Endocrine Abstracts (2017) 49 EP1124 | DOI: 10.1530/endoabs.49.EP1124

Etiopathogenetical aspects of endocrine infertility

Gulyamova Xilola & Ibragimova Kamilla


Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan.


Urgency: According to WHO the frequency of infertile unions is high amount 25–30% in developed countries. There are following reasons of infertility by women: 1) tubal infertility; 2) endocrine infertility-it takes the 2nd place among the reasons of infertility; 3) anomalies of the vagina and uterus; 4) immunological reasons, that are caused by sensibilisation of female organism, also there are patients, the reason of infertility of that is not ‘explainable’, when there not obvious violations of reproductive system, it is called ‘unexplained infertility’ – 8–10% and an emotional form of infertility.

Research aim: Studying etiological and pathogenetic mechanisms of infertility’s development by women.

Materials and methods: Retrospective analyses of scientific literature from 2010 to 2016 years.

Results of the research: Endocrine infertility- complex of hormonal disorders, that follow irregular ovulation or its absence. By every 3rd infertile woman the reason is the pathology of endocrine system. These are: 1) unovulation; 2) hypothalamic-pituitary dysfunction; 3) hyperandrogenism of ovarial or adrenal henesis; 4) function disorders of thyroid; 5) estrogen and progesterone deficiency; 6) severe somathic pathology; 7) obesity; 8) resistance ovary syndrome, when there is an insensivity to the gonadotrophini, that stimulates an ovulation, that is manifested with amenorrhea; 9) premature menopause in younger women to 35–38 y.o; 10) mutations of sex chromosomes. Abortions and infections, that cause tube- peritoneal forms of infertility among to 50% of all patients with infertility. According to WHO more than 20% of patients with infertility have expressed anatomical changes of fallopian tubes. Obstruction of FT we can see by 11–15% of observing, 30% of cases-endometrioid heterotopia.

Conclusions: For prophylaxis of endocrine infertility: 1) preventing of child infections, chronic tonsillitis, rheumatism; 2) preventing the developing of patholodical birth, abortion, inflammatious infections of women reproductive system; 3) proper maintenance of pregnancy, judicious use of hormones during the pregnancy.

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