Diabetes therapy

ea0049ep579 | Diabetes therapy | ECE2017

A modelling approach for cost-savings in the elderly ontarian population with type 2 diabetes due to reduction in mild hypoglycemia events for SGLT-2 inhibitor versus sulfonylurea (SU) initiation after metformin

Background: Mild hypoglycemia in elderly is associated with significant chronic consequences leading to physical and cognitive dysfunction and eventually frailty and disability. Mild hypoglycemia appears to be under-recognized in real-world clinical settings in the elderly and can lead to significant costs for patients.Objective: To calculate cost-savings due to mild hypoglycemia reduction for SGLT-2 inhibitor versus SU initiation after metformin for eld...

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ea0049ep580 | Diabetes therapy | ECE2017

Do adding B vitamins and folate to metformin has beneficial effect on renal function and lipids in type 2 diabetic patients

Shargorodsky Marina , Omelchenko Elena

Introduction: Metformin is effective in reducing cardiovascular mortality, however may decrease vitamin B12 and folate levels, and increase levels of homocysteine. Hyperhomocysteinemia is associated with adverse impact on lipid parameters and renal function. The present study was designed to determine the effect of homocysteine lowering therapy by using group B vitamins and folate supplementations on lipid metabolism especially HDL cholesterol as well as kidney function assess...

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ea0049ep581 | Diabetes therapy | ECE2017

The role of sodium-glucose co-transporter 2 inhibitors as add-on therapy in type 2 diabetes

Ponce Maria Hayon , Blanquez Martinez David , Jimenez Maria Jose Jimenez , Cordova Rossana Sofia Manzanares , Laguna Maria del Carmen Serrano , Charneco Miguel Quesada , Casares Martin Lopez de la Torre

Objective: SGLT2 inhibitors, have been shown to improve glycaemic control, stabilize insulin dosing and mitigate insulin-associated weight gain in patients whose type 2 diabetes mellitus (T2DM) was inadequately controlled. The objective is to evaluate the real-world efficacy and safety of adding iSGLT-2 therapy in inadequately controlled patients with oral antidiabetic drugs and with or without insulin therapy.Materials and methods: This observational st...

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ea0049ep582 | Diabetes therapy | ECE2017

Abstract withdrawn....

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ea0049ep583 | Diabetes therapy | ECE2017

Hypoglycemia, weight changes and health related quality of life (HRQoL) instruments for diabetes care

Akladious Carolyn , Farahani Pendar

Background: Diabetes is a chronic disease with significant negative impact on quality of life. Hypoglycemia and weight gain are two important variables that can impact HRQoL negatively in patients with diabetes under treatment with medication.Objective: The objective of this study was to evaluate HRQoL tools and questionnaires and to explore if the HRQoL instruments address issues related to hypoglycemia and weight gain, which impact HRQoL along other do...

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ea0049ep584 | Diabetes therapy | ECE2017

Use of an innovative Technology Enabled Care service (TECS) ‘Florence’ to empower patients and enhance adherence to BP treatments in diabetes

Irwin Susan , De Parijat

Background: Social deprivation is high within our large ethnic and diabetes prevalent population. Compliance is a major stumbling block in the achievement of Blood Pressure (BP) targets. Given the above, we took the opportunity to enrol with West Midlands Academic Health Science Network (WMAHSN) Florence (Flo) Exemplar project mobile phone texting service. Flo sends advice and collects patient information which clinicians can access through any device connected to the internet...

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ea0049ep585 | Diabetes therapy | ECE2017

The decreased adiponectin level after the treatment with glibenclamide is associated with deterioration of left ventricular function

Emini Merita , Haliti Edmond , Car Nikica , Begolli Luljeta , Ahmeti Artan , Bajraktari Gani

Background and aim: Hyperglycemia is an important pathogenetic factor, which causes abnormalities at the cardiac myocyte level, leading to structural and functional abnormalities and diabetic cardiomyopathy (DCM). It has been proposed that DCM could also occur as a consequence of other metabolic alterations. Adiponectin concentration is negatively associated with obesity, insulin resistance (IR), oxidative stress and endothelial dysfunction. It can be considered as a predictiv...

