Diabetes (to include epidemiology, pathophysiology)

Several studies have shown a link between pro-inflammatory activity and the presence or relative deficit of some fatty acids. A low amount of omega 3 fatty acids, appears to promote an inflammatory profile. The omega 6 fatty acids have also the same effect. It is well known that a chronic low-grade inflammation is associated to several diseases, namely, diabetes. The follow-up of children and young people with Type 1 diabetes involves the periodic evaluation of their lipidic p...

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ea0049ep404 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Sitagliptin use may reduce oral cancer risk in patients with type 2 diabetes

Tseng Chin-Hsiao

Background: Whether sitagliptin may affect oral cancer risk has not been investigated.Methods: The reimbursement database of the National Health Insurance in Taiwan was used. Diabetic patients newly treated with sitagliptin (n=50033) or other antidiabetic drugs (n=277038) within 19992008 were followed for oral cancer until December 31, 2011. The treatment effect was estimated by Cox regression adjusted for propensity score (PS) or...

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ea0049ep405 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Does a first-degree family history of diabetes impact placental vascular circulation and placental inflammatory response?

Bar Jacob

Background: Experimental and clinical studies have demonstrated that heritability of diabetes is associated with marked hyperinsulinemia, impaired endothelial function, and inflammatory up-regulation. However, no studies have examined whether a family history of diabetes effects placental maternal and fetal vascular circulation, or placental inflammatory response. The present study was designed to investigate the impact of first-degree family history of diabetes (FHD) on place...

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ea0049ep406 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Episodes of poorly controlled diabetes in 1486 patients admitted in Orthopedic Surgery and Traumatology

Vega Maria Molina , Mora Pilar Losada , Castro Alfonso M Garrido , Almeida Jose M Garcia , Linares Juan L Carrillo , Fuentes Miguel Damas , Garcia Carmen Rodriguez , Perdigones Cristina Diaz

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objectives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted in Orthopedic Surgery and Traumatology (OST) area.Material and methods: Descriptive analysis of patients admitted to OST Service who presented abnormally high or decreased blood g...

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ea0049ep407 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Episodes of poorly controlled diabetes in 173 patients admitted in Vascular Surgery

Vega Maria Molina , Mora Pilar Losada , Castro Alfonso M Garrido , Almeida Jose M Garcia , Linares Juan L Carrillo , Fuentes Miguel Damas , Garcia Carmen Rodriguez , Perdigones Cristina Diaz

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objetives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted to the area of Vascular Surgery and Angiology (VS).Material and methods: Descriptive analysis of patients admitted to the VS Service who presented abnormally high or decreased bloo...

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ea0049ep408 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Postprandial triglyceride responses and insulin resistance among night shift health care workers

Keithellakpam Kiranmala , Mohd Aslam , Mishra Brijesh , Jhamb Rajat , Sri Venkata Madhu

Background: A higher cardiometabolic risk has been reported in night shift workers. Post prandial hypertriglyceridemia (PPHTg) is recognized as an independent cardiovascular risk marker. Few studies have shown that acute disruption of circadian rhythm is followed by significantly altered insulin secretion and lipid tolerance.Aim and objectives: In this study we compared the postprandial triglyceride (PPTG) responses to standard oral fat meal between heal...

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ea0049ep409 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Improving safety in diabetes management and reducing insulin errors in hospital – practically achievable or a utopian fantasy?

Burbridge Wyn , Braycotton Lynne , Puttanna Amar , Yadagiri Mahender , Ilsley Dee , Mukhopadhyay Sagnik , Munichoodappa Karthik , De Parijat

42 insulin related incidents were reported within our Trust in 2014. Subsequent Root Cause Analysis revealed numerous insulin errors, hyperglycemia mismanagement and highlighted significant deficits in diabetes knowledge amongst nursing staff. To address the above issues, new safety interventions were introduced and five key outcomes are:1. A new stand-alone insulin prescription chart introduced May15 has seen insulin incidents dec...

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ea0049ep410 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Heterozygote c.313delC (p.H105TfsX11) mutation of Glucokinase gene in patient with Waardenburg syndrome type 1

Korkmaz Huseyin Anil

Background: Waardenburg syndrome is known as an inherited disorder associated with sensorineural deafness and pigmentary abnormalities affecting the skin, hair, and eye. There are rare case reports of Waardenburg syndrome with diabetes mellitus in the literature.Case: A 9-years-old boy from consanguineous family was admitted to pediatric endocrine department because of fasting and postprandial hyperglycemia. In the medical history, it was learned that hi...

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ea0049ep411 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus

Crispim Daisy , Duarte Guilherme , Assmann Tais , Dieter Cristine , de Souza Bianca , Canani Luis

Background and Aims: The transcription factor Gli-similar 3 (GLIS3) plays a key role in the development and maintenance of pancreatic beta-cells as well as in the regulation of Insulin gene expression in adults. Accordingly, genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 diabetes mellitus (T1DM) and glucose metabolism traits. Therefore, the aim of this study was to investigate the association of the rs7020673 (G/C) and r...

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ea0049ep412 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Vitamin D level in naïve Type2 Diabetes Mellitus in Fayoum University Hospital

Fahmy Eman , Mashahit Mohamed

Vitamin D deficiency has become a worldwide problem, although vitamin D deficiency had associated with increased insulin resistance, obesity and HbA1c in patients with T2D.It is uncertain whether vitamin D deficiency causes diabetes or its due to confounding. The active metabolite 1α,25-dihydroxyvitamin D3 may affect the receptors of pancreatic β-cells and hence affect insulin secretion, also it may have impact on insulin sensitivity.<p cla...

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ea0049ep413 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Association of wolfram syndrome with chronic renal failure in a boy

Korkmaz Huseyin Anil

Wolfram syndrome, rare neurodegenerative disorder, is known to be DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). There are rare case reports of Wolfram syndrome with chronic renal failure in the literature.A 19-year-old male patient was admitted to our pediatric emergency department because of headache, chest pain and diurnal and nocturnal enuresis. He had been diagnosed with ...

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ea0049ep414 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Hypoglycaemia in hospital is associated with longer hospital stay and decline of renal function

Fonseca Ricardo , Duarte Joao Sequeira , Bello Carlos , Capitao Ricardo , Santos Francisco Sousa , Roque Catarina , Ferrinhos Catia , Vasconcelos Carlos

Background and aims: Hypoglycemia is a common complication of diabetes treatment and its associated with poor outcomes. A link between severe hypoglycemia and renal dysfunction was suggested. No studies evaluated the impact of hypoglycemia of inpatients in microvascular or macrovascular complications. The aim of our work was to study the evolution of renal function between admission and final visit, and the impact of nephropathy in the presence of hypoglycemia in inpatie...

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ea0049ep415 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Could we prevent insulin induced lipohypertrophy in diabetic patients?

Volkova Natalya , Davidenko Ilya , Porksheyan Maria , Zibarev Alexander , Harlamov Alexey

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that caused by frequent subcutaneous injections of insulin. Nowadays, on the basis of results of ultrasonography of subcutaneous fat prevalence of LH in diabetic patients is still high.Design: The aim has been to develop prevention of insulin induced LH in diabetic patients. This study was done on 140 diabetic patients who had been under the treatment with insulin a mean 8 ...

