ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Vitamin D status and MPV changes in differentiated thyroid cancer
Kevser Onbasi 1 , Turkan Pasalı Kilit 1 & Aysenur Beyazıt Ucgun 2
1Dumlupinar University, Kutahya, Turkey; 2Suleyman Demirel University, Isparta, Turkey.
Thyroid cancer is the most common cancer in the endocrine system. Thyroid follicular epithelial-derived cancers are papillary, follicular, and anaplastic cancer. Risk factors for differentiated cancers are radiation exposure, and family history. Possible risk factors like occupational and environmental exposures, increased parity, late age at first pregnancy, and hepatitis C-related chronic hepatitis are potential but not proven risk factors. In order to evaluate other potential risk factors have we investigated the vitamin D status and MPV (mean platelet volume) in thyroid cancer patients and in other benign thyroid disorders. 25-OH vitamin D3 levels were low and MPV values have been found to be low. Low vitamin D may be a risk factor for thyroid cancer. Decreased MPV values may be used as a predictor of thyroid cancer.
| Thyroid cancer (n=47) | Hashimoto thyroiditis (n=30) | Graves disease (n=30) | Healthy controls (n=30) | P | |
| Age (years) | 45.96 (21–84) | 41.43 (17−59) | 42.37 (18–75) | 45,37 (19−69) | − |
| Gender (male/female) | 4/43 | 4/26 | 14/16 | 6/24 | − |
| WBC (×109/l) | 7.42±2.19 | 7.34±1.42 | 7.92±1.91 | 7.39±2.16 | 0.174 |
| Hb (g/dl) | 13.11 (9.3–16.8) | 13.47 (11.1−15.3) | 13.98 (10.9–17) | 13.55 (8.50−16.80) | 0.035* |
| Platelets (×109/l) | 279.14±81.98 | 293.43±66.27 | 272.8±67.90 | 266.57±61.10 | 0.145 |
| MPV (femtoliters,fl) | 8.22 (6–10.7) | 8.41 (6.9−10.6) | 8.38 (6.5–11.2) | 8.56 (6.40−10.90) | 0.001* |
| 25-OH Vitamin D3 | 13.82±8.01 | 19.94±11.68 | 20.05±12.63 | 18.94±11.70 | 0.006 |
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