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ea0049ep586 | Diabetes therapy | ECE2017

Effects of inositol on glucose homeostasis: systematic review and meta-analysis of randomized controlled trials

Minambres Inka , Cuixart Gemma , Goncalves Ana , Corcoy Rosa

Aim: To analyze the effects of inositol administration on parameters related to glucose homeostasis.Material and methods: Systematic review and meta-analysis of articles published in Medline or Web of Science Until February 1, 2016. We included studies that met the following criteria: i) Randomized controlled clinical trials of inositol/inositol isomer supplementation against placebo in parallel design, ii) performed in humans, iii) with information abou...

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ea0049ep587 | Diabetes therapy | ECE2017

A rare pediatric presentation of type 1 diabetes mellitus with duchenne muscular dystrophy - what to expect in the future?

Elena-Iuliana Pascu-Gabara , Ioana Arhire Amalia , Sorin Ioacara , Simona Fica

Introduction: Duchenne muscular dystrophy (DMD) is a genetic condition caused by mutations in the X-linked dystrophin-gene leading to muscle degeneration and early death in males.Since DMD is characterized by aggressive inflammation it is recommended the use of pharmacological treatment with corticosteroids (CS). Type-1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood and is caused by insulin deficiency resulting from the autoimmune destruction ...

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ea0049ep588 | Diabetes therapy | ECE2017

Significant effect of a group education program on glycemic control and incidence of hypoglycemia in patients with diabetes mellitus type 1: A case-controlled study

Mouslech Zadalla , Somali Maria , Livadas Sarantis , Daramilas Christos , Chatzi Alexandra , Papagianni Maria , Mastorakos George , Savopoulos Christos , Hatzitolios Apostolos I.

DM1 constitutes a real challenge in everyday practice for both physicians and patients. Due to the complexity of the disease and its unpredictable nature, structured education and training programs are nowadays implemented that ensure active patient involvement and self-care behaviors to achieve adequate glycemic control, prevent diabetic complications and improve the quality of life of patients. These programs provide patients with the necessary knowledge and skills to self-m...

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ea0049ep589 | Diabetes therapy | ECE2017

Dapagliflozin induced vulvovaginitis in an atopic patient with type 2 diabetes mellitus

Nasiroglu Imga Narin , Catak Merve , Berker Dilek

Introduction: Dapagliflozin is sodium-glucose co-transporter receptor 2 (SGLT2) inhibitor that is recently discovered an oral antidiabetic (OAD) agent that improves glycemic control by increasing the renal excretion of glucose. Vulvovaginal candidiasis (VVC) is the infection of the vaginal vestibuler area. We present a case of VVC accompanied by use of dapagliflozin.Case: A-48-year-old woman who had T2DM since 8 years was admitted to the endocrinology cl...

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ea0049ep590 | Diabetes therapy | ECE2017

Efficacy of body weight reduction on SGLT-2 inhibitor in people with type 2 diabetes mellitus

Kim Chong Hwa , Cho Hyun A , Jung Su Jin , Lee Ki Young , Kim Sung Rae

Objective: Dapagliflozin, sodium-glucose cotransporter-2 (SGLT-2) inhibitor, reduces hyperglycemia and body weight by inhibiting renal glucose reabsorption. However, only a few studies have shown the efficacy of dapagliflozin in type 2 diabetic patients. We evaluated the efficacy and safety of body weight reduction of dapagliflozin in real practice with type 2 diabetes in Korea.Methods: This is a retrospective, observational study, data from 61 patients ...

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ea0049ep591 | Diabetes therapy | ECE2017

Modification of lifestyle and influence on leptin and insulin resistance to prevent type 2 diabetes mellitus

Elena Shishko , Elena Mokhort

The aim of the present study was to determine the change of fasting serum leptin and insulin levels and insulin resistance in patients with risk factors of diabetes mellitus of type 2 (DM 2) including impaired glucose tolerance/impaired fasting glucose (IGT/IFG), obese and first-degree relatives of patients with diabetes after lifestyle modification.Material and methods: The study included 100 patients (32 men, 68 female) 2565 years old at risk fac...

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ea0049ep592 | Diabetes therapy | ECE2017

Australian women with diabetes survey of contraceptive use and beliefs about safety of contraceptive options

Chalasani Santhi , Kozan Pinar , Myszka Rickie , Black Kirsten , Park Kris , Hibbert Emily

Introduction: Women with diabetes mellitus (DM) are at increased risk of adverse maternal and foetal outcomes. Preconception planning is required to minimize risks, including good understanding of contraceptive options.Objectives: To determine in Australian women with DM beliefs regarding safety of various contraceptive methods in DM, information sources regarding contraception, recent and previous contraceptive use, knowledge of pregnancy risks, access ...

