Diabetes complications

Introduction: The focus on diabetic complications has increased over the years yet it is only recently that research has identified a link between ethnicity and the development of diabetic complications.Aims: To establish the relationship between ethnic group and the prevalence of either diabetic nephropathy or neuropathy.Method: A retrospective note review was undertaken for all diabetic patients who had a status of current&...

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ea0049ep499 | Diabetes complications | ECE2017

Correlation of homocysteine with macro and microvascular complication in patients with diabetes mellitus type 2

Krstevska Marija , Kostovska Ksenija Bogoeva

In recent years, plasma homocysteine (Hcy) level, has been reported to be associated with the vascular complications of diabetes mellitus type 2 (DM2). In patients with DM2, elevated Hcy levels were associated with insulin resistance and nephropathy. The aim of this study was to investigate the association of hyperhomocysteinaemia with micro and macrovascular complications, increased levels of HbA1c and lipid parameters in patients with DM2 in a Macedonian population. 80 DM2 p...

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ea0049ep500 | Diabetes complications | ECE2017

Overweight and obesity in pregnant with diabetes mellitus type 1

Moreno-Moreno Paloma , Rebollo-Roman Angel , Palomares-Ortega Rafael , Munoz-Jimenez Concepcion , Alhambra-Exposito Maria Rosa , Galvez-Moreno Maria Angeles

Objectives: Pregnant women who are overweight or obese have an increased risk of complications during pregnancy, as do pregnant women with type 1 diabetes mellitus (DM1). The objective of this study is to describe the prevalence of overweight/obesity in pregnant women with DM1, and associated complications.Patients and methods: Retrospective descriptive study of pregnant women with DM1 (20042014). Variables analyzed: age, initial body mass index (B...

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ea0049ep501 | Diabetes complications | ECE2017

Does empowerment from an ‘ABC approach’ and ‘Telemedicine’ improve outcomes in a nurse-led diabetes kidney clinic?

Irwin Susan , De Parijat

Aims: Implementation of a protocol-driven, nurse-led clinic to see influence on cardiovascular risk and renal disease progression using a simple ABC approach target HbA1c <7%, BP <125/75 mm Hg and Cholesterol <4 mmol.Method: Weekly Diabetes Specialist Nurse (DSN) clinic with emphasis on ABC approach and guided FLORENCE Telehealth free texting technology for medication reminders and self-monitoring of BP (machines provided)....

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ea0049ep502 | Diabetes complications | ECE2017

Causes of diabetic ketoacidosis: type 1 diabetes versus type 2 diabetes

Omri Marwa , Mohamed Rayene Ben , Rezgani Imen , Mhidhi Sana , Temessek Aroua , Mami Faika Ben

Aim: The aim of our study was to compare the clinical profile of type 1 and type 2 diabetic patients who are hospitalized in our service for diabetic ketoacidosis.Methodology: This was a descriptive study involving 121 diabetic patients hospitalized for diabetic ketoacidosis in the C department of diabetology of the national institute of nutrition of Tunis.Results: Of the 121 subjects studied, 57.85% are type 2 diabetic patients an...

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ea0049ep503 | Diabetes complications | ECE2017

Abstract withdrawn....

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ea0049ep504 | Diabetes complications | ECE2017

Is proteinuria always associated with diabetes mellitus?! Do we always make right diagnosis?!

Katamadze Natia , Shamanadze Anna

Introduction: Proteinuria is a condition in which urine contains an abnormal amount of protein. Proteinuria is a sign of chronic kidney disease (CKD), which can result from diabetes, high blood pressure and other diseases that cause inflammation in the kidneys. If CKD progresses, it can lead to end-stage renal disease, when the kidneys fail completely.Case presentation: Sixty-three years old female patient attended our clinic as her glycaemia was poor co...

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ea0049ep505 | Diabetes complications | ECE2017

A Review of the literature: What are the impacts of hypoglycaemia in insulin-dependent diabetic adults?

O'Donovan Charles , O'Donovan Olivia

Background: The prevalence of diabetes has reached epidemic proportions and according to the World Health Organisation (WHO) more than 220 million people worldwide have diabetes. The main complication in insulin-dependent diabetes mellitus (IDDM) patients is hypoglycaemia, with approximately 90% of all IDDM patients having experienced a hypoglycaemic episode. Hypoglycaemia has a substantial clinical impact in terms of mortality, morbidity and quality of life.<p class="abst...

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ea0049ep506 | Diabetes complications | ECE2017

A protective effect of lobeglitazone on renal fibrosis in unilateral ureteral obstruction mice model

Kim Hye-Soon , Bae Kwi Hyun , Jung Gwon Soo , Ham Hye Jin , Park Bo Yoon , Choi Yeon Kyung , Seo hyun Ae , Seo Jung Beom , Park Keun Gyu

Renal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor-gamma (PPARγ) agonists have a protective effect on diabetic nephropathy, much less is known about their direct effects in renal fibrosis. This study aimed to investigate possible beneficial effects of lobeglitazone, a novel PPARγ agonist, on renal fibrosis in mice with unilateral uret...

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ea0049ep507 | Diabetes complications | ECE2017

Using the plastic closure techniques of wound defecting treatment of patients with diabetic foot syndrome

Prystupiuk Maksym , Onofriichuk Iuliia , Naumova Liudmyla , Prystupiuk Lev , Naumova Marianna

Purpose: To improve methods of plastic closure of wound defects in patients with diabetic foot syndrome using skin flaps on vascular pedicle of the perforating vessels.Methods: The study involved patients with diabetes type 2 complicated with diabetic foot syndrome neuroischemic form. The study included 31 patients, 15 people in the study group and 16 people - the control group. Area wounds ranged from 3.8 to 21 cm2. Cleansing the wounds was p...

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ea0049ep508 | Diabetes complications | ECE2017

Insulin therapy with an impact on inflammation can change the risk for cardiovascvular diseases in type 2 diabetes

Ljubic Spomenka , Jazbec Anamarija , Tomic Martina , Antal Ivana , Smircic-Duvnjak Lea

Introduction: Patients with diabetes (DM) are at increased risk for cardiovacular disease (CVD). Possible effects of insulin therapy on development of atherosclerosis and CVD were studied.Patients and methods: Relevant metabolic parameters were determined in 348 patients assigned into groups with DM2 on oral hypoglycemic drugs (DM2-OH) and insulin (DM2-INS), and with DM1.Results: A significant among-group difference was found in ad...

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ea0049ep509 | Diabetes complications | ECE2017

Prayer marks in immigrants from Bangladesh with diabetes mellitus who live in Greece

Papadakis Georgios , Zambelis Thomas , Konstantopoulos Kostas , Chatzipanagiotou Stylianos

Introduction: Prayer marks (PMs) have been reported in the literature among Muslim prayers. PMs are found most often on the forehead, knees, ankles and dorsa of the feet. The most common changes consist of thickening, lichenification and hyperpigmentation of the skin, the causative factors being repeated pressure and friction during pray.Objectives: Immigrant populations are disproportionately affected by diabetes and its complications. Moreover, diabeti...

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ea0049ep510 | Diabetes complications | ECE2017

Therapy of hormonal disorders in women with acne

Naumova Liudmyla , Prystupiuk Lev , Prystupiuk Maksym , Naumova Marianna , Onofriichuk Iuliia

Introduction and objectives: About 9% of world population suffer from acne, which occupies the 8th place among all human diseases, and the 3d place among dermatological disorders. Acne is diagnosed in 54% of 18 year aged women. Acne manifests mostly in 1214 year age and regresses after 20 year age, even though more and more women have recently addressed their doctors for acne problem developing after 20 year age. Location of this dermatosis in open areas of skin leads to...

