospital

Shukla Ravindra , Sharma Praveen , Singh Vikram , Vohra Gopal

Introduction: DHEAS is weak androgen with specific role in human physiology illdefined. Various studies have implicated role of DHEAS in autoimmune arthritis including SLE and RA. Recently EULAR consensus statement has approved CSA (clinically significant arthralgia) for incipient RA.Methods and material: 34 follow up patients of primary hypothyroidism rated their symptom score on CSA (clinically suspect arthralgia) as given by EULAR(1) Their DHEAS level...

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ea0049ep1334 | Thyroid (non-cancer) | ECE2017

A thyroid storm in a context of diabetic ketoacidosis: case report

Mghari Ghizlane El , Oukit Loubna , Ansari Nawal El

Introduction: The association of a thyroid storm and diabetes ketoacidosis is relatively rare. We report two cases.Observations: The first one is a 20 years old woman, with no history of diabetes, who came with ketoacidosis, a history of non medicated thyrotoxicosis, and she was complaining about fever, a thyrotoxicosis syndrome, a vascular goiter, and exophtalmos. Her general condition had improved significantly after the treatment in emergency and unde...

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ea0049ep1335 | Thyroid (non-cancer) | ECE2017

Hyalinizing trabecular adenoma of the thyroid

Gul Ozen Oz , Cander Soner , Sisman Pinar , Ersoy Canan

Introduction: Hyalinizing trabecular adenomas (HTA) of the thyroid gland is a rare neoplasm of follicular cell origin. HTA can be present as a thyroid nodule or incidental finding in a thyroidectomy specimen. HTA is generally accepted to be a benign tumor, but their cytological features can be similar to those of papillary thyroid carcinoma (PTC).Case report: A 59 year old woman, who had cholangiocellular carcinoma, admitted to our institution with a sol...

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ea0049ep1336 | Thyroid (non-cancer) | ECE2017

Amiodaron induced hyperthyreosis and recurrent ventricular tachycardia

Kołodziejczak Roman , Łuczyńska-Kołodziejczak Alicja , Syrenicz Anhelli

52 years old man medicated with amiodaron 12 months, with laboratory confirmed hyperthyroidism, in us-examination 45 ml Basedow goiter, TRAb positive; ventricular tachycardia 180/min intermittent with sinusal tachycardia 120/min, thiamasol 120 mg i.v./daily, hydrocortisone 400 i.v. daily, crystalloids, beta blockers, diazepam, albumin. J131 scintigraphy no iodine uptake. natriumperchlorate 1500 mg daily initially, continued next month 900 mg coused iodine uptake 17%. Fi...

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ea0049ep1337 | Thyroid (non-cancer) | ECE2017

Autoimmune thyroiditis in patients with latent autoimmune diabetes of adults (LADA)

Nawal El Ansari , Zaher Fatima Zahra , Elmghari Ghizlane

Introduction: Latent autoimmune diabetes in adults (LADA) is an endocrine disorder characterized by a progressive destruction of pancreatic beta cells by an autoimmune mechanism leading to absolute insulin deficiency. In patients with an autoimmune endocrine disease, there is a high risk of development of another autoimmune endocrine disorder. The purpose of our work is to assess the prevalence of thyroid autoimmunity among our LADA patients.Patients and...

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ea0049ep1338 | Thyroid (non-cancer) | ECE2017

Thyroid and metabolic disorders in patient with kidney injury undergoing renal biopsy

Sztembis Joanna , Kołodziej-Kłęk Aneta , Gala-Błędzińska Agnieszka , Świder Grzegorz

There are a several known interactions between kidney functions, thyroid and metabolic balance. Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR and increased RAA activation. Chronic kidney disease is characterized by low T3 syndrome, increased primary hypothyroidism and subclinical hypothyroidism. The hyperthyroidism increases CKD progression while hypothyroid state lowers it. Proteinuria, especially in nephrotic syndrome, often resul...

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ea0049ep1339 | Thyroid (non-cancer) | ECE2017

Reversible thyrotoxic pulmonary hypertension with heart failure: 2 cases

Khattak Aftab , Wong Eleanor , Mak George , O'Hare James A

Introduction: Heart failure is a complication of thyrotoxicosis. We present 2 unusual cases presenting with pulmonary hypertension with isolated right heart failure that reversed after treatment.Case description: Case 1: A 55-year-old man presented with weight loss, dyspnoea and leg swelling. HR: atrial fibrillation 51/min. He had a raised JVP, tricuspid regurgitation and severe pitting oedema. Pro-BNP: 4995 pg/...

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ea0049ep1340 | Thyroid (non-cancer) | ECE2017

Peripheral neuropathy in hypothyroidism - about a clinical case

Marcalo Jose , Araujo Alexandra , Faria Carolina , Wessling Ana , Carvalho Maria Raquel , Nobre Ema , Bugalho Maria Joao

Introduction: Hypothyroidism can affect the nervous system, commonly causing mono and polyneuropathies which show a variable frequency and pattern. Its mechanisms are not fully understood. Symptoms usually correlate better with the duration of the dysfunction rather than with its severity and typically improve significantly after medical therapy.Case report: A 58-year-old woman was admitted at our hospital with a one-year history of progressive weakness ...

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ea0049ep1341 | Thyroid (non-cancer) | ECE2017

Is Levothyroxine requirement the same for tablet and soft gel formulation in postsurgical hypothyroidism?

Di Donna Vincenzo , Paragliola Rosa Maria , De Waure Chiara , De Rosa Annapina , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: In a previous publication we identified the major predictive factors of levothyroxine (LT4) requirement and proposed an efficient nomogram to calculate LT4 substitutive starting dose after total thyroidectomy for benign disease. The aim of this study was to assess whether the LT4 requirement differs between the tablet and the soft gel capsules formulations.Methods: One hundred and three consecutive patients su...

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ea0049ep1342 | Thyroid (non-cancer) | ECE2017

Immune reaction to food antigens in Graves’disease (GD) patients: role of gliadin and other food antigens

Covelli Danila , Colucci Giuseppe , Salvi Mario , Kaiser Ulrike , Eckstein Anja , Burlacu Maria Cristina , Daumerie Chantal , Richell Gez , Perros Petros , Draman Mohd Shazli , Ludgate Marian , Masetti Giulia , Biscarini Filippo

As known, an imbalance of the gut microbiota is associated with a higher risk for autoimmune diseases. Moreover the increased rates of autoimmunity reported in urban residential areas worldwide suggest a possible influence of diet. We report on the antibody response to food antigens in GD patients. Since 10% of celiac patients develop an autoimmune thyreopathy we focused on gliadin (DGP), transglutaminases (tTG) and 40 other food antigens (FA). Commercially available ELISA ass...

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ea0049ep1343 | Thyroid (non-cancer) | ECE2017

Neutrophil/lymphocyte (N/L) ratio should not be used as an indicator of inflammation in hyperthyroid patients

Dagdeviren Murat , Akkan Tolga , Celiker Dilek , Karakaya Serdar , Ertugrul Derun Taner , Altay Mustafa

Introduction: Neutrophil/lymphocyte (N/L) ratio is considered as a sign of systemic inflammation in recent years. In our study, we aimed to investigate N/L ratio in hyperthyroid patients and healthy control group.Material & methods: A total of 121 hyperthyroid patients (71 patients with Graves disease and 50 patients with other causes of hyperthyroidism) and 40 healthy volunteers were enrolled. Complete blood count was obtained from both group ...

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ea0049ep1344 | Thyroid (non-cancer) | ECE2017

Quality of life in patients with hyperthyreosis and hypothyreosis in slovak republic

Bielik Jan , Slavikova Emilia , Melus Vladimir

Objectives: The prevalence of thyreoid diseases eg hyperthyreosis and hypothyreosis in Slovak Republic is about 240 000 patients. The objective of this study was to find out the level of quality of life (QoL) in patients and other relevant characteristics of diseaseas.Methods: The primary method used for the analysis of QoL was the own orginal combined questionnaire. Statistical methods from Excel 2010 were used in results evaluation.<p class="abstex...

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ea0049ep1345 | Thyroid (non-cancer) | ECE2017

Broken heart by thyroid? A rare case of Graves’ disease associated to Takotsubo cardiomiopathy

Constantinescu Georgiana , Plesoianu Carmen , Raileanu Cezara , Ardeleanu Iuliana , Negru Mihaela , Zmau George , Arsenescu-Georgescu Catalina , Vulpoi Carmen

Introduction: Takotsubo disease is a non-ischemic, reversible form of cardiomyopathy, triggered by intense emotional or physical stress. Characterized by normal coronaries and a particular ventricular contraction, it is also known as apical ballooning syndrome. Thyrotoxicosis, especially Graves disease, has been associated with Takotsubo cardiomyopathy.Case report: We report the coexistence of Takotsubo cardiomyopathy in a 37 year old f...

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ea0049ep1346 | Thyroid (non-cancer) | ECE2017

The association of gene polymorphisms with the clinical outcome of Graves’ disease

Dauksiene Dalia , Mickuviene Narseta , Dauksa Albertas

The aim: Of this study was to investigate the association between two common CTLA-4 gene SNPs (49A/G in exon 1 and CT60 A/G in 3UTR) and Graves disease outcome in Lithuanian population.Methods: This case-control study was performed in the Hospital of Lithuanian University of Health Sciences. Graves disease patients (n=105) were divided into remission and failed treatment groups according to the final outcome of the disease. The...

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ea0049ep1347 | Thyroid (non-cancer) | ECE2017

The impact of levothyroxine sodium treatment on dynamic thiol/disulphide homeostasis in overt hypothyroidism

Bicer Cemile , Ates Ihsan , Aydin Murat , Altay Mustafa , Topcuoglu Canan , Neselioglu Salim , Erel Ozcan , Yilmaz Fatma Meric

Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in...

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ea0049ep1348 | Thyroid (non-cancer) | ECE2017

The role of vitamin D receptor gene FokI (rs2228570) polymorphism in the pathogenesis of thyroid associated orbitopathy

Maciejewski Adam , Kowalczyk Michal , Czyzyk Adam , Gasinska Teresa , Lacka Katarzyna

Introduction: Vitamin D, known mainly as a calcium-phosphorus homeostasis regulator, turned out to play also a significant role in the immune system modulation. Vitamin D deficiency has been reported in some autoimmune disorders. It is also suspected that polymorphisms of vitamin D-related genes comprise a risk factor for different autoimmune diseases. Therefore the aim of our study was to assess vitamin D receptor (VDR) gene FokI polymorphism in thyroid associated orbitopathy...

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ea0049ep1349 | Thyroid (non-cancer) | ECE2017

Lymphoid hyperplasia in Graves’ disease: about 2 cases

Hadjkacem Faten , Ghorbel Dorra , Mnif Fatma , Elfekih Hamza , Rekik Nabila , Mrabet Houcem , Ammar Mouna , Charfi Nadia , Abid Mohamed

Introduction: Graves disease GD is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes. Though quite rare, this disease can also manifest with lymphoid hyperplasia.Case report: Two cases are reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia from 2006 to 2016 associated GD with lymphoid hyperplasia reaction. The first case was a 32 years old male with history...

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ea0049ep1350 | Thyroid (non-cancer) | ECE2017

Effects of hypothyroidism on nutritional status: which impact?

Ghizlane El Mghari , Bouznad Naima , El Ansari Nawal

Introduction: Hypothyroidism is a common disease in Morocco because of the iodine deficiency frequency. The metabolic and nutritional effects of hypothyroidism are known in the literature. The hypothyroidism is classically described among the causes of secondary obesity. The aim of the study is to evaluate the nutritional status and anthropometric parameters in patients having hypothyroidism.Patients and methods: Patients were recruited from the out-pati...

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ea0049ep1351 | Thyroid (non-cancer) | ECE2017

Outcome of radioiodine therapy in patients with hyperthyroidism

Machado Catarina , Tavares Patricia , Monteiro Sara , Rocha Gustavo , Silva Fernando , Oliveira Jose Manuel , Oliveira Maria Joao

Introduction: Radioiodine treatment (RAIT) is an effective definitive treatment for Graves Disease (GD) and Toxic Nodular Goiter (TNG). The aim of this study was to analyze demographic and clinical factors affecting the outcome of RAIT in patients with hyperthyroidism.Methods: Retrospective review of patients treated with RAIT for hyperthyroidism. A fixed dose of 10 mCi was administered to patients with GD and 15 mCi to patients with TNG. Treatment...

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ea0049ep1352 | Thyroid (non-cancer) | ECE2017

An unusual case of subacute thyroiditis after alemtuzumab treatment

Baltzinger Philippe , Dumitrescu Alina , Wagner Clothilde , Collongues Nicolas , De Seze Jerome , Bahougne Thibault , Jeandidier Nathalie

Introduction: Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Thyroid side-effects such as Graves disease have been already described. We describe one case of unusual subacute thyroiditis after alemtuzumab treatment.Clinical case: A 38 year-old-female was treated by alemtuzumab for 2 years. She was referred for hyperthyroidism with 10 kg weight loss, diar...

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ea0049ep1353 | Thyroid (non-cancer) | ECE2017

Pattern of amiodarone-induced thyrotoxicoxis before and after universal salt iodization

Trifanescu Raluca , Popa Cristina , Goldstein Andrei , Alexiu Florin , Purice Mariana , Poiana Catalina

Background: Prevalence and type of amiodarone-induced thyroid dysfunction in a population depend on geographical iodine intake.Aims: To assess differences in amiodarone-induced thyrotoxicosis pattern before and after iodine supplementation.Patients and methods: 84 patients (41M/43F) with amiodarone-induced thyrotoxicosis, aged 60.1±11.9 years, were retrospectively reviewed. 28 patients were resident in former iodine-deficient ...

