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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep146 | Endocrine tumours and neoplasia | ECE2017

Glucose metabolism abnormalities and insulin resistance are frequent in well diferentiated digestive NETs

Santos Ana P , Santos Ana C , Castro Clara , Raposo Luis , Torres Isabel , Henrique Rui , Monteiro Mariana P , Cardoso M Helena

Introduction: Incidence of Digestive NETs (DNETs) has increased in the last 40 years. Visceral obesity, metabolic syndrome (MetS) and insulin resistance (IR) have been associated with several types of cancer.Aim: To evaluate possible associations of obesity, hyperinsulinemia and IR with well-differentiated (WD) DNETs through a case control study.Materials and methods: Ninety-six patients with gastrointestinal (75.0%) and pNET (22.9...

ea0049ep147 | Endocrine tumours and neoplasia | ECE2017

Clinical and hormonal characteristics of adrenal incidentalomas

Belaid Rym , Oueslati Ibtissem , Mimita Wafa , Khiari Karima , Mchirgui Nadia , Abdallah Nejib Ben

Introduction: Widespread use of abdominal imaging has led to the identification of an increasing number of adrenal incidentalomas (AI) in the last decades. Causes of these adrenal masses are multiple.Aim: The aim of this study was to investigate the clinical and hormonal characteristics of AI.Materials and methods: The study was a retrospective monocentric analysis of 44 patients with AI who underwent radiographic and endocrine eva...

ea0049ep148 | Endocrine tumours and neoplasia | ECE2017

Pituitary insufficiency, the beginning of a diagnostic journey

Arhire Amalia Ioana , Cima Lumnita , Petrescu Simona , Adrian Miron , Andrei Florin , Barbu Carmen Gabriela

Introduction: We report a case of a pituitary insufficiency apparently resistant to treatment.Case report: A 74 year old patient was admitted through the ER in our department for a recently discovered pituitary macroadenoma. His general condition was poor in spite of the initiation of corticotherapy. Evaluation: Smoker, with no significant medical history, the BP: 100/60 mmHg, no orthostatic hypotension, disoriented, confused, with moderately altered gen...

ea0049ep149 | Endocrine tumours and neoplasia | ECE2017

Thyroid carcinoma in multiple endocrine neoplasia type 1

El Houda Khelil Nour , Lotfi Loudjedi , Med Meghelli Sidi , Necib Berber

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a cancer syndrome characterized by the development of neuroendocrine tumors of the pituitary gland, parathyroid and pancreas, and other neoplasms such as adrenocortical tumors and carcinoid.Observation: We report the case of a 70-year-old women with acromegaly that diagnosed 15 years ago, in relation with pituitary macroadenoma (30×25 mm) invading the left cavernous sinus and in contact wit...

ea0049ep150 | Endocrine tumours and neoplasia | ECE2017

Small pancreatic neuroendocrine incidentalomas: an observational prospective study

Villabona C , Busquets J , Martin L San , Planas A , Pelaez N , Fabregat J , Teule A , Peiro I

Background: Diagnosis of small pancreatic neuroendocrine incidentalomas (PNETs-I) is increasing during last years and often their management remains unclear.Objective: To describe our experience with patients with PNETs-I in our institution.Methods: Since March 2000, patients with non functioning PNETs-I ≤30 mm were evaluated in our center, prospectively. A descriptive analysis of all patients and a comparative study between ...

ea0049ep151 | Endocrine tumours and neoplasia | ECE2017

Potential inhibitory effect of progesterone on breast cancer metastasis via the regulation on protein expression of apoptosis- and EMT-related genes

Kim Gyu-Sik , Jeon So-Ye , Choi Kyung-Chul

Breast cancers that are estrogen receptor (ER)/progesterone receptor (PR)-positive are more likely to respond to hormone-related treatments than tumors that are ER/PR-negative. The present study investigated the effect of progesterone (P4) on 17β-estradiol (E2)-induced cell proliferation, apoptosis, EMT, and migratory and invasive features of MCF-7 clonal varient (CV) breast cancer cells that are ER/PR-positive. Preferentially, E2 was verified to induce breast cancer prog...

ea0049ep152 | Endocrine tumours and neoplasia | ECE2017

Incidental paraganglioma, diagnosis and follow-up – case report

Violante Alice , Lemme Roberto , Galvao Sarah , Naliato Erika

Paragangliomas and Pheochromocytomas are tumors originated from chromaffin cells (Pheochromocytomas (PHEO): adrenal glands; Paragangliomas (PGL):paravertebral thoracic, abdominal, and/or pelvic sympathetic ganglia, and glossopharyngeal and vagal neck and skull base parasympathetic ganglia). Catecholamine hypersecretion predominates in PHEO, while PGL are oligosymptomatic with compression-related symptoms. The authors report the case of a 33-year-old male with an incidental ret...

