Endocrine Abstracts (2017) 49 EP447 | DOI: 10.1530/endoabs.49.EP447

Relationship with T helper 1 cytokines and type 2 diabetes

Havva Gonca Tamer1, Ozge Telci Caklili2, Ilkay Kartal3, Kagan Gungor4 & Hasan Huseyin Mutlu5


1Division of Endocrinology and Metabolism, Department of Internal Medicine, Medeniyet University, Göztepe Training and Research Hospital, Istanbul, Turkey; 2Department of Internal Medicine, Medeniyet University, Göztepe Training and Research Hospital, Istanbul, Turkey; 3Division of Endocrinology and Metabolism, Department of Internal Medicine, Medeniyet University, Göztepe Training and Research Hospital, Istanbul, Turkey; 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Medeniyet University, Göztepe Training and Research Hospital, Istanbul, Turkey; 5Department of Family Medicine, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.


Objectives: T helper1 (Th1) cells were determined to have important roles in the development of type 2 diabetes (T2D). We aimed to investigate relationship between Th1 cytokines (IFN γ, IL-2 and TNF-α) and T2D.

Material and methods: The study included 32 newly diagnosed type 2 diabetic patients (T2DPs) who had not begun to take antidiabetic agents except from insulin and 30 healthy subjects (CG) who did not have glucose intoerance (fasting or after glucose load). Serum IFN-γ, IL-2 and TNF-α levels were measured using ELISA method. Serum levels of those ctokines in T2DPs were compared with those in controls.

Results: TNF-α levls of T2DPs were higher (P<0.05) than those in controls. There were no differences between the IFN-γ and IL-2 levels of T2DPs and controls (P>0.05).

Conclusion: TNF-α levels increase in T2D. Decreased insulin action in T2D may be due to the increased TNF-α levels, since TNF-α has been suggested to down regulate the tyrosine kinase activity of the insulin receptor.

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