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ea0049ep1354 | Thyroid (non-cancer) | ECE2017

They think it’s all ovar(ii)

Tanday Raj , Grant Bonnie , Kollipara Premila , Casey Edel , Nikookam Khash

A 37 year old woman was referred to the endocrinology clinic from the gynaecologists. She was awaiting an 8 cm left ovarian cyst removal and found to be hyperthyroid (fT3 7.8 pmol/l, fT4 of 19.0 pmol/l, TSH <0.01 mU/l). She described 4 months of palpitations, change in bowel habit and menstrual irregularity. She had no tremor or tachycardia. She had no palpable goitre or eye signs. She had a past medical history of asthma on inhalers. There was no family history of thyroid...

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ea0049ep1355 | Thyroid (non-cancer) | ECE2017

Perinatal outcome in graves-basedow disease during pregnancy

Mihajlovska Snezana , Mihajlovska Marija

The purpose of this study is to assess the treatment outcome of pregnant patients with Graves-Basedow disease. In the period of 20 years 59 pregnancies in hyperthyroid patients were registered with Graves-Basedow disease in the Department of Nuclear Medicine in Clinical Hospital Bitola. Thyrostatic therapy was applied in 29 (56.5%) pregnant patients divided into 2 groups. The first group were patients who used methimazole therapy (MMT) or 50400 mg propiltiuracil (PTU). O...

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ea0049ep1356 | Thyroid (non-cancer) | ECE2017

TSH receptor stimulating immunoglobulins – performance of an automated immunoassay

Tavares Patricia , Machado Catarina , Pedroso Jose Carlos , Vieira Joana , Rocha Gustavo , Monteiro Sara , Sousa Ana Margarida , Rodrigues Pedro , Lira Agostinho , Oliveira Maria Joao

Introduction: Graves disease (GD) hyperthyroidism is caused by autoantibodies against TSH receptor (TRAb). Three varieties of TRAb are now recognized: stimulating (TSI), blocking and neutral antibodies. Current TRAb immunoassays detect and quantify serum immunoglobulins that interact with the TSH receptor but without discriminating their function. An automated immunoassay for the detection and quantification of TSI is available.Objective: Our study...

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ea0049ep1357 | Thyroid (non-cancer) | ECE2017

Genetic variation in NFE2L2 and SEPS1S associated with increased risk of Hashimoto’s thyroiditis

Santos Liliana R , Duraes Cecila , Pestana Ana , Esteves Cesar , Neves Celestino , Carvalho David , Simoes Manuel Sobrinho , Soares Paula

Hashimotos thyroiditis (HT) is the most common chronic autoimmune thyroid disease, which is characterized by alteration of the thyroid function. HT is a multifactorial disorder and several candidate genetic loci have been identified as contributing to HT. The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. The relevance of selenoproteins in follicular thyroid cell physiology and in mole...

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ea0049ep1358 | Thyroid (non-cancer) | ECE2017

Safety and efficacy of cholestyramine in the adjuvant management of Graves thyrotoxicosis

Gulfam Taimur , Nag Sath

Introduction: Gravess disease is an autoimmune condition both cell and antibody-mediated, which is associated with thyrotoxicosis and extra thyroid features.Case report: A 35-year-old female presented with symptomatic hyperthyroidism due to graves thyrotoxicosis. She developed adverse reactions, including severe dermatitis and hepatotoxicity, to two of the thionamide drugs (carbimazole and propylthiouracil). Eventually we decided for definitive tre...

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ea0049ep1359 | Thyroid (non-cancer) | ECE2017

A slow but continuous growth: Case study of a thyroid nodule

Verissimo David , Pires Vitoria , Passos Dolores , Serra Filipa , Silva Joao , Lopes Luis , Castro Joao Jacome de , Marcelino Mafalda

Thyroid nodules are a common clinical finding, with an estimated prevalence of palpable thyroid nodules to be approximately 5% in women and 1% in men. The clinical importance of thyroid nodules rests with the need to exclude thyroid cancer. The prevalence of malignancy reported for palpable thyroid lesions ranges from 5.0% to 6.5%. Patients with benign thyroid nodules are unlikely to suffer morbidity or mortality due to thyroid cancer. A 53 aged man presented with a 20-year hi...

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ea0049ep1360 | Thyroid (non-cancer) | ECE2017

Mirela Tirnovan¹, Anamaria Bursuc¹, Alina Daniela Belceanu¹, Adina Manolachie¹, Ioana Armasu¹, Iulia Crumpei¹, Georgiana Constantinescu¹, Luminita Apostu², Carmen Vulpoi¹

Tirnovan Mirela , Bursuc Anamaria , Belceanu Alina Daniela , Armasu Ioana , Crumpei Iulia , Manolachie Adina , Apostu Luminita , Vulpoi Carmen

Introduction: Many causes of malabsorbtion of levothyroxine (LT4) in patients with hypothyroidism have been thoroughly described in literature. Pseudomalabsorption, poor compliance of the patient is most common cause of failure of LT4 and/or liothyronine (LT3) treatment.Case report: 27 years old woman, normopondeal, presented from the age of 11 years for short stature. Further investigations found pluritrope pituitary insufficiency ...

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ea0049ep1361 | Thyroid (non-cancer) | ECE2017

Oxidative profiles in patients with autoimmune thyroid diseases

Mnif Fatma , Elfekih Hamza , Elleuch Mouna , Hadjkacem Faten , Mrabet Houcem Elomma , Rekik Nabila , Ghorbel Dorra , Mnif Mouna , Abid Mohamed

Introduction: Autoimmune thyroid diseases are known to be associated with oxidative stress.Objectives: We studied the oxidative profiles in plasma and thyroid tissue of 82 patients having Graves disease (GD) or Hashimoto thyroiditis (HT) or hashitoxicosis (HTX) vs 65 healthy controls in order to evaluate the antioxidant enzymes activity and the lipid peroxidation.Results: The lipid peroxidation was objected with a signi...

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ea0049ep1362 | Thyroid (non-cancer) | ECE2017

Levothyroxine absorption test in the management of a patient with persistent hypothyroidism

Monteiro Joana , Ferreira Marta , Pires Miguel , Vieira Alexandra , Guelho Daniela , Pereira Teresa , Pinhal Fernanda , Fernandes Celio

Nonadherence to levothyroxine therapy is one cause of persistent hypothyroidism. To distinguish nonadherence from malabsorption, a levothyroxine absorption test (LAT) is sometimes required. The authors report a case of a 60-year-old female patient suffering from hypothyroidism resistant to oral levothyroxine (LT4) substitution after radioiodine therapy for Graves disease. Despite the continuous increases of LT4, over 10 years, to a maximum of 1 mg/d...

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ea0049ep1363 | Thyroid (non-cancer) | ECE2017

Serum irisin level in different thyroid dysfunction states and its relation to markers of muscle dysfunction

Halawa Mohamed Reda , Abdelsalam Mona Mohamed , Mostafa Bassem Mourad , Ahmed Amira Galal

Introduction: Irisin is a myokin secreted by myocytes responsible for transmission of signals from muscles to other body tissues. It improves systemic metabolism by increasing energy expenditure and has a significant influence on the body metabolism and thermogenesis. Thyroid disorders are characterized by a disrupted thermo-metabolic state and muscular damage, and the underlying mechanisms still not clear.Aim: To evaluate serum Irisin levels in patient ...

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ea0049ep1364 | Thyroid (non-cancer) | ECE2017

Iodine deficiency is still prevalent in pregnant women from Romania after universal salt iodization

Gheorghiu Monica Livia , Ursu Horea Ioan , Dumitrascu Irina , Pascanu Ionela , Georgescu Carmen , Mihu Dan , Delia Corina Elena , Toma Geanina Mirela , Stanciu Mihaela , Popescu Dragos , Lichiardopol Corina , Vlad Mihaela , Aldea Ramona , Tudorache Stefania , Vasile Mihaela , Igna Claudia Podia , Purice Mariana , Ghemigian Adina

Introduction: Even mild to moderate maternal iodine deficiency during pregnancy is associated with impaired child cognition. Iodine deficiency is especially problematic in pregnant women, who have a higher iodine requirement (250 μg/day) than non-pregnant women (150 μg/day).Objective: To assess iodine status (median urinary iodine concentration, UIC) in pregnant women from multiple endemic or non-endemic areas in Romania, 13 years after impleme...

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ea0049ep1365 | Thyroid (non-cancer) | ECE2017

The potential of smartphone applications in management and compliance to recommended lifestyle in Hashimoto’s patients

Tabor Vedrana Hogqvist , Tabor Mikael Hogqvist

Background: Hashimotos thyroiditis (HT), a chronic autoimmune disease caused by an interaction between genetic factors and the environmental is treated by thyroid supplementation as the first line of treatment. However, many of the symptoms are unrelated to the failing thyroid function, but seem to be connected to the autoimmune disease, remain. Literature has reported on many of the environmental triggers of autoimmune response, however patients do not have a unified wa...

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ea0049ep1366 | Thyroid (non-cancer) | ECE2017

Dynamic risk stratification for predicting recurrence in patients with differentiated thyroid cancer treated without radioactive iodine remnant ablation therapy

Park Suyeon , Kim Won Gu , Song Eyun , Oh Hye-Seon , Kim Mijin , Kwon Hyemi , Jeon Min Ji , Kim Tae Yong , Shong Young Kee , Kim Won Bae

Background: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy.Methods: This historical cohort study included 357 pat...

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ea0049ep1367 | Thyroid (non-cancer) | ECE2017

Association between lymph node metastasis and patients’ age in papillary thyroid microcarcinoma

Oh Hye-Seon , Jeon Min Ji , Park Suyeon , Kim Mijin , Kwon Hyemi , Song Eyun , Kim Won Gu , Shong Young Kee , Kim Won Bae , Kim Tae Yong

Background: Recent studies presented that younger patients with papillary thyroid microcarcinoma (PTMC) had poorer clinical outcomes compared to older PTMC patients. The aim of this study is to investigate the impact of patients age on the lymph node metastasis (LNM) status of PTMC, a risk factor for recurrence and poor clinical outcome of PTMC.Methods: The study evaluated 2068 PTMC patients who underwent thyroid operation with lymph node (LN) diss...

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ea0049ep1368 | Thyroid (non-cancer) | ECE2017

Breast cancer and family history for breast cancer in patients with differentiated thyroid carcinoma

Akin Safak , Tutal Esra , Sencar Erkam , Karakose Melia , Ozcelik Ozgur , Apaydin Mahmut , Aslan Muyesser Sayki , Unsal Ilknur , Ucan Bekir , Ozbek Mustafa , Cakal Erman

Background and aim: The risk for breast cancer in patients with thyroid cancer has been investigated in previous studies, and has been found to be increased. In this study we, therefore present retrospective analysis of the patients with differentiated thyroid carcinoma in respect to breast cancer and family history for breast cancer.Methods: We conducted a retrospective study involving 455 patients with a diagnosis of differentiated thyroid carcinoma be...

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ea0049ep1369 | Thyroid (non-cancer) | ECE2017

Differential diagnosis between Anaplastic Thyroid Cancer and Primitive Lymphoma of the Thyroid gland: A 66-cases study

Kohler Florence , Vantyghem Marie-Christine , Carnaille Bruno , Leteurtre Emmanuelle , Boury Samuel , Terriou Louis , Do Cao Christine

A rapidly growing neoplastic mass of the neck can either be caused by an anaplastic thyroid cancer (ATC) or a primitive lymphoma of the thyroid gland (PLT). These two malignancies share the same clinical features but vary widely in their treatment and outcome. Only histologic criteria through biopsy can provide a definitive diagnosis. The aim of this study was to assess biological and radiological differences between ATC and PLT in order to hasten differential diagnosis. Sixty...

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ea0049ep1370 | Thyroid (non-cancer) | ECE2017

The role of preoperative serum thyroglobulin values in the diagnosis of differentiated thyroid cancer

Dyrmishi Blertina , Olldashi Taulant , Lumi Ema , Puca Entela , Ylli Dorina , Ikonomi Majlinda , Fureraj Thanas

Introduction: Thyroglobulin (TG) is the most important protein produced by the thyroid. TG is considered a reliable marker of recurrent disease in patient with differentiated thyroid carcinoma (DTC). Before surgery, high serum TG values may be due to an abnormally large thyroid, excessive thyroid stimulation, or physical damage to thyroid etc.Methods: We evaluated in the retrospective study 20 patients (mean age 49.6±12 S.D., range fr...

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ea0049ep1371 | Thyroid (non-cancer) | ECE2017

Is there an impact of the concurrent presence of chronic autoimmune thyroiditis in differentiated thyroid cancer patients?

Martin Sorina , Budianu Oana , Ion Oana , Grigore Andreea , Sirbu Anca , Barbu Carmen , Giulea Cosmin , Miron Adrian , Andrei Florin , Fica Simona

Background: The association between differentiated thyroid carcinoma (DTC) and autoimmune thyroiditis (AT) has been reported in numerous studies, yet the impact of the concurrent presence of AT and DTC remains controversial.Methods: We retrospectively analysed the files of 493 patients submitted to thyroidectomy in our surgery department between January 2012 and September 2015.Results: A total of 86 patients with DTC were enrolled,...

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ea0049ep1372 | Thyroid (non-cancer) | ECE2017

20,000 euros for diagnosis of one thyroid cancer case: It is not too much?

Maciejewski Marek , Sawicka Agnieszka , Slomian Michal , Gasiorek Malgorzata , Budzynska-Nosal Renata , Marczewski Krzysztof

Introduction: Thyroid cancer is a major public health problem, and fine-needle biopsy is an established method of its early detection. However, there are still some controversy about the indication for BACC depending on the clinical data and the results of diagnostic imaging. An important role is also played by economic criteria, including socially acceptable, so-called equitable cost of obtaining additional year of life, which in our country is determined to three times the a...

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ea0049ep1373 | Thyroid (non-cancer) | ECE2017

Unilateral Graves’ disease with papillary carcinoma of the hyperfunctioning lobe

Papadakis Georgios , Rodriguez Elena Gonzalez , Allenbach Gilles , Lalonde Marie Nicod , Gorostidi Francois , Sandu Kishore , Bongiovanni Massimo , Sykiotis Gerasimos P.