ea0049ep153 | Endocrine tumours and neoplasia | ECE2017

Primary hepatic neuroendocrine tumor with multiple liver metastases treated with somatostatin analogues: case report

Golu Ioana , Balas Melania , Amzar Daniela , Cornianu Marioara , Vlad Mihaela

Introduction: Somatostatin analogues (SSA) have been used as first line treatment to control the symtoms in hormonally active neuroendocrine tumors (NET), for over three decades. Primary hepatic neuroendocrine tumors (PHNETs) are rare neoplasms. Despite increased incidence of PHNETs over time, these tumors remain a rarity. According to the previously reported cases, primary neuroendocrine carcinoma of the liver is usually multicentric, often mimicking liver metastases. The dem...

ea0049ep154 | Endocrine tumours and neoplasia | ECE2017

Development of an everolimus-resistant BON1 cell line with altered cell cycle and c-Met activity

Prada Elke Tatjana Aristizabal , Maurer Julian , Spottl Gerald , Auernhammer Christoph , Nolting Svenja

Introduction: Pancreatic neuroendocrine tumors (panNETs) are often inoperable at diagnosis. The mTORC1 inhibitor everolimus is approved for the treatment of advanced NETs. Unfortunately, the development of resistance against everolimus limits its clinical efficacy.Aim: Our aim was to establish an everolimus-resistant panNET cell line to find common mechanisms of resistance.Methods: Pancreatic neuroendocrine tumor cells (BON1) were ...

ea0049ep155 | Endocrine tumours and neoplasia | ECE2017

False positive findings on 6-[18F]fluor-L-3,4-dihydroxyphenylalanine Positron Emission Tomography (18F-FDOPA-PET) performed for imaging of neuroendocrine tumors

Berends MA , Bolt JW , Kerstens MN , Links TP , Korpershoek E , de Krijger RR , Walenkamp AME , Noordzij W , van Etten B , Kats-Urgurlu G , Brouwers AH , van der Horst-Schrivers ANA

Background/Aim: Neuroendocrine tumors (NETs) are rare tumors arising from neuroendocrine cells throughout the body. Positron Emission Tomography (PET) scanning with 6-[18F]fluor-L-3,4-dihydroxyphenylalanine (18F-FDOPA) has been shown to be a valuable technique for the imaging of NETs. While the sensitivity has been assessed numerously, studies systematically describing false positive results, other than physiological variants, are lacking. Our aim was to systematica...

ea0049ep156 | Endocrine tumours and neoplasia | ECE2017

Imaging follow-up of non-functioning adrenal masses at Vilnius University Hospital Santariskiu Klinikos: 2010–2016

Svaikeviciene Kristina , Girdziute Milda , Visockiene Zydrune

Background: Current guidelines suggest against further imaging follow-up (FU) of patients with non-functioning adrenal masses with clear benign features on imaging studies.Aim: To analyse the data of patients with non-functioning adrenal masses who had FU at Vilnius University Hospital Santariskiu Klinikos (VUHSK) from 2010 to 2016.Methods: Cases coded as D35.0; D44.1; C74.1; C74.9; E26.0; E27,8; E24,8 according to ICD-10 classific...

ea0049ep157 | Endocrine tumours and neoplasia | ECE2017

Medullary thyroid carcinoma and pheochromocytoma in multiple endocrine neoplasia type 2A – a reversed order diagnosis

Gomes Ana Coelho , Silvestre Catarina , Marcalo Jose , Carvalho Maria Raquel , Bugalho Maria Joao

Introduction: RET germline mutation in codon 634 of exon 11 is one of the most frequent mutations of classical multiple endocrine neoplasia type 2A (MEN2A). Virtually all patients with classical MEN2A develop medullary thyroid carcinoma (MTC), which is often the first manifestation of the disease and usually occurs early in life. Pheochromocytomas (PHEOs) tend to be diagnosed several years later or simultaneously with the MTC.Case report: The pa...

ea0049ep158 | Endocrine tumours and neoplasia | ECE2017

Bilateral pheochromocytomas, asyptomatic medullary thyroid carcinoma associated with left side thyroid hemiagenesis in a patient with MEN2A: diagnostic correlations

