Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Diabetes therapy & complications 1

ea0049gp93 | Diabetes therapy & complications 1 | ECE2017

microRNA expression profile in plasma from patients with diabetic kidney disease

Assmann Tais Silveira , Punales Marcia , Tschiedel Balduino , Canani Luis Henrique , Bauer Andrea Carla , Crispim Daisy

Introduction: Diabetic kidney disease (DKD) is the major cause of end-stage renal disease; however, the pathogenesis of this disease is not fully understood. Currently available therapies are not totally efficacious in the treatment and prognosis of DKD, suggesting that further understanding of the molecular mechanisms underlying the pathogenesis of this disease is necessary to improve its management. Recently, research on microRNAs (miRNAs) has become a hotspot because of the...

ea0049gp94 | Diabetes therapy & complications 1 | ECE2017

The A allele of the -866G/A polymorphism in UCP2 gene decreases high glucose-induced UCP2 expression in HUVECs

Assmann Tais , Crispim Daisy , Rodrigues Michelle , Silva Liana , Boucas Ana Paula , Carlessi Rodrigo , Brondani Leticia , Canani Luis Henrique , Souza Bianca

Uncoupling protein 2 (UCP2) is a mitochondrial protein located in the mitochondrial inner membrane, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing reactive oxygen species (ROS) formation by mitochondrial respiratory chain. ROS overproduction is related to diabetic retinopathy (DR), a chronic complication of diabetes mellitus (DM). Recently, our group reported that the -866A/55Val/Ins haplot...

ea0049gp95 | Diabetes therapy & complications 1 | ECE2017

The relation between PON-1 activity and 25-OH hydroxyvitamin D3 levels and other biochemical parameters in diabetic patients with respect to obesity and diabetic complications

Karakaya Pinar , Mert Meral , Karagoz Hamide , Ozdemir Bahar

Objective: To evaluate the relation of mean platelet volume (MPV) levels with serum paraoxonase-1 activity in diabetic patients with respect to obesity and diabetic complications.Methods: A total of 201 diabetic patients grouped with respect to obesity obese (n=89) and non-obese (n=112) and diabetic complications with (n=50) or without (n=150) microvascular complications and with (n=91) or without (n=...

ea0049gp96 | Diabetes therapy & complications 1 | ECE2017

High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with diabetic nephropathy and the role of netrin-1 levels

Kor Ahmet , Baldane Suleyman , Ipekci Suleyman Hilmi , Marakoglu Kamile , Altinok Ali , Unlu Ali , Colkesen Fatih , Ozturk Bahadir , Kirac Cem Onur , Kebapcilar Levent

Background: Netrin-1 is an early biomarker of acute kidney injury. Besides, recent studies have showed that netrin-1 promotes angiogenesis; but its usefulness for peripheral artery disease (PAD) in type 2 diabetes patients is unknown.This study aimed at investigating whether netrin-1 levelsare increased in peripheral artery disease among patients with type 2 diabetes and also investigating possible associationsbetween diabetic nephropathy (DN) and PAD.Ma...

ea0049gp97 | Diabetes therapy & complications 1 | ECE2017

Comparison of current perception threshold measured by Neurometer in patients with type 2 diabetes mellitus to a group of normal individuals

Tseng Chin-Hsiao

Purpose: To determine the proportion of abnormal current perception threshold (CPT) in patients with type 2 diabetes mellitus.Methods: A total of 1360 patients with type 2 diabetes mellitus involved in an epidemiological study received an examination of CPT measured by Neurometer® CPT/C (Neurotron, Inc., Baltimore, Maryland, USA) on a supine position. The measurement was taken for three frequencies, i.e., 5, 250 and 2000 Hz at three sites: the preau...

ea0049gp98 | Diabetes therapy & complications 1 | ECE2017

Gestacional diabetes mellitus: the new screening criteria and its outcomes

Gouveia Pedro , Sa Maritza , Resende Eduarda , Ferreira Margarida , Abreu Silvestre

Background: Gestational Diabetes Mellitus (GDM) is one of the most common illness of pregnancy. Despite its frequency, there’s no worldwide accepted screening criteria for GDM. In 2011, Carpenter and Coustan (CC) screening (50-g glucose challenge test (GCT) followed by 100-g glucose tolerance test (OGTT) if GCT screen was positive) was abandoned and began the implementation of the screening of the International Association of Diabetes and Pregnancy Study Group (IADPSG) 20...

ea0049gp99 | Diabetes therapy & complications 1 | ECE2017

Higher levels of adiponectin might contribute to lower bone mass observed in patients with type 1 diabetes, through alterations in osteocalcin energy circuit signaling of bone cells.

Tsentidis Charalampos , Gourgiotis Dimitrios , Kossiva Lydia , Doulgeraki Artemis , Marmarinos Antonios , Karavanaki Kyriaki

Introduction: Recent advances in energy homeostasis revealed a significant interconnection between bone and adipose tissue through osteocalcin. Reduced bone mass documented in type 1 diabetes mellitus (T1D) could be related to disregulation of adipokine signaling on bone.Materials and Methods: We evaluated 40 children and adolescents with T1D (mean±S.D. age 13.04±3.53 years, mean±S.D. T1D duration 5.15±3....

ea0049gp100 | Diabetes therapy & complications 1 | ECE2017

Type 1 diabetes and hearing loss: a meta-analysis

Mujica-Mota Mario , Patel Neel

Objective: Evidence shows type 1 diabetes leads to vascular damage and neuropathy. The purpose of this study was to perform a systematic review and a meta-analysis to asses the evidence of the effects of type 1 diabetes on hearing function.Methods: Three different electronic databases were used to identify eligible studies including a manual searching of references. The articles obtained were independently reviewed by two authors using predefined inclusi...

ea0049gp102 | Diabetes therapy & complications 1 | ECE2017

Comparison of the effects of combinations of different antihypertensive therapies on microalbuminuria and renal functions in type 2 diabetic patients

Erek Muge , Ersoy Alparslan , Ersoy Canan

Renin angiotensin system blockers are currently used in the treatment of diabetic nephropathy. Carvedilol, 3. generation beta-blockers, may provide additional benefits in diabetic patients. Its antiproteinuric activity is not investigated in patients with diabetic nephropathy. We aimed to compare short-term additive effects of losartan with cilazapril or carvedilol combination on blood pressure, proteinuria and renal functions in microalbuminuric patients with type 2 diabetes ...