Background: Graves disease (GD) typically manifests as an autoimmune hyperfunction of both thyroid lobes. Less than 10 cases of unilateral GD have been described, and the pathophysiology of unilateral GD remains unknown. Co-existence of malignancy has never been reported. We report a case of GD of the left lobe with simultaneous discovery of a papillary carcinoma within the hyperfunctioning lobe.Case description: A 49-year-old patient of Middle-Eas...

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ea0049ep1374 | Thyroid (non-cancer) | ECE2017

Trends in the clinicopathological features and clinical outcomes of medullary thyroid carcinoma – an Israeli multicenter study

Hirsch Dania , Twito Orit , Levy Sigal , Bachar Gideon , Robenshtok Eyal , Gross David J , Mazeh Haggi , Benbassat Carlos

Background: The massive use of neck sonography has led to a dramatic increase in the incidence of thyroid cancer detection, predominantly small papillary carcinomas. However, changes in the presentation and course of medullary thyroid carcinoma (MTC) over time remain unclear.Objective: To evaluate trends in the presentation and outcomes of MTC.Methods: Patients treated for MTC at four medical centers in Israel were divided into two...

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ea0049ep1375 | Thyroid (non-cancer) | ECE2017

Association of preoperative neutrophil lymphocyte ratio and platelet lymphocyte ratio with clinical features of differentiated thyroid cancer

Taskiran Bengur , Cansu Guven Baris , Yorulmaz Goknur , Mutluay Ruya

Introduction: Platelets and neutrophils take part in proliferation of cancer cells, angiogenesis, and metastasis. Studies on various cancer types showed relation between prognosis and absolute numbers of neutrophils, lymphocytes, and the ratio in-between (NLR) and platelet/lymphocyte ratio (PLR). We aimed to evaluate NLR and PLR and their relation with features of differentiated thyroid carcinoma (DTC).Materials and methods: Electronic data of 330 patien...

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ea0049ep1376 | Thyroid (non-cancer) | ECE2017

Differentiated thyroid cancer in patients taking lithium for bipolar affective disorder: a case series

Ali Tam Abbas , Aydin Cevdet , Ozdemir Didem , Bilginer Muhammed Cuneyt , Ersoy Reyhan , Cakir Bekir

Aim: Lithium bicarbonate is a drug used in the initial treatment of bipolar disorders. Lithium is an element of alcali metal group and besides being a causative agent for goiter and hypothyroidism primarily, it has also some antithyroid effects. Rarely, lithium may cause hyperthyroidism secondary to thyroiditis or probably autoimmune mechanisms. The association between lithium and thyroid cancer is very little known subject. In this case series, we presented differentiated thy...

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ea0049ep1377 | Thyroid (non-cancer) | ECE2017

Predictive value of CHAID Algorithm in the diagnosis of malignancy in thyroid nodules with Bethesda III (AUS/FLUS) cytology

Ersoy Reyhan , Aydin Cevdet , Topaloglu Oya , Ozdemir Didem , Baser Husniye , Cuhaci Fatma Neslihan , Ali Tam Abbas , Ogmen Berna , Polat Sefika Burcak , Dellal Fatma Dilek , Dirikoc Ahmet , Bestepe Nagihan , Kilic Mehmet , Altinboga Aysegul Aksoy , Cakir Bekir

Introduction: Artificial intelligence is an information-processing technology developed and inspired by the information processing technique of human brain. Artificial intelligence applications are used with an increasing ratio in medicine; particularly in the fields of breast cancer, radiology, cardiology, health management and drug effects analysis. There is not any study concerning thyroid diseases and artificial intelligence applications in the literature. In t...

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ea0049ep1378 | Thyroid (non-cancer) | ECE2017

Thyroid autoimmunity and risk of incidental thyroid microcarcinoma in non-toxic nodular thyroid diseases

Askitis Dimitrios , Efremidou Eleni I , Karanikas Michail A , Tripsianis Grigorios , Giatromanolaki Alexandra , Polychronidis Alexandros , Lyratzopoulos Nikolaos

Aim: Thyroid cancer comprises the most common endocrine malignancy and a variety of studies have investigated the role of thyroid autoimmunity as an independent risk factor for the manifestation of differentiated thyroid cancer in otherwise benign thyroid disorders. Objective of the current retrospective study is the assessment of any possible correlation between thyroid autoimmunity, in terms of elevated thyroid autoantibodies, and incidental thyroid microcarcinoma (ITC) in n...

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ea0049ep1379 | Thyroid (non-cancer) | ECE2017

Effects of combination of metformin and pioglitazone on AMPK/mTOR signal pathway, p53 and apoptosis in human anaplastic thyroid cancer cells

Kutbay Nilufer Ozdemir , Erdogan Mehmet , Yurekli Banu Sarer , Kurt Cansu Caliskan , Gunduz Cumhur , Avci Cigir Biray

Thyroid cancer is the most common malignant tumor of the human endocrine system. Recently, its incidence has increased significantly. Anaplastic cancer constitutes 24% of thyroid cancers and remains aggressive. The life expectancy is 26 months. It is often beyond the surgical margin. External radiation therapy or chemotherapy are the treatment options. Therefore, new therapeutic approaches are needed. Peroxisome proliferator-activated receptor (PPAR) gamma is a DNA...

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ea0049ep1380 | Thyroid (non-cancer) | ECE2017

Vitamin D status and MPV changes in differentiated thyroid cancer

Onbasi Kevser , Kilit Turkan Pasalı , Ucgun Aysenur Beyazıt

Thyroid cancer is the most common cancer in the endocrine system. Thyroid follicular epithelial-derived cancers are papillary, follicular, and anaplastic cancer. Risk factors for differentiated cancers are radiation exposure, and family history. Possible risk factors like occupational and environmental exposures, increased parity, late age at first pregnancy, and hepatitis C-related chronic hepatitis are potential but not proven risk factors. In order to evaluate other potenti...

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ea0049ep1381 | Thyroid (non-cancer) | ECE2017

BRAFV600E status and Stimulated Thyroglobulin at ablation time increase prognostic value of American Thyroid Association (ATA) classification systems for persistent disease in Differentiated Thyroid Carcinoma (DTC)

Repaci Andrea , Vicennati Valentina , Paccapelo Alexandro , Salituro Nicola , Cavicchi Ottavio , Monari Fabio , Tallini Giovanni , Gruppioni Elisa , Altimari Annalisa , Fiorentino Michelangelo , Pagotto Uberto

Background: Stimulated Thyroglobulin levels measured at the time of remnant ablation (Htg-A) and BRAFV600E mutation were shown to have prognostic value in predicting persistent disease in DTC. The aim of this study was to evaluate the prognostic role of Htg-A combined with BRAFV600E status in association with revised American Thyroid Association (ATA) risk stratification.Patients and methods: 620 patients treated for a DTC were included in this study wit...

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ea0049ep1382 | Thyroid (non-cancer) | ECE2017

High sensitivity of BRAF detection method does not alter response to therapy of papillary thyroid cancer of known BRAF status

Walczyk Agnieszka , Kowalska Aldona , Kowalik Artur , Kopczynski Janusz , Palyga Iwona , Gasior-Perczak Danuta , Mikina Estera , Lizis-Kolus Katarzyna , Szyska-Skrobot Dorota , Szymonek Monika , Hurej Stefan , Kajor Maciej , Chrapek Magdalena , Gozdz Stanislaw

Background: A dynamic risk stratification with modified initial estimated risk based on response to therapy and disease course is one of the crucial changes adopted recently by the American Thyroid Association (ATA). The analysis of BRAF status is not routinely recommended by ATA, although this finding may be advantageous to individualized risk-adapted approach in papillary thyroid cancer (PTC). The methods used to detect the BRAF V600E are known of variation...

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ea0049ep1383 | Thyroid (non-cancer) | ECE2017

Thyroid nodules ultrasound classification and the importance of the endocrinologist clinical feeling

Madeo Bruno , Brigante Giulia , Ansaloni Anna , Taliani Erica , Simoni Manuela , Rochira Vincenzo

Background and aim of the study: Several ultrasound (US) classifications for estimating thyroid nodules risk have been proposed. Since most of them are hardly applicable in clinical practice, we created a local tool, named Modena classification (MC), considering US characteristics and clinician subjective impression. The aim is to verify the diagnostic accuracy of MC and to compare it to US classifications of American Thyroid Association(ATA) (1) and British Thyroid Associatio...

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ea0049ep1384 | Thyroid (non-cancer) | ECE2017

Five-year follow-up of thyroid cold nodules with somatic oncogene mutations in Hungarian patients

Tobias Balint , Balla Bernadett , Soltesz Petra , P Kosa Janos , Horanyi Janos , Jaray Balazs , Szekely Eszter , Istok Roland , Szekely Tamas , Lakatos Peter

Cold nodules are one of the most common findings on scintiscans and ultrasound examinations of the thyroid gland. About 5-10% of these nodules turn out to be histologically malignant. Our aim was to examine the predictive value of somatogenetic alterations associated with thyroid cancer in FNA samples of thyroid cold nodules being citologically benign at the beginning of the study. These alterations included single nucleotide mutations (BRAF, HRAS, NRAS, KRAS) and genetic tran...

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ea0049ep1385 | Thyroid (non-cancer) | ECE2017

Usefulness of preoperative ultrasonography and computed tomography for evaluation of recurrent laryngeal nerve invasion by Papillary Thyroid microcarcinoma

Ohkuwa Keiko , Osaku Tadatoshi , Maeda Tetsuyo , Ogimi Yuna , Masaki Chie , Akaishi Junko , Hames Kiyomi Y , Tomoda Chisato , Suzuki Akifumi , Matsuzu Kenichi , Uruno Takashi , Kitagawa Wataru , Nagahama Mitsuji , Sugino Kiminori , Ito Koichi

Background: Papillary thyroid microcarcinoma (PTMC) has low malignant potential and an extremely good prognosis. However, surgical findings of asymptomatic PTC, can occasionally reveal tumor invasion into the recurrent laryngeal nerve (RLN). The present study assessed the feasibility of evaluating tumor invasion into the RLN using ultrasonography (US) and computed tomography(CT).Materials and methods: Of 7,916 patients with a PTC who underwent surgery at...

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ea0049ep1386 | Thyroid (non-cancer) | ECE2017

Solitary metastasis of papillary thyroid cancer in the sellar region and cavernous sinus

Brakni Lila , Haffaf Lounes , Aribi Yamina , Hameg F , Ouldkablia Samia

The commonest site of metastasis from papillary carcinoma is regional lymph nodes. Distant metastases are rare, most presenting synchronously. Brain metastases in papillary carcinoma are rare, reported with a frequency of 0.15% and cavernous sinus metastasis is extremely rare.Case report: A 62-year-old woman presented with a history of non-secretory pituitary macroadenoma present with symptoms of hypopituitarism. MRI of the brain revealed a 4.5&#21...

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ea0049ep1387 | Thyroid (non-cancer) | ECE2017

Calcitonin: clinical and laboratory evaluation in a tertiary hospital

Silvestre Catarina , Bugalho Maria Joao , Sampaio Joaquim , Proenca Helena , Carvalho Raquel

Background: Calcitonin is a hormone secreted by thyroid C cells, and is considered an excellent marker for medullary thyroid carcinoma (MTC). However, the use of calcitonin to screen patients with nodular thyroid disease (NTD) remains controversial.Objective: Defining the frequency of hypercalcitoninemia among NTD patients followed at a tertiary referral hospital.Methods: Retrospective analysis of basal calcitonin measurements and ...

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ea0049ep1388 | Thyroid (non-cancer) | ECE2017

Neuroendocrine progression of medullary thyroid cancer – case report

Sepp Krisztian , Besenyi Zsuzsanna , Tiszlavicz Laszlo , Valkusz Zsuzsanna

: Thyroid cancers represent approximately 1% of new cancer diagnoses. Thyroid malignancies are divided into papillary carcinomas (80%), follicular carcinomas (10%), medullary carcinomas (510%), anaplastic carcinomas (12%) other rare tumours (primary thyroid lymphomas, primary thyroid sarcomas). The main therapeutic options are surgery (mainly total thyreoidectomy), radioiodine treatment (depending on the type and stage of the tumour), levothyroxine therapy (thyroid...

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ea0049ep1389 | Thyroid (non-cancer) | ECE2017

Cytohistologic correlation of thyroid nodules

Barka Ines , Ouerdani Senda , Chaieb Molka , Ben Abdelkrim Asma , Maaroufi Amel , Kacem Maha , Ach Koussay

Background: The discovery of a thyroid nodule exposes the problem of the possibility of thyroid cancer. The difficulty of management of this situation is the fact that only the histopathological examination can confirm or refute the malignancy. Fine-needle aspiration (FNA) is used as a diagnostic tool to assess thyroid nodules. The purpose of our study is to correlate the clinical, ultasonographic, the FNA results and final pathology to determine the predictors of malignancy o...

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ea0049ep1390 | Thyroid (non-cancer) | ECE2017

Importance of central compartment neck metastasis in the differentiated thyroid microcarcinomas

Cunha Catia , Guedes Vitor , Garrao Antonio , Cid Olimpia

: Elective central compartment neck dissection in the treatment of differentiated thyroid carcinomas (CDT) remains controversial. In a series of 1500 patients undergoing thyroid surgery, the authors evaluated the prognosis related to central compartment neck metastasis in differentiated microcarcinomas....

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ea0049ep1391 | Thyroid (non-cancer) | ECE2017

The impact of age and gender on the presentation and prognosis of medullary thyroid cancer – an Israeli multicenter study

Twito Orit , Grozinsky-Glasberg Simona , Benbassat Carlos , Llevy Sigal , Bachar Gideon , Gross David J , Hirsch Dania

Background: Data regarding the effect of gender and age on medullary thyroid cancer (MTC) presentation and prognosis is limited. Although older age and male sex were found to correlate with poorer prognosis in some studies, this correlation may reflect differences in MTC presentation between sex and age groups, or a mixture of hereditary and sporadic MTC forms.Objective: To evaluate the impact of age and sex on the presentation and outcomes of MTC.<p...