Lungu Ionela , Georgescu Carmen Emanuela , Ciurea Anca , Georgiu Carmen , Petrescu Denisa , Cosma Daniel Tudor , Silaghi Horatiu , Silaghi Cristina Alina

Multiple endocrine neoplasia 2A (MEN2A), an autosomal dominant genetic syndrome caused by germline mutation in RET proto-oncogene, associates medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO) and primary hyperparathyroidism (HPT). Thyroid hemiagenesis (TH), the absence of one lobe, is a rare congenital abnormality (300 cases are reported in literature). Most cases of TH are diagnosed when patients present a lesion in the functioning lobe. TH was observed among members...

ea0049ep159 | Endocrine tumours and neoplasia | ECE2017

Follow-up of adrenal incidentalomas after the initial approach

Rebollo-Roman Angel , Moreno-Moreno Paloma , Prior-Sanchez Inmaculada , Herrera-Martinez Aura-Dulcinea , Barrera-Martin Ana , Galvez-Moreno Maria-Angeles

Aim: To describe the follow-up of adrenal incidentalomas (AI) classified as non-functioning and no suspicious for malignancy in the first approach.Patients and methods: Observational retrospective study of a cohort of patients who consulted in the Endocrinology service between 2005 and 2015 because of an AI. Statistical analysis performed with SPSS 19th version.Results: Two hundred and one patients with IA were firstly evaluated. T...

ea0049ep160 | Endocrine tumours and neoplasia | ECE2017

A case of silent pancreatic neuroendocrine tumour of carcinoid variety masquerading as an insulinoma

Elhadd Tarik , Suleiman Noor , Bashir Mohamed , Naem Emad , Mohamed Khalid , Elaffandi Ahmed , Samra Abdul Badie Abou

Objective: To highlight an unusual cause of hyperinsulinaemic hypoglycemiaMethods: Case Report: Results or Case PresentationA previously healthy and fit 52 year old gentleman of Asian descent presented with recurrent severe neuroglycopenic hyperinsulinemic hypoglycemic symptoms, suggestive of insulinoma. On several occasions he was confirmed to have severe hypoglcaemia with venous blood glucose values ranging between 1.5 and 2.7 mm...

ea0049ep161 | Endocrine tumours and neoplasia | ECE2017

CYP2W1*6 polymorphism as a potential predictive marker of sensitivity to mitotane treatment in adrenocortical carcinoma.

Altieri Barbara , Herterich Sabine , Sbiera Silviu , Volante Marco , Kroiss Matthias , Casa Silvia Della , Pontecorvi Alfredo , Terzolo Massimo , Fassnacht Martin , Ronchi Cristina L.

Mitotane is the only approved drug for the treatment of advanced adrenocortical carcinoma (ACC) and we recently demonstrated that a high expression of cytochrome P450 2W1 (CYP2W1) correlated with response to mitotane. The association between CYP2W1 alleles and a generally increased cancer risk is under debate. Aim of the study was to evaluate the frequency of CYP2W1 polymorphisms and its correlation with the response to mitotane treatment in ACC patients.<p class="abstext"...

ea0049ep162 | Endocrine tumours and neoplasia | ECE2017

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ea0049ep163 | Endocrine tumours and neoplasia | ECE2017

Ectopic ACTH-syndrome – 31 consecutive patients from the Helsinki University Hospital

Toivanen Sanna , Leijon Helena , Sane Timo , Schalin-Jantti Camilla

Background: Ectopic ACTH syndrome (EAS) is rare and published series are scarce.Aim: To increase the understanding of EAS we describe 31 consecutive cases in years 1997–2016.Results: Of the 31 patients, 65% (20/31) were women and 35% (11/31) men. Median follow-up was 23 months (0–217). Median age at diagnosis was 62 years (21–78), with peak incidences in age groups 30–39 and 60–69 years. Most patients prese...

ea0049ep164 | Endocrine tumours and neoplasia | ECE2017

Ectopic Cushing’s syndrome caused by a pulmonary adrenocorticotropic hormone secreting tumour: a case report

Pauliukiene Renata , Prakapiene Edita , Koreiviene Rasa , Klimaite Raimonda , Barsiene Lina , Sarauskas Valdas

Introduction: Ectopic adrenocorticotropic hormone (ACTH) production by the pulmonary neuroendocrine tumour (p-NET) is rare, and is considered an aggressive variant of carcinoid tumours with poor prognosis.Case presentation: 59-year-old male with fast progressing generalized fatigue, abdominal discomfort, and diarrhea was hospitalized in gastroenterology unit of Hospital of Lithuanian University of Health Sciences, Kauno klinikos (HLUHS KK). Digestive tra...

ea0049ep165 | Endocrine tumours and neoplasia | ECE2017

Could alcohol ablation become the standard of care for benign insulinomas?