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ea0049ep593 | Diabetes therapy | ECE2017

Management and control of hospital hyperglycemia in the health area of cuenca (Spain)

Perez-Rodriguez Jose , Garcia-Notario Paula , Martin-Iglesias David , Guerra-Navarro Lidia , Alramadan Mubarak , Aranda-Regules Santiago , Calderon-Vicente Dulce

Introduction and objectives: Hyperglycemia is a common problem in hospitalized patients that increases infections, mortality, costs and the hospital stay. The objective of this study is to know the management and control of hyperglycemia in our hospital.Methods: We designed a cross-sectional observational study. We included patients admitted in the hospital every three days in two months. We excluded patients younger than 15 years, stays less than three ...

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ea0049ep594 | Diabetes therapy | ECE2017

Impact of the insulin pump therapy on quality of life children and adolescents with diabetes mellitus type 1

Nikolaeva Nataliia

Objectives: To investigate the changes parameters of quality of life (QoL) in children and adolescents with diabetes mellitus type 1 (T1DM), using different regimes insulin therapy.Research design and methods: Thirty patients with diabetes mellitus type 1, aged 518 years (mean 13.3±3.04 yr), with disease duration from 1 to 10 years (mean 5.4±3.4 yr) took part in paired study. QoL was assessed with the PedsQL (Generic Core Scales and Diabe...

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ea0049ep595 | Diabetes therapy | ECE2017

Efficacy of insulin detemir treatment in type 2 diabetes mellitus is associated with a allele od the catechol o-methyltransferase polymorphism

Bozek Tomislav , Blazekovic Antonela , Perkovic Matea Nikolac , Gotovac Kristina , Smircic-Duvnjak Lea , Pivac Nela , Borovecki Fran

Introduction: Growing evidence suggests that nutrients and hormonal signals converge and directly act on brain centers, leading to changes in energy metabolism and stable body weight over time. Catechol O-methyltransferase (COMT) is one of the major enzymes involved in catecholamine and estrogen degradation. There is a well-established association between the COMT Val108/158Met polymorphism and abdominal obesity, blood pressure increase and T2DM. Basal insulin detemir besides ...

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ea0049ep596 | Diabetes therapy | ECE2017

A dramatic improvement in metabolic parameters and cutaneous manifestations of insulin-resistance in a type 2 diabetic patient with Congenital Generalized Lipodystrophy (Berardinelli-Seip Syndrome) treated with pioglitazone

Chaves Carolina , Moniz Catarina , Pereira Bernardo Dias , Sousa Isabel , Anselmo Joao , Cesar Rui

Background: Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a autosomal recessive disorder with only up to 500 reported cases. It is characterized by generalized absence of fat since birth and severe metabolic derangements such as insulin resistance, hyperglycemia and dyslipidemia. Diabetes mellitus generally develops during the second or third decade of life. This is a rare clinical condition, with worldwide prevalence of 1 in 10 million people and incidence of 1:500.000...

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ea0049ep597 | Diabetes therapy | ECE2017

Comparison of neonatal outcome in women with gestational diabetes on different pharmacoglogical agents dilevered at term

Elhadd Tarik , Jacob Sindu , Boama Vincent , Ashawesh Khaled , Dukhan Khaled , Beer Stephen , Satti Hiba

Objective: Though many studies have looked at the neonatal outcomes in patients with gestational diabetes on different medications, there is no consensus on the preferred drug for initiation of therapy. We aim to compare the neonatal outcome in a cohort of patients attending our service, to determine if one modality is superior to the other.Methods: This study is a prospective observational study from 1-07-2015 to 31-04-2016. The data of all gestational ...

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ea0049ep598 | Diabetes therapy | ECE2017

The hypolipidemic and hepatoprotective efficacies of a fixed-dose combination of essential phospholipids with methionine (EPL+M) during atorvastatin (A) therapy in hyperlipidemic patients with cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM) (OLYMP trial)

Bubnova M G , Aronov D M , Bubnoa Marina , Aronov David

Objective: Objective to study the hypolipidemic efficacy, hepatoprotective activity, and tolerance of the fixed-dose combination of essential phospholipids with methionine (EPL+M) - Eslidine in the combination therapy with A in patients (pts) with cardiovascular diseases (CVD) and type 2 DM who suffer from hyperlipidemia (HL) in order to optimize their treatment in daily clinical practice.Subjects and methods: The trial enrolled 60 pts (mean age 58.1&#17...