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ea0049ep1392 | Thyroid (non-cancer) | ECE2017

Is post-treatment whole body scan useful in differentiated thyroid cancer after thyroid ablation?

Prior-Sanchez Inmaculada , Rosa Alhambra Exposito Maria , Rebollo Roman Angel , Barrera Martin Ana , Moreno Ortega Estefania , Antonio Vallejo Casas Juan , Angeles Galvez Moreno Maria

Background: The short-term follow-up of patients with differentiated thyroid cancer (DTC) after the initial treatment is based on the measurement of stimulated thyroglobulin (s-Tg) and the use of diagnostic whole body scan (WBS).Objective: To evaluate the clinical utility of WBS performed at 612 months after thyroidectomy. Examine the correlation between s-Tg and results of WBS.Methods: We retrospectively evaluated all patien...

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ea0049ep1393 | Thyroid (non-cancer) | ECE2017

Evolution in the management of thyroid cancer: an observational study in two Belgian referral centres

Peene Bernard , Van den Bruel Annick , Moyson Carolien , Decallonne Brigitte

Background: Thyroid cancer incidence is increasing, especially the cancers ≤1 cm (T1a). Previous evidence suggests underuse of FNA. Several international guidelines for the management of thyroid cancer have been published. Especially the year 2006 was a hallmark, with the publication of both the ETA consensus and ATA guidelines.Aim: Compare thyroid cancer subtypes and management before and after 2006.Methodology: Retrospectiv...

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ea0049ep1394 | Thyroid (non-cancer) | ECE2017

Retrospective analysis of unusual thyroid tumours with clear cell features: morphology and differential diagnosis

Abrosimov Alexander , Sidorin Alexei

Background: In accordance with the WHO Classification of tumours of endocrine organs (Lyon, 2004) clear cell thyroid lesions have not been separated in one category as they are occurred quite rare, characterized by various cellular origin, heterogeneous morphological type, and malignant potential. Difficulties of morphological diagnosis of clear cell thyroid lesions are also obvious.Aim: Retrospective morphological study of clear cell thyroid tumours has...

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ea0049ep1395 | Thyroid (non-cancer) | ECE2017

Stimulated calcitonin levels as a predictor of medullary thyroid cancer

Alexandra Gheorghiu Cristina , Corneci Cristina , Jercalau Simona , Dobrescu Ruxandra , Mihai Daniel , Badiu Corin

Abstract: Medullary thyroid cancer (MTC) is a highly aggressive neuroendocrine tumour originating in the thyroid parafollicular cells. Calcitonin measurement and RET gene ascertainment have been used as markers for early diagnosis of MTC. Since pentagastrin is not available, calcium stimulation test helps to preclude gray zone values of basal calcitonin, diagnose minimal residual disease and help the early diagnosis of C cell hyperplasia.Aim:...

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ea0049ep1396 | Thyroid (non-cancer) | ECE2017

The relationship between extrathyroidal extension and BRAFV600E mutation in papillary thyroid cancer

Celik Mehmet , Yilmaz Bulbul Buket , Ayturk Semra , Can Nuray , Tastekin Ebru , Sezer Atakan , Ustun Funda , Guldiken Sibel

Aim: BRAF is one of the serine threonin kinases that activates mitogen activated protein kinase (MAPK) signal pathway.The aim of this study is to evaluatethe relationship between extrathyroidal extension (ETE) and BRAFV600E mutation in the subjects with papillary thyroid cancer.Materials and methods: Clinical and laboratory data of 455 patients, who had been followed-up in our clinic between the years 2010 and 2015 for PTC, were evaluated. The relationsh...

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ea0049ep1397 | Thyroid (non-cancer) | ECE2017

Insulin resistance and BRAFV600E mutation in the patients with differentiated thyroid carcinoma

Celik Mehmet , Yilmaz Bulbul Buket , Ayturk Semra , Tastekin Ebru , Can Nuray , Sezer Atakan , Ustun Funda

Aim: The incidence of nodular thyroid disease is high among patients with insulin resistance. The aim of this study is to evaluate the relationship between BRAFV600E mutation and insulin resistance in the patients with papillary thyroid cancer.Materials and methods: We examined clinical and laboratory data of 103 patients who had been followed up by our department between the years 2010 and 2015. The diagnosis of insulin resistance (IR) was made when the...

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ea0049ep1398 | Thyroid (non-cancer) | ECE2017

Beware a rapidly enlarging Thyroid mass- a case of Thyroid Lymphoma

Ashraff Suhel , Sharefi Ahmed Al , Nag Satyajit

Primary Thyroid Lymphoma is rare comprising less than 5% among all thyroid malignancies. It is historically associated with Hashimotos thyroiditis. It typically presents as a rapidly enlarging, painless goitre resulting in compression symptoms. Thyroid ultrasound and FNA cytology, using flow cytometry and immunohistochemistry, remain the primary modalities to confirm the presence of lymphoma. Treatment depends on the immunohistology. The prognosis is subtype depended and is ge...

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ea0049ep1399 | Thyroid (non-cancer) | ECE2017

Complementary thyroidectomy in papillary thyroid cancer

Durmus Yusuf , Celik Mehmet , Bulbul Buket Yilmaz , Ayturk Semra , Tastekin Ebru , Can Nuray , Sezer Atakan , Ustun Funda , Guldiken Sibel

Aim: ATA guideline recommends complementary thyroidectomy after thyroid lobectomy in case of tumor diameter>1 cm, in the presence of metastatic tumor, invasion, history of radiation therapy, familial history of thyroid cancer, multifocal or agressive variant tumor. In this study, we aimed to evaluate the relationship between the necessity of complementary thyroidectomy and post-surgery clinical, radiologic and histopathologic results in the patients who underwent complemen...

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ea0049ep1400 | Thyroid (non-cancer) | ECE2017

A case report: co-occurence of medullary thyroid carcinoma and papillary thyroid carcinoma

Camur Beliz , Celik Mehmet , Bulbul Buket Yilmaz , Ayturk Semra , Tastekin Ebru , Can Nuray , Sezer Atakan , Ustun Funda , Guldiken Sibel

Introduction: Co-occurence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same patient is unusual. We report a case with this rare event.Case: A 39 year old woman was presented with cough and shortness of breath. She had no prior history of radiation exposure, cigarette or alcohol consumption and no family history of thyroid cancer. On physical examination, a 3x5 cm thyroid nodule was palpated in the middle portion of thyroid gland...

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ea0049ep1401 | Thyroid (non-cancer) | ECE2017

Thyroid papillary carcinoma in the patients with resistance to thyroid hormone

Celik Mehmet , Bulbul Buket Yilmaz , Guldiken Sibel , Gurkan Hakan , Ayturk Semra , Can Nuray , Tastekin Ebru , Sezer Atakan , Ustun Funda

Resistance to thyroid hormone (RTH) is a genetic disease characterized by a reduced target tissue responsiveness to thyroid hormones and increased or normal TSH level despite elevated levels of thyroid hormones. This condition is mainly caused by mutations of thyroid hormone receptor beta (THRB) gene. The role of THRB mutation in carcinogenesis is still unclear. In here, we report a case of papillary thyroid carcinoma (PTC) with RTH, with a past medical history of subtotal thy...

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ea0049ep1402 | Thyroid (non-cancer) | ECE2017

A rare case: papillary thyroid carcinoma in the ectopic thyroid

Durmus Yusuf , Celik Mehmet , Bulbul Buket Yilmaz , Ayturk Semra , Tastekin Ebru , Can Nuray , Sezer Atakan , Ustun Funda , Guldiken Sibel

Ectopic thyroid tissue is the localization of thyroid tissue at any place other than the normal localization of the thyroid during the migration of embryonic period. Concurrent normal thyroid tissue may accompany. It usually is seen in women and in the midline. Very rarely thyroid carcinoma can develop. Treatment is like normal thyroid carcinomas, suggesting simultaneous thyroidectomy if accompanied by normal thyroid tissue. A 42-year-old female patient presented with complain...

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ea0049ep1403 | Thyroid (non-cancer) | ECE2017

Co-occurrence of papillary and follicular thyroid carcinoma in a patient

Yigitbasi Ahmet , Celik Mehmet , Bulbul Buket Yilmaz , Ayturk Semra , Can Nuray , Tastekin Ebru , Sezer Atakan , Ustun Funda , Guldiken Sibel

Occurance of papiller carcinoma with foliculer thyroid carcinoma is a rare situation. We report a 49-year-old male with asymptomatic goiter. The first biopsy from the right tyroid lobe from a 6×6×4 cm iso-hypoechogen heterogeneous nodule showed bening, hurthe cell and thyrocyte rich cytology. Two months later the patient went through right lobectomy which patology defined as 4.3 cm minimal invasive follicular carcinoma. Two months after right thyroidectomy, a second ...

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ea0049ep1404 | Thyroid (non-cancer) | ECE2017

A rare cause of respiratory failure: Anaplastic carcinoma

Celik Ece , Celik Mehmet , Bulbul Buket Yilmaz , Ayturk Semra , Can Nuray , Serez Bilkay , Guldiken Sibel

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal human malignancies. The median survival time following diagnosis is typically six months or less. Rapidly growing tumors may cause respiratory failure by compressing trachea. A 71-year-old woman presented with 1-month history of dyspnea, cyanosis and rapidly enlarging neck mass for the past 2 weeks. She had been suffering from multinodular goiter disease. Physical examination revealed a large, fixed an...

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ea0049ep1405 | Thyroid (non-cancer) | ECE2017

Our experience of strain elastography in the evaluation of thyroid nodules

Fenkci Semin Melahat , Coşkun Mehmet , Topsakal Senay , Yaylalı Guzin Fidan

Introduction: Thyroid nodule is a common finding in neck ultrasonography performed in adult age group. Appropriate management of patients with thyroid nodules accuretly is very difficult process. Fine needle aspiration biopsy (FNAB), is the traditional invasive method used to identify nodules. Investigations are continuing for noninvasive techniques. Elastography is the imaging new technic,to evaluate the nodules. Aim of this study to evaluate the results of FNAB and elastogra...

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ea0049ep1406 | Thyroid (non-cancer) | ECE2017

Association of TIMP-3 expression and BRAF V600E mutation status in papillary thyroid cancer

Zarkesh Maryam , Hedayati Mehdi , Zadeh-Vakili Azita , Daneshafrooz Afsoon , Razavi S Adeleh , Fanaei S-Ahmad , Foroughi Forough , Azizi Fereidoun

Background: The aim of this study was to assess the association between tissue inhibitor of metalloproteinase-3 (TIMP-3) gene expression and B-Raf Proto-Oncogene (BRAF) V600E mutation in marginal and tumoral tissues of papillary thyroid carcinoma (PTC) patients.Methods: Sixty fresh frozen tissues of PTC including 55.3% women were collected during thyroidectomy surgery. All clinicopathologic features of subjects were collected which confirmed by a patholo...

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ea0049ep1407 | Thyroid (non-cancer) | ECE2017

Histologically-proven Hashimoto’s thyroiditis significantly decreases the risk of structural recurrence in patients with low risk intra-thyroidal papillary thyroid cancer

Marotta Vincenzo , Sciammarella Concetta , Chiofalo Maria Grazia , Gambardella Claudio , Bellevicine Claudio , Grasso Marica , Conzo Giovanni , Botti Gerardo , Losito Simona , Troncone Giancarlo , Pezzullo Luciano , Colao Annamaria , Faggiano Antongiulio

Introduction: Due to the absence of randomized controlled trials, management of low risk papillary thyroid cancer (PTC), which represents the most commonly diagnosed form of thyroid malignancy, remains controversial. Hashimotos thyroiditis (HT) is significantly more frequent in patients with PTC, as compared with subjects carrying benign lesions as well as different tumour histotypes. Despite still controversial, HT is considered a protective factor in PTC being associat...

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ea0049ep1408 | Thyroid (non-cancer) | ECE2017

Evaluation of disease outcome in patients affected with differentiated thyroid carcinoma treated with total thyroidectomy or lobectomy

Colombo Carla , De Leo Simone , Perrino Michela , Di Stefano Marta , Cantoni Gianmaria , Vicentini Leonardo , Fugazzola Laura

Abstract: An individualized risk-based approach to the treatment of thyroid cancer is being extensively discussed in the recent literature, but controversies remain about the ideal surgical approach. In particular, if some data showed that properly selected thyroid cancer patients can be treated with lobectomy (LT) with excellent clinical outcomes, other results demonstrated an increased incidence of persistent recurrent disease in patients submitted to LT with respect to thos...

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ea0049ep1409 | Thyroid (non-cancer) | ECE2017

Does the delayed risk stratification system help to evaluate the risk of unfavorable clinical outcome in pT1aN0/Nx stage patients with differentiated thyroid cancer treated without radioactive iodine?

Gasior-Perczak Danuta , Palyga Iwona , Szymonek Monika , Walczyk Agnieszka , Kopczynski Janusz , Sluszniak Anna , Mezyk Ryszard , Gozdz Stanislaw , Kowalska Aldona

Introduction: In ATA recommendations (2016) a delayed risk stratification (DRS) system proposed by D.P. Momesso et al. was accepted as a diagnostic tool for the risk stratification of unfavorable clinical outcome and for monitoring the clinical outcome in differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI).The aim of the study: To evaluate the DRS system in patients with low clinical stage (pT1aN0/Nx).<p class="abste...

