Endocrine Abstracts (2017) 49 EP418 | DOI: 10.1530/endoabs.49.EP418

Vitamin D levels in newly diagnosed type I diabetes mellitus and relationship with organ specific autoimmune disorders

Belgin Efe1, Gonca Akdere2 & Goknur Yorulmaz1

1ESOGU Faculty of Medicine Department of Endocrinology, Eskisehir, Turkey; 2ESOGU Faculty of Medicine Department of Internal Medicine, Eskisehir, Turkey.

Based on the effects of Vitamin D on immune system it has been suggested that vitamin D may play a role in the pathogenesis of type I diabetes mellitus (T1D) and other organ specific autoimmune disorders. In our study, we aimed to show the effect of Vitamin D deficiency in the development of newly diagnosed T1D and other autoimmune disease that may associated with T1D such as autoimmune thyroid disease (ATD), celiac disease, Addison’s disease, vitiligo and atrophic gastritis. In addition to 50 newly diagnosed T1D patients and 60 healthy controls, we evaluated the data of the formerly diagnosed 50 T1D patients. The frequency of vitamin D deficiency in newly diagnosed T1D patients was found 88%. 30% of these patients were anti parietal cell antibody (APA) positive which is marker for pernicious anemia, 24% of had ATD, 10% of was positive for anti-tissue transglutaminase IgA which is marker for celiac disease and 2% of had vitiligo. Levels of 25(OH)D were statistically significant lower in newly diagnosed T1D patients with positive APA than patients with negative APA. Frequency of vitamin D deficiency was 66.7% in healthy controls and 84% in formerly diagnosed T1D patients. When we considered all T1D patients, we found the frequency of ATD was 25%, frequency of positive APA was 28%, frequency of positive anti-tissue transglutaminase IgA was 10% and frequency of vitiligo was 2%. We found that ATD and predisposition of celiac disease were much frequent in T1D patients than healthy controls. Vitamin D levels were found lower; in patients with T1D than healthy controls; when we evaluate all subjects we found that patients with ATD had lower vitamin D levels than patients without ATD and also patients with ATD and positive APA had lower vitamin D levels than patients without ATD and negative APA.

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