Endocrine Abstracts

Vitamin D deficiency has become a worldwide problem, although vitamin D deficiency had associated with increased insulin resistance, obesity and HbA1c in patients with T2D.

It is uncertain whether vitamin D deficiency causes diabetes or its due to confounding. The active metabolite 1α,25-dihydroxyvitamin D3 may affect the receptors of pancreatic β-cells and hence affect insulin secretion, also it may have impact on insulin sensitivity.

Several trials revealed that vitamin D improved glycaemic control in T2DM patients. However, the outcome of these trials often was not clinically relevant.

The aim of this study is to reveal to the relation between vitamin D and naïve type 2 DM. This is a case control study that was conducted on 90 Egyptian diabetic subject of both gender their ages was between 25 to 70 years, Exclusion criteria are, post-menopausal females, pregnant & lactating females, presence of mal-absorption disorders like Crohn’s disease, celiac disease and cystic fibrosis, presence of any endocrinal disorder, presence of renal and hepatic disorders.

First group included 47 naïve type 2 diabetic patients (HbA1C above 7) including 51.1% male diabetic and 48.9% female diabetic patient and 46 healthy control including 47.8% male subject and 52.2%female subjects.

The 47-diabetic group their mean age was 40±0.5 years and their mean BMI was 28±3.6 while the 26 control subjects their mean ages is 42±7.8 years and their mean BMI was 28±3.8.

Vitamin D level was 22.47±10.5 and 23.57±9.7 ng/ml in diabetic group and in control group respectively, there were no statistically difference when comparing vitamin D level between the two groups. In this study, we found a negative correlation between vitamin D level and hyperglycemia.

Also, we found a positive correlation between vitamin D level and age, while vitamin D level was negative correlated with Body mass index.