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ea0049ep1410 | Thyroid (non-cancer) | ECE2017

The impact of post-radioiodine therapy SPECT/CT on risk stratification in differentiated thyroid cancer; a bi-institutional study

Szujo Szabina , Sira Livia , Bajnok Laszlo , Bodis Beata , Gyory Ferenc , Nemes Orsolya , Rucz Karoly , Kenyeres Peter , Valkusz Zsuzsanna , Sepp Krisztian , Schmidt Erzsebet , Szabo Zsuzsanna , Szekeres Sarolta , Zambo Katalin , Barna Sandor , Nagy Endre V , Mezosi Emese

Objective: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of post-radioiodine therapy SPECT/CT of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis.Patients and Methods: 323 consecutive patients, 181 at the University of Pecs and 142 at the University of Debrecen, were investigated after their first radioiodine treat...

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ea0049ep1411 | Thyroid (non-cancer) | ECE2017

Clinical features of medullary thyroid carcinoma (MTC) in simultaneous occurrence with differentiated thyroid cancer (DTC)

Simeakis George , Saltiki Katerina , Anagnostou Elli , Apostolakis Michalis , Vasileiou Vasiliki , Alevizaki Maria

Objective: Simultaneous occurrence of MTC and DTC is frequently found. It is unclear whether there is a common pathogenic mechanism. Aim of our study was to characterize clinical features of MTC when coexisting with DTC.Methods: Of 273 MTC patients followed-up in our department 39 (14.3%) had MTC simultaneously with DTC. They were divided in 4 subgroups according to size. Clinical histopathological data were recorded.Results: The p...

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ea0049ep1412 | Thyroid (non-cancer) | ECE2017

Concomitant thyroid inflammatory myofibroblastic and follicular tumors

Laukiene Romena , Padlipskaite Audra , Zurauskas Edvardas

Abstract: We present a rare clinical case. Inflammatory myofibroblastic tumors (IMT) are extremely rare neoplasms of unknown etiology and most commonly found in lungs and gastrointestinal tract. A rare clinical case of the thyroid IMT occurred in a 50-year-old lithuanian female patient with clinical manifestation of breathlessness, dry cough, hemoptysis, neck mass, arrhythmia and loss of consciousness. Because of elevated D dimers values, pulmonary artery thromboembolism was s...

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ea0049ep1413 | Thyroid (non-cancer) | ECE2017

Is thyroid imaging reporting and data system useful in prediction of malignancy in thyroid nodules with persistent nondiagnostic cytology?

Baser Husniye , Topaloglu Oya , Faki Sevgul , Alkan Afra , Omer Yazicioglu Mustafa , Tatli Dogan Hayriye , Ersoy Reyhan , Cakir Bekir

Introduction: Although malignancy rate is low in thyroid nodules with nondiagnostic (ND) cytology, it is reported as higher in persistent ND nodules. We aimed to determine the role of ultrasonography (US) features and Thyroid Imaging Reporting and Data System (TIRADS) in the prediction of malignancy in patients with persistent ND cytology.Methods: 246 patients who underwent thyroidectomy with an indication of at least two ND cytologies were included in t...

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ea0049ep1414 | Thyroid (non-cancer) | ECE2017

Significant difference between the prevalence of C cell hyperplasia (CCH) in benign thyroid nodules without histological thyroiditis (HT) and in papillary/follicular thyroid cancers (PTC/FTC) at histology

Pieruzzi Letizia , Molinaro Eleonora , Agate Laura , Bottici Valeria , Torregrossa Liborio , Ugolini Clara , Basolo Fulvio , Vitti Paolo , Elisei Rossella

Background: CCH and serum hypercalcitoninemia (iperCT) can be found in benign thyroid diseases such as thyroiditis and in some cases of papillary (PTC) or follicular (FTC) thyroid microcarcinomas. The question of whether the association with these latter is related to the malignancy of the nodule is still unclear.Aim of the study: To evaluate the difference in the CCH prevalence, at histology, in a series of benign (BTN) and malignant (PTC/FTC) thyroid n...

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ea0049ep1415 | Thyroid (non-cancer) | ECE2017

Primary thyroid lymphoma: a differential diagnosis to be considered

Teresa Gallego M , Vera Lucia , Del Peso Cristina , Meoro Amparo , Martin Manuel , Candel Marife , Terol Emilio , Pastor Francisco

Introduction: Primary lymphoma of the thyroid, although rare, should be considered in the differential diagnosis of patients with thyroid nodules or goiter, because its prognosis and treatment differ substantially from that of the other disorders. Thyroid lymphomas are nearly always of the non-Hodking type (7080% B cell lineage). There is a 4:1 female predominance and the mean and median ages at diagnosis are between 65 and 75 years. Hashimotos thyroiditis is the o...

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ea0049ep1416 | Thyroid (non-cancer) | ECE2017

Relation between TSH levels and the aggressiveness of differentiated thyroid carcinomas

Aydinli Esra , Kulaksizoglu Mustafa , Kaya Ahmet , Karakurt Feridun

Aim: Differentiated thyroid carcinomas (DTC) composes 95% of all thyroid malignancies originating from thyroid follicular epithelial cells. DTC expresses TSH receptors so long time TSH stimulation may cause cancer occurrence or malignancy progression. So we aimed to assess the role of TSH levels in predicting thyroid cancer stage or aggressiveness.Methods: We retsopectively searched thyroid cancer patients fort he last 10 years in our instution. Totally ...

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ea0049ep1417 | Thyroid (non-cancer) | ECE2017

Ultrasonographic features of thyroid nodules with suspicious or malignant cytology

Chambidis Vasileios , Siolos Athanasios , Lazarou Lazaros , Efstathiadou Zoe , Panagiotou Athanasios , Adamidou Fotini , Kita Marina

Introduction: Thyroid sonography has become the first line diagnostic procedure for thyroid nodules. The characterization of specific sonografic patterns associated with high risk of malignancy has enabled physicians to determine which nodules are more likely to be malignant and thus merit further evaluation.Aim: We investigated whether the ultrasonographic nodule characteristics proposed in the literature were able to predict cytology findings after ult...

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ea0049ep1418 | Thyroid (non-cancer) | ECE2017

Development of papillary thyroid carcinoma in a patient with multiple solid cell nests of the thyroid

Liarigkovinos Theodoros , Daraki Vasiliki , Floroskoufi Paraskevi , Moustou Helen , Kalikakis George , Papavasiliou Stathis

Introduction: Solid cell nests (SCNs) of the thyroid are considered embryological remnants of the ultimobranchial bodies and the thyroid diverticulum. They are frequently (6189%) detected in the thyroid gland, but their biological significance remains disputable. According to the fetal cell thyroid carcinogenesis hypothesis SCNs may act as a source for specific thyroid cancer stem cells generating distinct thyroid cancer phenotypes. We report a case of a patient with con...

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ea0049ep1419 | Thyroid (non-cancer) | ECE2017

Statistical analyses on thyroid cancer in Romania

Purice Mariana , Goldstein Andrei Liviu , Chiriac Iulia Andreea , Radulescu Monica , Rusu Sorin , Mihai Alexandra-Cristina , Giurgi Andreea , Olteanu Madalina , Ghemigian Adina Mariana , Poiana Catalina

For over 50 years the casuistic of patients with thyroid cancer registered in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, Romania, has over 12 000 cases. In the last 6 years, a total of 2580 new cases have been added. They are organized in a classic file format. As a necessity and the first step in order to build a digital national database, we developed the BIOMAT-ENDO software as a Windows Forms application that stores...

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ea0049ep1420 | Thyroid (non-cancer) | ECE2017

Prognostic value of preoperative serum calcitonin concentration on primary surgery outcomes in medullary thyroid cancer

Gawlik Tomasz , Kukulska Aleksandra , Wygoda Zbigniew , Krajewska Jolanta , Stobiecka Ewa , Czarniecka Agnieszka , Jarzab Barbara

Calcitonin assessment in thyroid diseases is recommended when medullary thyroid cancer (MTC) is suspected in fine needle biopsy, as well as in suspicious for a follicular neoplasm class, especially oxyphilic type, in patients with germinal RET proto-oncogene mutation and in nondiagnostic biopsy when no surgical treatment is planned. This assessment is also suggested before any planned thyroid surgery to exclude MTC. Beyond diagnosis confirmation it is also suggeste...

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ea0049ep1421 | Thyroid (non-cancer) | ECE2017

Standardized mortality of thyroid cancer in Korea between 1985 and 2015: analysis of Korean national data

Choi Yun Mi , Kim Won Gu , Kwon Hyemi , Jeon Min Ji , Han Minkyu , Kim Tae Yong , Shong Young Kee , Hong Sang Mo , Hong Eun-Gyoung , Kim Won Bae

Background: The prevalence of thyroid cancer has increased very rapidly in Korea. However, there is no data focusing on thyroid cancer mortality in Korea. In this study, we aimed to evaluate standardized thyroid cancer mortality using national data from Statistics Korea.Methods: Population and mortality data from 1985 to 2015 were obtained from Statistics Korea. Age-standardized mortality rates (ASMR) of thyroid cancer per 100 000 were calculated accordi...

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ea0049ep1422 | Thyroid (non-cancer) | ECE2017

Incidental thyroid uptake detected by ⁶⁸Ga-DOTANOC positron Emission Tomography: is it clinical significant?

Silva Tiago Nunes da , Santos Joaquim Gomes , Matos Ana Catarina , Teixeira Joao Pedro , Oliveira Carla , Castanheira Joana , Carmona Susana , Duarte Hugo , Costa Durval , Oliveira Luis , Santos Ana Isabel , Portugal Jorge

Background: The detection of thyroid incidental uptake of radiopharmaceuticals has been increasing. Those detected by 18F-fluorodeoxyglucose positron emission tomography (PET) have been associated with a significant risk of malignancy (864%). Gallium-68 (Ga-68) labelled peptides are now the standard imaging modality for staging neuroendocrine tumours (NET). Its high sensitivity has increased the discovery of incidental findings. The aim of this study was to ev...

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ea0049ep1423 | Thyroid (non-cancer) | ECE2017

An association between breast cancer and the development of thyroid cancer

Brakni Lila

Introduction: Women with breast cancer (BC) have an increased risk of developing thyroid cancer (TC), specifically papillary and follicular thyroid carcinomas at a median of 5 years. The aim of the present retrospective study is to describe the clinical characteristics of women who present this association.Results: A total of 260 patients with an authenticated TC who were the median age at diagnosis is 41 years old (3665). All our patients live in ...

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ea0049ep1424 | Thyroid (non-cancer) | ECE2017

Lung metastases from differentiated thyroid carcinoma: long term outcome and its prognostic factors related to progression free survival

Sohn Seo Young , Kim Hye In , Kim Sun Wook , Chung Jae Hoon

Background: Distant metastasis rarely occurs in differentiated thyroid carcinoma (DTC), but represents most common cause of death in patients with DTC. Lung and bone are the most frequent sites of distant metastases. This study investigated long term outcomes of lung metastasis in DTC patients and its prognostic factors influencing disease progression and cancer specific survival (CSS).Methods: A total of 134 DTC patients presenting with lung metastasis ...

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ea0049ep1425 | Thyroid (non-cancer) | ECE2017

Is Hashimoto’s thyroiditis a risk factor for papillary thyroid cancer?

Cetin Zeynep , Baser Ozden Ozdemir , Berker Dilek , Guler Serdar

Aim: Hashimotos thyroiditis (HT) is the commonest autoimmune thyroid disease. Papillary thyroid cancer (PTC) is the most often thyroid cancer and its incidence is increasing yearly. It is not clear that HT is a predisposing factor for PTC. We studied PTCs frequency among HT patients went to total thyroidectomy.Materials and methods: Five hundred and thirty four patients done total thyroidectomy by general surgery were evaluated retrospectivel...

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ea0049ep1426 | Thyroid (non-cancer) | ECE2017

A new strategy to estimate levothyroxine requirement after total thyroidectomy and radioiodine remnant ablation for ‘intermediate’ and ‘high’ risk differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: The approach for initial thyroid hormone suppression in patients who undergo surgery for differentiated thyroid cancer (DTC), is based upon the risk of disease recurrence. In particular, recent American Thyroid Association guidelines suggest to maintain TSH levels between 0.1 and 0.5 mU/l and less than 0.1 mU/l for patients with intermediate and high risk respectively. The aim of the study is to identify the major predictive factors of LT4...

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ea0049ep1427 | Thyroid (non-cancer) | ECE2017

Follicular thyroid carcinoma in a patient with graves’ disease

Cheikhrouhou Nesrine , Elbez Intidhar , Limam Kaouthar , Mhiri Aida , Ltaeif Bechir , Benslimene Mohamed Faouzi

Introduction: Follicular cancer has a low incidence in Graves disease when compared to papillary thyroid cancer. Some studies have not reported any follicular cancer in patients with Graves disease. We describe a rare occurrence of follicular cancer in a patient with Graves disease.Observation: A 37-year-old female patient presented to our institute with symptoms of thyrotoxicosis. She had no family history of thyroid cancer or of radia...

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ea0049ep1428 | Thyroid (non-cancer) | ECE2017

Papillary thyroid carcinoma in children: report of 15 cases

Elbez Intidhar , Cheikhrouhou Nesrine , Limam Kaouthar , Mhiri Aida , Slim Ihsen , Ltaeif Bechir , Slimene Med Faouzi Ben

Papillary thyroid carcinoma is rare in young patients and have a good prognosis, although it is often diagnosed at the stage of lung metastases. Our multicenter study included 15 children aged between 5 and 18 years with female predominance, followed for differentiated thyroid cancer with lung metastases. All these patients underwent a whole body scan with I-131, serum thyroglobulin, chest radiography and/or cervico-thoracic CT. Scintigraphy had shown pulmonary miliary among a...

