Endocrine Abstracts (2017) 49 EP425 | DOI: 10.1530/endoabs.49.EP425

Anti-islet cell antibodies in a sample of Egyptian females with gestational diabetes and its relation to development of type 1 diabetes mellitus

Hanan M Amer1, Rania S Abd elbaky1, Merhan S Nasr1, Laila M Hendawy1, Mohamed O Taha2 & Wessam A Ibrahim1


1Ain Shams University Division of Endocrinology and Diabetes, Cairo, Egypt; 2Ain Shams University Division of Gynecology and Obstetrics, Cairo, Egypt.


Background: Gestational diabetes mellitus is any degree of glucose intolerance with first diagnosis during pregnancy; it affects 3–10% of pregnancies. The presence of diabetes-related autoantibodies has shown to be able to predict the development of type 1 diabetes before hyperglycemia arises.

Aim of work: To recognize the prevalence of islet cell antibodies among a sample of Egyptian females with gestational diabetes and its possible relation of development of Type 1 diabetes within 1 year.

Design and methodology: Our cross sectional study was conducted on 150 Egyptian pregnant females with gestational diabetes aged 19–39 years diagnosed by 75-g 2-h oral glucose tolerance test. All females were subjected to full history, thorough clinical examination and laboratory measurement of anti-islet cell antibodies, those females with positive antibodies were followed up 6 months and 1 year after delivery for their fasting insulin, fasting blood glucose and 2 h post prandial levels.

Results: The prevalence of pregnant females with gestational diabetes having positive anti islet cell antibodies was (44%), the prevalence of females diagnosed to have diabetes mellitus was (37.88%) 6 months and (51.52%) 1 year postpartum.

Conclusion: Gestational diabetes can be of type 1 diabetes due to islet cell antibodies and not only type 2 diabetes due to increased insulin resistance

Keywords: Pregnancy; Gestational diabetes; anti-islet cell antibodies; Type 1 diabetes; Type 2 diabetes; Insulin resistance

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