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ea0049ep599 | Diabetes therapy | ECE2017

Pancreas transplantation: experience in a central hospital

Martins Ana Claudia , Vasques Miguel , Bogalho Paula , Aires Ines , Ferreira Anibal , Remedio Francisco , Paulino Jorge , Nolasco Fernando , Martins Americo , Agapito Ana

Introduction: Pancreas transplantation is an established treatment for selected patients with type 1 diabetes mellitus (T1DM) and severe chronic kidney disease (CKD), reducing mortality and morbidity.Methods: We retrospectively reviewed the cases of pancreas transplantation performed at our centre from 1-January-2011 to 30-June-2016.Results: In this period, 53 transplants were performed: 48 simultaneous pancreas-kidney transplants ...

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ea0049ep600 | Diabetes therapy | ECE2017

Correlates of health-related quality of life in Bulgarian patients with type 2 diabetes mellitus

Levterov Georgi , Levterova Boryana , Orbetzova Maria

Background: Diabetes mellitus (DM) is one of the greatest threats to global health and development of the 21th Century worldwide. In Bulgaria, it affects 9.6% of residents between ages 18-69 and has a profound impact on healthcare, economy and individuals. Diabetes and its complications are major causes of early death in our country - each year 4 125 women and 4 000 men die of diabetes-related complication. Diabetes not only reduces patients physical wellbeing but also c...

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ea0049ep601 | Diabetes therapy | ECE2017

Effects of sitagliptin monotherapy on insulin resistance and immune functions in type 2 diabetic patients

Almacioglu Serdar , Oz Gul Ozen , Cander Soner , Ersoy Canan

Background: Sitagliptin, unlike the some major antihyperglycemic drugs, is not associated with weight gain and has neutral effects on body weight. It is unclear whether sitagliptin treatment alters immune functions and insulin resistance in people with type 2 diabetes. The aim of the present study was to assess the effect of sitagliptin on insulin resistance and immune functions in patients with type 2 diabetes mellitus.Methods: Twenty type 2 diabetic su...

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ea0049ep602 | Diabetes therapy | ECE2017

Real practice experience: Degludec vs Glargina U300

Exposito Maria Rosa Alhambra , Sanchez Inmaculada Prior , Moreno Paloma Moreno , Moreno M Angeles Galvez

Background: In last year, different analogues of very long duration basal insulin have appeared, which favors the flexibility in its use. Both ensure a decrease in the rate of hypoglycemia and improve glycemic control in clinical trials. However, in real practice we have few data in real practice.Objective: To compare the two ultralente insulin analogues in real practice. To analyze if they are cost effective.Material and methods: ...

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ea0049ep603 | Diabetes therapy | ECE2017

Glycemic control and weight evolution in DM2 patients with canaglifozina

de Linares Lidia Urbon Lopez , Soto Cristina Crespo , Terroba Concepcion , Garrote Sara , Ventosa Marta , Marin Tomas , Cuellar Luis

In the late years ISGLT2 have became an usual choice to treat diabetes. The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine. Therefore hyperglycemia decreases and so does weight. This is a very convenient side effect since type 2 DM is highly associated with overweight/obesity. We show the results of HbA1c and weight evolution after starting canaglifozina 100...

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ea0049ep604 | Diabetes therapy | ECE2017

Intralesional epidermal growth factor treatment on diabetic foot ulcers

Cifci Aydin , Oktas Birhan , Durmaz Senay Arikan , Gungunes Askin , Karahan Irfan , Sarak Taner

Objective: Treatment of diabetic foot ulcer is complex and difficult. Blood glucose regulation, debridment and surgical revascularization are used in management of diabetic foot ulcer. Intralesional Epidermal Growth Factor (EGF) is a new treatment approach for diabetic foot ulcer. We report our experience with eight patients with diabetic foot ulcer who were treated by intralesional EGF.Patients and methods: A total of eight patients whose diabetic foot ...

