Endocrine Abstracts (2017) 49 EP379 | DOI: 10.1530/endoabs.49.EP379

Isolated low HDL-Cholesterol in patients with type 2 diabetes about 168 cases

El Ansari Nawal, Habra Bahia & El Mghari Ghizlane

Endocrinology, Diabetes and Metabolic Diseases Mohammed the 6th University Hospital, Faculty of Medicine, Cadi Ayyad University, Marrakesh, Morocco.

Introduction: Lipid abnormalities in diabetics both quantitative and qualitative contribute to the increased cardiovascular risk.

Aim: The aim of this study is to determine the prevalence of isolated hyoHDLémie in type 2 diabetics and assess cardiovascular risk in two populations of type 2 diabetes with and without Low HDL-Cholesterol isolated.

Patients and methods: Prospective study started in diabetic patients seen in diabétologic consultation at the University Hospital of Marrakech.

Preliminars Results: One hundred and sixty eight patients were identified, 72% female, The average age of patients was 55 years, average duration of diabetes was 7 years, hyoHDLémie was found in 40.4% of cases (68 patients), the prevalence of isolated hyoHDLémie is estimated at 26.19% (44 cases), with overall cardiovascular risk estimated at more than 20% in the group of patients with isolated Low HDL-Cholesterol.

Discussion: Lipid disturbances are widely studied in diabetic patients, but few studies have examined the Low HDL-Cholesterol isolated. In diabetic patients, current treatment guidelines target low-density lipoprotein cholesterol (LDL-C) with statins. In patients with elevated TGs, non-HDL-C is considered a secondary target of therapy. Despite the use of statin therapy in diabetes, a significant number of fatal and nonfatal coronary heart events still occur, indicating the need to target other modifiable risk factors for coronary heart disease, including Low HDL-Cholesterol. This study shows a high prevalence of isolated diabetics correlated with cardiovascular risk also important that the interests of the target Low HDL-Cholesterol by lipid-lowering therapy to reduce cardiovascular morbidity and mortality in diabetics.

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