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ea0049ep511 | Diabetes complications | ECE2017

N-Terminal pro-B-type natriuretic peptide level in type 2 diabetic patients

Vasilkova Volha , Mokhort Tatiana , Naumenko Elena , Zmailik Margarita

Objective: A diabetic state is causally related to heart failure (HF) which is a leading cause of mortality. Early detection of high-risk individuals is imperative for primary prevention. The aim of this study was to investigate the role of N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) in patients with diabetes type 2 (DT2).Methods: We investigated 86 patients both sexes with DT2 aged 65.54±11.37 years (from 50 to 65 years) without clinical ...

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ea0049ep512 | Diabetes complications | ECE2017

Metabolic risk factors in adolescent girls with type 1 diabetes

Pinheiro Marta Isabel , Oliveira Juliana , Silva Rita Santos , Correia Cintia Castro , Fontoura Manuel

Background: Adolescent girls with type 1 diabetes (T1DM) have a higher incidence of metabolic risk factors like hypertension, dyslipidemia, non-alcoholic hepatic steatosis (NASH), abdominal adiposity and polycystic ovarian syndrome (PCOS) when compared with their non-diabetic peers. Moreover, metabolic risk factors seem to appear even in T1DM girls without overweight or obesity. We aimed to determine the prevalence of several metabolic risk factors in adolescent T1DM females, ...

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ea0049ep513 | Diabetes complications | ECE2017

Transcultural prevalence of depression in type 2 diabetic patients in Egypt and Yemen

Aboshady M. M. , Halawa M. R. , Elewa A. A. , El-Khouly G. , Bin-Nabhan A. S.

Background and aims: Depression is a common co-morbidity among people with diabetes that reduces quality of life and is associated with morbidity, mortality, and health care costs. We aimed to assess the prevalence of depression among patients with type 2 diabetes in two Arabic nations, Egypt and Yemen and to examine its relationship with socio-demographic data and diabetes complications.Methods: We conducted a cross-sectional analysis on 200 subjects wi...

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ea0049ep514 | Diabetes complications | ECE2017

Telmisartan attenuates hyperglycemia-aggravated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by increasing GSK3β-Ser⁹ phosphorylation

Cho Du-Hyong , Bae Sun-Ju , Song Kee-Ho

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

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ea0049ep515 | Diabetes complications | ECE2017

Continuous glucose monitoring system in the value of diabetes mellitus type 1 control

Mokhort Tatiana , Makhlina Elena , Kapliyeva Marina , Navmenova Yana , Savosteeva Irina

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation ...

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ea0049ep516 | Diabetes complications | ECE2017

Chronic kidney disease in elderly patients with type 2 diabetes: 6 years of follow-up study

Kim Soo-Kyung , Kim Kyung-Soo , Park Seok Won , Cho Yong-Wook

Objective: To evaluate prevalence of chronic kidney disease (CKD) and risk factors for decline of renal function in elderly patients with type 2 diabetes (T2DM) after 6 years of follow-up.Methods: A cohort of 208 elderly patients (65 years or older) with T2DM participated in an examination during 2005, a 6-years follow-up examination during 2011. An estimated glomerular filtration rate (eGFR) was calculated using the modification of diet in renal disease...

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ea0049ep517 | Diabetes complications | ECE2017

Association of metabolic risk factors with hyperfiltration and urine albumin creation ratio in represent Korean population (Korea National Health and Nutrition Examination Survey 2011–2014) without chronic kidney disease

Hong Eun-Gyoung , Hong Sangmo , Choi Yun Mi

The development of glomerular hyperfiltration precede the diagnosis of diabetes, but most study had undertaken with diabetes or obesity patients. In this study, we determine the association between glomerular hyperfiltration and other metabolic risk factors which associated diabetes in represent Korean population without chronic kidney disease. We analyzed 19 244 subjects with a estimated glomerular filtration rate(eGFR) above 60 ml/min per 1.73 m2 and urine albumin...

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ea0049ep518 | Diabetes complications | ECE2017

Clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy

Pchelin Ivan , Shishkin Alexander

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 13). Glomerular filtration rate...

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ea0049ep519 | Diabetes complications | ECE2017

Non-alcoholic steatohepatitis and diabetes mellitus: a case report

Branco Sara Castelo , Vasques Miguel , Matos Lurdes G. , Filipe Edite , Milheiro Adelaide

Non-alcoholic steatohepatitis (NASH) is a clinical entity characterized by the infiltration of fat into the liver associated with hepatic inflammation. The etiology is unknown, however its most frequently observed in patients with type 2 diabetes mellitus (DM 2), obesity or insulin resistance. DM 2 is an independent risk factor for the progression of NASH. Usually there are no symptoms, so it is not possible to estimate its prevalence. The treatment focuses on the control of a...

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ea0049ep520 | Diabetes complications | ECE2017

A novel lipid tetrad index as predictor of premature coronary artery disease in diabetic patients

Das Saswati , Gupta S. K.

Background: The aim of this study was to explore if evaluation of lipid risk factors like Lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of Diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care centre, New Delhi, India, over a period of 18 months. CAD pati...

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ea0049ep521 | Diabetes complications | ECE2017

Assessing the impact of ‘nephrogenic’ risk factors on the development of cardiac pathology in patients with long duration diabetes type 1

Arutyunova Margarita , Glazunova Alexandra , Klephortova Inna , Martynov Sergey , Manchenko Oxana , Ulianova Irina , Ilyin Alexandr , Shamkhalova Minara , Shestakova Marina

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 14 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...

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ea0049ep522 | Diabetes complications | ECE2017

Abstract withdrawn....

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ea0049ep523 | Diabetes complications | ECE2017

The prevalence of common risk factors for depression development in diabetes mellitus of the type 1

Navmenova Yana , Mahlina Eelena , Mohort Tatyana

Objective: To evaluate the frequency of common risk factors for depression development in patients with the diabetes mellitus of the type 1 (DM1).Materials and methods: 163 patients with DM1 at the age of 1865 years old, period of DM is 11.18 (4.28; 22.33) years. The evaluation of the anxiety and depression level was carried out with the use of the Hospital anxiety and depression scale (HADS); a questionnaire was carried out with the use o...

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ea0049ep524 | Diabetes complications | ECE2017

Comorbilities and morbimortality of patients with hospital hyperglycemia in the health area of Cuenca (Spain)

Perez-Rodriguez Jose , Calderon-Vicente Dulce , Aranda-Regules Santiago , Guerra-Navarro Lidia , Garcia-Notario Paula , Alramadan Mubarak , Martin-Iglesias David

Introduction and objectives: Hyperglycemia (HG) is a common problem in hospitalized patients that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the association of the HG with cardiovascular risk factors (CVRF), stress factors, hospital stay and mortality.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every three days in two months. We exclude...

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ea0049ep525 | Diabetes complications | ECE2017

Diabetes and mental health disorders: not a good combination

Tauni Rahat , Ali Nida , Tanna Ravina , Charles-Obi Debbie , Bhudia Jyotsna , Banerjee Ritwik

A 49 year old lady presented to the hospital unconscious with severe hypoglycaemia. She had type 1 diabetes for 24 years and coeliac disease. She was hypo-unaware and had multiple admissions with DKA and hypoglycaemia over the years. She did not engage in the self-management of diabetes, therefore, insulin was being injected by the carers in the community and by nurses in the hospital. Her erratic and unpredictable glycaemic control was attributed to non-compliance. She admitt...

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ea0049ep526 | Diabetes complications | ECE2017

Management of diabetic peripheral neuropathy (DPN) using low frequency pulsed electro magnetic field (LF-PEMF)

Wasoori Satish Chander , Pande Deepak G. , Bhardwaj Chetan , Naik Manoj

Objective: To evaluate the effectiveness of low frequency pulsed electro magnetic field (LF-PEMF) in the management of diabetic peripheral neuropathy (DPN) symptoms.Methods: A comparative observational study of 60 patients, male and female (1:1) aged 6085 years. Enrolment criteria known diabetics, HbA1c 79 and DPN of 15 years. Patients were randomized into 2 treatment groups G1 and G2. The study period was 4 weeks (w) with result...

