Objectives: To evaluate sexual function in women with Turner syndrome (TS) in the relation with sex hormones.
Methods: The study was undertaken in Lithuanian University of Health Sciences. 65 women with genetically confirmed TS (1845 years) were enrolled and compared with 65 age-matched healthy controls. Sexual function was evaluated using The Female Sexual Function Index (FSFI). Risk for sexual dysfunction was defined as FSFI score ≤ 26.55. BMI, waist-hip ratio (w_h), concentrations of estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG) were evaluated. TS patients were divided into 3 groups: natural estrogens users (NE2), combined oral contraceptives users (COCs) and untreated (no_E).
Results: 38% (n=27) TS had sexual intercourse and filled out FSFI. 33% (n=9) of TS and 42% (n=25) of controls were at risk for sexual dysfunction (P>0.05). No difference in FSFI score depending on karyotype (classic or mosaicism) was found. No significant relation between age, BMI, w_h, E2, T, SHBG concentrations, duration of E2 use and FSFI domains in TS patients was detected. 41% (n=11) of TS used NE2, 26% (n=7) were on COCs and 33% (n=9) were in no_E group. NE2 or COCs users had higher total FSFI score (25.36±9.10 vs 17.89±13.62; P=0.008) and reported better lubrication (4.60±1.84; P=0.031), satisfaction (4.83±1.72 vs 3.20±2.57; P=0.008), pain (4.67±1.69 vs 2.97±2.46;=0.03) during sexual intercourse compared with no_E. NE2 users had better desire (3.81±1.36 vs 2.01±2.15,=0.005), lubrication (4.58±1.78 vs 2.35±2.48; P=0.014), arousal (4.03±1.63 vs 2.37±2.33; P=0.009), orgasm (3.85±1.86 vs 2.20±2.37; P=0.05), satisfaction (4.54±1.81 vs 2.71±2.83; P=0.001), pain (4.90±1.73 vs 2.26±2.46; P=0.011) and total FSFI score (25.74±9.33 vs 14.09±14.38; P=0.001) when compared with COCs users.
Conclusion: Sexual function in TS did not differ compared with controls. Higher FSFI score was found in E2 users compared with untreated patients and in NE2 users compared with COCs users.
20 - 23 May 2017
European Society of Endocrinology