ECE2017 Guided Posters Diabetes therapy & complications 1 (10 abstracts)
Higher levels of adiponectin might contribute to lower bone mass observed in patients with type 1 diabetes, through alterations in osteocalcin energy circuit signaling of bone cells.
Charalampos Tsentidis 1 , Dimitrios Gourgiotis 2 , Lydia Kossiva 1 , Artemis Doulgeraki 3 , Antonios Marmarinos 2 & Kyriaki Karavanaki 1
1Diabetes Clinic, Second Pediatric Department, University of Athens, “P&A Kyriakou” Children’s Hospital, Athens, Greece; 2Biochemistry Laboratory, Second Pediatric Department, University of Athens, “P&A Kyriakou” Children’s Hospital, Athens, Greece; 3Department of Bone and Mineral Metabolism, Institute of Child Health, “Aghia Sophia” Children’s Hospital, Athens, Greece.
Introduction: Recent advances in energy homeostasis revealed a significant interconnection between bone and adipose tissue through osteocalcin. Reduced bone mass documented in type 1 diabetes mellitus (T1D) could be related to disregulation of adipokine signaling on bone.
Materials and Methods: We evaluated 40 children and adolescents with T1D (mean±S.D. age 13.04±3.53 years, mean±S.D. T1D duration 5.15±3.33years) and 40 healthy age- and gender-matched controls (mean±S.D. age 12.99±3.3years). Adiponectin, leptin and bone metabolism markers were measured, while lumbar spine (LS) and total body (TB) Bone Mineral Density (BMD) were evaluated with dual energy X-ray absorptiometry (DXA).
Results: Lower BMD values have already been documented in patients, as well as lower osteocalcin (log(osteocalcin) 3.44±0.5 vs 3.6±0.51). Patients had higher levels of adiponectin (18078±8645 vs 13536±6703 ng/ml, P=0.007) while leptin levels were comparable between groups (8.85±8.73 vs 10.03±8.75 pg/ml, P=0.13). Both adipokines were associated with Body Mass Index (BMI) in both groups. Adiponectin was positively associated with osteocalcin only in controls (Rho=0.31, P=0.05) possibly indicating altered energy signaling in bone of T1DM patients, whereas in patients it was negatively associated with IGF1 (Rho=−0.30, P=0.05) and positively associated with HbA1c (Rho=0.38, P=0.01) and i-phosphorus (Rho=0.39, P=0.01). No associations of leptin with bone markers were observed.
Conclusion: Increased adiponectin might contribute to lower bone mass observed in young T1D patients with altered interconnection of energy signaling in bone cells, through osteocalcin circuit.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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