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ea0049ep1429 | Thyroid (non-cancer) | ECE2017

Evaluation of differentiated thyroid cancer patients according to different scoring systems: a single center experience

Cakir Bekir , Aydin Cevdet , Ogmen Berna Evranos , Tam Ali Abbas , Polat Sefika Burcak , Baser Husniye , Cuhaci Neslihan , Kahramanca Fatma Dilek , Bestepe Nagihan , Bilginer Cuneyt , Faki Sevgul , Kilic Mehmet , Kilicarslan Aydan , Ersoy Reyhan

Introduction: True risk evaluation is important in the management of thyroid cancer. We aimed to evaluate patients with differentiated thyroid cancer (DTC) according to the different staging systems.Method: Data of patients diagnosed with DTC between 2007 and 2014 at our institution were analysed retrospectively. TNM, MACIS, EORTC, AMES, De Groot, ETA, LATS, and ATA staging systems were applied to patients according to their original description. In ATA ...

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ea0049ep1430 | Thyroid (non-cancer) | ECE2017

A rare association of thyroid micro carcinoma and thyroid tuberculosis

Elbez Intidhar , Cheikhrouhou Nesrine , Limem Kaouthar , Slim Ihsen , Mhiri Aida , Ltaeif Bechir , Slimene Med Faouzi Ben

Introduction: Thyroid tuberculosis is a rare disease, its frequency is 0.150.2% of autopsic data. We report a case of micro papillary carcinoma of thyroid revealed by thyroid tuberculosis.Observation: Mrs. K.J aged 54 years presented a multinodular goiter without ultrasound signs of malignancy. The patient underwent total thyroidectomy. Histological examination revealed a granulomatous and giganto cellular inflammation which is in favor of a tuberc...

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ea0049ep1431 | Thyroid (non-cancer) | ECE2017

GA/GG Heterozygosity of ARG280HIS polymorphism in XRCC1 GENE: Genetic susceptibility genotype in differentiated thyroid cancer?

Kirnap Nazli Gulsoy , Tutuncu Neslihan Bascil , Yalcin Yaprak , Verdi Hasibe , Nar Asli , Atac Belgin

Background: Thyroid carcinomas are the most frequent endocrine malignancies of which more than nighty percent are differentiated thyroid carcinomas (DTC). Its known that genetic variation plays 75% role in the development of papillary thyroid carcinoma (PTC).Material and methods: In a case control setting subjects between January 2005 and December 2015 were evaluated for inclusion in the study. We aimed to compare the genotype frequency distributio...

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ea0049ep1432 | Thyroid (non-cancer) | ECE2017

Expression analyses of HABP2 in neoplastic and normal thyroid tissues: could this gene play a role in the pathogenesis of familial non medullary thyroid cancer?

Muzza Marina , Colombo Carla , Proverbio Maria Carla , Ercoli Giulia , Perrino Michela , Cirello Valentina , Vicentini Leonardo , Ferrero Stefano , Fugazzola Laura

Recently, the G534E variant of the HABP2 gene was reported as the underlying genetic defect in large kindred with non-syndromic familial non medullary thyroid cancer (FNMTC), but these data were not confirmed in additional cohorts. Consistently, we found in our wide series of FNMTC that the HABP2G534E variant is frequent, but does not segregate with the disease. Nevertheless, a possible role for this gene in the pathogenesis of FNMTC cannot definitely ruled out also because co...

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ea0049ep1433 | Thyroid (non-cancer) | ECE2017

Abstract withdrawn....

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ea0049ep1434 | Thyroid (non-cancer) | ECE2017

Mutation analysis of papillary thyroid cancers using a newly developed targeted multi-gene panel in Hungarian population

Kocsis-Deak Barbara , Arvai Kristof , Balla Bernadett , Tobias Balint , Kovesdi Andrea , Kosa Janos , Jaray Balazs , Szekely Tamas , Horanyi Janos , Lakatos Peter

Thyroid cancer is the most common malignancy of endocrine organs and its incidence is steadily growing worldwide. Approximately 80% of differentiated thyroid tumors are papillary carcinomas. Next-generation sequencing (NGS) allows for high-throughput sequencing analysis of large number of samples at a time in a cost effective manner. We have developed a targeted sequencing parallel testing panel for multiple mutations in genes involved in thyroid cancer pathology. A custom-mad...

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ea0049ep1435 | Thyroid (non-cancer) | ECE2017

K1 cell line in vitro: the impact of diagnostic absorbed doses from ¹³¹I

Stasiolek Mariusz , Adamczewski Zbigniew , Karwowski Boleslaw , Dedecjus Marek , Lewinski Andrzej

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake the phenomenon called thyroid stunning. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

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ea0049ep1436 | Thyroid (non-cancer) | ECE2017

Massive thyroid gland metastasis from nonsmall cell lung cancer

Simoniene Diana , Daneliene Milda , Klimaite Raimonda , Mikalauskaite Rasa

Despite that the thyroid gland is one of the most vascular organs of the body but thyroid gland is an uncommon site for metastasis [1]. It represents less than 4% of thyroid malignancy in clinical and surgical studies [2, 3]. 58-year-old male, a prior smoker, was diagnosed with nonsmall cell lung cancer T4N3M1 St IV, histopathological findings - infiltrative adenocarcinoma, G1. About eight months he was treated with chemotherapy. At the beginning of the disease, the patient wa...

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ea0049ep1437 | Thyroid (non-cancer) | ECE2017

Papillary thyroid cancer and chronic lymphocytic thyroiditis presenting with diffuse microcalcifications without focal mass on ultrasound

Vainikonyte-Kristapone Jelena , Makstiene Jurgita , Valickas Raimondas , Jakuboniene Neli , Kozloviene Dalia , Kuprionis Gintaras

The detection and characterization of PTC are based on the evaluation of specific ultrasonographic features of thyroid nodes. However, there is limited data regarding diagnostics without typical malignant-appearing nodules. We report a very rare case of PTC in underlying chronic lymphocytic thyroiditis ultrasonographically manifested with diffuse microcalcification without focal mass. A 22-year-old woman visited our institution complaining of weight loss, general weakness, and...

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ea0049ep1438 | Thyroid (non-cancer) | ECE2017

Columnar cell variant of papillary thyroid carcinoma

Hlavačkova Marie

Columnar cell variant is rare variant of papillary thyroid carcinoma. It occurs in both genders with the most common occurence in the middle age of life. It differs from common PTC both in morphology and especially in biological behavior. The cancer cells also commonly harbor BRAF mutation. We describe a case of young women, who came for the examination of the thyroid gland before in vitro fertilization. We found normal thyroid function tests, negative antibodies. A s...

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ea0049ep1439 | Thyroid (non-cancer) | ECE2017

A higher frequency of papillary thyroid carcinoma in myotonic dystrophy

Ben Hamou Adrien , Dhaenens Claire Marie , Espiard Stephanie , Benomar Kanza , Tiffreau Vincent , Caiazzo Robert , Aubert Sebastien , Vantyghem Marie Christine

Background and purpose: Type 1 myotonic dystrophy (MD), associates neuromuscular, cardiac, respiratory and endocrine disorders. The aim of this study was to determine the prevalence of thyroid disorders and of any causal factors.Methods: A retrospective single centre study was conducted, between 2000 and 2016, in 127 MD patients, diagnosed by familial genetic screening after informed consent. Clinical examination, TSH assay, 120-min glucose and insulin l...

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ea0049ep1440 | Thyroid (non-cancer) | ECE2017

Management of treatment-related toxicity caused by multi kinase inhibitors administered due to advanced thyroid carcinoma

Krajewska Jolanta , Kukulska Aleksandra , Handkiewicz-Junak Daria , Paliczka-Cieslik Ewa , Olczyk Tomasz , Gawlik Tomasz , Ledwon Aleksandra , Michalik Barbara , Jarzab Barbara

Multi kinase inhibitors (MKIs) constitute a new therapeutic option in advanced RAI-refractory differentiated thyroid cancer (DTC) and medullary thyroid carcinoma (MTC). To date four different MKIs demonstrated a beneficial effect on progression free survival in DTC (sorafenib, lenvatinib) and MTC (vandetanib and cabozantinib). However, the treatment related toxicity, which potentially may limit their clinical use and lead to a negative impact on the quality of life, have been ...

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ea0049ep1441 | Thyroid (non-cancer) | ECE2017

Cooperation between an endocrine nurse, psychologist and physician and their mediating role in the care of depression in patients treated with multi kinase inhibitors due thyroid cancer

Rozanska Alina , Syska-Bielak Anna , Kraus Justyna , Ocieczek Malgorzata , Wojtyna Ewa , Krajewska Jolanta

The treatment with multi kinase inhibitors (MKI) under clinical trials due to advanced thyroid cancer (TC) may postpone moving on the patients with advanced disease to the palliative care stage. However, chronic and escalating somatic symptoms during the treatment may promote the appearance of depressive reactions. It can be expected that a cognitive image of the disease, as a collection of subjective beliefs concerning patients own illness and treatment, will be an impo...

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ea0049ep1442 | Thyroid (non-cancer) | ECE2017

Malignancy risk stratification in thyroid nodules according to the Bethesda system for reporting thyroid cytopathology

Kowalska Aldona , Suligowska Agnieszka , Kopczynski Janusz , Niemyska Kornelia , Gozdz Stanislaw

Introduction: Fine needle aspiration biopsy (FNAB) plays a crucial role in the diagnosis of thyroid nodules. The choice of further therapeutic strategy depends largely on its result. Knowledge of the risk of malignancy in each diagnosis class in the population is necessary. The aim of the research was to analyse the risk of malignancy in thyroid nodules in each diagnosis class according to Bethesda system.Materials and methods: Retrospective research inc...

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ea0049ep1443 | Thyroid (non-cancer) | ECE2017

The sensitivity and positive predictive value (PPV) of 131I-post-therapy whole body scan is higher than serum Tg values in detecting metastases in early stage of differentiated thyroid cancer patients

Campenni Alfredo , Pignata Salvatore Antonio , Siracusa Massimiliano , Vicchio Teresa Manuela , Trimarchi Francesco , Ruggeri Rosaria Maddalena , Baldari Sergio

The work-up of Differentiated Thyroid Cancer (DTC) patients includes thyroid surgery, thyroid remnant ablation (TRA) with 131-radioiodine and long life follow-up. 131I-post therapy whole body scan (pT-WBS) and thyroglobulin (Tg) are used in identifying metastatic patients. Some authors suggested to use post-surgical Tg (ps-Tg) values in deciding for or against TRA. The aim of our study was to verify the sensitivity and PPV of 131I-pT-WBS compared to serum Tg levels in detectin...

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ea0049ep1444 | Thyroid (non-cancer) | ECE2017

Evaluation of clinicopathological factors in papillary thyroid cancer with cervical lymph node metastasis

Buyruk Betul Aydin , Kebapci Medine Nur , Yorulmaz Goknur , Buyruk Aytug , Kebapci Mahmut

Introduction and purpose: More than 90% of differentiated thyroid cancers are papillary thyroid cancer (PTC). Lymph node metastasis is common in PTC and has been reported to have no effect on prognosis. The risk of cervical metastasis is high in the presence of clinicopathologic factors including extrathyroidal extension, multifocality and lymphovascular invasion. In this study, it was aimed to evaluate the clinicopathological features of lymph node metastasis development....

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ea0049ep1445 | Thyroid (non-cancer) | ECE2017

Theranostic management of medullary thyroid cancer (MTC) with (111In/177Lu) CP04: how close are we to a clinical solution?

Hubalewska-Dydejczyk Alicja , Erba Paola , Decristoforo Clemens , Zaletel Katja , Mikolajczak Renata , Maecke Helmut , Maina-Nock Theodosia , Konijnenberg Mark , Kolenc-Peitl Petra , Trofimiuk-Muldner Malgorzata , Przybylik-Mazurek Elwira , Virgolini Irene , Pawlak Dariusz , de Jong Marion , Froberg Alide C , Rangger Christine , Goebel Georg , Scarpa Lorenza , Skorkiewicz Konrad , Lezaic Luka , Garnuszek Pirotr , Sowa-Staszczak Anna , Nock Berthold A , Bergant Damijan , Rep Sebastijan , Glowa Boguslaw

Effective targeted therapy for advanced endocrine malignancies is a goal of modern endocrinology. We herein present promising results of the first phase of clinical part of European project (Gran-T-MTC) aimed to assess the safety of gastrin analogue CP04 (DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) i.v. administration in dose (50 μg) useful for translation to 177In-CP04 for PRRT. CP04 has been selected for MTC therapy based on a high CCK-2 receptor...

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ea0049ep1446 | Thyroid (non-cancer) | ECE2017

Medullary thyroid carcinoma – diagnosis and outcome of patients treated in a tertiary center

Prokop Joanna , Palha Ana , Sabino Teresa , Neves Carolina , Cortez Luisa , Silva-Nunes Jose , Santos Cristina , Matos Lurdes , Candeias Natercia , Afonso Antonio , Fonseca Fernando , Agapito Ana

Medullary thyroid carcinoma (MTC) is a rare tumor of C cell origin, that may be sporadic or familial. Diagnosis is often delayed and its course variable.Objectives: Evaluation of clinical characteristics and outcome of patients diagnosed with MTC.Methods: Retrospective analysis of clinical records of patients with MTC between 2005 and 2016. We considered undetectable serum calcitonin as criteria of cure.Resul...

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ea0049ep1447 | Thyroid (non-cancer) | ECE2017

Papillary carcinoma of thyroglossal duct cyst with cervical lymph node metastasis

Hafsa Si Youcef , Amani Boussata , Said Azzoug , Someya Fedala Nora

Introduction: Neoplasias in the thyroglossal duct cyst (TDC) are rare, their prevalence varies from 1 to 1.5%. The most common cancer is papillary cancer representing 85% of cases. The diagnosis is often fortuitous following to the anatomopathological examination of the surgical specimen.Patient and method: Our patient has 33-years-old, with no previous medical history, which underwent a resection of a TDC of 29 mm in diameter, diagnosed by an anterior c...

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ea0049ep1448 | Thyroid (non-cancer) | ECE2017

Impact of RAC1/1b signalling on Sodium Iodide symporter regulation

Faria Marcia , Matos Paulo , Bugalho Maria Joao , Silva Ana Luisa

The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid cells. Its expression in thyroid tumors allows the use of radioactive iodine (131I) as co-adjuvant therapeutic tool to eliminate remaining tumor cells and metastases after total thyroidectomy. Nevertheless, certain subsets of patients with advanced forms of thyroid cancer lose the ability to respond to radioiodine therapy, which drastically reduces their survival rates. Recent studies ...

