Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Diabetes & complications 2

ea0049gp83 | Diabetes & complications 2 | ECE2017

Vitamin D metabolites and IL1β RS16944 polymorphism in type 2 diabetes patients: evidence for functional interaction

Nejatian Nojan , Penna-Martinez Marissa , Badenhoop Klaus

We investigated the SNP rs16944 in German type 2 diabetes (T2D) patients and healthy controls (HC) and correlated the findings with concentrations of VD metabolites.Methods: 504 T2D patients and 447 HC were genotyped by a Taqman assay. Additionally 25(OH)D3 and 1,25(OH)2D3 plasma levels of 76 T2D patients and 267 HC were measured by radioimmunoassay.Results: The AA genotype was significantly less fr...

ea0049gp84 | Diabetes & complications 2 | ECE2017

Antidiabetic medication use and the risk of fracture in type 2 diabetic patients: a nested case-control study

Losada Eladio , Soldevila Berta , Ali M. Sanni , Martinez-Laguna Daniel , Nogues Xavier , Diez-Perez Adolfo , Puig-Domingo Manel , Mauricio Didac , Prieto-Alhambra Daniel

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures. Anti-diabetic oral agents and insulin may also impact on fracture risk. There is however scarce data available on the effect of such therapies combined as usually prescribed in real-life practice conditions.Objectives: The objective of this study was to compare the risk of fracture among T2DM patients who are users of different antidiabetic treatments...

ea0049gp86 | Diabetes & complications 2 | ECE2017

Increased incidence of diabetes mellitus 30 years after the radiation impact in persons exposed to ionizing radiation during the Chernobyl NPP accident

Kaminskyi Oleksii , Afanasyev Dmitrii , Kopilova Olga , Chikalova Irina , Muravyova Irina , Tepla Olena , Pronin Oleksii , Kiselova Irina , Dombrovska Natalia , Bazyka Dimitrii

Several million people in Ukraine and other countries had been exposed to ionizing radiation during the Chernobyl nuclear power plant accident (ChNPPA) on April 26, 1986. The ChNPPA clean-up personnel involved in emergency and recovery works in the 30-kilometer exclusion zone of power plant in the nearest days or months and/or for a long time had received the highest radiation doses due to external gamma-exposure and from incorporated radioactive isotopes with high affinity to...

ea0049gp87 | Diabetes & complications 2 | ECE2017

Baicalin lowers glucose intolerance by controlling pancreatic hormone in high fat-induced obese diabetic rats

Park Kahui , Kim Jung Hye , Lee Sang Bae , You Ji Hong , Kim Yusik , Nam Ji sun , Park Jong Suk , Ahn Chul Woo

Objective: Bacalin was known as an allosteric modulator of the benzodiazepine sites of the γ-aminobutyric acid A receptor (GABAAR), which produce anxiolytic effects in mice without myorelaxant or sedative effects. Baicalin occur flavonoid found in naturally in the genus Scutellaria. It has been recently shown to exert metabolic effects by attenuating hyperglycemia-induced mitochondrial damage in β-cells in diabetic rats, high-fat diet- (HFD-) indu...

ea0049gp88 | Diabetes & complications 2 | ECE2017

Effect of insulin on neurotrophins’ levels in the muscular wall of mice intestine and colon

Alqudah Mohammad , Mustafa Ayman , Allouh Mohammad , Alshboul Othman , AlDwairi Ahmad

Background: Neurotrophins are implicated in the physiology and pathophysiology of the mature gastrointestinal tract (GIT) such as motility and inflammatory bowel disease. Moreover, GIT disturbances has been attributed to hyperinsuliemia. Insulin-neurotrophins interactions in the (GIT) have not been investigated yet.Aim: To test the effect of Insulin on the expression of neurotrophins in the muscular wall of mice intestine and colon.<p class="abstext"...

ea0049gp89 | Diabetes &amp; complications 2 | ECE2017

Clinical assessment of trabecular bone microstructure in type 2 diabetes mellitus with Trabecular Bone Score (TBS)

Perez Maria Dolores Aviles , Martin Antonia Garcia , Rodriguez Cristina Novo , Serrano Rafael Nieto , Vela Elena Torres , Torres Manuel Munoz

Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporotic fractures although bone mineral density is increased. As such, there is a need for improved approaches to estimate fracture risk in such individuals. The Trabecular Bone Score (TBS) is a new technique to determine the trabecular bone microarchitecture.Objective: Our aim was to evaluate evaluate the usefulness of TBS in T2DM patients.Methods: We compared...

ea0049gp90 | Diabetes &amp; complications 2 | ECE2017

The G allele of the BDKRB1 rs12050217 polymorphism is associated with protection for diabetic retinopathy

Brondani Leticia A. , Pisco Julia , Guimaraes Jorge A. , Crispim Daisy , Berger Markus

Background: Diabetic retinopathy (DR) is a chronic diabetic complication occurring in most diabetic patients after 20 years of disease. Progression of DR to its sight threatening stages is usually associated with worsening of underlying retinal vascular dysfunction and disease. The plasma kallikrein kinin system is activated during vascular injury, mediating important functions in inflammation, blood flow, and coagulation. Bradykinin B1 receptor (B1R) is expressed in human ret...

ea0049gp91 | Diabetes &amp; complications 2 | ECE2017

Dipeptidyl peptidase-4 inhibitor therapy and risk of diabetic retinopathy: a population based study

Kim Nam Hoon , Kim Hye Suk , Yoo Hye Jin , Seo Ji A , Kim Nan Hee , Choi Kyung Mook , Baik Sei Hyun , Lee Juneyoung , Noh Jung Hyun , Kim Sin Gon

Background: Given the possible association between dipeptidyl peptidase-4 (DPP-4) inhibitor and risk of diabetic retinopathy (DR), we examined whether DPP-4 inhibitors are beneficial or harmful for DR compared with other glucose-lowering agents.Methods: From a Korean population-based cohort, we identified 67,743 adults with type 2 diabetes treated with oral glucose-lowering agents between 2008 and 2013. Matching (1:1) was done for comparative groups: eve...

ea0049gp92 | Diabetes &amp; complications 2 | ECE2017

Non-genetic rat model of nephropathy in type 2 diabetes with attenuated streptozotocin-induced tubular alteration

Bayrasheva Valentina , Babenko Alina , Pchelin Ivan , Arefjeva Anna , Chefu Svetlana , Shatalov Ivan , Dmitriev Yurii , Ivanova Alexandra , Andoskin Pavel , Aliev Parvis , Grineva Elena

Non-genetic animal models of diabetic nephropathy (DN) are most commonly reproduced by using streptozotocin (STZ) which preferentially gets into β-cells via GLUT2 transporters. However, STZ administration results in nephrotoxic effects as well, due to expression of GLUT2 by renal tubular epithelial cells. We hypothesized that nicotinamide (NA), which is considered to attenuate the severity of STZ-induced β-cell damage, could also prevent tubular alteration. Starting ...