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ea0049ep416 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Relation between serum leptin concentration and insulin resistance syndrome in patients with type 2 diabetes mellitus

Shebl Tamer , El Azeem Nour El Dein Abd , El Kareem Hosny Abd

Type 2 diabetes mellitus is known for its morbidity and mortality all over the globe. It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type 2 diabetes.Objectives: The aim of the present study was to assess the relation between serum leptin levels and insulin resistance syndrome in type 2 diabetic patients.Methods: Eighty persons were enrolled in this study an...

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ea0049ep417 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Epidemiological and clinical study of diabetes in immigrants from Bangladesh in Athens versus Greek patients

Papadakis Georgios , Zambelis Thomas , Konstantopoulos Kostas , Chatzipanagiotou Stylianos

Objectives: Diabetes risk for Asians is related to a greater tendency to adiposity, which increases insulin resistance. Various studies have highlighted the fact that people from South Asia have a younger age of onset of diabetes, greater upper-body adiposity and lower body mass index (BMI) and higher risk compared to those from other nations. Greece has experienced a large wave of immigration from Asian countries, especially Bangladesh. The purpose of this study was to explor...

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ea0049ep418 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Vitamin D levels in newly diagnosed type I diabetes mellitus and relationship with organ specific autoimmune disorders

Efe Belgin , Akdere Gonca , Yorulmaz Goknur

Based on the effects of Vitamin D on immune system it has been suggested that vitamin D may play a role in the pathogenesis of type I diabetes mellitus (T1D) and other organ specific autoimmune disorders. In our study, we aimed to show the effect of Vitamin D deficiency in the development of newly diagnosed T1D and other autoimmune disease that may associated with T1D such as autoimmune thyroid disease (ATD), celiac disease, Addisons disease, vitiligo and atrophic gastri...

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ea0049ep419 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Is secreted frizzled-releated protein 4 (SFRP-4) a possible biomarker for β cell dysfunction?

Baldane Suleyman , Ipekci Suleyman , Abusoglu Sedat , Unlu Ali , Kebapcilar Levent

Introduction: SFRP-4 is a recently described inflammatory cytokine influencing insulin secretion from human β cells as an extracellular modulator of Wingless (Wnt) pathway. The aim of this study is to compare serum SFRP-4 levels in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes (T2DM), and to investigate its relation with other parameters.Methods: The study included 152 patients who applied to the ...

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ea0049ep420 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The clinical efficacy of the nucleo CMP forte usage in the combined treatment of diabetic peripheral neuropathy

Martynyuk Larysa , Makarchuk Nadiya , Shved Mykola , Mykhailiv Lesia

Introduction: The protocols of medical care of diabetic peripheral neuropathy (DPNP) are developed but positive effect cannot be achieved in all patients. New medications in DPNP have to be studied.The aim: To evaluate the efficacy of Nucleo CMP Forte (Cytidine 5- disodium monophosphate and Uridine 5- trisodium triphosphate) in the combined treatment of patients with DPNP.Methods: It was examined 59 (41&#1...

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ea0049ep421 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Effect of glucose ingestion on serum fractalkine levels in healthy subjects and diabetic patients

Baldane Suleyman , Kendir Ismail Can , Ipekci Suleyman , Tekin Gulsum , Unlu Ali , Kebapcilar Levent

Introduction: Current studies suggest that fractalkine (FKN) could be a pathogenic factor associated with adipocyte dysfunction and type 2 diabetes (T2DM) and have shown that FKN serum levels are increased in T2DM patients. The aim of this study was determined as evaluating the change of FKN levels that will occur with oral glucose tolerance test (OGTT).Methods: The study included 67 patients to whom OGTT was applied. The patients with the history of dia...

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ea0049ep422 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Epidemiological features of type 1 diabetes in children and adolescents in the Republic of Armenia

Aghajanova Yelena M , Bayburdyan Gayane M , Navasardyan Lusine V , Markosyan Renata L , Kalantaryan Lusine G

Background: Diabetes is the most prevalent chronic metabolic disorder in children and adolescents, and incidence rates for both type-1 and type-2 diabetes are increasing worldwide. In recent years, the number of patients with type 1 diabetes is increasing mainly due to children under 5-years-old.Objective: To study the epidemiological indicators of T1DM among children of the Republic of Armenia (RA) from 2007 to 2016. Methods: Retrospective analysis of t...

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ea0049ep423 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

High incidence of glucose metabolism disorders in patients undergoing coronary angiography without history of diabetes

Paschou Stavroula A , Kiokas Sotirios , Avdikos Grigorios , Lazaris Efstathios , Vryonidou Andromachi

Introduction: The aim of this study was to investigate the incidence of glycemic disorders in patients undergoing coronary angiography with no prediagnosed type 2 diabetes (T2D), as well as the association of the glycemic status with the extent of the coronary artery disease (CAD).Patients and methods: We studied 170 consecutive patients (134M/36W), 63.9±13.1 (2395) years old, with not known T2D, who underwent coronary angiography. HbA1c was m...

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ea0049ep424 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The relation between type II diabetes and chronic depression in primary care practice in Jordan

Alzoubi Abdallah , Naser Renad Abu , Khasawneh Ady , Khasawneh Aws

Diabetes is a major health problem that affects 8.5% of adults worldwide, and 13.2% of adults in Jordan. Studies suggest a bidirectional relationship between diabetes and chronic depression. Diabetic patients are twice as likely to suffer from depression that is symptomatically worse when compared to nondiabetic individuals. Depressed diabetics suffer from poor glycemic control and increased risk of diabetes complications. Because little is known about the bidirectional relati...

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ea0049ep425 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Anti-islet cell antibodies in a sample of Egyptian females with gestational diabetes and its relation to development of type 1 diabetes mellitus

M Amer Hanan , Abd elbaky Rania S , Nasr Merhan S , Hendawy Laila M , Taha Mohamed O , Ibrahim Wessam A

Background: Gestational diabetes mellitus is any degree of glucose intolerance with first diagnosis during pregnancy; it affects 310% of pregnancies. The presence of diabetes-related autoantibodies has shown to be able to predict the development of type 1 diabetes before hyperglycemia arises.Aim of work: To recognize the prevalence of islet cell antibodies among a sample of Egyptian females with gestational diabetes and its possible relation of dev...

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ea0049ep426 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

A retrospective analysis of the impact of new diagnostic criteria for gestational diabetes mellitus on the endocrinology service at a tertiary hospital

Htet Thaw Dar , Lam Alice , Banakh Iouri , Sriamareswaran Rumes , Wu Samuel , Felsinger Jasmina , Mattheisson Kati , Nye Elisabeth

Background: The prevalence of gestational diabetes mellitus (GDM) may increase with the implementation of revised diagnostic criteria (as recommended by the International Association of the Diabetes and Pregnancy Study Groups) aimed at identifying pregnancies at increased risk of adverse perinatal outcomes. There are clear implications for health-care services in terms of resources and the associated cost-benefit relationship. Our study analysed the impact on clinic visits, th...

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ea0049ep427 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Insulin autoimmune syndrome-a case report

Alaguney Elif Sevil , Efe Belgin , Yorulmaz Goknur , Acu Berat , Durmus Insaf

Introduction: Hypoglycemia is a medical emergency that can have many different causes in etiology. Autoimmune hypoglycemia in patients with very high insulin levels should also be considered in the differential diagnosis.Case: A 50-year-old man was admitted to our clinic for investigation and treatment of hypoglycemic episodes. He did not have any evidence for the use of oral antidiabetic medications, insulin, herbal substances. However, in our history, ...

