Hypothyroidism is a common endocrine disorder which is easily treatable by an appropriate thyroid hormone replacement therapy in the majority of patients. In some patients, hypothyroidism is refractory to oral levothyroxine substitution. Common causes of lack of response to levothyroxine replacement comprise non-compliance and impaired absorption. We report a case of pseudomalabsorption of levothyroxine. Here, we report two female patients with hypothyroidism who had multinodüler goiter and thyroid papillary carcinoma with total thyroidectomy, despite the use of levothyroxine sodium at very high doses (800 mcg/day to 1100 mcg/day). Desired blood TSH and fT4 levels were reached soon after the days of administration of levothyroxine by parenteral routes(intramusculer- intravenosus) to the patient who had malabsorption but no detectable etiology. By investigation during hospitalization in the endocrinology department. Symptoms of the patients have declined. Clinical and laboratory improvement in pollinic follow-ups continued in these two patients. With these findings, these two patients were diagnosed as pseudomalabsorbtion.
20 - 23 May 2017
European Society of Endocrinology