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ea0049ep605 | Diabetes therapy | ECE2017

Efficacy and safety of evoglipitin monotherapy in patients with type 2 diabetes

Kim Doo-Man , Park Sungwoo , Lee Mookyu , Yoon Kunho

Background and aims: To evaluate the efficacy and safety of the newly developed dipeptidyl peptidase-4 (DPP-4) inhibitor evogliptin in drug-naïve patients with inadequately controlled type 2 diabetes.Materials and methods: In randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase III study, 160 patients with type 2 diabetes were randomized to evogliptin 5 mg or placebo for 24 weeks. The primary efficacy outcome measure was ...

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ea0049ep606 | Diabetes therapy | ECE2017

Rabson mendenhall syndrome-a dilemma to treat in a resource poor country

Tabassum Shehla , Masood Qamar

Background: Rabson Mendenhall Syndrome (RMS) is a rare genetic syndrome that is caused by the mutation in the insulin receptor gene. Such mutation consequently results in severe insulin resistance. Patients suffering from RMS develop constant hyperglycemia from a progressive decline of endogenous insulin secretion. Drug therapy for RMS includes metformin, pioglitazones, large doses of insulin alongwith recombinant human methionyl leptin or IGF-1. Here we describe a case of RMS...

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ea0049ep607 | Diabetes therapy | ECE2017

Does tolerance develop toward GLP-1 receptor agonists’ glucose-lowering effect?

Sedman Tuuli , Krass Maarja , Runkorg Kertu , Vasar Eero , Volke Vallo

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a popular tool for the treatment of type 2 diabetes. Unlike many other antidiabetic drug classes, distinct GLP-1 RAs have different therapeutic profiles, mostly due to their different pharmacokinetic properties. Animal experiments and human data indicate that tolerance develops toward at least some of their effects, e.g., gastric motility. Whether tolerance develops toward the glucose-lowering effect...

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ea0049ep608 | Diabetes therapy | ECE2017

Comparative evaluation the effects of bariatric surgery and exenatide treatment on the clinical and laboratory parameters in obese type 2 diabetic patients

Elbasan Onur , Sisman Pinar , Peynirci Hande , Oz Gul Ozen , Cander Soner , Erturk Erdinc , Ersoy Canan

Background: Obesity and diabetes are major causes of morbidity and mortality that are increasing all over the world. As obesity is a major risk factor for type 2 diabetic patients, weight loss has an important place in the treatment of type 2 diabetic patients. In our study, its aimed to evaluate the effects of exenatide and laparoscopic sleeve gastrectomy (LSG) in obese diabetic patients on the clinical and laboratory parameters.Subjects and metho...

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ea0049ep609 | Diabetes therapy | ECE2017

Increase in time in target when using a basal-bolus algorithm for insulin dosing with insulin glargine U300 during hospital stay

Mader Julia K , Donsa Klaus , Aberer Felix , Lichtenegger Katharina , Lanz Christian , Smajic Edin , Holl Bernhard , Beck Peter , Pieber Thomas R , Plank Johannes

Background and aims: Insulin therapy and the use of clinical decision support systems to achieve glycaemic control in hospitalized patients with hyperglycaemia are recommended by clinical guidelines. The aim of this evaluation was to assess time in target by continuous glucose monitoring (CGM) achieved by a basal-bolus insulin algorithm using insulin glargine U300 during hospital stay in patients with type 2 diabetes (T2D).Material and methods: 30 patien...

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ea0049ep610 | Diabetes therapy | ECE2017

Intensity of dapagliflozin induced glycosuria correlates with previous glycemic control but not with body weight or duration of type 2 diabetes

Cayon-Blanco Manuel , Mateos Carolina Garcia-Figueras

Introduction: Inhibitors of sodium-dependent glucose co-transporter 2 (SGLT2i) reduce circulating glucose concentrations via a renal mechanism. Its metabolic effects have not been fully described and there is a discrepancy on some clinical results found in studies on SGLT2i. Our aims were to detect if there are some predictor factors to identify what patients will have higher response to dapagliflozin, a SGLT2i, and second, to explore whether intensity of glycosuria is correla...

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ea0049ep611 | Diabetes therapy | ECE2017

How can dapagliflozin affect blood pressure response in a real-life cohort of people with type 2 diabetes and hypertension?