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ea0049ep428 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Incidence estimate of type 1 Diabetes in Youth in Dhaka

Balsa Ana , Zabeen Bedowra , Ogle Graham , Tayyeb Samin , Azad Kishwar

Introduction: Analysis of epidemiologic patterns in diabetes helps with understanding of etiology, natural history and current and future needs. Bangladesh is a low-middle-income, densely populated country where there is limited information regarding incidence of childhood diabetes.Aim: To assess the type of diabetes in children and young adults in Dhaka, Bangladesh, from July 2011 until June 2016, and estimate minimum incidence of type 1 diabetes (T1D)....

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ea0049ep429 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Is thiol/disulfide homeostasis related to parity and gravidity in gestational diabetes?

Yildiz Faruk , Bicer Cemile , Senyurt Mahmut , Alisik Murat , Carlioglu Ayse

Purpose: The purpose of this study was to evaluate the relation gestational diabetes mellitus (GDM) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Material/Methods: Thirty one subjects diagnosed with GDM and 30 healthy pregnant women were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method in this study. After native thiol, t...

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ea0049ep430 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Endocrine factors associated with postprandial hypoglycaemia in patients with cystic fibrosis: a pilot study

Elamin Yasir , Crowley Rachel , Mckone ED , Twomey Patrick , Hatton Siobhan , Martin-Grace Julie , Kearns S

Postprandial hypoglycaemia in patients with cystic fibrosis (PWCF) is frequently reported but poorly understood. The aim of this pilot study was to investigate the aetiology of postprandial hypoglycaemia in PWCF. Serum cortisol, insulin and C-Peptide were measured at the 2 hour timepoint of the annual glucose tolerance test in 32 PWCF not known to have CF-related diabetes. Hypoglycaemia was defined as glucose < 3.3 mmol/l. Patients were classified as Normal glucose toleran...

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ea0049ep431 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Vascular dementia and type 2 diabetes: incidence and outcomes in elderly patients in a ten year study

Munoz-Rivas Nuria , Canizo-Gomez Francisco Javier del , Mendez-Bailon Manuel , Andres Ana Lopez-de , de Miguel-Yanes Jose Maria , Hernandez-Barrera Valentin , de Miguel-Diez Javier , Jimenez-Garcia Rodrigo

Background: To describe trends in the incidence and outcomes for vascular dementia in elderly patients with and without type 2 diabetes (T2DM) in Spain between 2004 and 2013.Methods: We used National Hospital Discharge Data to select all patients aged 70 years or over discharged from hospital with a vascular dementia primary diagnosis. Discharges were grouped by diabetes status (T2DM or non-diabetic). Incidence was calculated overall and stratified by di...

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ea0049ep432 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Study of the glycemic control in the hospitalized patient

Pacheco Lucia Vera , Redondo Lorena Rentero , Navalon Carles Iniesta , Aviles Amparo Meoro , Garcia Maria Teresa Gallego , Del Peso Gilsanz Cristina , Valera Maria Amparo Egea , Espin Noelia Victoria Garcia-Talavera , Sanchez M. Bienvenida Gomez

Objective: To evaluate the degree of compliance of the glycemic objectives in non-critic-hospitalized patient and determinate the factors associated to the lack of compliance of the aforesaid objectives.Material and method: Retrospective observational study in hospitalized patients during 2014. Adult patient age 18 or older, who had at least two points of care de glucose measurements (capillary blood glucose) during their hospitalization, were included. ...

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ea0049ep433 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Hypoglycaemia: Prevalence and factors associated in the old-hospitalized patient

Pacheco Lucia Vera , Redondo Lorena Rentero , Navalon Carles Iniesta , Garcia Maria Teresa Gallego , Aviles Amparo Meoro , Gilsanz Cristina Del Peso , Valera Maria Amparo Egea , Espin Noelia Victoria Garcia-Talavera , Sanchez M^a Bienvenida Gomez

Objective: To determine the hypoglycaemia prevalence in an old-patient hospitalized and to stablish the factors associated with its appearance and to study the association between the hypoglycaemia with the stay in hospital and the mortality during the hospitalization.Material and method: A retrospective study in which all patients, older than 65 years old that were hospitalized during 2014 and at least two glycemic control have been realised, were inclu...

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ea0049ep434 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The importance of islet antigen-2 and glutamic acid decarboxylase antibodies in proper diagnosis of diabetes mellitus at the age ≥30 and <70 years

Kondrotiene Aiste , Danyte Evalda , Zalinkevicius Rimantas , Verkauskiene Rasa

Objective: Misclassification of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) is quite common and crucial to choice of appropriate therapy. The aim of the study was to evaluate the correspondence of islet antigen-2 (Anti IA2) and glutamic acid decarboxylase (Anti GAD65) antibodies with clinical diagnosis.Methods: The Anti IA2 and Anti GAD65 were measured in 583 patients (337 males and 246 females) diagnosed with T1DM or T2DM with not typical manifest...

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ea0049ep435 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The increase in unsaturated fatty acids is related with an anti-inflammatory profile in the hypothalamus of non-diabetic IRS2-deficient mice

Barrios Vicente , Vinaixa Maria , Frago Laura M. , Canelles Sandra , Valverde Angela M. , Argente Jesus , Yanes Oscar

Background: IRS2-deficient (IRS2-/-) mice are considered a good model to analyze the development of diabetes as some of them present an increase in glycemia comparable to that observed in diabetes onset in humans, whereas a high proportion of these mice do not develop diabetes. Energy homeostasis regulation by the hypothalamus can be disturbed by an inflammatory environment, which predisposes an individual to the onset of diabetes. Saturated fatty acids induce hypot...

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ea0049ep436 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Epidemiological indicators and prevalence of risk factors of diabetes type 2 among the inhabitants of Almaty city and Almaty region of Kazakhstan

Danyarova Laura , Tashmanova Akmaral , Shyman Zhanmedet

Relevance: The main risk factors for developing diabetes type 2, such as obesity, overeating and a sedentary lifestyle are common to a variety of chronic non-infectious diseases.Purpose of the study: Investigate the source of epidemiological indicators, risk factors for type 2 diabetes based on cross-sectional study of the population of Almaty city and Almaty region of Kazakhstan.Methodology: The material for the research were popu...

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ea0049ep437 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Association of FGF21 soluble levels with metabolic profile in Gestational Diabetes patients

Saucedo-Toral Cristian A. , Lazo-de-la-Vega-Monroy Maria L. , Fajardo-Araujo Martha E. , Espinosa-Nava Manuel A. , Anaya-Torres Francisco J. , Ibarra-Reynoso Lorena del R. , Ruiz-Noa Yeniley

Introduction: Gestational Diabetes Mellitus (GDM) has been associated with complications both in the neonate and in the mother; including increased risk of Type 2 Diabetes Mellitus (DM2), obesity, and cardiovascular disease. Fibroblast growth factor 21 (FGF21) is a key regulator of glucose and lipid metabolism. Recently, the relationship between FGF21 and metabolic component diseases such as diabetes mellitus and obesity has been demonstrated. In addition, FGF21 mRNA and prote...