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ea0049ep527 | Diabetes complications | ECE2017

Correlation of NGAL and thyroid function in patients with type 1 diabetes

Sazonava Alena , Mokhort Tatiana , Shyshko Volha , Mokhort Alena , Karlovich Natalia

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

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ea0049ep528 | Diabetes complications | ECE2017

Impaired awareness of hypoglycemia in adults with type 1 diabetes is not associated with peripheral neuropathy

Tsitlakidis Damianos , Djordjevic Milena , Muller Nicolle , Muller Ulrich , Kloos Christof

Objective: The impaired awareness of hypoglycemia (IAH) affects people with type 1 diabetes and is a risk factor for severe hypoglycemia. This study aims to evaluate the association between the impaired awareness of Hypoglycemia by diabetes type 1 and the peripheral neuropathy (PNP).Methods: 276 adults with type 1 diabetes, 135 men and 141 women, were studied from Mai 2015 to January 2016 to the outpatient department of University hospital of Jena. A cro...

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ea0049ep529 | Diabetes complications | ECE2017

A rare presentation of diabetic ketoacidosis: Rhino-orbito-cerebral mucormycosis

Gungunes Askin , Durmaz Senay Arikan , Yalcin Selim , Cifci Aydin , Burulday Veysel , Carlioglu Ayse

Aim and objective: Mucormycosis is a rare life-threatening fungal infection. Immunocompromised patients are often affected. We report a rare diabetic patient with pancreatic adenocarcinoma who was presented diabetic ketoacidosis and rhino-orbito-cerebral mucormycosis.Case presentation: A 66 years old man with pancreatic adenocarcinoma and type 2 diabetes mellitus was presented diabetic ketoacidosis and severe infection of the facial sinuses, orbita, and ...

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ea0049ep530 | Diabetes complications | ECE2017

Renal function preservation with Manidipine vs Amlodipine in type 2 diabetic hypertensive patients with persistent microalbuminuria

Quintana-Arroyo Sara , Acosta-Calero Carmen , Arnas-Leon Claudia , Santana-Suarez Ana Delia , Kuzior Agnieszka , Saiz-Satjes Margarita , Nivelo-Rivadeneira Manuel , Martinez-Martin Francisco Javier

Objectives: The AMANDHA randomized study (PROBE design) showed that the addition of Manidipine 20 mg vs Amlodipine 10 mg for 2 years in 91 hypertensive type 2 diabetic patients with persistent microalbuminuria, uncontrolled with a renin-angiotensin system inhibitor (given full-dose for at least the 6 previous months) was more effective in reducing albuminuria in spite of similar blood pressure control. Patients with significant renal impairment (PlCr >1.4 mg/dl in women an...

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ea0049ep531 | Diabetes complications | ECE2017

Significance of hemorheological approach for screening diabetic nephropathy in the type II diabetes mellitus

Lee Sangbae , Park Kahui , Kim Jung Hye , You Ji Hong , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients and assessed their possible role as a diagnostic tool for diabetic nephropathy.Methods: Four hundred-seventy patients with type 2 diabetes were included in this study. Hemorheologic parameters, including erythrocyte deform...

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ea0049ep532 | Diabetes complications | ECE2017

New features of pathogenetic treatment of diabetic neuropathy (DN) at on early stage

Yerdesova Kulshara , Myrzabaeva Aknur

Goal of research: To evaluate the clinical efficacy of phosphocreatine in the combined metabolic therapy of diabetic neuropathy at an early stage.Materials and methods: A pilot study was carried out with participation of 36 patients suffering from DM 2. Using the method of randomization the patients were divided into two groups. Apart from the standard therapy the main group (n=24) received phosphocreatine (intravenous infusion dose 2 g per 100....

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ea0049ep533 | Diabetes complications | ECE2017

The effect of different antihypertensive treatment protocoles on glycemic control and lipid profile in type 2 diabetic patients with microalbuminuria and stage 1 hypertension

Erek Muge , Ersoy Alparslan , Ersoy Canan

In hypertensive diabetic patients, renal angiotensin system blockers are first preferred due to their antihypertensive and antiproteinuric activities. Carvedilol, a third generation beta blocker, may provide additional benefits in diabetic patients. We aimed to compare the short-term efficacy of losartan treatment alone and in combination with cilazapril or carvedilol on blood pressure, glycemic control and lipid profile in microalbuminuric type 2 diabetic patients.<p clas...

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ea0049ep513 (1) | Diabetes complications | ECE2017

Transcultural prevalence of depression in type 2 diabetic patients in Egypt and Yemen

Aboshady M. M. , Halawa M. R. , Elewa A. A. , El-Khouly G. , Bin-Nabhan A. S.

Background and aims: Depression is a common co-morbidity among people with diabetes that reduces quality of life and is associated with morbidity, mortality, and health care costs. We aimed to assess the prevalence of depression among patients with type 2 diabetes in two Arabic nations, Egypt and Yemen and to examine its relationship with socio-demographic data and diabetes complications.Methods: We conducted a cross-sectional analysis on 200 subjects wi...

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ea0049ep514 (1) | Diabetes complications | ECE2017

Telmisartan attenuates hyperglycemia-aggravated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by increasing GSK3β-Ser⁹ phosphorylation

Cho Du-Hyong , Bae Sun-Ju , Song Kee-Ho

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

0 shares

ea0049ep515 (1) | Diabetes complications | ECE2017

Continuous glucose monitoring system in the value of diabetes mellitus type 1 control

Mokhort Tatiana , Makhlina Elena , Kapliyeva Marina , Navmenova Yana , Savosteeva Irina

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation ...

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ea0049ep516 (1) | Diabetes complications | ECE2017

Chronic kidney disease in elderly patients with type 2 diabetes: 6 years of follow-up study

Kim Soo-Kyung , Kim Kyung-Soo , Park Seok Won , Cho Yong-Wook

Objective: To evaluate prevalence of chronic kidney disease (CKD) and risk factors for decline of renal function in elderly patients with type 2 diabetes (T2DM) after 6 years of follow-up.Methods: A cohort of 208 elderly patients (65 years or older) with T2DM participated in an examination during 2005, a 6-years follow-up examination during 2011. An estimated glomerular filtration rate (eGFR) was calculated using the modification of diet in renal disease...

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ea0049ep517 (1) | Diabetes complications | ECE2017

Association of metabolic risk factors with hyperfiltration and urine albumin creation ratio in represent Korean population (Korea National Health and Nutrition Examination Survey 2011–2014) without chronic kidney disease

Hong Eun-Gyoung , Hong Sangmo , Choi Yun Mi

The development of glomerular hyperfiltration precede the diagnosis of diabetes, but most study had undertaken with diabetes or obesity patients. In this study, we determine the association between glomerular hyperfiltration and other metabolic risk factors which associated diabetes in represent Korean population without chronic kidney disease. We analyzed 19 244 subjects with a estimated glomerular filtration rate(eGFR) above 60 ml/min per 1.73 m2 and urine albumin...

0 shares

ea0049ep518 (1) | Diabetes complications | ECE2017

Clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy

Pchelin Ivan , Shishkin Alexander

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 13). Glomerular filtration rate...

0 shares

ea0049ep519 (1) | Diabetes complications | ECE2017

Non-alcoholic steatohepatitis and diabetes mellitus: a case report

Branco Sara Castelo , Vasques Miguel , Matos Lurdes G. , Filipe Edite , Milheiro Adelaide

Non-alcoholic steatohepatitis (NASH) is a clinical entity characterized by the infiltration of fat into the liver associated with hepatic inflammation. The etiology is unknown, however its most frequently observed in patients with type 2 diabetes mellitus (DM 2), obesity or insulin resistance. DM 2 is an independent risk factor for the progression of NASH. Usually there are no symptoms, so it is not possible to estimate its prevalence. The treatment focuses on the control of a...