Cayon-Blanco Manuel , Mateos Carolina Garcia-Figueras

Introduction: In clinical trials, dapagliflozin has been shown to lower blood glucose, reduce weight and blood pressure in people with type 2 diabetes (T2D). However, there are limited published data on quantitative changes on blood pressure of this drug in routine clinical practice. Our aim was to examine the clinical efficacy of dapagliflozin in patients with T2D and hypertension in a real-life cohort.Methods/design: Prospective study including patient...

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ea0049ep612 | Diabetes therapy | ECE2017

Trends in prescription of Sodium-glucose co-transporter-2 inhibitors (SGLT2i) over the last three years in a specialized setting

Mateos Carolina Garcia-Figueras , Cayon-Blanco Manuel

Introduction: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are a newly developed class of oral anti-diabetic drugs with a unique mechanism of action and its use is becoming more widespread. Given that dapagliflozin was the first drug of this class used in Spain, available since December 2013, 3 years after its inception, we aimed to investigate whether there have been differences in prescription patterns of SGLT2i (using dapagliflozin as reference) in a Sanitary distric...

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ea0049ep613 | Diabetes therapy | ECE2017

The insulin delivery system and its impact on quality of life and on psychopathological symptomatology

Pereira Miguel , Neves Celestino , Esteves Cesar , Oliveira Sofia , Arteiro Cristina , Coelho Rui , Carvalho Davide

Introduction: In chronic diseases a good psychological and behavioral adaptation is essential. Concerning diabetes the Insulin Delivery System (IDS) adopted tend to be an important factor of adaptation, global satisfaction and, above all, quality of life (QoL).Objectives: To analyze the QoL and IDS satisfaction and its relationship with psychopathological symptomatology in patients on continuous subcutaneous insulin infusion (CSII) therapy.<p class="...

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ea0049ep614 | Diabetes therapy | ECE2017

New long-acting insulins in type 1 diabetes: implications for real clinical practice

Damas-Fuentes Miguel , Diaz-Perdigones Cristina , Munoz-Garach Araceli , Molina-Vega Maria , Hernandez-Garcia Carmen , Cornejo-Pareja Isabel , Mancha-Doblas Isabel , Tinahones-Madueno Francisco J

The emergence of a new generation of long-acting insulin analogues (insulin degludec -ID- and insulin glargine 300 U/ml -IG300-) has increased treatment options in type 1 diabetes (T1D), demonstrating in clinical trials better metabolic control with lower hypoglycemia rates.Objectives: To assess characteristics of T1D patients who were given ID and IG300 in clinical practice and to evaluate their effect on metabolic control, weight, insulin dose and hypo...

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ea0049ep615 | Diabetes therapy | ECE2017

Effect of oral nitrate administration on glucose metabolism and inflammation in obese type 2 diabetic rats

Ghasemi Asghar , Gheibi Sevda

Introduction: Type 2 diabetes is associated with impaired nitric oxide (NO) bioavailability; nitrate administration might act as a potential therapeutic agent in diabetes through nitrate/nitrite/NO pathway. The aim of this study was to determine the effects of sodium nitrate on glucose tolerance, insulin sensitivity, inflammation, glucose-stimulated insulin secretion (GSIS), and islet insulin content in obese type 2 diabetic male rats.Methods: Male Wista...

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ea0049ep616 | Diabetes therapy | ECE2017

Impact of a universal educational animation movie in an hour workshop on the knowledge of patients with gestational diabetes

Cheikh Chainese , Lacquement Emilie , Cohen Regis , Hatem Ghada

This study assessed the dietary and medical knowledge before and after a group workshop viewing a 5-min animation film in patients with gestational diabetes (GD) (https://www.youtube.com/watch?v=Maf-Uos9oLQ). This animation movie (without speech) explains the course of the patients suffering from GD by emphasizing the stakes, the diet and the medical measures.Patients and methods: This is a prospective self-assessment study of 10 questions in 100 consecu...

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ea0049ep617 | Diabetes therapy | ECE2017

Insulin requirements in pregnant women with DM 1 with different duration of the disease

Sharipova Juliya , Gaysina Leila , Gazizova Gulnaz , Valeeva Farida , Khasanova Kamilya

Background and aims: To study the need for insulin during pregnancy, depending on the duration of the disease.Methods: We studied 108 pregnant women with DM 1 receiving insulin with insulin pumps. Patients were divided into three groups: in the 1st group diabetes duration was less than 5 years, in the 2nd 5 to 15 years, 3rd more than 15 years. We evaluated the daily need for insulin on 12, 2225, 3032 weeks of gestation.<p cl...