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ea0049ep438 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Site-specific cancer risk in people with type 2 diabetes: Nationwide population-based cohort study in Korea

Cho Du-Hyong , Jang Ju-Young , Kim Suk Kyeong , Kim Dong-Lim , Song Kee-Ho

Background: Many studies indicated an increased cancer incidence and cancer mortality in subjects with diabetes mellitus. But most of studies have been surveyed in western countries and have problems in applying the results to Korean. We aimed to evaluate the site specific cancer risk of diabetic patients in Korea over 30 years, and investigate causal relationship and temporal relationship by analyzing the organ-specific cancer risk in diabetics according to duration.<p cl...

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ea0049ep439 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Erosio interdigitalis blastomycetica- discrete and early sign for diabetes mellitus

Chiriac Anca E. , Azoicai Doina

Erosio interdigitalis blastomycetica is a special form candidiasis commonly seen in the third web space of digits, but can spread to all web spaces. Diagnosis is clinically suspected in the presence of maceration and ulceration, erythema, sometimes associated with pain. The main predisposing condition is chronic maceration (for example in launderers), irritant chronic agents and prolonged moisture affect skin barrier with subsequent colonization of Candida spp. Direct...

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ea0049ep440 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Postpartum Tip 2 DM follow-up after gestational diabetes mellitus

Sancak Seda , Ozdemir Ali , Abacar Kerem Yiğit , Celik Ayhan , Okuroğlu Nalan , Sertbaş Yaşar , Aydin Hasan

Purpose: GDM is defined as any degree of carbonhydrate intolerance that is first diagnosed during pregnancy. Patients diagnosed with GDM are expected to have complications such as Type II DM, obesity, hypertension in the long term. Prevalence of GDM diagnosis during pregrancy changes between 2 and 10%. Our purpose is to revaluate the OGTT of the patients diagnosed with GDM, with regard to their postpartum Type II DM progress.Materials and methods: 450 pr...

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ea0049ep441 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Diabetic nephropathy in type 1 diabetes mellitus

Barka Ines , Chikhrouhou Nesrine , Maaroufi Amel , Kacem Maha , Chaieb Molka , Ach Koussay

Nephropathy is a serious complication of Type 1 diabetes mellitus (T1DM) with a grave prognosis after the onset of proteinuria. End stage of renal disease remains the major cause of excess morbidity and premature mortality in patients with T1DM. The aims of the present study were to investigate the prevalence of diabetic nephropathy and to evaluate risk factors for its development among patients developing T1 DM. Seventy six patients with T1DM history over 20 years were includ...

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ea0049ep442 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Diabetes and smoking: epidemiological study in two ethnic groups

Papadakis Georgios , Zambelis Thomas , Konstantopoulos Kostas , Chatzipanagiotou Stylianos

Objectives: Smoking tobacco is a risk factor for several diseases and has been increasing in many developing countries. Smoking cessation counseling should be a routine component of diabetes care. The aim of the present study was to examine the association between smoking status in two different groups of patients with diabetes: Immigrants from Bangladesh who live in Greece and Greek-born subjects.Methods: A total of 166 immigrants with diabetes (122 wit...

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ea0049ep443 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Prevalence of hyperglycemia in patients hospitalized in the health area of cuenca (Spain)

Perez-Rodriguez Jose , Guerra-Navarro Lidia , Alramadan Mubarak , Garcia-Notario Paula , Martin-Iglesias David , Aranda-Regules Santiago , Calderon-Vicente Dulce

Introduction and objectives: Hyperglycemia is a common problem in hospitalized patients, that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the prevalence of hyperglycemia in our hospital.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every 3 days in 2 months. We excluded patients younger than 15 years, stays less than 3 days and those of the...

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ea0049ep444 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Testosterone levels in men with diabetes mellitus. What relation?

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: Low serum testosterone (LST) is associated with some chronic diseases, changes in body composition and resistance to insulin. Diabetes is one condition that has high prevalence of LST.Objetive: To determine the prevalence of LST in men with diabetes and its relationship with age, anthropometric and biochemical data.Material and methods: A cross-sectional study of 65 men with type 1 and type 2 diabetes was conducted, wit...

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ea0049ep445 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Vitamin D and testosterone in diabetes mellitus: cross-sectional study results

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: In the recent years, Vitamin D role has grown in cardiovascular and inflammatory diseases, and some relations were made with low serum testosterone (LST) levels. It is equally known that in patients with diabetes, the prevalence of LST is higher.Objetive: To determine the prevalence of low levels of vitamin D and its relation with LST in men with diabetes.Material and methods: A cross-sectional study of 65 men with type...

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ea0049ep446 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The relationship between serum uric acid and insulin resistance and sensitivity parameters in Turkish type 2 diabetes mellitus patients

Ekiz-Bilir Betul , Bilir Bulent , Soysal-Atile Neslihan , Elbuken Gulsah

Summary: Hyperuricemia is associated with glucose metabolism disorders clinically. In this study, we evaluated the relationship between serum uric acid concentrations and some insulin resistance/sensitivity parameters in Turkish type 2 diabetes mellitus patients.Methods: The anthropometric and laboratory data of 87 type 2 diabetes patients of both sexes (35 male, 52 female) were evaluated retrospectively. HOMA-IR (homeostatic model of insulin resistance)...

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ea0049ep447 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Relationship with T helper 1 cytokines and type 2 diabetes

Gonca Tamer Havva , Caklili Ozge Telci , Kartal Ilkay , Gungor Kagan , Mutlu Hasan Huseyin

Objectives: T helper1 (Th1) cells were determined to have important roles in the development of type 2 diabetes (T2D). We aimed to investigate relationship between Th1 cytokines (IFN γ, IL-2 and TNF-α) and T2D.Material and methods: The study included 32 newly diagnosed type 2 diabetic patients (T2DPs) who had not begun to take antidiabetic agents except from insulin and 30 healthy subjects (CG) who did not have glucose intoerance (fasting or af...

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ea0049ep448 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Adipocytokines, incretins, insulin resistance and body composition coherence in women with previously diagnosed gestational diabetes mellitus

Francaite-Daugeliene Migle , Velickiene Dzilda

Introduction: Adipose tissue is a major source of adipocytokines. It plays an important role for the development of insulin resistance (IR). Data implicate that incretins enhance insulin sensitivity. One aspect of the pathophysiology of gestational diabetes (GDM) is IR. The relationship between adipocytokines, incretins and GDM might be closely associated.Aim: To evaluate the coherence of adipocytokines (adiponectin and leptin), incretins (GLP-1, GIP), i...

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ea0049ep449 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The coherence of carbohydrate metabolism and metabolic parameters (adipocytokines, incretins, insulin resistance) in women with previously diagnosed gestational diabetes mellitus

Francaite-Daugeliene Migle , Velickiene Dzilda

Introduction: There is growing evidence that gestational diabetes mellitus (GDM) significantly increases the risk of adverse consequences, the most significant of which is a predisposition to the development of metabolic syndrome and diabetes mellitus (DM). The reasons why some women develop DM, while the others not, are still studied. The relationship between various metabolic parameters and GDM might be closely associated.Aim: To evaluate the coherence...