0 shares

ea0049ep520 (1) | Diabetes complications | ECE2017

A novel lipid tetrad index as predictor of premature coronary artery disease in diabetic patients

Das Saswati , Gupta S. K.

Background: The aim of this study was to explore if evaluation of lipid risk factors like Lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of Diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care centre, New Delhi, India, over a period of 18 months. CAD pati...

0 shares

ea0049ep521 (1) | Diabetes complications | ECE2017

Assessing the impact of ‘nephrogenic’ risk factors on the development of cardiac pathology in patients with long duration diabetes type 1

Arutyunova Margarita , Glazunova Alexandra , Klephortova Inna , Martynov Sergey , Manchenko Oxana , Ulianova Irina , Ilyin Alexandr , Shamkhalova Minara , Shestakova Marina

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 14 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...

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ea0049ep522 (1) | Diabetes complications | ECE2017

Abstract withdrawn....

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ea0049ep523 (1) | Diabetes complications | ECE2017

The prevalence of common risk factors for depression development in diabetes mellitus of the type 1

Navmenova Yana , Mahlina Eelena , Mohort Tatyana

Objective: To evaluate the frequency of common risk factors for depression development in patients with the diabetes mellitus of the type 1 (DM1).Materials and methods: 163 patients with DM1 at the age of 1865 years old, period of DM is 11.18 (4.28; 22.33) years. The evaluation of the anxiety and depression level was carried out with the use of the Hospital anxiety and depression scale (HADS); a questionnaire was carried out with the use o...

0 shares

ea0049ep524 (1) | Diabetes complications | ECE2017

Comorbilities and morbimortality of patients with hospital hyperglycemia in the health area of Cuenca (Spain)

Perez-Rodriguez Jose , Calderon-Vicente Dulce , Aranda-Regules Santiago , Guerra-Navarro Lidia , Garcia-Notario Paula , Alramadan Mubarak , Martin-Iglesias David

Introduction and objectives: Hyperglycemia (HG) is a common problem in hospitalized patients that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the association of the HG with cardiovascular risk factors (CVRF), stress factors, hospital stay and mortality.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every three days in two months. We exclude...

0 shares

ea0049ep525 (1) | Diabetes complications | ECE2017

Diabetes and mental health disorders: not a good combination

Tauni Rahat , Ali Nida , Tanna Ravina , Charles-Obi Debbie , Bhudia Jyotsna , Banerjee Ritwik

A 49 year old lady presented to the hospital unconscious with severe hypoglycaemia. She had type 1 diabetes for 24 years and coeliac disease. She was hypo-unaware and had multiple admissions with DKA and hypoglycaemia over the years. She did not engage in the self-management of diabetes, therefore, insulin was being injected by the carers in the community and by nurses in the hospital. Her erratic and unpredictable glycaemic control was attributed to non-compliance. She admitt...

0 shares

ea0049ep526 (1) | Diabetes complications | ECE2017

Management of diabetic peripheral neuropathy (DPN) using low frequency pulsed electro magnetic field (LF-PEMF)

Wasoori Satish Chander , Pande Deepak G. , Bhardwaj Chetan , Naik Manoj

Objective: To evaluate the effectiveness of low frequency pulsed electro magnetic field (LF-PEMF) in the management of diabetic peripheral neuropathy (DPN) symptoms.Methods: A comparative observational study of 60 patients, male and female (1:1) aged 6085 years. Enrolment criteria known diabetics, HbA1c 79 and DPN of 15 years. Patients were randomized into 2 treatment groups G1 and G2. The study period was 4 weeks (w) with result...

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ea0049ep527 (1) | Diabetes complications | ECE2017

Correlation of NGAL and thyroid function in patients with type 1 diabetes

Sazonava Alena , Mokhort Tatiana , Shyshko Volha , Mokhort Alena , Karlovich Natalia

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

0 shares

ea0049ep528 (1) | Diabetes complications | ECE2017

Impaired awareness of hypoglycemia in adults with type 1 diabetes is not associated with peripheral neuropathy

Tsitlakidis Damianos , Djordjevic Milena , Muller Nicolle , Muller Ulrich , Kloos Christof

Objective: The impaired awareness of hypoglycemia (IAH) affects people with type 1 diabetes and is a risk factor for severe hypoglycemia. This study aims to evaluate the association between the impaired awareness of Hypoglycemia by diabetes type 1 and the peripheral neuropathy (PNP).Methods: 276 adults with type 1 diabetes, 135 men and 141 women, were studied from Mai 2015 to January 2016 to the outpatient department of University hospital of Jena. A cro...

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ea0049ep529 (1) | Diabetes complications | ECE2017

A rare presentation of diabetic ketoacidosis: Rhino-orbito-cerebral mucormycosis

Gungunes Askin , Durmaz Senay Arikan , Yalcin Selim , Cifci Aydin , Burulday Veysel , Carlioglu Ayse

Aim and objective: Mucormycosis is a rare life-threatening fungal infection. Immunocompromised patients are often affected. We report a rare diabetic patient with pancreatic adenocarcinoma who was presented diabetic ketoacidosis and rhino-orbito-cerebral mucormycosis.Case presentation: A 66 years old man with pancreatic adenocarcinoma and type 2 diabetes mellitus was presented diabetic ketoacidosis and severe infection of the facial sinuses, orbita, and ...

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ea0049ep530 (1) | Diabetes complications | ECE2017

Renal function preservation with Manidipine vs Amlodipine in type 2 diabetic hypertensive patients with persistent microalbuminuria

Quintana-Arroyo Sara , Acosta-Calero Carmen , Arnas-Leon Claudia , Santana-Suarez Ana Delia , Kuzior Agnieszka , Saiz-Satjes Margarita , Nivelo-Rivadeneira Manuel , Martinez-Martin Francisco Javier

Objectives: The AMANDHA randomized study (PROBE design) showed that the addition of Manidipine 20 mg vs Amlodipine 10 mg for 2 years in 91 hypertensive type 2 diabetic patients with persistent microalbuminuria, uncontrolled with a renin-angiotensin system inhibitor (given full-dose for at least the 6 previous months) was more effective in reducing albuminuria in spite of similar blood pressure control. Patients with significant renal impairment (PlCr >1.4 mg/dl in women an...

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ea0049ep531 (1) | Diabetes complications | ECE2017

Significance of hemorheological approach for screening diabetic nephropathy in the type II diabetes mellitus

Lee Sangbae , Park Kahui , Kim Jung Hye , You Ji Hong , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients and assessed their possible role as a diagnostic tool for diabetic nephropathy.Methods: Four hundred-seventy patients with type 2 diabetes were included in this study. Hemorheologic parameters, including erythrocyte deform...

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ea0049ep532 (1) | Diabetes complications | ECE2017

New features of pathogenetic treatment of diabetic neuropathy (DN) at on early stage

Yerdesova Kulshara , Myrzabaeva Aknur

Goal of research: To evaluate the clinical efficacy of phosphocreatine in the combined metabolic therapy of diabetic neuropathy at an early stage.Materials and methods: A pilot study was carried out with participation of 36 patients suffering from DM 2. Using the method of randomization the patients were divided into two groups. Apart from the standard therapy the main group (n=24) received phosphocreatine (intravenous infusion dose 2 g per 100....

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ea0049ep533 (1) | Diabetes complications | ECE2017

The effect of different antihypertensive treatment protocoles on glycemic control and lipid profile in type 2 diabetic patients with microalbuminuria and stage 1 hypertension

Erek Muge , Ersoy Alparslan , Ersoy Canan

In hypertensive diabetic patients, renal angiotensin system blockers are first preferred due to their antihypertensive and antiproteinuric activities. Carvedilol, a third generation beta blocker, may provide additional benefits in diabetic patients. We aimed to compare the short-term efficacy of losartan treatment alone and in combination with cilazapril or carvedilol on blood pressure, glycemic control and lipid profile in microalbuminuric type 2 diabetic patients.<p clas...

