Background: Gestational diabetes mellitus is any degree of glucose intolerance with first diagnosis during pregnancy; it affects 310% of pregnancies. The presence of diabetes-related autoantibodies has shown to be able to predict the development of type 1 diabetes before hyperglycemia arises.
Aim of work: To recognize the prevalence of islet cell antibodies among a sample of Egyptian females with gestational diabetes and its possible relation of development of Type 1 diabetes within 1 year.
Design and methodology: Our cross sectional study was conducted on 150 Egyptian pregnant females with gestational diabetes aged 1939 years diagnosed by 75-g 2-h oral glucose tolerance test. All females were subjected to full history, thorough clinical examination and laboratory measurement of anti-islet cell antibodies, those females with positive antibodies were followed up 6 months and 1 year after delivery for their fasting insulin, fasting blood glucose and 2 h post prandial levels.
Results: The prevalence of pregnant females with gestational diabetes having positive anti islet cell antibodies was (44%), the prevalence of females diagnosed to have diabetes mellitus was (37.88%) 6 months and (51.52%) 1 year postpartum.
Conclusion: Gestational diabetes can be of type 1 diabetes due to islet cell antibodies and not only type 2 diabetes due to increased insulin resistance
Keywords: Pregnancy; Gestational diabetes; anti-islet cell antibodies; Type 1 diabetes; Type 2 diabetes; Insulin resistance
20 - 23 May 2017
European Society of Endocrinology