Endocrine Abstracts

: Pancreatic neuroendocrine tumours (pNETs) are rare neoplasms arising from the endocrine pancreas. The fist line treatment is surgery that is often not curative in the presence of metastatic disease. Therefore, there is an increasing need for medical therapy. Sunitinib is a multi-target receptor tyrosine-kinase (RTK) inhibitor, described as having as main target VEGF receptor, with antitumor and antiangiogenic effects, approved for pNETs medical treatment. This study is aimed...

Finding new preclinical models to study the effects of anticancer drugs is one of the aims of biomedical research. Indeed, testing different in vitro systems can lead to a better understanding of the molecular pathways regulating tumor development and growth, and help to find new therapeutic approaches. This is crucial especially in the settings of pancreatic neuroendocrine tumours (pNET), where one of the main drugs approved for medical treatment is Sunitinib, a mult...

Introduction: Von Hippel–Lindau syndrome (VHL) is an autosomal dominantly inherited neoplastic disorder with marked phenotypic variability, characterized by a broad spectrum of clinical manifestations in central nervous system (CNS) and viscera. Specific gene mutation can be demonstrated; however imaging plays an important role in diagnosis. 68Ga-labelled somatostatin analog (68Ga-DOTANOC) PET-CT is routinely employed for somatostatin receptor (SSTR) imaging, mainly for n...

Introduction: GEP-NETs incidence increased markedly over the past decades probably due to increased imaging. GEP-NETs are generally indolent but often have unpredictable biological behavior and aggressive clinical course.Aims: To collect information regarding demographics, presentation, pathology characteristics, treatment and outcome of GEP-NETs.Methods: Following approval of our institutional ethical board, pathology and clinical...

Backgraund: Insulinoma is the most common functional pancreatic neuroendocrine tumor originating from β-cells, with unregulated insulin production and rarely associated with MEN-I syndrome. Diagnosis and treatment of insulinoma are a challenge in the practice of endocrinologist.Aim: To determine on the basis of retrospective analysis the optimal approaches to the management of patients with organic hyperinsulinism.Materials an...

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome and is the second most common cause of tumor-related hypoglycemia following insulinoma. Its prevalence is not known and is likely that many cases would go undiagnosed. In here, we describe a patient with PNET who presented with severe hypoglycemia.A 37-year-old male with known metastatic Pancreatic neuroendocrine tumors (PNET) presented with weight loss, sweating, and tremor, epi...

Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation. The clinical behavior seems to be influenced by the neuroendocrine component. We report a patient with mixed adenoneuroendocrine carcinoma of cecum who presented 18 years after her initial diagnosis and treatment.Case report: A 59-year-old woman presented with a 3-month hist...

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

Introduction: Hypoglycemia is a rare clinical problem in patients not being treated for diabetes mellitus and requires further evaluation and management if Whipple’s triad is present. Insulinoma commonly presents with fasting hypoglycemia. Insulinoma is rarely associated with type 1 multiple endocrine neoplasia, when tumors are usually multiple and more frequently malignant. The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin con...