Endocrine Abstracts (2017) 49 EP474 | DOI: 10.1530/endoabs.49.EP474

Debut diabetes characteristics

María Rosa Alhambra Expósito, Inmaculada Prior Sánchez, Paloma Moreno Moreno & María Ángeles Gálvez Moreno

Hospital Universitario Reina Sofía, Córdoba, Spain.

Background: The diabetes type 1 (DM1) is a chronic autoimmune disease, it tends to appear in childhood, its incidence continues to rise and the complications arising from improper care poses serious health problems for those who suffer. LADA diabetes is autoimmune diabetes which appear in adults.

Objetive: To describe the characteristics of the new diabetes debut in our environment.

Material and methods: We included all patients who attended the Diabetes Day Hospital of our hospital for unknown type 1 or MODY diabetes from October 2015 to September 2016.

Results: A total of 43 patients were enrolled. With an average age of 36±13 years, 48.8% were men. The 34.9% were LADA type diabetics and the rest DM1. At diagnosis they had a mean BMI of 23±4 kg/m2, with an abdominal perimeter of 86±12 cm, mean arterial tension 116±17/70±12 mmHg. An average glucose concentration of 238±106 mg/dl and an HbA1c of 11±3%, initial cholesterol of 173±40 mg/dl, HDL 46±16 mg/dl, LDL 103±34 mg/Dl was noted. The level of peptide C at the diagnosis was 0.3±0.2 ng/dl (N up to 0.5 ng/dl). In DM-1, 72% of patients had positive anti-GAD antibodies and 78% had anti-IA2 antibodies. In the patients with diabetes type LADA 61% had positives only the Anti IA2, 24% antiGAD, the rest had positives both. Of the patients, 8% associated autoimmune thyroid disease. Without other autoimmune comorbidities.

Conclusions: The incidence of type 1 diabetes and MODY type diabetes is increasing in recent years. In our setting, 78% of patients with DM-1 have positive antibodies. There were few comorbidities al diagnosis.

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