Mazarico Isabel , Subias David , Junquera Felix , Vilardell Carme , Saigi Ignasi , Cano Albert , Casamitjana Laia , Gimenez-Palop Olga , Albert Lara , Capel Ismael , Caixas Assumpta , Rigla Mercedes

Introduction: Surgical resection is currently considered the standard treatment for symptomatic insulinomas; however, its morbidity is high (>10%) and it is restricted to suitable candidates. In recent years, alternative minimally invasive therapies, such as endoscopic ultrasound (EUS)-guided ethanol ablation (EA), have emerged as new therapeutic options, especially for small lesions or poor surgical candidates. We report two cases of insulinoma ablated with EA.<p clas...

ea0049ep166 | Endocrine tumours and neoplasia | ECE2017

Clinical characteristics and survival of patients with paraganglioma: a single center experience

Elezovic Valentina , Macut Djuro , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Bozic-Antic Ivana , Bogavac Tamara , Ilic Dusan , Bankovic Jovana , Damjanovic Svetozar

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare neuroendocrine tumors that derived from pluripotent neural crest stem cells. PCCs are derived from the adrenal medulla, while PGLs are histologically identical tumors derived from ganglia outside the adrenal gland. Even though the majority of tumors are benign, they are associated with high morbidity rates caused by excessive catecholamine secretion. We retrospectively analyzed 71 patients (36 female and 35 males) wit...

ea0049ep167 | Endocrine tumours and neoplasia | ECE2017

Corticotroph deficiency in patients with insulinoma

Kacem Faten Hadj , Ammar Mouna , Elleuch Mouna , ghorbel Dorra , Abdallah Rihab Ben , Charfi Nadia , Sefi Wajdi , Mnif Mouna , Abid Mohamed

Introduction: The metabolic stressor, hypoglycemia, elicits integrated counterregulatory responses, including activation of the hypothalamic–pituitary–adrenal axis. However, it is suggested that recurring insulin-induced hypoglycemia can impair this counter-regulation. Here we report three cases of patients with isulinoma and corticotroph deficiency.Case reports: The first case, 38-year-old man was referred because of recurrent episode...

ea0049ep168 | Endocrine tumours and neoplasia | ECE2017

Hyperinsulinemic hypoglycemia in a 71-year-old patient with a suspected case of β-cells hyperplasia of pancreatic body and tail- case report

Pancic Jelena Malinovic , Caric Bojana , Popovic Bojana

B-pancreatic cells are programmed to react to plasma glucose level with insulin secretion. Insulin secretion is precisely regulated and in the physiological conditions fasting glucose levels are maintained in the range 3.5–5.5 mmol/l. In hyperinsulinemic hypoglycemia, a disorder of the regulation of insulin secretion, insulin secretion continues at low concentrations of plasma glucose. In adults hyperinsulinemic hypoglycemia is the cause of 0.5 to 5.0% of hypoglicaemias a...

ea0049ep169 | Endocrine tumours and neoplasia | ECE2017

Respiratory symtoms lead to a diagnosis of pheochromocytoma: An unusual presentation

Teles Luis , Neves Joao Sergio , Souteiro Pedro , Oliveira Sofia Castro , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...

ea0049ep170 | Endocrine tumours and neoplasia | ECE2017

A rare cause of secondary endocrine hypertension in a young woman with hypokaliemia and recurrent transient ischemic attacks

Martinez-Martin Francisco Javier , Quintana-Arroyo Sara , Acosta-Calero Carmen , Arnas-Leon Claudia , Santana-Suarez Ana Delia , Nivelo-Rivadeneira Manuel , Kuzior Agnieszka , Gonzalez-Rodriguez Elisa

Clinical Case: A 39-year-old woman was referred to our Hypertension Clinic for workup after three episodes of TIA with SBP >180 mmHg in the last 6 months. Diagnosed and treated of hypertension and hypokaliemia since she was 15 years old, no secondary cause had been searched. She was treated with Telmisartan/Amlodipine/Hydrochlorothiazide 80/10/25 mg plus Carvedilol 12.5 mg BID and potassium supplements. She had no history of diabetes or dyslipidemia and did not smoke. Heig...

ea0049ep171 | Endocrine tumours and neoplasia | ECE2017

Atypical symptoms of hypoglycemia, hiding a diagnosis of insulinoma: a case report

