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Endocrine Abstracts (2017) 49 EP306 | DOI: 10.1530/endoabs.49.EP306

1Department of Endocrinology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania; 2Department of Endocrinology, Emergency County Hospital, Timisoara, Romania; 3Department of Pathology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

Background: Primary and secondary hyperparathyroidism (HP) are associated with increased risk for cardiovascular complications and high mortality. Risk factors correlated with hypertension in HP are hyperlipidemia, glucose intolerance, insulin resistance, vitamin D deficiency, etc. The aim of the study was to assess the incidence of cardiovascular complications in HP.

Material and methods: The study included 45 patients (15 men, 30 women), with a mean age of 45 years (range 21–65 years). Thirty-two patients were diagnosed with primary HP and 13 with secondary HP due to chronic kidney disease (stages 3 and 4). The patients were evaluated by biochemical, hormonal parameters, imagistic tests, and cardiac sonography.

Results: Vitamin D deficiency was documented in all patients with secondary HP and in 24 patients with primary HP (75%). Other metabolic disturbances and risk factors for cardiovascular diseases were as follows: diabetes mellitus (24.4%), smoking (28.8%), obesity (22.2%), and dyslipidemia (46.6%). The incidence of mitral and/or aortic valvular stenosis (caused by calcifications) was similar in the two groups, affecting 31.1% of the patients. Hypertension prevailed in the group of secondary HP (12 cases), as compared to primary HP (10 cases, P=0.0002, Fisher’s exact test). Peripheral atherosclerotic manifestations were noted in 11 cases (24.4%). Seven patients (15.5%) experienced an acute coronary event and three patients underwent PTCA procedures with stent implantation. Ten patients showed ventricular hypertrophy (22.2%); the incidence was similar in the two groups (eight patients with primary HP, respectively two with secondary HP).

Conclusion: Our study shows that hyperparathyroidism is associated with higher incidence of severe cardiovascular complications, occurring at younger ages as compared to general populations.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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