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ea0049ep450 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Instable diabetes revealing pheochromocytoma

Abderrahmane Samir Ait , Boulmarka Imad , Chenegreha Mounia , Brakni Lila , Ouldkablia Samia , Oudjit Brahim

Introduction: Pheochromocytomas are secreting tumors, producing catecholamines (dopamine, noradrenaline and adrenaline), responsible for arterial hypertension; Pheochromocytoma in the diabetic may be responsible for an unbalanced glycemic and this considerably modifies the management. We present the case of a patient for whom the diagnosis of pheochromocytoma was posed before a glycemic imbalance.Clinical case: A 70-year-old patient is hospitalized for u...

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ea0049ep451 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Unacylated ghrelin does not seem to influence glucose homeostasis in obese women

Silva-Nunes Jose , Brito Miguel , Silva Carina , Oliveira Ana , Veiga Luisa

Background and Aim: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a non-functional peptide, soon after UAG has been associated to a negative action on energy balance, suppression of hepatic glucose production and decrease in circulating levels of insulin. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual interference ...

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ea0049ep452 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Influence of a part of Korean red ginseng on blood glucose control and complication markers of type 2 diabetic NSY rats

Kim Jung Hye , Park Kahui , Lee Sang Bae , You Ji Hong , Kim Yusik , Park Jong Suk , Nam Ji Sun , Ahn Chul Woo

Objective: Ginsenoside or saponin, is considered as the major bioactive component mediating the therapeutic properties of Korean red ginseng (KRG). However, the exact physiological mechanism underlying anti-diabetic effects is still not fully Clarified. More than 30 different saponins together account for only about 34% of KRG, thereby, it is assumed that non-saponin fraction of KRG also carry potential anti-diabetic effects; however, there is no study reporting the diff...

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ea0049ep453 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The prevalence of diabetic neuropathy, painful diabetic neuropathy and the at risk diabetic foot in Qatar

Elhadd Tarik , Ponirakis Georgios , Ashawesh Khaled , Dukhan Khaled , Samra Adel Badie Abou , Malik Rayaz

Objective: To define the prevalence of Diabetic Peripheral Neuropathy (DPN), painful diabetic neuropathy (PDN) and the at risk diabetic foot in 2 out of the 3 National Diabetes Centres in Qatar.Methods: 712 people with Type-1 & Type-2 diabetes recruited from Alwakra Hospital and Hamad General Hospital underwent assessment for DPN & PDN using the Neurothesiometer and the DN4 questionnaire, respectively.Results: The average a...

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ea0049ep454 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Changes in gene expression MADCAM1, S1PR1, CXCR4 and CCR7 in offspring of rats with experimental gestational diabetes

Prozorova Tanya , Kamyshny Alex , Kamyshna Vita

Introduction: Mesenteric lymph nodes (MLN) is a major transition point for recirculating lymphocytes of GALT. Homing of lymphocytes in MLN is regulated with adressin MAdCAM-1, chemokine receptors CXCR4 and CCR7. Sphingosine-1-phosphate receptors S1PR1 activate T-cell exit from MLN.Methods: We use RT-PCR method for investigating of mRNA expression levels of genes MAdCAM-1, CXCR4, CCR7 and S1PR in MLN of the offspring of rats with experimental gestational ...

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ea0049ep455 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Study of expression of genes mTOR, Foxp3, IL1β and IL17A in parapancreatic adipose tissue of rats with streptozotocin-induced diabetes and after metformin administrations

Putilin Denis , Kamyshny Alex , Kamyshna Vita

Introduction: mTOR is not only a central regulator of lipid metabolism, controlling the processes of adipogenesis and lipolysis, but also a regulator of immunometabolism of immune cells infiltrating the adipose tissue. In its turn, the level of progression of diabetes is largely limited by Treg subpopulation, the complexity and heterogeneity of which is confirmed by the detection of numerous tissue-specific Tregs, including the so-called VAT Tregs (visceral adipose tissue CD4+...

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ea0049ep456 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Response to stroke in diabetic versus non-diabetic patients. Should Diabetes education systematically include advise on stroke symptoms and the correct response to them?

Gonzalez-Lazaro Paloma , Silva-Fernandez Julia , Garcia-Ruiz Rafael , Garcia-Ruiz Rosa , Gomez-Alfonso Francisco Javier , Del Val-Zaballos Florentino , Torres-Arroyo Belvis , Gonzalez-Pereira Carolina

Introduction: Stroke is the second cause of death in the world and the first cause of disability. It is also the second cause of Diabetes-related death. The success of reperfusion therapies is time-dependent, with most delays being patient-related. We investigated the response to stroke in diabetic patients (DM), as their risk of stroke is increased by 1,8-6 times.Material and Methods: Consecutive patients with acute stroke or transient ischemic attack w...

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ea0049ep457 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The T allele of the rs1746661G/T polymorphism in FNDC5 (irisin) gene is associated with increased systolic blood pressure

Brondani Leticia A. , Boucas Ana Paula , Assmann Tais S. , Reichelt Angela J. , Martins-Costa Sergio , Weinert Leticia S. , Silveiro Sandra P. , de Souza Bianca M. , Crispim Daisy

Background: Gestational diabetes mellitus (GDM) is a risk factor for type 2 diabetes and both conditions are characterized by insulin resistance (IR) and decreased insulin production by pancreatic beta-cells. FNDC5 gene encodes a type I membrane protein that is proteolytically processed to form a hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene e...

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ea0049ep458 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The relations of apelin with the carbohydrate metabolism in hypertensive patients with type 2 diabetes or without it

Koval Sergiy , Iushko Kostiantyn , Starchenko Tatyana

Purpose: The aim of the study was to evaluate the relationships of apelin with the parameters of the carbohydrate metabolism in hypertensive patients with type 2 diabetes (T2D) and without T2D.Methods: The study involved 93 patients with hypertension grades 23 combined with T2D or without it (45 men and 48 women) in age from 43 to 70 years old. The investigation complex included measuring levels of fasting blood glucose, fasting blood insulin with ...

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ea0049ep459 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Maturity-onset diabetes of the young type 5 (mody 5): a case report

Vaca Carlos Silva , Fernandez Elena Garcia , Rodriguez Juan Carlos Romero , Martinez Guillermo

Introduction: MODY 5 is a rare type of dominantly inherited diabetes mellitus. It is asociated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene. They are mostly missense mutations that produce truncated proteins with a variable clinical spectrum that encompasses among others: kidney, genital and pancreatic abnormalities.Case-report: A 35 years-old man without relevant medical history, presented with acute hypergycemia (541 mg/dl) an...

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ea0049ep460 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

New-onset diabetes after transplantation (NODAT): an evaluation of risk factors in renal transplantation

Almeida Raquel , Campos Andreia , Martins La Salete , Dores Jorge

Background: The identification of patients with high risk of diabetes mellitus (DM) after renal transplantation in the pre-transplantation period is crucial for the prevention of this pathology and reduction of the risk of cardiovascular morbidity and mortality. With this study we intended to identify the risk factors for NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/20...

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ea0049ep461 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Malnutrition and sarcopenia in diabetic institutionalized older people: are there differences with non diabetic people?

Lardies-Sanchez Beatriz , Sanz-Paris Alejandro , Verdes-Sanz Guayente , Perez-Fernandez Leticia

Backgrounds and aims: The aims of the study were, on the one hand, to analize the prevalence of type 2 diabetes mellitus in a population of institutionalized older people and, on the other hand, to evaluate if the anthropometric parameters and the prevalence of malnutrition and sarcopenia were different in diabetic patients compared with the group of non-diabetics.Methods and material: A total of 312 institutionalized elderly people volunteers with a mea...