Petrenaite Agne , Jagucianskaite Greta , Juskiene Rasa , Ziukaite Rasa , Visockiene Zydrune

Introduction: Insulinoma is a rare pancreatic tumor, typically sporadic, solitary and benign. However, nonspecific symptoms of hypoglycemia, negative laboratory investigations and small size of these tumors can retard the diagnosis, and symptoms may be misattributed to psychiatric, cardiac, neurological disorders.Case presentation: A 35-year-old male had history of night time seizures with hallucinations, delirium and spasms, lasting from 10 minutes to 1...

ea0049ep172 | Endocrine tumours and neoplasia | ECE2017

A nomogram consisted of routine biochemical tests may increase the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine tumors

Vurnek Ivan , Kruljac Ivan , Ćaćić Miroslav , Perić Božidar , Filipović-Grčić Maja , Mirošević Gorana , Kust Davor , Vrkljan Milan

Introduction: Falsely elevated serum chromogranin A (CgA) is associated with the use of proton pump inhibitors, the presence of renal impairment and systemic inflammation. We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram, in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).Methods: Our retrospective study included 155 subject...

ea0049ep173 | Endocrine tumours and neoplasia | ECE2017

Concentration of dehydroepiandrosterone sulphate in 109 males and 54 females with adrenal tumors

Banisauskaite Ilona , Simaityte Paulina , Sarkinaite Milda , Bakstyte Viktorija , Baksanskaite Juste , Steponaviciute Rasa , Vitkauskiene Astra , Urbanavicius Vaidotas , Matulevicius Valentinas

Relation of dehydroepiandrosterone sulphate (DHEAS) concentration and adrenal tumors (AT) has never been investigated systematically. After promising Terzolo group (1995, 1996, 2000) investigations, there was made a recommendation in the last clinical guidelines for adrenal incidentaloma (2016) to assess concentration of DHEAS in special clinical situations. Here we present the first systemic study of DHEAS in adrenal tumors.The aim was to analyse the cl...

ea0049ep174 | Endocrine tumours and neoplasia | ECE2017

Jejunum/ ileum Neuroendocrine Tumours: results of a multicentric retrospective study

Marques Ana Paula , Santos Ana Paula , Claro Isabel , Sanches Ana Cristina , Fernandes Isabel , Lopes Jose Manuel , Preto John , Rodrigues Fernando , Catarino Ana Luisa , Mellidez Juan , Pereira Bernardo , Rocha Gustavo , Bugalho Maria Joao , Neuroendocrinos Grupo Estudos Tumores

Introduction: The Neuroendocrine Tumors Study Group of the Portuguese Endocrine Society (SPEDM) performed the first observational study between November 2012 and July 2014 too assess the profile of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NET) patients (pts) followed at the main Portuguese hospitals. Several demographic and clinical data were collectedObjective: Characterize the clinicopathological features and treatment of patients with NET or...

ea0049ep175 | Endocrine tumours and neoplasia | ECE2017

Follow-up in neuroendocrine tumors: is chromogranin A the confounder?

Martins Diana , Baptista Carla , Velez Ana , Macario Fernando , Carrilho Francisco

Introduction: Chromogranin A continues to be one of the most valuable markers for neuroendocrine tumors (NETs) however, it has several limitations, including its reduced specificity.Methods: The authors present the case of a patient diagnosed with a midgut NET, during follow-up.Results: Male patient, 61 years old, with chronic renal disease (CRD), underwent right hemicolectomy owing to ileo-cecal valve lesion; hist...

ea0049ep176 | Endocrine tumours and neoplasia | ECE2017

Large intestinal metaplasia is a precancerous lesion present in patients with gastric neuroendocrine neoplasms type 1

Boutzios Georgios , Alexandraki Krystallenia , Mavroeidi Vassiliki , Koukoulioti Eleni , Papanikolaou Ioannis , Kaltsas Gregory

Background: Intestinal metaplasia (IM) of the gastric mucosa is a relatively frequent precancerous lesion. The aim of the study was to assess the prevalence and the kind of IM and also to find parameters that could predict the presence of IM in gastric neuroendocrine neoplasms type 1 (GNEN1).Methods: Fifty-nine (45 females) patients with GNEN1 were retrospectively studied. All patients included in the study had positive parietal-cell antibodies. All pati...

ea0049ep177 | Endocrine tumours and neoplasia | ECE2017

Pancreatic neuroendocrine tumors (PNETs) in patients with MEN1 syndrome

Isailovic Tatjana , Macut Djuro , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Milicevic Ivana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