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ea0049ep534 | Diabetes complications | ECE2017

Impact of skin bundle implementation on hospital aquired pressure foot ulcers and lenght of stay in inpatients with diabetes

Ashawesh Khaled , Elyousfi Asma , Alam Masoud , Bloomer Lynda , Safi Abdul Wajid

Objective: To assess the impact of launching SKIN (Surface, Keep moving, Incontinence, Nutrition) bundle on development of pressure foot ulcers among in-patients with diabetes.Methods: SKIN Bundle was launched at Dudley Group of Hospitals Foundation Trust in mid- February 2011. Data on pressure foot ulcers were collected among patients with and without diabetes admitted during February 2010 February 2011 and then from February 2011March 2012,...

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ea0049ep535 | Diabetes complications | ECE2017

Continuous glucose monitoring system in patients with gestational diabetes mellitus: a prospective study

Marquez-Pardo Rosa , Torres-Barea Isabel , Baena-Nieto Mgloria , Cruzado-Begines Concepcion , Cayon-Blanco Manuel , Lopez-Velasco Rosario , Garcia-Garcia-Doncel Lourdes

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24 h.Methods: Women with GDM in gestational weeks 2632 were allocated a CGMS (IproTM2) after diagnosis in an observational prospective study. It was analysed:- CGMS: Mean glucose and standard deviation...

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ea0049ep536 | Diabetes complications | ECE2017

The analysis of interrelation of filtrational ability of kidneys and indicators of the androgenic state at patients with diabetes mellitus type 1

Vaschenko Elena , Mokhort Tatjana

Objective: To analyze correlation between the duration of diabetes mellitus (DM), renal function and androgenic state indicators in patients with DM type 1.Material and methods: 191 males with DM 1 type in the age of 1855 years. The control group included 25 almost healthy males in the age 2141 years. The compensation of DM was estimated by the level of glycosylated hemoglobin. Also, the indicators of lipid profile, glomerular filtration rate...

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ea0049ep537 | Diabetes complications | ECE2017

PDE5i preserves renal function in models of Diabetic Nephropathy: from bench to bedside

Pofi Riccardo , Fiore Daniela , Feola Tiziana , Giannetta Elisa , Grazie Giulia Le , Dato Carla Di , Gianfrilli Daniele , Barbano Biagio , Venneri Mary A. , Lenzi Andrea , Isidori Andrea M.

One third of diabetic patients suffer from Diabetic Nephropathy (DN) that leads to end-stage renal disease (ESRD). The molecular pathways involved remain underexplored. We showed that chronic phosphodiesterase-5 inhibition (PDE5i) improve vascular inflammation [1] and tissue remodelling, reducing proteinuria [2] in murine diabetes. Our aim was to investigate the effect of PDE5i on animal and human models of DN.Materials and methods: 16 mice were randomly...

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ea0049ep538 | Diabetes complications | ECE2017

Relationship between microvascular complications of Diabetes Mellitus and trace element levels

Afşar Zeliha Temurer , Tutuncu Yasemin , Aycicek Bercem , Sennaroğlu Engin , Berker Dilek , Guler Serdar

Objective: To determine whether relationship between trace element levels and microvascular complications of type 2 Diabetes Mellitus (T2DM).Methods: One hundred eighteen patients with type 2 DM (mean age: 56±6.2 years) and 40 control subjects (mean age: 40.0±8.8 years) were included in the study. Group 1 (n=40 patients) was composed of patients with no had microvascular complications and it divided into two subgroup, first subgroup (<...

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ea0049ep539 | Diabetes complications | ECE2017

The frequency of different risk factors for diabetic ketoacidosis in real clinical practice in Russia

Dzherieva Irina , Volkova Natalia , Anchutin Pavel , Nechayeva Valerya

The purpose: To estimate the frequency of appearance of different risk factors for the DKA (diabetic ketoacidosis) developing in a real clinical practice in Rostov-on-Don.Materials: Patients who had a diagnosis of DKA.Methods: Survey about the character of nutrition, alcohol drinking and other risk factors.Design: All patients were divided into two groups according to their age. The first group-12 patients yo...

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ea0049ep540 | Diabetes complications | ECE2017

Somnological parameters for patients with type 1 diabetes and nocturnal hypoglycemia

Darashkevich Ina , Mokhort Tatiana , Nikanava Lola , Smirnova Ludmila , Tishkovsky Serhej

Objective: To determine the effects of hypoglycemia while sleeping on somnological parameters for patients with type 1 DM.Materials and methods: The study included 57 person with type 1 DM (Group 1 patients with blood glucose levels (BGL) during sleep <3.9 mmol/l; Group 2 Patients with BGL from 3.9 to 10.0 mmol/l. The examination included: daily monitoring of blood glucose by CGMSGold (MedtronikMINIMED (US...

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ea0049ep541 | Diabetes complications | ECE2017

The value of blood glucose levels for the parameters of nocturnal sleep for patients with type 1 diabetes

Darashkevich Ina , Mochort Tatiana , Niconova Lola , Tishkovsky Serhey

Objective: To establish the differences in terms of sleep for patients with type 1 diabetes, depending on the level of blood glucose levels (BGL) during the night.Materials and methods: The study included 43 participants with type 1 diabetes (Group A patients with BGL during sleep from 3.9 to 7.4 mmol/l, Group B 7.510.0 mmol/l. Patients had daily monitoring of BGL CGMSGold by MedtronikMINIMED (USA), polysomnogr...

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ea0049ep542 | Diabetes complications | ECE2017

Emotional state association with microvascular complications, disease duration and glycaemic control in type 1 diabetic patients

Prakapiene Edita , Zukas Karolis , Radzeviciene Lina , Verkauskiene Rasa

The aim: Of the study was to determine the relationship between depression and anxiety symptoms and chronic diabetes complications, disease duration, glycaemic control in type 1 diabetic patients.Methods: 1854 year old 215 patients with T1DM were enrolled in the study. Participants filled questionnaires about DM, disease duration, complications and Becks depression (DB) and anxiety (BA) inventory. All patients were evaluated for microvascular...

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ea0049ep543 | Diabetes complications | ECE2017

The trigger off severe vomiting and hypertension during pregnancy in type 1 diabetic patient: case report

Kreivaitiene Egle , Kriksciuniene Ruta , Danyte Evalda

Diabetic mothers have an increased risk for pregnancy (early pregnancy loss, polyhydramnios, pre-eclampsia, premature labor) and progression of diabetic complications. We present a case of the progression of diabetic-related complications including autonomic neuropathy (AN) which caused severe vomiting during pregnancy. A 27-year-old type 1 diabetic woman with pregnancy of 8 weeks gestational age (GW) was admitted to our hospital for glycemia and diabetic-related complications...

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ea0049ep544 | Diabetes complications | ECE2017

Predictor factors of hypertension induced in pregnancy in patients with gestacional diabetes mellitus

Sanchez-Lechuga Begona , Lopez-Tinoco Cristina , Caro Antonio Campos , Martin Raquel De la Varga , Gavira Isabel Mateo , Lopez Francisco Javier Vilchez , Diosdado Manuel Aguilar

Gestational diabetes mellitus (GDM) is associated with an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to screen for PIH and preeclampsia. To date, there are no data regarding ABPM in women with GDM. Currently, little is known in GDM about the role of inflammatory biomarkers in PIH development and their impact on perinatal morbility and the risk of future complications. With this study we aim to identify, in ...

