Endocrine Abstracts (2017) 49 EP1147 | DOI: 10.1530/endoabs.49.EP1147

The determinants of thyroid autoimmunity in patients with polycystic ovary syndrome

Alice Albu1,2, Oana Petre2, Irina Nicolaescu2, Ivona Gheorghe2 & Dragos Albu1

1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2Elias Hospital, Bucharest, Romania.

It was suggested that polycystic ovary syndrome (PCOS) patients have an increased risk for autoimmune thyroid disease. However the mechanisms underlying this association are incompletely clarified. The aim of the present study is to evaluate the factors associated with thyroid autoimmunity in patients with PCOS. We performed a retrospective study which included 126 PCOS patients (mean age 24±4.5 years, mean body mass index, BMI 27±7.33 kg/sqm) diagnosed based on Rotterdam criteria between January 2015 and January 2016. We found that anti-thyroid peroxidase antibodies (ATPO) serum levels were positively correlated with HOMA-IR (r=0.234, P=0.019), fasting insulin (r=0.218, P=0.025), waist circumference (WC, r=0.267, P=0.007) and BMI (r=0.203, P=0.04). We found no association between ATPO and total testosterone, free androgen index, gonadotropins, TSH, leptin and adiponectin serum levels. In a multivariate linear regression model with ATPO as dependent variable only HOMA-IR was an independent predictor of ATPO values after adjustment for adiposity markers. In conclusion, in PCOS patients insulin resistance seems to be the main factor involved in thyroid autoimmunity.

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