Endocrine Abstracts (2017) 49 EP1122 | DOI: 10.1530/endoabs.49.EP1122

Relationship between anabolic hormones and benign lesions in different organs in premenopousal women

Zeynep Nilüfer Tekin1, Berçem Ayçiçek1 & Tuna Demirbaş2


1Darıca State Hospital, Kocaeli, Turkey; 2Tekirdağ State Hospital, Tekirdağ, Turkey.


Objective: We aim to detect co-occurence of uterine myomas, thyroid nodules and breast lesions in premenoposual women with menstruel disorders and investigate association between these benign tumors with anabolic hormon levels.

Design: Records of 8008 premenopausal women were analyzed who had been admitted to the hospital for routine breast image investigation which was performed by the same radiologist in between 2010 and 2015.

Study and Methods: 251 patients who had both Thyroid Ultasound (US), Pelvic Ultrasound (US) and Breast Imaging Reporting and complain about menstruel disorders in the same year, were extracted from 8008 premenapousal woman. All data were obtained from file records and ICD-10 diagnosis code of electronic database of the hospital. For breast examination, Breast Imaging Reporting and Data System (BIRADS) terminology had been used. Tiroid stimulating hormone (TSH) and Estrodiol (E2) levels were recorded for investigate of situation of anabolic hormon levels, which had been taken from premenopousal women at the time of third day of menstruel cycle.

Results: The mean age of the patients at the admission to the hospital was 32±5.7 years. From 251 patients only 9 patients had benign lesions in all three organs, whereas 63 patients had both thyroid nodules and breast lesions and 5 patients had thyroid nodules and uterine myoma, and seven patients had BIRADS 2,3 lesions and uterine myoma, respectively. There was only found a relationship between age and existence of myoma uteri and thyroid nodule. (P=0.008, for both). Only TSH levels were found lower in patients with BIRADS 2,3 lesions than with BIRADS 1 (P=0.017).

Conclusion: Our study indicate that no association between E2 levels and existence of benign lesions in different organs according to the radiologic investigations in premenopausal women. And, TSH levels were found related to upper BIRADS grades in premenopausal women.

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