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ea0049ep462 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

New onset diabetes after transplantation (NODAT): frequency and characterization of patients in renal transplantation

Almeida Raquel , Campos Andreia , Martins La Salete , Dores Jorge

Background: The identification of patients with NODAT in renal transplantation is essential to establish adequate treatment and to reduce cardiovascular risk and graft failure. With this study we intended to evaluate the frequency of NODAT and to characterize patients with NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/2009 and 12/31/2013 were retrospectively evaluated. ...

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ea0049ep463 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Incidence of diabetic ketosis and ketoacidosis in Caucasian adults with type 2 diabetes mellitus: a population-based study

Ćaćić Petra , Kruljac Ivan , Ćaćić Miroslav , Perić Božidar , Filipović-Grčić Maja , Mirošević Gorana , Vrkljan Milan

Aims: Diabetic ketosis (DK) and diabetic ketoacidosis (DKA) are known complications of type 1 diabetes mellitus (T1DM). However, DK and DKA have been described in T2DM. Referred to as ketosis-prone T2DM, this subtype of T2DM has been described in Hispanics and Afro-Americans of sub-Saharan Africa, but the incidence and pathogenesis remains unknown. We aimed to analyze characteristics of patients with diabetic ketosis (DK) and diabetic ketoacidosis (DKA) in Ca...

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ea0049ep464 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

HOMA-IR and HOMA-islet indices in the evaluation of different carbohydrate metabolism disorders during glucocorticoid therapy

Nurrulina Guzel , Valeeva Farida , Khasanova Kamilya

Introduction: Diabetogenic effect limits the use of glucocorticoids (GC).Aim: To evaluate the role of modified HOMA-IR and HOMA-islet indices in different carbohydrate metabolism disorders (CMD) during oral (OGCT) and PULSE (GCPT) glucocorticoid therapy (GCT).Patients and methods: A study including 165 patients with systemic lupus erythematosus (n=53), systemic vasculitis (n=45) and chronic glomerulonephritis (<em...

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ea0049ep465 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Carbohydrate metabolism disorders associated with different glucocorticoid therapy schemes

Nurrulina Guzel , Valeeva Farida , Khasanova Kamilya

Introduction: Glucocorticoid therapy (GCT) is one of the risk factors of carbohydrate metabolism disorders (CMD) in patents with systemic inflammatory diseases. CMD development is a concern not only with long-term therapy, but also during intensive short-term glucocorticoid (GC) administration, which can lead to different CMDs, including impaired glucose tolerance (IGT) and diabetes mellitus (DM).Aim: To evaluate the prevalence of CMD after long-term and...

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ea0049ep466 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Type B insulin resistance syndrome in a patient with connective tissue disease

Lebkowska Agnieszka , Krentowska Anna , Adamska Agnieszka , Piasecka Beata , Lipinska Danuta , Kowal-Bielecka Otylia , Semple Robert , Gorska Maria , Kowalska Irina

Introduction: Type B insulin resistance syndrome is an autoimmune disorder characterized by the production of autoantibodies against the insulin receptor. It leads to glucose metabolism disorders, extreme insulin resistance, hyperandrogenism and is associated with other features of autoimmunity.Case report: A 27-year-old man, with a 2-years history of psoriasis, was admitted to our Department because of loss of weight (20 kg in 1 year) and fatigue. He al...

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ea0049ep467 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Parvovirus B19 infection may have a role in the etiopathogennesis of type 1 DM

Gumuscu Hasan Huseyin , Onbasi Kevser , Kasifoglu Nilgun

Parvovirus (Erythrovirus) B19 (EVB19) infection may trigger autoimmune diseases like SLE, RA, and vasculitis. Parvovirus B19 belongs to the parvoviridae family and to the erythrovirus genus. The etiopathogenesis of autoimmune diabetes mellitus could not been explained yet. The aim of our study was to investigate whether EVB19 may have a role in the etiopathogenesis of type 1 DM. Therefore have we examined whether EVB19 is more frequent among type 1 diabetics. 32 patients with ...

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ea0049ep468 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Hyperinter study: evaluation of glycemic values in acute inpatients from medical and surgical units. population without diabetes

Goncalves Helena Santos , Paixao Anusca Lopes , Lameirao Cristina , Rafael Ana , Gomes Marta , Silva Rita , Queiros Rita , Lopes Natalia , Rebelo Ana Filipa , Marques Paula Vaz

Introduction: Although inpatients hyperglycemia is a current uneasiness among the medical community, its prevalence in Portugal in unknown. We aim to identify Stress hyperglycemia and New onset diabetes cases in inpatients in a district hospital.Methods: We evaluated inpatients from Internal Medicine (IM), General Surgery (GS), Orthopedics and Traumatology (OT) and Stoke Unit (SU) departments, admitted from the emergency departmen...

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ea0049ep469 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Evaluation of oral glucose tolerance test as a screening test detecting glucose metabolism impairment in patients chronically treated with glucocorticoids without previous history of diabetes

Nowak Karolina , Romanowska-Prochnicka Katarzyna , Bornikowska Katarzyna , Zgliczynski Wojciech , Papierska Lucyna

Introduction: One of the most common side effects of glucocorticoid treatment is glucose intolerance and diabetes. Although glucocorticoids cause mainly postprandial hyperglycaemia the International Diabetes Federation, American Diabetes Association and The European League Against Rheumatism recommend to screen patients chronically treated with glucocorticoids by regularly determining fasting plasma glucose. Such an approach can lead to false negative results. Since pre-diabet...

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ea0049ep470 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Impact of exercise training on insulin sensitivity estimated by HOMA model in elite athletes: association with body composition

Djelic Marina , Mazic Sanja , Dumanovic Mirjana Sumarac , Jeremic Rada , Vujovic Ankica , Durmic Tijana , Cvetkovic Snezana , Micic Dragan

It has been shown that low values of insulin sensitivity have been related to metabolic diseases. Exercise prescription is crucial to prevent low insulin sensitivity in general population, and athletes are good physiological model. If this assumption is correct, examine insulin sensitivity in elite athletes should reflect the positive effect of exercise on insulin sensitivity. The aim of this study was to investigate the effects of regular exercise on insulin sensitivity estim...

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ea0049ep471 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Abstract withdrawn....

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ea0049ep472 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Dysregulation of the splicing machinery could represent an early, predictive event in the development of type 2 diabetes

Alors-Perez Emilia , Rio-Moreno Mercedes del , Pedraza-Arevalo Sergio , Camargo Antonio , Delgado-Lista Javier , Lopez-Miranda Jose , Gahete Manuel D , Castano Justo P , Luque Raul M

Metabolic syndrome (MetS) and type-2 diabetes (T2D) development is critically affected by the loss of phenotypic flexibility (i.e. the difficulty to cope with stressors to maintain metabolic homeostasis). Thus, it is essential to identify key modifiers of phenotypic plasticity that define individual susceptibility to develop T2D. Particularly, there is emerging evidence that alternative mRNA splicing is dysregulated under adverse metabolic-conditions, such as T2D, in several t...

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ea0049ep473 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Abstract withdrawn....

