Endocrine Abstracts (2017) 49 EP156 | DOI: 10.1530/endoabs.49.EP156

Imaging follow-up of non-functioning adrenal masses at Vilnius University Hospital Santariskiu Klinikos: 2010-2016

Kristina Svaikeviciene1,2, Milda Girdziute3 & Zydrune Visockiene1,2


1Vilnius University Faculty of Medicine, Vilnius, Lithuania; 2Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania; 3Antakalnis Clinic, Vilnius, Lithuania.


Background: Current guidelines suggest against further imaging follow-up (FU) of patients with non-functioning adrenal masses with clear benign features on imaging studies.

Aim: To analyse the data of patients with non-functioning adrenal masses who had FU at Vilnius University Hospital Santariskiu Klinikos (VUHSK) from 2010 to 2016.

Methods: Cases coded as D35.0; D44.1; C74.1; C74.9; E26.0; E27,8; E24,8 according to ICD-10 classification were retrieved from database. Electronic data capture system was used to extract CT scans and biochemical testing data retrospectively.

Results: There were 714 subjects assessed for adrenal masses from 2010 to 2016 at VUHSK. At least one FU and non-functioning adrenal masses with obvious benign features on CT scan had 216 subjects and thus were included into further analysis. They were 61.6±11.2 years of age (184 female) with tumour size at baseline of 22.8±12.8 mm. Average FU time was 4.1±1.4 years (from 2 to 7), during which tumour size increased in 84 (39%), decreased in 48 (22%), did not change in 84 (39%) cases. Significant increase (by > 20% in addition to at least 5 mm increase in maximum diameter) was observed in 19 (8.8%) cases. Average size of 19 significantly enlarged tumours changed from 19.37±7.60 mm to 30.58±13.68 mm in 2.7±1.4 years. All these tumours were associated with female gender. Despite tumour size enlargement, none of them became functioning during observation time.

Conclusions: Our study showed, that the significant enlargement of non-secreting initially benign adrenal masses during follow up of about 2.7 years occurred in 8.8% of cases and was associated with female gender. Further larger studies with longer follow up are needed to suggest time-frame for imaging follow up in order not to miss the enlargement of the adrenal masses that could require surgery and also to estimate possible enlargement prediction factors.

Article tools

My recent searches

No recent searches.