ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Obesity (81 abstracts)
Genetic variants of the adiponectin gene and its association with adiponectin level in metabolic syndrome women
Abhishek Gupta 1, , Sunita Tiwari 1 , Suraksha Agrawal 3 , Arun Kumar Singh 1 , Bhola Nath Paul 4 & Katherine Cianflone 5
1Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India; 2Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; 3Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 4Immunobiology Division, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India; 5Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada.
Background: Adiponectin is an adipocyte-derived adipokine, down-regulated in obesity linked disorders. Here, we investigated the genotypic variability of adiponectin (at position; +T45G and +G276T) and its association with circulating adiponectin and metabolic syndrome in North Indian adult women.
Methods: We compared metabolic syndrome (MetS; 269) women to without metabolic syndrome (wMetS; 272) women of North India. Genotype frequencies of the adiponectin gene were performed using PCR-RFLP method and circulating adiponectin estimated by sandwich ELISA method.
Results: Low level of adiponectin (P<0.001) and high HOMA-IR were found (P<0.001) in MetS women. Gene frequency of combined mutant genotype (TG+GG) at position +45T/G of adiponectin was found to be significantly less (P=0.017) while mutant G allele was significantly high (P=0.008) in MetS women as respective to wild type. However, frequency of mutant T allele in MetS women was found to be significantly (P=0.027) less as compared to wMetS at position +276G/T of adiponectin gene. The mutant genotype GG of +45T/G and TT of +276G/T of adiponectin were significantly associated with lower adiponectin level and higher HOMA-IR (all P<0.001) in adult metabolic syndrome.
Conclusions: Results suggest that adiponectin gene variants might be associated with lower adiponectin level and metabolic syndrome.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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