PNETs represent the leading cause of mortality in MEN1 patients. Yet, their characteristics, behaviour, and therefore management, are still uncertain.The aim of this study was to describe the main clinical characteristics of NETs in MEN1, and to compare them with sporadic NETs.We investigated 164 patients with PNETs retrospectively, treated in one centre from 2004–2016. We identified 15 (9.1%) patients with MEN1. All patients ...

ea0049ep178 | Endocrine tumours and neoplasia | ECE2017

Dysregulation of the components of the splicing machinery in neuroendocrine tumors and its association with malignancy and aggressiveness

Pedraza-Arevalo Sergio , Alors-Perez Emilia , Herrera-Martinez Aura D. , del Rio-Moreno Mercedes , Sanchez-Sanchez Rafael , Ortega-Salas Rosa , Serrano-Blanch Raquel , Galvez-Moreno Maria A. , Gahete Manuel D. , Luque Raul M. , Castano Justo P.

Dysregulation of the splicing machinery is emerging as a novel cancer hallmark due to its association with multiple dysfunctions in tumor cells. An inappropriate function of the components of this machinery (spliceosome) could be primarily linked with the generation of tumor-associated aberrant splicing variants. In line with this, we have previously reported that overexpression of aberrantly spliced variants of somatostatin receptor 5 (sst5TMD4) and ghrelin (In1-ghrelin) is d...

ea0049ep179 | Endocrine tumours and neoplasia | ECE2017

Serum succinate: investigation of its putative role as a new biomarker in malignant SDH-x mutated pheochromocytoma-paraganglioma patients?

Lamy Constance , Hadoux Julien , Mercier Lionel , Bailleux Dorian , Hescot Segolene , Paci Angelo , Baudin Eric , Broutin Sophie

Introduction: Malignant paraganglioma/pheochromocytoma (MPP) are very rare neuroendocrine tumors with heterogeneous prognostic and no gold-standard treatment. MPP can be associated with germline mutations at SDH-x genes which encode for the succinate dehydrogenase that catalyzes the oxidation of succinate to fumarate. SDH-x mutations lead to inactivation of the enzyme and thus accumulation of succinate.Aim: This project aims to evaluate...

ea0049ep180 | Endocrine tumours and neoplasia | ECE2017

Survival analysis of patients with gastroenteropancreatic neuroendocrine tumors

Sampedro-Nunez Miguel , Maillo-Nieto Angeles , Ramos-Levi Ana Maria , Huguet Isabel , Campos Sandra , Fernandez Elena , Aguirre Nerea , Munoz de Nova Jose Luis , Martin Elena , Marazuela Monica

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patients’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

ea0049ep181 | Endocrine tumours and neoplasia | ECE2017

Insulinoma – clinical features and outcome of patients diagnosed at a central hospital

Prokop Joanna , Martins Ana Claudia , Neves Carolina , Sabino Teresa , Bogalho Paula , Nunes Jose Silva , Fonseca Fernando , Agapito Ana

Insulinoma, a rare neuroendocrine tumor (NET), is benign in more than 90% of cases. We present a review of patients diagnosed with insulinoma at our Department.Methods: Retrospective review of clinical records of patients diagnosed with insulinoma between 2011 and 2016.Results: Six female patients were diagnosed with insulinoma (age at presentation 30–66, follow-up: 0.25–3.25 years). Episodes of sweating, palpitations, tr...

ea0049ep182 | Endocrine tumours and neoplasia | ECE2017

Effects of ketoconazole on ACTH-producing and non ACTH-producing neuroendocrine tumor cells

Herrera-Martinez Aura D , Feelders Richard , Castano Justo , Dogan Fadime , Koetsveld Peter van , Hofland Leo

Prolonged spontaneous remission of hypercortisolemia in ectopic ACTH syndrome after long-term treatment with steroidogenesis inhibitors has been described. Direct drug effect on the adrenal glands, effects on tumoral ACTH secretion and/or POMC gene expression have been suggested. Medical treatment could be used for symptoms, but also for disease control.Materials and methods: In human BON-1 and DMS-79 cells, we have evaluated the effects of keto...

ea0049ep183 | Endocrine tumours and neoplasia | ECE2017

Treatment with (177Lu)-DOTATATE in patients with advanced metastatic somatostatin receptor-positive tumors

Martin-Portugues Antonio Ballesteros , Garcia Maria Isabel Del Olmo , Arques Pilar Bello , Huerta Angel Segura , Gomez Rosa Camara , Torres Juan Francisco Merino

