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Endocrine Abstracts (2017) 49 EP1028 | DOI: 10.1530/endoabs.49.EP1028

Endocrinology Research Centre, Moscow, Russia.


Objective: To analyze registry data on patients with acromegaly.

Materials and methods: Russian hypothalamic and pituitary tumors registry database (on-line platform), which contains data on 3719 patients with acromegaly.

Results: According to the database, highest prevalence of acromegaly per 100 000 inhabitants is registered in: Penza region (7.3), Kirov region (7.3), Krasnoyarsk region (6.2). Most common clinical presentations in registered acromegalic patients were: headaches (72%) maxillofacial changes (68%), arthralgias (48%) excessive sweating (39%). Information about tumor size was available in 1543 patients: by the time of diagnosis, 516 (33.4%) had pituitary microadenomas and 1027 (66.6%) had macroadenomas. 59.5% of registered patients were prescribed medical therapy: 65.9 and 34.1% were treated with somatostatin receptor ligands (SRL) and dopamine agonists respectively. 29.9% of patients were primarily treated surgically and remaining 10.6% underwent radiotherapy. Remission is registered in 22% cases, 23% of patients have only partial disease control, 41% have an active disease and 14% of records have no data regarding disease state.

Conclusions: Russian hypothalamic-pituitary tumors registry is a promising instrument for epidemiologic and clinical data acquisition. Data suggest that multimodal treatment approach is essential to achieve higher remission rates in patients with acromegaly.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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