Objectives: T helper1 (Th1) cells were determined to have important roles in the development of type 2 diabetes (T2D). We aimed to investigate relationship between Th1 cytokines (IFN γ, IL-2 and TNF-α) and T2D.
Material and methods: The study included 32 newly diagnosed type 2 diabetic patients (T2DPs) who had not begun to take antidiabetic agents except from insulin and 30 healthy subjects (CG) who did not have glucose intoerance (fasting or after glucose load). Serum IFN-γ, IL-2 and TNF-α levels were measured using ELISA method. Serum levels of those ctokines in T2DPs were compared with those in controls.
Results: TNF-α levls of T2DPs were higher (P<0.05) than those in controls. There were no differences between the IFN-γ and IL-2 levels of T2DPs and controls (P>0.05).
Conclusion: TNF-α levels increase in T2D. Decreased insulin action in T2D may be due to the increased TNF-α levels, since TNF-α has been suggested to down regulate the tyrosine kinase activity of the insulin receptor.
20 - 23 May 2017
European Society of Endocrinology