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ea0049ep1449 | Thyroid (non-cancer) | ECE2017

The usefulness of the study of sodium iodide symporter expression in thyroid primary tumors

Tavares Catarina , Coelho Maria Joao , Eloy Catarina , Melo Miguel , da Rocha Adriana Gaspar , Pestana Ana , Batista Rui , Ferreira Luciana Bueno , Rios Elisabete , Cavadas Bruno , Pereira Luisa , Selmi-Ruby Samia , Simoes Manuel Sobrinho , Soares Paula

Thyroid cancer therapy is based on surgery followed by radioiodine treatment of tumor remnants and metastases. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS), normally present in thyroid follicular cells membrane. We studied the expression of NIS in a series of 229 thyroid primary tumors using real time PCR and immunohistochemistry, and searched for possible associations between NIS expression and clinicopathological feature...

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ea0049ep1450 | Thyroid (non-cancer) | ECE2017

Concomitant occurrence of papillary thyroid cancer (PTC) in a branchial cleft cyst (BCC) and an occult multifocal PTC in the thyroid gland

Szczepanek-Parulska Ewelina , Borowczyk Martyna , Kluk Alina , Dworacki Grzegorz , Orłowski Marcin , Ziemnicka Katarzyna , Ruchała Marek

Introduction: BCC is a congenital epithelial neck cyst, which occurs due to failure of the second branchial cleft to obliterate during embryogenesis. Development of PTC inside the cyst is extremely rare.Case description: A 29-year-old female presented to the endocrinology clinic with a gradually increasing painless mass in the right lateral region of the neck, identified on ultrasound examination as an anechoic cyst of size 2×2×5 cm with a smoo...

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ea0049ep1451 | Thyroid (non-cancer) | ECE2017

Comparative analysis of clinicopathological characteristics between Korean and Italian thyroid cancer patients

An Jee Hyun , Kim Sin Gon , Kim Hoon Yub , Jung Kwang Yoon , Chae Yang Seok , Dionigi Gianlorenzo , Rausei Stefano , Tanda Maria Laura , Piantanida Eliana , Rosa Stefano La

Background: The incidence of thyroid cancer in South Korea has increased rapidly. Increase in medical surveillance and access to health care services have enhanced the detection of asymptomatic tumors. We investigated the differences of tumor characteristics between South Korean patients and Northern Italian patients subject to different healthcare systems.Methods: The demographic, histopathologic and management features of thyroid cancer operated in two...

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ea0049ep1452 | Thyroid (non-cancer) | ECE2017

Malignant struma ovarii and synchronous tumour of thyroid gland in the same patient: a single pathway for two different tumours?

Capitao Ricardo , Saraiva Catarina , Santos Francisco , Ferrinho Catia , Roque Catarina , Bello Carlos , Vasconcelos Carlos

Background: Struma ovarii (SO) is the presence of thyroid tissue as a major cellular component in an ovarian tumour.Case report: A 35-year-old, Caucasian female, asymptomatic and with normal physical examination was submitted to left oophorectomy due to an ovarian mass (8.2×7.0×6.0 cm) detected in routine pelvic examination. Her mother also had history of oophorectomy for an ovarian tumour and partial thyroidectomy for benign thyroid nodule. Th...

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ea0049ep1453 | Thyroid (non-cancer) | ECE2017

Does Preoperative Serum Neopterin Level Predict Differentiated Thyroid Carcinoma?

Tuna Mazhar Muslum , İmga Narin Nasıroğlu , Başaran Mehtap Navdar , Doğan Bercem Aycicek , Topcuoğlu Canan , Berker Dilek , Guler Serdar

Introduction: The frequency of thyroid surgery for suspected malignancy but postoperative resulted with benign pathology tends to increase in the worldwide. Therefore, additional preoperative markers are needed to prevent excessive surgery. Neopterin is a new molecule secreted by monocytes and macrophages and indicates the activation of cellular immunity. Therefore it can be used as a marker of immune activation. We aimed to evaluate the diagnostic value of serum neopterin lev...

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ea0049ep1454 | Thyroid (non-cancer) | ECE2017

Unexpectedly low thyroglobulin levels in differentiated thyroid carcinoma – case report

Norton-Brandao Francisco , Ferreira Teresa , Carvalho Manuel Rio , Carvalho Ines Patrocinio , Sousa Rita , Ratao Pedro , Salgado Lucilia , Simoes-Pereira Joana , Leite Valeriano

Case report: 66 year old male with a neck growing mass performed an ultrasonography and fine-needle aspiration biopsy which was suspicious for papillary carcinoma. The patient was submitted to total thyroidectomy and central and left lateral compartments lymph node dissection. The histological report showed a follicular carcinoma of 9 cm, with multiple lymphovascular invasions and skeletal muscle invasion. There was a focally positive surgical margin and resected lymph nodes h...

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ea0049ep1455 | Thyroid (non-cancer) | ECE2017

Papillary thyroid microcarcinoma: is it worth ablating the patients with radioiodine?

Urhan Muammer , Cagiltay Eylem , Deniz Ferhat

Objective: Recently, radioablation has been offered for patients with thyroid microcarcinoma, however some authors favor just follow-up as the prognosis of this disease is excellent. In this study, we compared the long-term follow-up results, for a period of 16 years, in patients with thyroid microcarcinoma in a group of patients with thyroidectomy only and in another both thyrodectomized and radioablated.Methods: Two hundred sixty five patients with a p...

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ea0049ep1456 | Thyroid (non-cancer) | ECE2017

Anaplastic thyroid carcinoma and multinodular toxic goiter

Capraru Oana-Maria

A 69 years old female with cervical radiotherapy 25 years ago for an unknown condition, known with multinodular goitre and hyperthyroidism for 6 years, presented with a 6 months history of enlarged right supraclavicular mass, local pain with difficulty in mobilization of the right arm and weight loss. She also reported progressive bilateral exophtalmia especially on the right side, no dysphagia, hoarseness or dyspnoea. Thyroid hormone levels were normal on antithyroid drugs an...

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ea0049ep1457 | Thyroid (non-cancer) | ECE2017

Evaluate the effectiveness of the Bethesda system for reporting thyroid cytopathology in the prediction of thyroid cancer (TBSRTC) on fine needle aspiration (FNA) in Moscow region, Russia

Britvin Timur , Nechaeva Olga , Krivosheev Alexey , Bavykina Larisa , Kazaryan Armine , Dreval Alexander

Aim: To evaluate the effectiveness of the Bethesda system for reporting thyroid cytopathology in the prediction of thyroid cancer on fine needle aspiration (FNA).Materials and methods: This is retrospective study of 70 detected thyroid cancer. Thyroid ultrasound and FNA were performed on all patients. 66 of them with cancer suspicion were communicated to the thyroid surgeon, 4 cases of papillary carcinoma were accidentally diagnosed after hystological in...

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ea0049ep1458 | Thyroid (non-cancer) | ECE2017

Outcomes and imaging results in patients with medullary thyroid cancer

Htay Thein , Sharabiani Mansour TA , Nimalasena S , Newbold Kate , Morganstein Daniel

Medullary Thyroid Cancer (MTC) is sporadic in approximately 75% whilst 25% of MTC occurs as hereditary forms due to RET mutations. Prognosis is relatively good with 10-year survival rates of 65%. However, many patients develop recurrent disease and imaging is critical to localise the site of recurrence. Eighty-eight MTC patients, attending the Royal Marsden Hospital NHS Trust were included in an analysis of overall survival. Median Follow-up duration was 7.5 years (IQR: 4.5&#1...

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ea0049ep1459 | Thyroid (non-cancer) | ECE2017

Lymph node metastasis of differentiated thyroid cancer: role of thyroglobulin in the washout fluid of fine-needle aspiration biopsies

Marques Bernardo , Martins Raquel , Cunha Nuno , Couto Joana , Santos Jacinta , Martins Teresa , Moniz Ana Paula , Ilheu Olga , Bastos Joana , Figueiredo Paulo , Valido Frederico , Rodrigues Fernando

Introduction: Thyroglobulin (Tg) measurement in needle washouts from fine-needle aspiration biopsies (FNA-Tg) increases the sensitivity of lymph node (LN) metastasis diagnosis in differentiated thyroid cancer (DTC). However, the cutoff value for FNA-Tg has not been clearly established and there are large differences between clinical studies, which hinders its interpretation. Our study aimed to investigate the optimal cutoff value of FNA-Tg and evaluate its utility in the diagn...

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ea0049ep1460 | Thyroid (non-cancer) | ECE2017

The epidemiology of thyroid cancer within a center of excellence in Athens: Real life data

Pantazi Eleni , Travlos Alexios , Vogiatzi Evaggelia , Kostoglou-Athanassiou Ifigenia

Thyroid cancer is the most frequent endocrine cancer. Its incidence has been found to increase in recent years. Additionally, environmental factors, which may be implicated in the pathogenesis of thyroid disorders, such as iodine deficiency and salt iodine supplementation are changing and may have an impact on the epidemiology of thyroid cancer. The aim was to study the epidemiology of thyroid within a center of excellence in Athens in the modern world setting. A cohort of 63 ...

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ea0049ep1461 | Thyroid (non-cancer) | ECE2017

Is thyroglobulin at ablation a good predictor of the thyroid remnant size in differentiated thyroid cancer?

Martins Helder , Costa Gracinda , Isidoro Jorge , Gil Paulo , Silva Rodolfo , de Lima Joao Pedroso

Aim: Stimulated thyroglobulin (sTg), measured at radioiodine remnant-ablation (RRA) in patients with differentiated thyroid cancer(DTC), is an important predictive factor of persistent disease. However, Tg produced by normal thyroid cells may also contribute to the sTg value.We aimed to study the relationship between sTg-level in RRA and the thyroid remnant size (TRs), using post-therapy whole-body scan (131I-ptWBS), at different TSH stimulation method.<...

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ea0049ep1462 | Thyroid (non-cancer) | ECE2017

Prevalence of thyroid cancer in malaga and province

Hernandez-Garcia Carmen , Munoz-Garach Araceli , Doulatram Viyu , Perez-Villa Lidia , Mellado-Soria J , Robles-Cabeza L , Gonzalez-Hermoso C , Tinahones-Madueno Francisco

Introduction: Thyroid cancer is the most common endocrine neoplasia, being its papirally version the most frequent. (90% of all differentiated thyroid neoplasms). It is usually multifocal and metastasizes normally to regional lymph nodes.Objectives: To describe the prevalence of thyroid cancer and its histopathological variants in the different regions of the province of Malaga.Material and methods: We performed a retrospective des...

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ea0049ep1463 | Thyroid (non-cancer) | ECE2017

Lymph node metastases location (central vs lateral neck) in well-differentiated thyroid carcinoma: Is it important?

Marques Bernardo , Martins Raquel , Couto Joana , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Regional lymph node (LN) metastases have prognostic significance in differentiated thyroid cancer (DTC). Several studies demonstrated that lateral neck LN metastasis, classified as N1b, have a greater impact on overall survival than central LN metastasis. Our study aimed to assess the risk of N1a vs N1b involvement on outcome in patients with differentiated thyroid cancer (DTC), according to the 7th edition of the TNM staging system.Methods...

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ea0049ep1464 | Thyroid (non-cancer) | ECE2017

Two cases with metastatic thyroid cancer

Dagdeviren Murat , Altay Mustafa , Safak Ozge , Akkan Tolga

Although the thyroid gland has an abundant blood supply, metastasis to the thyroid gland is a rare condition. Its incidence varies from 0.1% and 3% in clinical series. First case. A 56-year-old man presented to emergency service with neurological symptoms. CT of brain revealed multiple hyperdens lesions. Posteroanterior chest X-ray showed increased opacity in the left lung. Metastatic lung cancer was considered as a preliminary diagnosis and PET/CT was performed. PET/CT showed...

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ea0049ep1465 | Thyroid (non-cancer) | ECE2017

Isolated bone metastases: a rare form of presentation of papillary thyroid carcinoma

Peyroteo Mariana , Ribeiro Catia , Martins Pedro C , Ferreira Ana , Giesteira Laurinda , Barbosa Rui , Carvalho Machado , Ramalho Antonio , Moreira Augusto , de Sousa Abreu

Background: Papillary thyroid cancer (PTC) is the most frequent type of well-differentiated thyroid cancer (WDTC) and frequently poses a management dilemma. Its indolent behavior associated with high long term survival support the trend towards a more conservative management approach. The authors present a case of isolated bone metastases as the form of presentation of papillary thyroid carcinoma. A 61-year-old man was admitted with complaints of lower back pain for the previo...

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ea0049ep1466 | Thyroid (non-cancer) | ECE2017

Association between preoperative serum MMP-9 and histopathological features of thyroid tumors

Dobrescu Ruxandra , Picu Catalina , Schipor Sorina , Padure Adriana , Parvu Liliana , Manda Dana , Ioachim Dumitru , Badiu Corin , Caragheorgheopol Andra

Introduction: Matrix metalloproteinase-9 (MMP-9) is a zinc dependent proteolytic enzyme used by cells for degradation of the extracellular matrix during invasion and migration. There are only a few reports regarding the role played by MMP-9 in papillary thyroid carcinoma (PTC).Aim: To evaluate the association between MMP-9 secretion, reflected by preoperative serum levels and the histopathological features of thyroid tumors.Materia...

