Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2017) 49 EP27 | DOI: 10.1530/endoabs.49.EP27

ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (86 abstracts)

Extra-gastrointestinal stromal tumor in the retroperitomeum which had difficulty in differential diagnosis with adrenal cancer

Naotetsu Kanamoto , Makiko Nagatsuji , Keiko Yamagami , Shinya Tokunaga & Masayuki Hosoi

Osaka City General Hospital, Osaka, Japan.

Extra-gastrointestinal stromal tumors (EGISTs) in the retroperitomeum are extremely rare. A 44-year-old man was referred from a private clinic suspicious of an adrenal tumor that was incidentally detected by abdominal ultrasound. Computed tomography (CT) scan showed a retroperitoneal mass of 12 cm harboring a feeding artery from the left adrenal gland contiguous with the left adrenal gland, which enhanced heterogeneously on post-contrast imaging. By magnetic resonance imaging, the tumor demonstrated heterogeneous low intensity in T1 weighted images and an extremely heterogeneous lesion composed of high and low signal intensity in T2 weighted images. PET CT imaging with fluorine-18-fluorodeoxyglucose (18F-FDG) demonstrated 18F-FDG accumulation in the tumor in the early and late phase. Iodine-123-metaiodobenzylguanidine and iodine-131-adosterol scintigram did not detect any accumulation in the tumor. The results of all conducted serum and urinary examinations of adrenocortical hormone and catecholamine were within the normal range. Adrenalectomy was performed. Histopathological diagnosis of the tumor was GIST. Immunohistochemical findings revealed that the neoplastic cells were positive for c-kit and CD34 and negative for S100 protein, alpha-SMA, and desmin. Mitotic activity (2–3/50 high power field) and the labeling index for MIB-1 (about 3.2%) were low. The GIST was diagnosed as a high-risk tumor because its diameter was over 5 cm. We started imatinib 400 mg/day according to the Japan GIST guideline 1 month after operation.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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