Endocrine Abstracts (2017) 49 EP1156 | DOI: 10.1530/endoabs.49.EP1156

Anti-Mullerian hormone level is independently affected only by the ovarian factor among clinical and endocrinological factors in polycystic ovary syndrome

Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Altankhuu Tungalagsuvd, Kiyohito Yano, Yiliyasi Mayila & Minoru Irahara

Tokushima University, Kuramoto-cho, Tokushima, Japan.

: Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 6–10% of women. We evaluated the correlations between the serum AMH level and various endocrine and metabolic features in PCOS. Serum AMH level was compared between 114 PCOS patient (PCOS group) and 95 normal menstrual cycle women (Control group). Correlations between serum AMH level and various endocrine and metabolic factors were analysed in PCOS group. The serum AMH level was significantly higher in the PCOS group (8.35±8.19 ng/ml) than in the Control group (4.99±3.23 ng/ml). The serum AMH level was independently affected by age and the presence of PCOS on multiple regression analysis. Ovarian volume per ovary (OPVO) showed the strongest positive correlation (r=0.62) with the serum AMH level among clinical factors. OPVO was the only independent factor that affected the serum AMH in PCOS on multiple regression analysis. Serum AMH level is determined only by ovarian morphological factor and the other pathophysiological factors such as androgen, severity of anovulation and insulin resistance are not determinant factors in PCOS even if significant relationship exists.

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