Endocrine Abstracts (2017) 49 EP1155 | DOI: 10.1530/endoabs.49.EP1155

Influence of BMI in response to ovarian stimulation and live birth in IVF

Patrícia Tavares1, Catarina Machado1, Lucinda Calejo2, Gustavo Rocha1, Ana Margarida Póvoa2, Sandra Soares2, Sónia Sousa2 & Maria João Oliveira1

1Centro Hospitalar Vila Nova de Gaia/Espinho, Endocrinology Department, Vila Nova de Gaia/Porto, Portugal; 2Centro Hospitalar São João, Reproductive Medicine Department, Porto/Porto, Portugal.

Introduction: The deleterious effects of obesity on spontaneous reproduction are well recognized, although the literature on obesity and assisted reproductive technology outcome remains heterogeneous and inconsistent.

Objective: To estimate the effect of BMI on ovarian stimulation response and live birth in women underwent in vitro fertilization (IVF).

Methods: Retrospective observational study that included women submitted to a first IVF cycle in an infertility center of a public hospital in 2015.

Results: We included 102 women with a mean age of 33.2 years (±3.7). 69 (67.6%) were in normal weight range, 22 (21.6%) were overweight and 11 (10.8%) were obese. The mean values of basal serum FSH and LH were 6.6 mIU/ml (±2.7) and 5.9 mIU/ml (±3.8) respectively. The antral follicles count (AFC) on day 2–3 of the cycle was on average 14.2 (±6.9). 46 (45.1%) women underwent IVF cycle and 56 (54.9%) underwent IVF with intracytoplasmic sperm injection. The average duration of stimulation and dose of FSH administered was 9.8 days (±2.3) and 1622.1UI (±647.7) respectively. There were no statistically significant differences in the 3 groups of BMI in relation to the women’s age, FSH levels, AFC and neither in relation to the number of oocytes obtained. In our sample, age and AFC were the factors that correlated with the number of oocytes (P<0.001). Obese women had significantly fewer live births than overweight women (P=0.027) and this last BMI group (average BMI 26±0.9) had more live births. There were no differences in embryo quality or number of embryos frozen in these three groups.

Conclusions: Increased age and decreased AFC are negative determinants in the number of oocytes obtained. Although BMI groups had no difference in the number or quality in the oocytes collected, obese women had a significant lower probability of having a live birth after IVF.

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