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ea0049ep618 | Diabetes therapy | ECE2017

Liraglutide restores the hyperglycemia-induced endothelial oxidative stress in vitro

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgios N

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

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ea0049ep619 | Diabetes therapy | ECE2017

Incretin-based therapies and pancreatic/biliary tract cancer

Boj-Carceller Diana , Cay-Melero Sara , Azcona-Monreal Isabel , Perez-Fernandez Leticia , Calmarza-Calmarza Pilar , Sanz-Paris Alejandro

Objective: To study the relation between incretin-based therapies, DPP-4 inhibitors and GLP-1 receptor agonists, and tumor stage at the time of diagnosis of pancreatic and biliary tract cancer.Methods: Retrospective study of type 2 diabetic patients with newly diagnosed of pancreatic or biliary tract cancer attended consecutively in a tertiary hospital between the years 2012 and 2015.Results: A total of 37 patients were included. T...

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ea0049ep620 | Diabetes therapy | ECE2017

Palpable purpura in an uncontrolled diabetic patient: an uncommon possible side effect of linagliptin

Topaloglu Omercan , Evren Bahri , Kara Mahmut , Yucel Seyfullah , Sahin Ibrahim

Introduction: Incretin based therapeutics have commonly been used in the last years for the management of patients with type 2 diabetes mellitus (DM). Linagliptin is a member of dipeptidyl peptidase 4 (DPP-4) inhibitors and often preferred owing to some advantages over the others. We present a diabetic case developing skin findings after the initiation of linagliptin.Case: 66 year-old woman with a history of type 2 DM for 10 years was admitte...

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ea0049ep621 | Diabetes therapy | ECE2017

Dulaglutide added on Empagliflozin improves blood pressure, body weight, glycemic control and albuminuria in obese diabetic patients

Acosta-Calero Carmen , Arnas-Leon Claudia , Santana-Suarez Ana Delia , Nivelo-Rivadeneira Manuel , Kuzior Agnieszka , Quintana-Arroyo Sara , Sablon-Gonzalez Nery , Martinez-Martin Francisco Javier

Objective: GLP-1 receptor agonists and SGLT2 inhibitors improve glycemic control, body weight, blood pressure and albuminuria by different pathways. However, their combination is not endorsed by ADA-EASD guidelines, and available data are scarce. Our objective in this open observational study was to elucidate the effect of added Dulaglutide in obese type 2 diabetic patients previously treated with Empagliflozin but insufficiently controlled.Methods: Dula...

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ea0049ep622 | Diabetes therapy | ECE2017

Modern treatment approaches of patients with type 2 diabetes and non-alcoholic fatty liver disease

Kondratiuk Kateryna , Kobyliak Nazarii , Bodnar Petro , Lysianyi Mykola , Belska Liudmyla , Kondratiuk Valentyna

Background: One of the most significant complications of type 2 diabetes (T2D) is non-alcoholic fatty liver disease (NAFLD). The search for new effective approaches to the treatment of patients with comorbid chronic condition such as type 2 diabetes and NAFLD is relevant.Methods: We have observed 118 patients, including 64 patients with T2D and NAFLD, 26 patients with T2D and 28 patients with NAFLD. The control group consisted of 25 healthy indivi...

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ea0049ep623 | Diabetes therapy | ECE2017

The role of diabetic educational programs in glycemic control in patients attending to our day hospital

Tome Mariana , de Pinillos Guillermo Martinez , Garcia Fernando , Cuellar Eyvee Arturo , Fernandez Ignacio , de Quiros Juan Manuel Garcia

Objective: To assess improvement in glycemic control in those diabetic patients who have received structured education in diabetes in our Day Hospital.Methods: A retrospective observational study was carried out in which 42 diabetic patients who had attended to educational courses in 1 year were included, determining the age of the patient, type of Diabetes, score obtained in the questionnaires at the beginning and end of the course, as well as HbA1c bef...

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ea0049ep624 | Diabetes therapy | ECE2017

Real-time detection of hazardous changes in blood glucose at the first trimester of pregnancy in women with type 1 diabetes: a pilot study

Barenholz-Goultschin Orit , Shauly-Aharonov Michal

Introduction: Type 1 diabetes (T1D) in pregnancy is known to be associated with increased risks of birth defects and miscarriages. Despite the technological improvement and availability of continuous glucose monitoring (CGM), women with T1D who are adequately controlled according to CGM average and HBA1C still face these complications. Glucose variability was suggested as an explanatory factor of the difference between actual obstetric outcome and the expected...