Introduction: The NETTER 1 trial resulted in markedly longer progression-free survival (PFS), with preliminary evidence of an overall survival benefit. We report the results of PFS and safety of (177Lu)-DOTATATE in patients treated in our hospital between 2014 and 2016.Methods: Transversal and descriptive study of seven patients with advanced, progressive, somatostatin receptor-positive tumors who had received previous treatments. All of them were treate...

ea0049ep184 | Endocrine tumours and neoplasia | ECE2017

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) followed in the endocrinology and nutrition service’s monographic outpatient clinics of neuroendocrine tumors in hospital clínico san carlos (HCSC). Description of its characteristics and evolution

Jimenez-Varas Ines , Amengual Angela , Penso Rona , Ortola Anna , Azkutia Ane , Herraiz Lorea , Miguel Paz de , Diaz Jose Angel

Introduction: The multidisciplinary approach of the patients with GEP-NETs is very important, having a fundamental role the participation of the endocrinologist.Methods: Description of cases of GEP-NETs followed in the Service of Endocrinology of the SCCH from 1990 to 2016.Results: 95 patients were included, 53.7% were males, age 61.2 years (IR: 50.5–73.5). The diagnosis was incidental in 53.8%. 27.6% presented clinical secret...

ea0049ep185 | Endocrine tumours and neoplasia | ECE2017

Descriptive and survival study of 142 cases of gastroenteropancreatic neuroendocrine tumor (GEP-NETs) diagnosed at the Hospital Clínico San Carlos (HCSC)

Penso Rona , Jimenez-Varas Ines , Amengual Angela , Herraiz Lorea , Azkutia Ane , Ortola Anna , Miguel Paz de , Diaz Jose Angel

Introduction: Neuroendocrine tumors (NETs) constitute a very heterogeneous group of rare neoplasms, although their incidence has increased in recent years. We describe its evolution and survival.Methods: Retrospective study. All patients with histopathological diagnosis of GEP-NETs performed at the HCSC between 2000 and 2016 were selected, data from the medical history were included. Statistical analysis were done with SPSS.Results...

ea0049ep186 | Endocrine tumours and neoplasia | ECE2017

Nonfunctional adrenal incidentaloma affects central blood pressures and arterial stiffness parameters

Akkan Tolga , Altay Mustafa , Unsal Yasemin Aydogan , Dagdeviren Murat , Beyan Esin

Introduction: In recent years, it is thought that cardiovascular risk is increased in patients with nonfunctional adrenal insidentaloma (NFAI). There are not enough studies in the literature that evaluating this condition in patients with NFAI who don’t have traditional cardiovascular risk factors. The aim of our study is to determine peripheral and central blood pressures and arterial stiffness in patients with NFAI who don’t have traditional risk factors and autono...

ea0049ep187 | Endocrine tumours and neoplasia | ECE2017

Landscape of sporadic adrenal tumours from surgical unit – histopathological audit of 101 cases from a single centre in Poland

Jodkowska Anna , Sroczynski Maciej , Sepek Monika , Tupikowski Krzysztof , Mazur Grzegorz

Laparoscopic surgery of adrenal tumours is widely used because of its high effectiveness, patients safety and relatively low cost. Current indications to adrenalectomy of oncological and endocrinological origin are highly accepted. However there is still lack of perfect clinical tool identifying malignant lesions. In everyday practice clinicians rely on low specific features, especially considering larger nonsecretory lesions to surgery.To show the lands...

ea0049ep188 | Endocrine tumours and neoplasia | ECE2017

An elevated chromogranin A: is it always a tumor progression?-case report

Bursuc Anamaria , Daniela Belceanu Alina , Armasu Ioana , Tirnovan Mirela , Manolachie Adina , Crumpei Felicia , Ciobanu Delia , Leustean Letitia , Vulpoi Carmen

Introduction: Pancreatic neuroendocrine tumors (PNET) are rare, with an incidence of 1/100,000/year. Chromogranin A (CgA) is the most valuable marker in the diagnosis and monitoring of PNET. One of the disadvantages is its low specificity and the existence of a number of processes leading to an increase in its concentration, which often results in confusion and diagnostic difficulties.Case report: We present a 44-years-old female patient...

ea0049ep189 | Endocrine tumours and neoplasia | ECE2017

An unknown giant neuroendocrine tumor

Rekik Nabila , Ghorbel Dorra , Mnif Fatma , Kalthoum Mahdi , Mrabet Houcem , Charfi Nadia , Elfekih Hamza , Mnif Mouna , Abid Mohamed

