Endocrine Abstracts (2017) 49 EP1361 | DOI: 10.1530/endoabs.49.EP1361

Oxidative profiles in patients with autoimmune thyroid diseases

Fatma Mnif, Hamza Elfekih, Mouna Elleuch, Faten Hadjkacem, Houcem Elomma Mrabet, Nabila Rekik, Dorra Ghorbel, Mouna Mnif & Mohamed Abid

Hedi-Chaker University Hospital, Sfax, Tunisia.

Introduction: Autoimmune thyroid diseases are known to be associated with oxidative stress.

Objectives: We studied the oxidative profiles in plasma and thyroid tissue of 82 patients having Graves’ disease (GD) or Hashimoto thyroiditis (HT) or hashitoxicosis (HTX) vs 65 healthy controls in order to evaluate the antioxidant enzymes’ activity and the lipid peroxidation.

Results: The lipid peroxidation was objected with a significant higher level of Malondialdehyde (MDA) in the plasma of our patients vs healthy controls (P<0.01 for HT, P<0.001 for GD and HTX). A very low antioxidative activity of Glutathione peroxidase (GPx) was found in our patients vs healthy controls (P<0.001 for HT and HTX, P<0.01 for GD). The Selenium which is GPx-cofactor and the Catalase were found to be reduced as well. For the proteins oxidation, we found a higher level in Carbonyl-group, MDA and a lower level of thiol-group in our patients vs healthy controls. Similar results were found in the thyroid tissue samples.

Conclusion: This study shows clearly the presence of an oxidative stress in both plasma and thyroid tissue in patients with autoimmune thyroid diseases.

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