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ea0049ep545 | Diabetes complications | ECE2017

Patient first admitted as diabetic ketoacidosis and diagnosed as MODY 3

Kaya Ahmet , Kulaksizoglu Mustafa , Cordan Ilker

A male patient aged 63 years old was admitted to the emergency department with the complaints of polydipsia, polyurea and dizziness. He had hypertension which was on a calcium channel blocker and his hypertension was in control. His plasma glucose was measured as 564 mg/dl and hospitalized due to his new onset diabetes. His family history showed that, his mother, uncle, aunt and all six brothers were diagnosed as diabetes mellitus. His uncle, aunt and aunts children were using...

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ea0049ep546 | Diabetes complications | ECE2017

Screening for macrovascular complications in diabetic patients in Korça, Albania

Lumi Ema , Ylli Dorina , Ylli Agron

Background: Diabetes mellitus (DM) is a common metabolic disorder and is associated with development of chronic macrovascular complications leading to significant morbidity and mortality. The aim of the study was to evaluate the prevalence and clinical profile of macrovascular complications in diabetic patients in Korca, Albania.Material and methods: A total of 456 cases with type 2 DM attending Department of Endocrine (outpatient/inpatient), from Januar...

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ea0049ep547 | Diabetes complications | ECE2017

Osteoprotegerin as a cardiovascular risk marker in diabetic patients

Dabrowska Anna , Wojtysiak-Duma Beata , Duma Dariusz , Torun-Jurkowska Anna , Mieszkowska Anna , Matyjaszek-Matuszek Beata , Tarach Jerzy

Introduction: Its known that type 2 diabetes is an independent risk factor for cardiovascular disease. Osteoprotegerin (OPG), a glycoprotein secreted mainly by osteoblasts, is also produced by heart muscle and vessels. Its role in the pathogenesis of atherosclerosis and future cardiovascular events is still discussed.Material and methods: The study was conducted in 113 patients (48 F, 65 M) with type 2 diabetes mellitus (DM2) and coronary heart dis...

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ea0049ep548 | Diabetes complications | ECE2017

Diabetic ketoacidosis in an intensive care unit – review

Oliveira Joana , Gomes Rodolfo , Picado Barbara , Goncalves Fernando , Araujo Jose

Diabetic ketoacidosis (DK) is one of the most serious complications of diabetes mellitus (DM). We performed a case review of DK patients admitted to the intensive care unit (ICU) of our Hospital between 1 June 2012 and 30 June 2016. A demographic analysis was made, time of DM evolution, the therapy and the factors that led to its decompensation. Thus, a total of 42 DK patients were admitted to the ICU in the referred period, mean age was 45 years, a clear predominance of femal...

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ea0049ep549 | Diabetes complications | ECE2017

Prognostic factors and all-cause mortality in patients with type 2 diabetes presenting with diabetic ketoacidosis: a population based, case-control study

Ćaćić Petra , Ćaćić Miroslav , Kruljac Ivan , Perić Božidar , Filipović-Grčić Maja , Mirošević Gorana , Vrkljan Milan

Introduction: Little is known about diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM). Moreover, the clinical impact of diabetic ketosis (DK) in T2DM is elusive. The aim of this study was to analyze characteristics and mortality of patients with DKA and DK and to identify possible prognostic factors.Methods: This was a population-based, cross-sectional study that included all patients with T2DM presenting to emergency department with DKA, ov...

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ea0049ep550 | Diabetes complications | ECE2017

Can the most frequent DRB1* gene’s alleles be associated with cardiovascular autonomic neuropathy among patients with type 1 diabetes mellitus? A case – control pilot study

Razanskaite-Virbickiene Dovile , Vezbaviciene Vilma , Skrodeniene Erika , Zalinkevicius Rimantas

Background and aim: HLA alleles are associated with type 1 diabetes (T1D) and a spectrum of risk can be from increased to neutral or to protective. We aimed to evaluate the association of cardiovascular autonomic neuropathy (CAN) with DRB1* genes alleles among T1D.Methods: The case control pilot study included 70 patients with T1D at the age 18-54 years. 36 patients with CAN were assigned to the case group and 34 patients without CAN ...

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ea0049ep551 | Diabetes complications | ECE2017

Genome-wide DNA methylation analysis for type 2 diabetes mellitus and cardiovascular disease: from a 23-year follow-up in the Da Qing diabetes prevention study

Dong Xiaonan , Chen Yanyan , Li Guangwei

Background: Cardiovascular disease (CVD) is a serious complication of diabetes mellitus (DM) and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetes and CVD.Objective: To assessed the alteration of DNA methylation in patients with/without diabetes but developed CVD in a cohort study of Chinese patients.Methods: 40 patients ...

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ea0049ep552 | Diabetes complications | ECE2017

Prevalence of eye complications and its correlation with kidney function: clinical practice data of diabetes patients

Dash Kalpana , Kumar Ch Sunil , Ahmed Aftab , Das Sambit , Jaganmohan Balaji , Tippisetty Surekha , Kolukula Vamsi Krishna , Seshadri Krishna G.

Background: Type 2 Diabetes Mellitus (T2D) patients are at very high risk to have eye complications. Purpose of the study was to determine the prevalence of diabetes eye complications (DEC) and its correlation with glomerular filtration rate (GFR) in diabetes population attending community clinics across India.Methods: A total of 1547 T2D patients (935 males and 612 females) EMR records were retrospectively analyzed. For DEC correlation with GFR, patient...

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ea0049ep553 | Diabetes complications | ECE2017

Atherosclerotic cardiovascular risk assessment score in diabetes patients: a retrospective analysis of clinical data

Shah Sanjiv , Jana Jayaprakashsai , Jaganmohan Balaji , Selvarajan Raja , Moazam SG , Kolukula Vamsi Krishna , Tippisetty Surekha , Joshi Shashank R

Background: The study aimed to minimize the risk causing factors and evaluate new atherosclerotic cardiovascular disease (ASCVD) risk score using Million Hearts® Longitudinal ASCVD risk assessment tool among type 2 diabetes mellitus (T2D) patients.Methods: A non-interventional retrospective analysis of electronic medical records of Apollo Sugar Clinics, India. A total of 365 patients data was collected, and were categorized into nor...

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ea0049ep554 | Diabetes complications | ECE2017

The association between pancreatic steatosis and diabetic retinopathy in patients with non-obese type 2 diabetes mellitus

Jeong Jee Sun , Kim Mee Kyung , do Han Kyung , Baek Ki-Hyun , Song Ki-Ho , Chung Dong Jin , Kwon Hyuk-Sang

Background: In the previous study, it was demonstrated that pancreatic steatosis was significantly associated with subclinical atherosclerosis in patients with non-obese T2DM. As the result, it was suggested that pancreatic steatosis might be related to macrovascular complication of T2DM. However, the association of pancreatic steatosis on microvascular complication of T2DM has been unknown.Objective: This study aimed to investigate the relation between ...

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ea0049ep555 | Diabetes complications | ECE2017

Dyslipidaemia and diabetes: a real world clinical evidence in Indian scenario

Duvvuru Shantharam , Das Sambit , Moazam SG , Rajendiran N , Venkataraman S , Narayanan NK , Keerthi AV Bhanu , Kolukula Vamsi Krishna , Joshi Shashank

Background: Dyslipidaemia, a major risk factor for cardiovascular disease (CVD) is considerably increasing in patients with diabetes. The purpose of the study was to evaluate the lipid profiles of diabetes patients attending Apollo Sugar Clinics across India.Methods: The current study was a retrospective analysis of electronic medical records of 1487 type 2 diabetes (T2DM) patients who registered at (Dec 2014 to Oct 2016) Apollo Sugar Clinics, across Ind...