Introduction: Neuroendocrine tumors may develop in almost any organ. These types of tumors may present with giant and asymptomatic mass. We describe a case of a large non functional neuroendocrine tumor reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia in 2016.Presentation of case: A 28 years old male presented with asthenia, gastric heaviness and epigastric pain. Further computerized tomography, a large ...

ea0049ep190 | Endocrine tumours and neoplasia | ECE2017

A challenging case of metastatic paraganglioma and metastatic melanoma and prolactinoma

Karim Rehmat , Mohammed Kamrudeen , Zaheer Shah Najeeb , Fahad Arshad Muhammad

Background: Paragangliomas are extremely rare endocrine tumours and can cause diagnostic difficulty, especially with a coexistent metastatic malignancy.Case: A 78-year-old man with diagnosed metastatic melanoma underwent a PET scan for staging of the malignancy. It showed a left upper quadrant mass with multiple skeletal deposits and a lesion in the pituitary all with intense focal uptake. The mass was unusual for a metastatic lesion from melanoma althou...

ea0049ep191 | Endocrine tumours and neoplasia | ECE2017

Biology and differential diagnosis of calcitonin secreting neuroendocrine tumors

Popovic Bojana , Macut Djuro , Elezovic Kovacevic Valentina , Isailovic Tatjana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Ognjanovic Sanja , Rodic Gordana , Petakov Milan , Damjanovic Svetozar

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

ea0049ep192 | Endocrine tumours and neoplasia | ECE2017

Cancerous neuroendocrine vs endocrine tumours: broad commonalities and differences

Jervis Nicola , Bouvier Catherine

Endocrine cancers are defined, by European Taskforce on Endocrine Cancer, as malignant tumours arising from endocrine organs including thyroid, adrenal, parathyroid, pituitary, as well as neuroendocrine tumours in general.Cancerous neuroendocrine tumours arise from neuroendocrine cells which can be found within the endocrine system: in the pituitary, pineal, parathyroid and (medulla of the) adrenal gland, or more scantily within the thyroid, pancreas, ov...

ea0049ep193 | Endocrine tumours and neoplasia | ECE2017

Short-term contralateral recurrence of a Litynski–Conn adenoma

Kuzior Agnieszka , Nivelo-Rivadeneira Manuel , Delia Santana-Suarez Ana , Arnas-Leon Claudia , Acosta-Calero Carmen , Quintana-Arroyo Sara , Martin-Perez Marta , Javier Martinez-Martin Francisco

Clinical Case: A hypertensive 60-year-old woman with nephroangiosclerotic stage IV chronic renal failure (eGFR 23.44 ml/min/1.73 m2) was referred to our hypertension clinic after the CT finding of a 26-mm left adrenal mass with adenoma density during hypertension workup, with normal right adrenal. Physical exam was unremarkable except for BP 167/98 mmHg. Plasma aldosterone was 353 ng/ml, PRA 1.3 ng/ml/h, ratio 90.2, K+3.1 mEq/l, and metanephrines were nor...

ea0049ep194 | Endocrine tumours and neoplasia | ECE2017

Acinic cell adenocarcinoma of the parotid gland associated with paraneoplastic Cushing’s syndrome – a rare clinical case

Castro Oliveira Sofia , Sergio Neves Joao , Souteiro Pedro , Belo Sandra , Isabel Oliveira Ana , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Primary acinic cell carcinoma (ACC) is an uncommon salivary gland (SG) tumor, making up 1–3% of all SG neoplasms, more frequent in women, at 40–60 year old. The cause is still unknown and the only well-established risk factor is ionizing radiation. ACC metastasize in 10–15% of the cases, 35% tends to recur and the rate of disease-associated death is about 16%. Surgical resection is the mainstay treatment, but radiation therapy may be used in some c...

ea0049ep195 | Endocrine tumours and neoplasia | ECE2017

Malignant pheochromocytoma – a challenging diagnosis with nonconsensual management

Castro Oliveira Sofia , Sergio Neves Joao , Souteiro Pedro , Lau Eva , Isabel Oliveira Ana , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytomas and extra-adrenal paragangliomas are rare neuroendocrine tumors, with a peak incidence between the 3rd–5th decades of life and about 10% are malignant. Although they have the same radiographic and histologic characteristics of their benign counterpart, malignant pheochromocytomas are diagnosed by the presence of local invasion or metastatic tumor in the non-chromaffin tissues, and offer a poorer prognosis. Treatment is typically extirpative...