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ea0049ep474 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Debut diabetes characteristics

Exposito Maria Rosa Alhambra , Sanchez Inmaculada Prior , Moreno Paloma Moreno , Moreno Maria Angeles Galvez

Background: The diabetes type 1 (DM1) is a chronic autoimmune disease, it tends to appear in childhood, its incidence continues to rise and the complications arising from improper care poses serious health problems for those who suffer. LADA diabetes is autoimmune diabetes which appear in adults.Objetive: To describe the characteristics of the new diabetes debut in our environment.Material and methods: We included all patients who ...

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ea0049ep475 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Effect of vitamin D supplementation on Glucose Tolerance, HOMA indices and on the risk of GDM in pregnant women with vitamin D deficiency - a prospective interventional study

Jayanthy Ramesh , Mudiganti Naga Satya Vani

Background: Vitamin D deficiency and GDM are highly prevalent with long term implications. Prospective studies to analyse the effect of vitamin D supplementation on glucose tolerance in pregnant women are limited.Objectives: Objectives of the study are: 1) To determine the relation between vitamin D deficiency and HOMA indices and glucose tolerance in the first trimester among pregnant women. 2) To study the effect of vitamin D supplementation on HOMA in...

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ea0049ep476 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Rapid tests use in the evaluation of neurocognitive effects of Ramadan fasting in type 2 diabetic patients: Results of a pilot study

Mghari Ghizlane El , Oukit Loubna , Moata Hanane , Baki Salwa , Ansari Nawal El

Introduction: Ramadan is the 9th month of the Muslim calendar, where people fast from the sunrise to the sunset. Despite medical recommendations, 100 million Muslims in the world with diabetes and 79% of patients with type 2 diabetes fast during Ramadan.The aim of our study is to determine the impact of fasting during Ramadan on the cognitive performances for patients with type 2 diabetes using two fast tests.Materials and methods:...

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ea0049ep477 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Lack of postpartum reclassification test in gestational diabetes – factors conditioning loss of follow-up

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Queiros Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for maternal-fetal complications and development of diabetes or intermediate hyperglycemia after pregnancy. The follow-up should be done by a multidisciplinary team. After delivery, all women diagnosed with GDM should undergo an oral glucose tolerance test (OGTT) for reclassificationAim: To evaluate the non-adherence factors to reclassification OGTT after GDM.Method...

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ea0049ep478 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Gonarthrosis, Diabetes Mellitus (Type 1 or 2), Leptin, Nesfatin-1

Yildiz Kadri , Cadirci Kenan

Gonarthrosis is a severe problem of movement system. It is a restrictive health problem for modern human. And also; it is the other restrictive problem which coexistence of diabetes mellitus (DM) and gonarthrosis. Perhaps; an other parameter that is deserved to research for this coexistence is metabolic syndrome. Today, relationship between this clinical conditions are clear enough. And also two lobotuary parameters as Leptin and Nesfatin-1 are an other headstone for obesity a...

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ea0049ep479 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

A right time for pregnant women with type 1 diabetes mellitus

Simoniene Diana , Mikalauskaite Rasa , Jakuboniene Neli

Objective: Pregnancy in women with type I diabetes mellitus (T1DM) is associated with an increased risk of various obstetric complications. The purpose of this study was to evaluate relation of HbA1c, delivery age and various diabetes aspects on pregnancy outcome and gestation in women with T1DM.Methods: This was a cross-sectional study. A total of 48 women hospitalized to the Hospital of Lithuanian University of Health Sciences Kauno klinikos Endocrinol...

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ea0049ep480 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The assessment of possible eating disorders among patients with type 2 diabetes mellitus using EAT-26 questionnaire

Labashova Veranika , Shepelkevich Alla , Brutskaya-Stempkovskaya Elena

Controversial data exist regarding the prevalence of eating disorders in individuals with diabetes. EAT-26 questionnaire is as a validated widely used self-reported tool recommended in general population for assessing eating disorder risk. The study aimed to determine the prevalence of abnormal eating behavior in patients with type 2 diabetes mellitus and a matched sample of nondiabetic control subjects.Research design and methods: A total 63 participant...

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ea0049ep481 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Mediterranean diet and glycaemic control in a Mediterranean population with type 1 diabetes: a pilot study

Kyriacou Alexis , Evans Josie M M , Kyriacou Angelos

Background: The Mediterranean diet (MD) is the traditional diet of the people living in the Mediterranean basin and has been linked with positive health outcomes e.g. reduced incidence of cardiovascular and neoplastic disease. No study has investigated the relationship between the MD and glycaemic control in a Mediterranean population with type 1 diabetes mellitus (T1DM). Furthermore, it is unknown how well controlled are such patients and whether they follow the MD.<p cla...

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ea0049ep482 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Analysis of zinc status in type 2 diabetic patients and its correlation with glycemic control

Elfaleh Emna , Mrad Mahdi , Oueslati Ibtissem , Bahlous Afef , Bchir Najla , Horchani Imen , Khiari Karima , Abdallah Nejib Ben

Introduction: Recent studies have highlighted zincs dynamic role as a cellular second messenger in the control of insulin signaling and glucose homeostasis. The aim of our study was to assess the concentration of serum and urinary zinc levels in type 2 diabetic patients and to investigate the correlation between this variable and glycemic control.Methods: Total 54 type 2 diabetic patients and 23 non diabetic healthy subjects (age matched) were enro...

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ea0049ep483 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Bone mineral density in male patients with type 2 diabetes mellitus, with and without hypogonadism

Vasileiou Agathi , Karathanassi Ioanna , Navrozidou Parthena , Vlychou Marianna , Koukoulis Georgios , Bargiota Alexandra

Introduction: Type 2 diabetes mellitus (T2DM) affects bone metabolism, but its relation with bone mineral density (BMD) remains controversial. It is also known that T2DM is associated with hypogonadism in males. Male hypogonadism can also affect BMD. Thus the aim of this study was to evaluate BMD in male patients with T2DM with and without hypogonadism.Methods/design: Hypogonadism was defined as serum free Testosterone (fT) value <5 ng/dl or 59...

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ea0049ep484 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Pregnancy outcome in relation to a disorder of glucose tolerance during pregnancy

Mladenovic Violeta , Nesic Jelena , Andjelkovic Marija , Gluvic Zoran , Djukic Aleksandar , Macut Djuro

Introduction: Pregnancy as a state of insulin resistance can predict diabetes development in some women, and is associated with increased risk for adverse outcome of neonate and for mother.Aim: The aim of this study is to analyse pregnancy outcome in relation to a disorder of glucose tolerance during pregnancy.Matherial and methods: The study included 77 healthy pregnant women in third trimester registered in Center for endocrinolo...

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ea0049ep485 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Single standard labour tactic at 39–40 weeks in pregnancy with gestational diabetes – is it the best policy?

Bettikher Ofelia , Zazerskaya Irina

Objective: To assess labour outcomes in pregnancies with gestational diabetes (GD) regarding different delivery tactics.Design and methods: The retro- and prospective study evaluating labour outcomes included 443 age matched patients with GD had given birth during 2014 (1st group n=251) and 2015 (2nd group n=192) according to the two clinical protocols, respectively. Expectant management in 2014 was supposed to use until 3...

