Endocrine Abstracts (2017) 49 EP1106 | DOI: 10.1530/endoabs.49.EP1106

The functional state of hypophysis - gonad axis in patients with polycystic ovary syndrome (PCOS)

Yulduz Urmanova1,2, Feruza Khodgaeva1,2, Dinara Alieva1,2, Salim Sodikov1,2, Nazira Rikhsieva1,2 & Maryam Abduvakhabova1,2

1Paediatric Medical Institute, Tashkent, Uzbekistan; 2Center of the Scientific and Clinical Study of Endocrinology, Tashkent, Uzbekistan.

The aim: To study the functional state of axis of hypophysis-gonads for women with PCOS.

Material and methods of investigation: Under our supervision in the department of neuroendocrinology of The Center of Endocrinology of PHM of Republic of Uzbekistan ambulatory in a period from September 2015 for July, 2016 120 patients of fertile age were inspected with polycystic ovary syndrome (PCOS). Middle age of patients – 25.5±4.3 years. The remoteness of disease hesitated in limits from 7 months to 9 years. 20 healthy women of corresponding age made a control group. The complex of researches, including clinical, biochemical hormonal, ultrasound investigations of uteri/ovaries, pituitary MRI was executed all patients.

Results: Patients were divided into two groups: 1 g – patients with primary sterility are 94 cases, 2 r. – patients with secondary sterility are 26 cases. In a 1 group of patients with primary sterility the reliable decline of both pituitary and ovarian hormones was marked on a background hyperandroenemiya and hyperprolactinemiya. In the second group of patients the reliable decline of pituitary hormones was also educed on a background hyperandroenemiya and hyperprolactinemiya. While an ovarian function was within the limits of norm.

Conclusions: In both groups of patients took place hypogonadotropinemiya combining moderate hyperprolactinemiya and hyperandrogenemiya.Thus, the most expressed violations of the system of pituitary – ovarian function were found out in the first group of patients with PCOS with primary sterility, at that the reliable decline of the functional state of pituitary-gonads was marked, namely decline of LH, FSH, estradiol and progesterone of plasma of blood on 14 day of menstrual cycle.

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