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ea0049ep556 | Diabetes complications | ECE2017

Markers of nonalcoholic fatty liver disease in patients with diabetes

Savasteeva Irina , Rusalenko Maria , Yarets Yulia , Selkina Veronika , Navmenova Yana , Kaplieva Marina , Makhlina Alena , Yeudachkova Tamara , Vaschenko Elena , Moskvicheva Tamara

Given the significant correlation between the indices of lipid metabolism, liver dimensions, glycated hemoglobin and indicators cytolysis of hepatocytes identified a number of predictors that have had a significant influence on the formation of NAFLD. At a BMI above 26.5 kg/m2, the relative risk (RR) for BMI was 20.02 and was statistically significant (8.25÷48.61). When VLDL level above 0.6 mmol/l relative risk for NAFLD also was statistically significant (RR=2...

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ea0049ep557 | Diabetes complications | ECE2017

Meal composition affects risk markers for kidney disease differently in type 2 diabetes and healthy subjects

Olofsson Camilla , Hilding Agneta , Orsini Nicola , Andersson Inga-Lena , Torffvit Ole , Brismar Kerstin , Ekberg Neda Rajamand

Background/aims: Oxidative stress and inflammation play a role in development of diabetic kidney disease. Postprandial hyperglycemia and hyperlipidemia are speculated to be associated with increased oxidative stress and inflammation. The aim was to examine the effect of meal composition on post-prandial risk markers for kidney disease among those with type 2 diabetes (T2D) and healthy subjects (HS).Material/methods: On four occasions 21 patients with T2D...

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ea0049ep558 | Diabetes complications | ECE2017

Audit of a nurse-led and pharmacist assisted diabetes renal out-patient clinic – does it help improve medicines management and clinical outcomes?

Irwin Susan , Kaur Gurpreet , Lacy Caroline , De Parijat

Aim: To audit clinical outcomes and adherence to prescription recommendations in a diabetes renal clinic.Method: Baseline data was compared to the final clinic visit within a 12 month period, using information from clinic letters and electronic records of patients attending our hospital diabetes renal clinic in 2016 (1st January 31st December). Patients with at least 1 follow-up within a 12 month period were included.Results...

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ea0049ep559 | Diabetes complications | ECE2017

Inhibin B levels and bone health in male adult patients with Type 1 Diabetes Mellitus

Barmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Navrozidou Parthena , Vlychou Marianna , Fezoulidis Ioannis , Koukoulis Georgios N. , Bargiota Alexandra

Introduction: Existing data suggest that Type 1 Diabetes Mellitus (T1DM) can affect both hypothalamic-pituitary-testis axis and bone health. The mechanisms by which sex steroids influence bone remodeling remain incompletely understood. Data linking gonadal function and bone turnover in male patients with T1DM are lacking. The purpose of this study was to examine any possible association between sex steroids levels and parameters of bone assessment in male adult patients with T...

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ea0049ep560 | Diabetes complications | ECE2017

Cardiovascular disease and risk factors in patients with type 1 diabetes mellitus

Tenu Irina , Bala Cornelia , Iancu Silvia , Roman Gabriela , Veresiu Ioan

Objective: The occurrence of cardiovascular disease (CVD) in patients suffering from type 2 diabetes is a widely discussed issue, less so in those with type 1 (T1DM). The purpose of this study was to evaluate the frequency of these complications as well as certain risk factors that they are associated with.Material and methods: We conducted a retrospective observational study by analyzing data from the observation charts of 106 patients evaluated in our ...

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ea0049ep561 | Diabetes complications | ECE2017

Platelet aggregation and physiological anticoagulants in acute insulin-induced hypoglycemia in patients with type 1 diabetes (DM1)

Sarkisova Karina , Jarek-Martynowa Ivona Renata , Shestakova Marina , Koksharova Ekaterina

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. The aim of this study was to assess the impact of insulin-induced hypoglycemia on the platelet activity, endothelial dysfunction and the physiological anticoagulant level in patients with DM1.Research design and methods: We studied seve...

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ea0049ep562 | Diabetes complications | ECE2017

Biomarkers status and their relation with the presence of type 2 diabetes with and without angiopathy

Valente Ana , Bicho Manuel , Duarte Rui , Raposo Joao , Costa Helena Soares

Introduction: A useful tool for disease clinical characterization and treatment of type 2 diabetes is the knowledge on the status of several biomarkers. The aim of this study was to evaluate the levels of cardiovascular, oxidative stress and nutritional biomarkers and their relationship with the presence of type 2 diabetes and angiopathy.Methods: A population-based case-control study in 150 Portuguese type 2 diabetic patients was performed. Group I &#150...

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ea0049ep563 | Diabetes complications | ECE2017

Severe hypoglycaemias in patients with unnoticed hypoglycaemias: a two-year follow up

Lloclla Eyvee Arturo Cuellar , Gordillo Guillermo Martinez de Pinillos , Marin Carmen Carretero , Perez Fernando Garcia , Porcel Jose Alvaro Romero , Pena Ignacio Fernandez , Munoz Juan Manuel Garcia de Quiros , Lopez Ignacio Fernandez , Fernandez-Ladreda Mariana Tome , Leon Maria Victoria Cozar

Introduction and objectives: Having frequent hypoglycaemias can enable the appareance of severe and unnoticed hypoglycaemias, as well as favouring vascular damage in these patients. Our objective is to evaluate de incidende of severe hypoglycaemias (SH) in patients with Diabetes Mellitus type 1 and the reduction of perceived hypoglycaemias.Material and methods: A prospective study was conducted. Patients attending to their Endocrinology appointments betw...

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ea0049ep564 | Diabetes complications | ECE2017

Small for gestational age and gestational diabetes – Should we be more permissive?

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for large for gestational age (LGA) newborns. The optimization of glycemic control and weight gain restriction during pregnancy according to BMI has contributed to decrease LGA but may increase the risk of small for gestational age (SGA).Aim: To evaluate the predictors of SGA in women with DGM.Methods: A cohort of 5271 Portuguese women from the National Registry of ...

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ea0049ep565 | Diabetes complications | ECE2017

A case of pulmonary tuberculosis presented with recurrent diabetic ketoacidosis

Okuroglu Nalan , Komoglu Sabiha , Usta Rojda , Tas Berrak , Sertbas Meltem , Ozdemir Ali

People with diabetes are at increased risk for developing tuberculosis than non-diabetics. We presented a patient with recurrent diabetic ketoacidosis who was later diagnosed with pulmonary tuberculosis.Case: A 22 year old male with type 1 diabetes for nine years was admitted to the emergency service due to nausea and vomiting. Detecting high anion gap with metabolic acidosis in his blood gas), and ketones in urine analysis,the patient was hospitalized f...

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ea0049ep566 | Diabetes complications | ECE2017

Which one is much more cause in osteoarthritis? Diabetes mellitus Type 1 or 2?

Yildiz Kadri , Cadirci Kenan

Osteoarthritis is a great public health problem indiscriminately; ie goanrthritis, coxarthritis or dejenerative spine diseases. Osteoarthritis is focude sixth decades in elderly people, espicially in women. Many studies assingned the efficiancy of Diabetes Mellitus in the etiology of Osteoarthritis. Correlations between bone-destructive characteristics and carbohydrate metabolism errors is now quite accused in this clinical views. A comparing between Diabetes Mellitus Type 1 a...

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ea0049ep567 | Diabetes complications | ECE2017

Prevalence of distal symmetric polyneuropathy in diabetic patients in general medicine wards

Lopes Ana , Goncalves Helena , Fonseca Liliana , Branco Catarina Castelo , Goncalves Joao , Sousa Luisa , Calejo Margarida , Martins Sara , Neves Joao , Teixeira Sofia

Background: Distal symmetric polyneuropathy (DSPN) is one of the most prevalent chronic complications of diabetes and the most common cause in the pathway to diabetic foot ulceration. Screening for DSPN enables early intervention and prevention of complications. The Semmes-Weinstein Monofilament Examination (SWME) is currently the method of choice to screen DSPN, but ideally two neurologic tests should be used. The Michigan Neuropathy Screening Instrument (MNSI), which evaluat...

