The aim: To study the functional state of axis of hypophysis-gonads for women with PCOS.
Material and methods of investigation: Under our supervision in the department of neuroendocrinology of The Center of Endocrinology of PHM of Republic of Uzbekistan ambulatory in a period from September 2015 for July, 2016 120 patients of fertile age were inspected with polycystic ovary syndrome (PCOS). Middle age of patients 25.5±4.3 years. The remoteness of disease hesitated in limits from 7 months to 9 years. 20 healthy women of corresponding age made a control group. The complex of researches, including clinical, biochemical hormonal, ultrasound investigations of uteri/ovaries, pituitary MRI was executed all patients.
Results: Patients were divided into two groups: 1 g patients with primary sterility are 94 cases, 2 r. patients with secondary sterility are 26 cases. In a 1 group of patients with primary sterility the reliable decline of both pituitary and ovarian hormones was marked on a background hyperandroenemiya and hyperprolactinemiya. In the second group of patients the reliable decline of pituitary hormones was also educed on a background hyperandroenemiya and hyperprolactinemiya. While an ovarian function was within the limits of norm.
Conclusions: In both groups of patients took place hypogonadotropinemiya combining moderate hyperprolactinemiya and hyperandrogenemiya.Thus, the most expressed violations of the system of pituitary ovarian function were found out in the first group of patients with PCOS with primary sterility, at that the reliable decline of the functional state of pituitary-gonads was marked, namely decline of LH, FSH, estradiol and progesterone of plasma of blood on 14 day of menstrual cycle.
20 - 23 May 2017
European Society of Endocrinology