Endocrine Abstracts (2017) 49 EP416 | DOI: 10.1530/endoabs.49.EP416

Relation between serum leptin concentration and insulin resistance syndrome in patients with type 2 diabetes mellitus

Tamer Shebl, Nour El Dein Abd El Azeem & Hosny Abd El Kareem


Alazhar Univesity, Assuit, Egypt.


Type 2 diabetes mellitus is known for its morbidity and mortality all over the globe. It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type 2 diabetes.

Objectives: The aim of the present study was to assess the relation between serum leptin levels and insulin resistance syndrome in type 2 diabetic patients.

Methods: Eighty persons were enrolled in this study and were divided into two groups. Twenty healthy persons as a control group and 60 patients with type 2 diabetes mellitus as a disease group. The disease group were further divided into those who have evidence of metabolic syndrome (30 patients), and those who do not (30 patients). Parameters like age, sex, anthropometric measurements and biochemical indicators such as fasting and post prandial blood sugar, HbA1c, lipid profile, leptin and fasting insulin were determined.

Results: Higher Leptin and insulin levels were observed in patients with metabolic syndrome (P<0.001).

Conclusion: High serum leptin is a good indicator and could provide a minimally-invasive marker for early detection of the insulin resistance syndrome.

Keywords: leptin concentration; insulin resistance syndrome; type 2 diabetes mellitus.

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