Endocrine Abstracts (2017) 49 EP1246 | DOI: 10.1530/endoabs.49.EP1246

Vitamin D levels in Graves' disease (GD) are lower than in general population but do not correlate with laboratory and clinical parameters in GD or SNPs associated with GD

Tereza Planck1,2, Bushra Shahida1, Johan Malm1,3 & Jonas Manjer1,4


1Lund University, Department of Clinical Sciences, Malmö, Sweden; 2Department of Endocrinology, Skåne University Hospital, Malmö, Sweden; 3Department of Clinical Chemistry, Skåne University Hospital, Malmö, Sweden; 4Department of Surgery, Skåne University Hospital, Malmö, Sweden.


Introduction: The role of vitamin D in GD is poorly understood. The aim was to compare vitamin D levels in newly diagnosed patients with GD with the general population and to correlate vitamin D levels at diagnosis with laboratory and clinical parameters in GD. Moreover, we examined genetic variation in genes involved in the vitamin D metabolism and their association with GD.

Material and methods: Levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP) and 1-alpha-hydroxylase (CYP27B1) were examined for association with GD and/or Graves’ ophthalmopathy (GO) in 708 patients and 1178 controls.

Results: Patients with GD had significantly lower levels of vitamin D compared to general population (55.0±23.2 vs 87.2±27.6 nmol/l, P<0.001). In patients with GD (n=219), there was no association between the levels of vitamin D and the levels of free thyroxine (fT4), free triiodothyronine (fT4), thyrotropin receptor antibodies (TRAb), GO at diagnosis, or relapse after terminating treatment with anti-thyroid drugs. Two SNPs in VDR were associated with GD, rs10735810 (OR 1.36, 95% CI 1.02–1.36, P=0.02) and rs1544410 (OR 1.47, 95% CI 1.03–1.47, P=0.02). However, there was no difference in mean vitamin D levels between genotypes in either rs10735810 (AA 55.9 nmol/l, AG 56.1 nmol/l, GG 54.1 nmol/l, P=n.s.) or rs1544410 (AA 56.6 nmol/l, AG 57.5 nmol/l, GG 54.8 nmol/l, P=n.s.).

Conclusion: Patients with GD have lower vitamin D levels compared with general population; however, the levels of vitamin D do not affect the laboratory or clinical parameters of the disease. SNPs in the VDR influence the risk of GD through mechanisms other than reducing the vitamin D levels.

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