Endocrine Abstracts (2017) 49 EP173 | DOI: 10.1530/endoabs.49.EP173

Concentration of dehydroepiandrosterone sulphate in 109 males and 54 females with adrenal tumors

Ilona Banisauskaite1, Paulina Simaityte1, Milda Sarkinaite1, Viktorija Bakstyte1, Juste Baksanskaite1, Rasa Steponaviciute2, Astra Vitkauskiene2, Vaidotas Urbanavicius3 & Valentinas Matulevicius1

1Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Department of Clinical Laboratory, Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania; 3Faculty of Medicine, Vilnius University, Kaunas, Lithuania.

Relation of dehydroepiandrosterone sulphate (DHEAS) concentration and adrenal tumors (AT) has never been investigated systematically. After promising Terzolo group (1995, 1996, 2000) investigations, there was made a recommendation in the last clinical guidelines for adrenal incidentaloma (2016) to assess concentration of DHEAS in special clinical situations. Here we present the first systemic study of DHEAS in adrenal tumors.

The aim was to analyse the clinical and laboratory characteristics (including DHEAS) of 109 males and 54 females with AT.

Methods: During 2014–2016 years concentration of DHEAS was determined in 5133 patients. Out of those case records of 590 females and 450 males were randomly selected for a detailed retrospective analysis. The relation between presence or absence of AT and DHEAS was established. Age and gender adjusted maximal values (R max) and minimal values (R min) of DHEAS concentration were used to express the results.

Results: AT were detected in 109 males and in 54 females. R max ≤0.4 was found in 64.81% of females starting from 45 years-old and in 67% of males starting from 60 years-old. R max value >1 was found in 11 cases of females (20.4%) and only in one case of males (0.92%). R min <1 value was detected in 13 cases of males (11.92%) and in two cases (3.7%) of females.

Conclusions: Out of all 163 cases of adrenal tumors, high level of DHEAS was found more frequently in females (7.36%), otherwise, low level of DHEAS was found more frequently in males (7.97%).