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ea0049ep625 | Diabetes therapy | ECE2017

Sense of coherence and glycaemic control among a sample of newly diagnosed type II diabetics in rural Crete

Anyfantakis Dimitrios , Anyfantakis Anastasios , Foukaki Michaela , Kastanakis Serafim

Aim: Currently there is much discussion on the protective effects of the sense of coherence (SOC) on health. Our aim was to examine possible associations between SOC and glycemic control among 60 newly diagnosed adults with type 2 diabetes.Methods and results: Thirty males and 30 females diagnosed 3 months before with type 2 diabetes mellitus were included in the study. SOC was measured with the Greek translated and validated version of Antonovskys...

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ea0049ep626 | Diabetes therapy | ECE2017

Gestacional diabetes mellitus with and without insulin therapy: a case study

Evora Francisco , Pinto Marta , Almeida Ceu

Introduction: Gestational Diabetes Mellitus (GDM) is a pregnancy complication that has experienced a worldwide growth. The use of insulin has to be considered as it may be beneficial for both the mother and the new-born.Methods: Retrospective analysis of all cases of GDM, and the respective new-borns (NB), followed in our obstetrics unit between 2012 and 2015. Clinical and workup parameters were evaluated in 2 groups: GDM with no insulin therapy (GDMNIT)...

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ea0049ep627 | Diabetes therapy | ECE2017

Evaluation and descriptive analysis of our type 1 diabetes population and their insulin therapy

Perdigones Cristina Diaz , Garach Araceli Munoz , Vega Maria Molina , Garcia Carmen Hernandez , Fuentes Miguel Damas , Madueno Francisco J. Tinahones

Objectives: To evaluate the different insulin regimens and types of insulin used in our population of type 1 diabetes (DM1) patients in the last revision in our clinic.Method: A descriptive study was carried out in our population of 535 DM1 patients. They had their initial diagnosis between 1967 and 2014.Results: In our population, 47.3% were women and 52.3% were men. The mean age of our patients was 33.8 years (S.D....

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ea0049ep628 | Diabetes therapy | ECE2017

Effects of dapagliflozin in treatment of gastroparesis considering the state of carbohydrate metabolism in patients with type 2 diabetes mellitus

Kostitska Iryna

Diabetic gastroparesis (DG) is associated with high morbidity and is the most common precipitating factor to decompensation of carbohydrate metabolism. SGLT2 inhibitors are becoming a common and useful drug to treat type 2 diabetes. Principle treatment of gastroparesis considering the state of carbohydrate metabolism in patients with type 2 diabetes mellitus are very limited. The aim of this study was to compare the effects of dapagliflozin for management patients with DG. 16 ...

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ea0049ep629 | Diabetes therapy | ECE2017

Self-monitoring of blood glucose: how are glycemic readers used in practice?

Haddad Meriem , Aouiche Samir , Boudiba Aissa

Introduction: In recent years, the technique of ASG has gained much in simplicity, speed and acceptability, using readers more and more reliable. Despite this, some patients do not acquire the skills needed to achieve it. The aim of this study is to evaluate the technical gestures of use of blood glucose readers in current practice.Material and method: This is a prospective descriptive study including 369 diabetics for over a year, followed in diabetic c...

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ea0049ep630 | Diabetes therapy | ECE2017

Determinants of patient’s adherence and its relation to therapeutic success after hospital admission for decompensated diabetes

Magalhaes Daniela , Saavedra Ana , Souteiro Pedro , Bettencourt-Silva Rita , Costa Maria Manuel , Castedo Jose Luis , Freitas Paula , Nogueira Claudia , Queiros Joana , Carvalho Davide

Introduction: Diabetes mellitus (DM) is a chronic disease that requires continuous medical care. Health care providers should adopt approaches that improve patient outcomes and adherence.Aims: To evaluate the adherence to Endocrinology ambulatory follow-up after elective hospital admission for decompensated DM and to determine the relationship between adherence and therapeutic success after discharge.Methods: Retrospective study of...

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19th European Congress of Endocrinology

BiosciAbstracts