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ea0049ep1467 | Thyroid (non-cancer) | ECE2017

Follicular thyroid carcinoma and follicular variant papillary thyroid carcinoma: Clinical and histological features depending on the initial size

Perez Fernando Garcia , Gordillo Guillermo Martinez de Pinillos , Fernandez-Ladreda Mariana Tome , Lloclla Eyvee Arturo Cuellar , Porcel Jose Alvaro Romero , Marin Carmen Carretero , Leon Maria Victoria Cozar

Introduction: Follicular Thyroid Carcinomas (FTCs) and Follicular Variant Papillary Thyroid Carcinomas (FVPTCs) may present absence of suspicious ultrasonography features more frequently than classic papillary carcinomas. Thus, some cases may be identified with the pattern of low suspicion rather than intermediate or high suspicion defined in the American Thyroid Association (ATA) guidelines of 2015. These guidelines establish a size cutoff of 1.5 cm to recommend f...

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ea0049ep1468 | Thyroid (non-cancer) | ECE2017

Ten years of TSH suppression therapy in differentiated thyroid cancer analysed by HR-pQCT

Germain Natacha , Nadin Katia , Estour Bruno , Galusca Bogdan

Introduction: TSH suppression therapy by thyroid hormones (TST) in patients with differentiated thyroid cancer (DTC) could be associated with adverse effects on bone metabolism in post-menopausal women. Recent recommendations suggest therefore to minimize time passed under TSH suppression therapy. However data in literature are controversial and few shows results on microarchitecture. This study evaluated bone microarchitecture using High-resolution peripheral quantitative com...

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ea0049ep1469 | Thyroid (non-cancer) | ECE2017

Metastatic papillary thyroid carcinoma with intraglandular dissemination in remission of Graves’ disease

Brdar Dubravka , Eterović Davor , Šošo Gordana , Majstorović Tina , Punda Ante

A 26-year-old woman was referred to our outpatient clinic, presenting with growing left sided neck mass. She was in remission of Graves disease for the last two years.Ultrasound examination revealed isoechogenic nodule with microcalcifications in the upper third of the left thyroid lobe measuring 9×6×6 mm and conglomerate of lymph nodes on the left side of the neck, the largest node measuring 37×21×13 mm. Behind the lower pole of the left thyroid lobe...

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ea0049ep1470 | Thyroid (non-cancer) | ECE2017

Thyroid nodule size and the risk of malignancy

Puca Entela , Lumi Ema , Olldashi Blertina , Bitri Sonila , Ylli Dorina , Ylli Agron , Puca Edmond

Introduction: Thyroid nodule size is routinely assessed and has been a cause for concern, if it is a carcinoma or not.Aim: Our aim was to evaluate the relationship between thyroid nodule size and cancer risk. It was a retrospective analysis of 386 patients with thyroid nodules who referred to surgery in our hospital from January 2011 to March 2016. Patients demographic data, nodules size, and final pathology were recorded. All data were analyses us...

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ea0049ep1471 | Thyroid (non-cancer) | ECE2017

Lateral cervical lymph node metastasis from papillary thyroid cancer of undetected primary: a case report

Panagiotou Athanasios , Adamidou Fotini , Anagnostis Panagiotis , Bobos Mattheos , Hatzibougias Dimitris , Tzelepi Keraso , Kita Marina

Background: Lymph node metastasis from papillary thyroid cancer without detectable primary within the thyroid gland is extremely rare. We describe a case of a young woman with a cervical metastasis, without detectable orthotopic or ectopic thyroid focus.Case report: A 30-year old woman with a history of adenocarcinoma of the ascending colon six years previously, presented at the 15th week of a normal second pregnancy, for management of subclinical Hashim...

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ea0049ep1472 | Thyroid (non-cancer) | ECE2017

Birt–Hogg–Dubé and papillary thyroid carcinoma: a case report

Barka Ines , Krompa Katherina , Baudry Camille , Caux Frederic , Bihan Helene

Background: BirtHoggDubé (BHD) syndrome has been reported to be associated with neoplastic conditions. Its association with thyroid carcinoma has been reported but remains controversial. Here we report the case of a BHD patient with a thyroid papillary carcinoma.Case report: A 47-year-old man presented with asymptomatic facial papules, which had been gradually increasing in number for 6 years. A biopsy was taken from a papule on the nose...

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ea0049ep1473 | Thyroid (non-cancer) | ECE2017

Diagnosis of papillary thyroid carcinoma: Is it time to reconsider?

Panousis Panagiotis , Vasileiadou Stella , Katsamakas Michael , Boudina Maria , Nikolaidou Anastasia , Chrysoulidou Alexandra , Pazaitou-Panayiotou Kalliopi , Zafeiriou George

Aim: The aim of this retrospective study was to evaluate the diagnostic significance of presurgical thyroid ultrasound in comparison with FNAC of thyroid nodules and their contribution in detecting thyroid cancer.Patients and methods: We retrospectively studied the files of 118 thyroid cancer patients, 18 men (15.2%) and 100 women (84.8%), who underwent thyroidectomy from January 2013 until December 2016, in the Department of Surgical Oncology of Theagen...

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ea0049ep1474 | Thyroid (non-cancer) | ECE2017

Patient with thyroid carcinoma showing thymus-like differentiation: a case study

Kałużna Małgorzata , Janicki Adam , Sygut Jacek , Marszałek Andrzej , Ziemnicka Katarzyna , Ruchała Marek

Thyroid carcinoma showing thymus-like differentiation (CASTLE) is an extremely rare thyroid neoplasm. This type of tumour may arise from branchial pouch remnants or ectopic thymus and is considered as independent clinicopathological entity of thyroid neoplasms. There have been only about 100 cases described in the literature, so far. Here, we have retrospectively analyzed the data from histopathology and clinics of a 70 year old female patient with thyroid CASTLE who underwent...

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ea0049ep1475 | Thyroid (non-cancer) | ECE2017

Minimally and widely invasive follicular thyroid carcinomas: are there significant differences in clinical behaviour and prognosis?

Martins Diana , Ribeiro Cristina , Melo Miguel , Saraiva Joana , Martins Maria Joao , Baptista Carla , Oliveira Diana , Ventura Mara , Lages Adriana , Cunha Nelson , Catarino Diana , Fadiga Lucia , Costa Gracinda , Carrilho Francisco

Introduction: The existence of clear differences between the biological course and clinical behaviour of minimally invasive (MI) and widely invasive (WI) follicular thyroid carcinomas (FTC) is still debatable. The present study was conducted to outline the clinical differences between MI and WI-FTC and evaluate outcomes in both tumors.Methods: We conducted a retrospective cohort study involving 80 cases of FTC. The comparison between MI-FTC and WI-FTC in...

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ea0049ep1476 | Thyroid (non-cancer) | ECE2017

Cystic masses of neck: a case report

Gallego M Teresa , Vera Lucia , Meoro Amparo , Peso Cristina Del , Martin Manuel

Introduction: Cystic masses of neck consist of a variety of pathologic entities. The age of presentation and clinical examination narrow down the differential diagnosis. In adults are considered to be malignancies until proven otherwise (thyroid lesions, salivary gland neoplasms, metastatic squamous cell carcinoma and lymphatic malformations such as the cystic lymphangioma. Ultrasound (US) is often used for initial evaluation. Computed tomography (CT) and MRI provides addition...

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ea0049ep1477 | Thyroid (non-cancer) | ECE2017

Staging of thyroid cancer at the time of its diagnosis in a single clinical centre

Bałdys-Waligorska Agata , Kolodziej Maciej , Buziak-Bereza Monika , Koziara Michal , Sokolowski Andrzej

Medical documentation of 976 patients treated and followed-up over the years 20012006 at our 131- radioiodine treatment centre was analysed with respect to their thyroid cancer staging. The mean age at their time of diagnosis was 59±15.1 years. From histopathology, papillary, follicular or poorly differentiated cancer was diagnosed in 87.6, 11.7, and 0.7% of these patients, respectively. The mean ages of patients with papillary, follicular or poorly differentiated c...

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ea0049ep1478 | Thyroid (non-cancer) | ECE2017

Cystic nodule and carcinoma of thyroid gland, diagnosis and treatment of cistic nodule

Mihajlovska Snezana , Mihajlovska Marija

The cystic nodule is by its origin a real or pseudo cyst. According to the date of literature the papillary thyroid carcinoma is being detected in the cystic nodule in up to 27% of the cases. Ultrasound is the best diagnostic method of the cystic nodule and fine needle aspiration under ultrasound examination is a diagnostic method for cytological diagnosis.Results: Seventy patients with detected cystic nodule underwent fine needle aspiration and the aspi...

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ea0049ep1479 | Thyroid (non-cancer) | ECE2017

Incidence of thyroid cancer in the gray bethesda categories

Barbosa Berta , da Costa Moreira , Valente Vitor , Borges Fatima , Carvalho Andre

Objective: The recommendations for action in a Bethesda category III are to repeat the cytology or to perform molecular tests, and if these are inconclusive, surveillance or surgical indication may be maintained, depending on the risk factors, ultrasound characteristics of the nodule and patient preference. In case of category IV of Bethesda, the recommendation is the surgery. The objective of this study was to evaluate the impact of age, gender and nodule size on the incidenc...

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ea0049ep1480 | Thyroid (non-cancer) | ECE2017

Sentinel lymph node biopsy in medullary thyroid microcarcinoma after methylene blue dye mapping – a pilot study

Dzodic Radan , Santrac Nada , Buta Marko , Goran Merima , Djurisic Igor , Markovic Ivan

Introduction: The aim was to analyse usefulness of sentinel lymph node (LN) biopsy of jugulo-carotid regions after methylene blue dye mapping for selection of clinically N0 patients with medullary thyroid microcarcinomas (MTMC) and lateral LN metastases for one-time modified radical neck dissection (MRND).Materials and methods: From 2007 to 2016th, 15 patients were operated in our institution due to MTMCs with serum calcitonin levels lower tha...

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ea0049ep1481 | Thyroid (non-cancer) | ECE2017

Lymph node categorization as a prognostic factor in a historical series of medullary thyroid cancer cases within a regional hospital

Moreno Nerea Aguirre , Gonzalez Elena Fernandez , Mena Sandra Campos , Azpiroz Monica Marazuela , Vargas Marcos Lahera

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

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ea0049ep1482 | Thyroid (non-cancer) | ECE2017

A case of bilateralmetastaticrenal tumorof thyroid carcinoma

Brakni Lila

Introduction: Distant metastasis caused by thyroid carcinoma is common and usually found in lung or bone. Clinically detectebale, welldifferenciated metastatic thyroid carcinoma to the kidney is rare. Only 16 cases have been reported in the littérature. We describe a case of metastatic vesicular thyroid carcinoma to the bilateral kidneys in a 61 years women, with bone, pulmonary lever and lynph nodes metastasis.Case report: A 61 old women with a pas...

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ea0049ep1483 | Thyroid (non-cancer) | ECE2017

Is prophylactic central cervical dissection in papillary carcinoma of the thyroid justified?

Barbosa Berta , da Costa Moreira , Valente Vitor , Borges Fatima , Carvalho Andre

Objective: Thyroid cancer is the most common of the endocrine tumors, with papillary being the most frequent. There is no consensus about prophylactic central cervical dissection in patients with papillary carcinoma of the thyroid. The aim of this study is to analyze surgical complications and the rate of recurrence of papillary carcinoma in patients undergoing total thyroidectomy and prophylactic central cervical dissection, and patients submitted to total thyroidectomy alone...

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ea0049ep1484 | Thyroid (non-cancer) | ECE2017

Thyroid cancer frequency over three decades

Sanchez-Ragnarsson Cecilia , Gonzalez Silvia , Menendez-Torre Edelmiro

Aim: To investigate the frequency of thyroid carcinoma and its subtypes in one region over three decades.Material and methods: Data retrospectively collected from a tissue bank where all hospitals in a region with a little above 1 million inhabitants should send samples from all operated tumors, from 1981 to 2010.Results: From 1981 to 1990 there where 156 thyroid cancers; 206 from 1991 through 2000 and 362 from 2001 through 2010, w...

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ea0049ep1485 | Thyroid (non-cancer) | ECE2017

Thyroid nodules: a huge dilemma!

Grant Bonnie , Goulden Bethan , Tanday Raj , Casey Edel , Pittathankal Antony , Ojo Akin , Syed Imran , Nikookam Khash

Current UK guidelines for thyroid nodules advise a thyroid ultrasound (ThyUSS) with U-Classification with or without Fine Needle Aspiration (FNA) with Thy-Classification to determine malignancy risk. We report four cases where thyroid carcinoma was diagnosed histologically following reassuring cytology and radiological examination. This is a case of 28-year-old female who presented with neck swelling. ThyUSS showed an enlarged left thyroid with cystic and solid components; FNA...

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ea0049ep1486 | Thyroid (non-cancer) | ECE2017

Timing to repeat thyroid fine-needle aspiration after a follicular lesion of undetermined significance result - does it matter?

Santos Francisco Sousa , Ferrinho Catia , Capitao Ricardo , Duarte Joao Sequeira , Chorao Martinha , Limbert Clotilde , Vasconcelos Carlos

Introduction: Regarding thyroid nodules, in case of follicular lesion of undetermined significance (FLUS), performing repeat fine-needle aspiration (FNA) is a common follow-up strategy. It has been suggested that a waiting period of at least 3 months between FNAs would increase the diagnostic yield. Our study aims to clarify the optimal time for repeat FNA in case of an initial FLUS result.Methods: We identified retrospectively all thyroid FNA FLUS resul...

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ea0049ep1487 | Thyroid (non-cancer) | ECE2017

Development of hypoparathyroidism due to targeted therapies

Gokcay Canpolat Asena , Aydogan Berna Imge , Canlar Sule , Gullu Sevim , Erdogan Murat Faik

Due to inhibition affect on proliferation, motility, resistance to apoptosis and growth of metastasis, the epidermal growth factor receptor (EGFR) inhibitor erlotinib and vascular endothelial growth factor receptor (VEGF) and EGFR inhibitor vandetanib are viable treatment options for treatment of advanced non-small cell lung cancer and thyroid cancer respectively. Advanced non-small cell lung carcinomas (NSCLC) or medullary and differentiated thyroid carcinomas (MTC and DTC) m...

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