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ea0049ep568 | Diabetes complications | ECE2017

Tubular and glomerular biomarkers of kidney injury on glucagon-like peptide-1 (GLP-1) therapy in type 1 diabetic patients

Zuraeva Zamira , Vikulova Olga , Mikhaleva Olga , Shestakova Marina , Ilyin Aleksandr , Shamkhalova Minara , Dedov Ivan

Background and aims: To evaluate the level of tubular and glomerular biomarkers of kidney injury as potential nephroprorotective effects of GLP-1R agonist (liraglutide) addition in type 1 diabetic patients compared to standard insulin therapy.Materials and methods: 12 T1DM patients with normo-(AER <20 mg/l, n=7) and microalbuminuria (AER<199 mg/l, n=5) with liraglutide 1.2 mg as add on to insulin for 6 month and 12 patients with...

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ea0049ep569 | Diabetes complications | ECE2017

Diabetic choroidopathy and renal function

Hermosilla Antonio Manuel Garrido , Muros Mariola Mendez , Portillo Cristobal Morales , Hernandez Tomas Martin , Rivera Natividad Gonzalez , Granda Maria Jesus Diaz , de la Rua Franch Enrique Rodriguez , Sanchez Estanislao Gutierrez

Objectives: Examine the relationship between choroidal thickness (CT) and renal function tests.Methods: Cross-sectional study with 42 eyes of 21 ocular treatment-naïve diabetic patients. Demographic and ocular data were analyzed as well as the following renal function tests: microalbuminuria, microalbumin/creatinine ratio and glomerular filtration rate (CKD-EPI and MDRD-4). Choroidal thickness was measured by swept-source ocular coherence tomography...

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ea0049ep570 | Diabetes complications | ECE2017

Risk factors of diabetic foot complications

Gharbi Radhouane , Chihaoui Melika , Rejeb Ons , Yazidi Meriem , Oueslati Ibtissem , Chaker Fatma , Slimane Hedia

Introduction: Diabetic foot disease is a major health problem. The identification of its risk factors should guide preventive measures. The aim of this study was to determine the factors associated with diabetic foot complications.Patients and methods: It is a retrospective study including 47 patients admitted at the department of Endocrinology in La Rabta hospital for diabetic foot complications during the years 2015 and 2016. Clinical and para-clinical...

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ea0049ep571 | Diabetes complications | ECE2017

Diabetes mellitus as an important comorbidity in patient with sepsis

Puca Entela , Puca Edmond , Ylli Agron , Pipero Pellumb

Sepsis represents the hosts systemic inflammatory response to a severe infection. It is a common condition in hospital settings and is associated with high rates of morbidity and mortality. Since1992 the knowledge about sepsis epidemiology has clearly improved. There are differences in epidemiologic data about sepsis identification in different countries. The aim of our study is to make a panoramic view of sepsis at the service of Infectious Diseases, University Hospital...

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ea0049ep572 | Diabetes complications | ECE2017

The prevalence of chronic kidney disease and albuminuria in patients with Type 1 and Type 2 diabetes attending a single centre

Majeed MS , Boran G , Behan LA , Sherlock M , Gibney J

Chronic kidney disease (CKD) is an important complication of diabetes and determinant of mortality. Albuminuria represents early diabetic nephropathy, and also indicates generalised vascular dysfunction. Understanding the epidemiology of CKD and albuminuria helps inform health planning and identify opportunities to prevent or delay progression of diabetic kidney disease. The last available serum creatinine and urine albumin/creatinine ratio (UACR) in patients with Type 1 (T1DM...

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ea0049ep573 | Diabetes complications | ECE2017

Two case reports of diabetic ketoacidosis: as lethal as avoidable

Gomes Rodolfo , Oliveira Joana , Picado Barbara , Goncalves Fernando , Araujo Jose

Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes mellitus (DM). We describe 2 cases of type-2 diabetic patients admitted by a surgical reason/trauma in which DM control was neglected. We present a 74-year-old patient with poor metabolic control (HbA1c 7,6%) treated with metphormin, sitagliptin and glibenclamide, admitted for orthopaedic surgery. During hospitalization, there were noted several episodes of disorientation with hyperglycae...

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ea0049ep574 | Diabetes complications | ECE2017

Characteristics of patients with cystic fibrosis and hydrocarbon alteration in an adult unit

Gonzalez Elena Fernandez , Moreno Nerea Aguirre , Caceres Layla Diab , Gutierrez Carmen Acosta , Ramos-Levi Ana , Nunez Miguel Sampedro , Moreno Isabel Huguet , Azpiroz Monica Marazuela , Moreno Rosa Maria Giron , Martin Alfonso Arranz

Introduction: Hydrocarbon Alteration (HA) is considered as the most common complication in Cystic Fibrosis (CF) and is related to a further deterioration of the lung function and the nutritional status.Objective: Analyze the prevalence of HA in patients with CF in an adult unit and its relationship with pulmonary complications.Material and methods: We conducted a retrospective study with 71 patients of our CF unit (age 30+/−9...

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ea0049ep575 | Diabetes complications | ECE2017

Management of diabetic ketoacidosis in haemodialysis patient

Hendra Heidy , Stacey Hannah , Abeygunasekara Sumith

Introduction: Diabetes mellitus is the commonest cause of chronic kidney disease leading to end-stage renal failure (ESRF). Fluid replacement is one of the cornerstone treatments of DKA, however anuric dialysis patients are at risk of fluid overload. Information for managing DKA in haemodialysis patients is relatively sparse.Case report: A 76-year-old gentleman with type 1 diabetes was admitted with drowsiness. He has twice weekly dialysis and on 700 ml/...

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ea0049ep576 | Diabetes complications | ECE2017

Severe diabetic gastroparesis – two cases of challenging treatment

Souteiro Pedro , Oliveira Sofia Castro , Neves Joao Sergio , Santos-Antunes Joao , Bettencourt-Silva Rita , Belo Sandra , Neves Celestino , Freitas Paula , Queiros Joana , Esteves Cesar , Carvalho Davide

Introduction: Gastroparesis is defined by a delayed gastric emptying without mechanical obstruction. It can be a debilitating complication of diabetes that is poorly understood and has limited therapeutic options.Case reports: 1st case - We report the case of a 34-year-old woman with type 1 diabetes mellitus (T1DM) with diabetic nephropathy and gastroparesis, and a reasonable glycaemic control...

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ea0049ep577 | Diabetes complications | ECE2017

Predictors of in-hospital mortality in diabetic patients – analysis of 958305 hospitalizations

Walicka Magdalena , Puzianowska-Kuznicka Monika , Chlebus Marcin , Sliwczynski Andrzej , Brzozowska Melania , Rutjowski Daniel , Kania Lidia , Czech Marcin , Jacyna Andrzej , Franek Edward

Background: Diabetes mellitus is a lifelong chronic disease with higher risk of mortality and morbidityObjective: To study the risk factors of death in hospitalized diabetic patientsMethods: Data obtained from the database of the National Health Fund (NHF), a public organization financing medical procedures in Poland regarded 958305 hospitalizations of adult (≥18 years old) patients with diabetes in 2014 year. Logistic regres...

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ea0049ep578 | Diabetes complications | ECE2017

Gestacional diabetes mellitus: 4 years study case at a tertiary level maternity hospital

Evora Francisco , Pinto Marta , Almeida Ceu

Introduction: Gestational diabetes mellitus (GDM) is a carbohydrate intolerance with onset or recognition during pregnancy. Timely screening and proper management of this condition is essencial to maximize pregnancy and neonatal outcomes.Methods: Retrospective analysis of all cases of GDM, and the respective new-borns, followed in our obstetrics unit between 2012 and 2015. Clinical and workup parameters were evaluated.Results: From...

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19th European Congress of Endocrinology

BiosciAbstracts