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ea0049ep486 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Insulin autoimmune syndrome: the relationship between insulin, c-peptide and glucose in active and recovering disease states

da Silva Tiago Nunes , Ferreira Ana Goncalves , Manita Isabel , Matos Ana Catarina , Carvalho Isabel , Font Paula , Prazeres Susana , Portugal Jorge

Insulin autoimmune syndrome (IAS) is a very rare cause of hypoglycaemia in western countries. One proposed mechanism is anti-insulin antibody capture of prandial insulin followed by the dissociation of insulin from anti-insulin antibody. The first objective was to study the relationship between glucose, insulin and C-peptide during a prolonged glucose load in two patients with active IAS. The second was to study the variation of these parameters between the active and the reco...

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ea0049ep487 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Lipoprotein particle size in women with type 1 diabetes mellitus and its relationship to carotid intima-media thickness

Gunness Anjuli , Ahmed Mohamed , Pazderska Agnieska , Phelan Niamh , Moore Kevin , Boran Gerard , Behan Lucy-Ann , Sherlock Mark , Gibney James

Although cardiovascular disease (CVD) is greatly increased in type 1 diabetes mellitus (T1DM), patients typically have apparently healthy lipid profiles. Simple measurement of plasma lipids however does not provide information regarding lipoprotein particle size which in the nondiabetic population is independently predictive of CVD. Plasma lipids and lipoprotein subclasses (using polyacrylamide gel-tube electrophoresis) were studied in reproductive age women with T1DM and comp...

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ea0049ep488 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The upper limb infection in diabetic patients (about 32 cases)

Nawal El Ansari , Bahia Habra , Ghizlane El Mghari

Introduction: The diabetic patient is vulnerable to infection compared to the general population. This is due to the deleterious effect of hyperglycemia on the basis of chemotaxis, phagocytosis and bactericide neutrophils → What weakens the defenses of the diabetic person to infections. Infections of the upper limb in diabetics are not uncommon, and are often characterized by severity and often unfavorable developments. The objective of this work: determine the prevalenc...

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ea0049ep489 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The peculiarities of structural and functional state of the myocardium and blood vessels in patients with type 2 diabetes mellitus and arterial hypertension depending on the dynamics of adipokines

Al-Trawneh Olena , Bilovol Oleksandr , Bobronnikova Lesya

Purpose: To study the features the structural and functional state of the myocardium and blood vessels in patients with diabetes mellitus and arterial hypertension depending on omentin level.Methods: A total of 65 patients (32 men and 33 women, mean age 51.6±5.2 years); 31- with type 2 diabetes and hypertension (group 1), 34 with isolated arterial hypertension (group 2). Control group 20 healthy volunteers. We evaluated data transthoracic ech...

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ea0049ep490 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Casuistic from Endocrinology Medical Consultation at Clinica Girassol 2015

LIRA Domingos , Castela Anselmo , Beu Gertrudes , Silva Francisca

Introduction: There are few studies either hospital bases or population based in Africa and in Angola we also have the same situation regarding endocrinology data. With this paper, the Angolan Society of Endocrinology Diabetes and Metabolism (SAEDM), wants to contribute to the systematic and continued study of endocrine pathology in Angola.Objective: Study of the casuistic of endocrine pathology in ambulatory setting regarding the year 2015.<p class=...

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ea0049ep491 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Depression and quality of life in patients with type 2 diabetes mellitus

Maric Andreja , Molnar Dunja , Premosa Tea , Novak Sonja , Vidovic Jurica , Kiric Maja Mikolaj

Introduction: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. People with DM have 2.44.3 times greater risk of depression than people without DM as well as patients (pts) treated with insulin. Women experience depression more often than men. Symptoms of depression can make it more difficult to successfully manage diabetes and prevent diabetes-related complications.Material...

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ea0049ep492 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Diabetes Mellitus type 1: characterization of patients at the endocrinology ambulatory follow up during the year 2015

Castela Anselmo , Beu Gertrudes , Silva Francisca , Lira Domingos

Introduction: Diabetes Mellitus is a chronic disease that has serious effects on the morbi-mortality. Diabetes type 1 is less prevalent, representing 510% of the total cases. Data collected in Africa are scarce, and prevalence and incidence at sub - Saharan Africa are about 3-12/100,000 and 1.12.1/100,000 people, respectively. The Angolan reality is not known.Objective: To show the casuistic of diabetes type 1 obtained from the ambulatory con...

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ea0049ep493 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Bronze diabetes – a rare secondary cause of diabetes

Souteiro Pedro , Neves Joao Sergio , Oliveira Sofia Castro , Belo Sandra , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Secondary causes of diabetes refer to a category in which diabetes is associated with other diseases. They are thought to constitute less than 2% of the total cases of diabetes.Case report: A 56 year-old caucasian man, with no relevant medical history, presented to the Emergency Department with fatigue, polyuria, polydipsia, polyphagia and involuntary weight loss (6 kg in two weeks). He was hemodynamically stable and exhibited a glycaemia o...

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ea0049ep494 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The epidemiology of type 2 diabetes mellitus and its complications in South Korea

Kang Ryungwoo , Chee Deborah

Background: The prevalence of diabetes in South Korea has drastically increased, and 8.611.0% of Korean adults aged ≥30 years were suffering for the disease in the early 2000s, according to the Korea National Health and Nutrition Examination Survey.Objective: The present study was performed to estimate the incidence and prevalence of type 2 diabetes mellitus (T2DM) and its complications in South Korea using the Health Insurance Review and Ass...

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ea0049ep495 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Prevalence of obesity and diabetes among in a developing country (Albania)

Ylli Dorina , Thomo Tomi , Hoxha Violeta , Kermaj Marjeta , Husi Gerond , Fureraj Thanas , Ylli Agron

It is well known nowadays the positive effect that early detection of prediabetes has in preventing and postponing the diabetes onset. The aim of our study is to explore the diabetes prevalence in Albania and to identify and stratify the population at risk for developing diabetes.Material and methods: A large scale multicentre screening was performed in Albania as part of a National Campaign. 15744 patients were consecutively recluted. The following data...

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ea0049ep496 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Maturity onset diabetes of the young - clinical characteristics of a portuguese cohort

Amado Ana , Almeida Raquel , Carvalho Andre , Amaral Claudia , Freitas Claudia , Bacelar Conceicao , Vilaverde Joana , Cardoso Maria Helena , Teixeira Sofia , Borges Fatima

Introduction: Maturity onset diabetes of the young (MODY) accounts for 1-2% of all forms of diabetes mellitus (DM). As classic criteria that lead to its suspicion have low sensitivity, patients are often misdiagnosed with type 1 or type 2 DM. Correct classification of this type of diabetes becomes essential for proper management of the disease. Our objective was to describe clinical features of patients with MODY diagnosed at our institution.Methods: We ...

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ea0049ep497 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

The relationship between Serum Vaspin and atherogenic risk factors in T2DM

Mohamed Magda Shokry , Abushady Manal Mohaned , Abdelsalam Mona Mohamed , Maher Maram Mohamed , Hendawy Lila Mahmoud , Ibrahim Rana Hashem

Introduction: Increased visceral adiposity is usually associated with a clustering of atherogenic risk factors, such as insulin resistance, hypertension, dyslipidemia, alterations in coagulation and inflammatory cytokine profiles. Visceral adipose tissue derived serpin (Vaspin) is an adipokine with insulin sensitizing effect which is markedly elevated in high body mass index (BMI) people.Aim: To evaluate serum Vaspin level in relation to atherogenic risk...

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19th European Congress of Endocrinology

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