Obesity

ea0049ep643 | Obesity | ECE2017

Association between meal intake behavior and body composition/psychological well-being in Japanese adults

Takao Toshihiro , Yamanaka Yoshiyuki , Fujimoto Sohachi , Kamada Tomoari

The study aims to evaluate the association between body composition/psychological well-being with meal intake behavior such as eating fast, snacking after dinner, dinner within 2 h before sleep. This cross-sectional study includes n=3066 participants aged 1989 who had participated in an annual health checkup in 2015. BMI, Waist circumference (WC) and the World Health Organization (WHO)-5 Well-Being Index were assessed to determine. The meal intake behavior were ...

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ea0049ep644 | Obesity | ECE2017

A comparison of the metabolic parameters of obese and non-obese nafld patients with insulin resistance

Karakaya Pinar , Pehlivan Bahar , Mert Meral , Karagoz Hamide , Okuturlar Yildiz

Introduction-aim: Non-alcoholic fatty liver disease (NAFLD) is a clinical condition of uncertain etiology, in whose pathogenesis several mechanisms are involved and which is defined by fat vacuoles in more than 5% of hepatic histiocytes in the absence of serious alcohol consumption. It is frequently comorbid with obesity and insulin resistance. However, NAFLD is also seen in non-obese individuals. The purpose of this study was to compare insulin resistance and metabolic parame...

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ea0049ep645 | Obesity | ECE2017

Associations between dietary food patterns and metabolic syndrome risk in Albanian adolescents

Themeli Alba , Pistja Edmond

Background: Adolescence is a period of rapid body growth and cognitive development, requiring balanced and sufficient nutrient intake. Since dietary habits are usually acquired in this period and could affect dietary practice in later life. It is crucial for adolescents to acquire healthy dietary behaviors for long-term health. However, the prevalence of diet-related metabolic syndrome risks such as obesity, glucose intolerance, elevated blood pressure, and dyslipidemia is inc...

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ea0049ep646 | Obesity | ECE2017

Type 1 diabetes and metabolic syndrome

Taieb Ach , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: Contrary to type 2 diabetes, type 1 often occurs in young people, without obesity or cardiovascular or metabolic diseases. The association of type 1 diabetes with an authentic metabolic syndrome including obesity is very rare, though possible, with a mixed clinical picture. The goal of our study is to evaluate the association of type 1 diabetes with the metabolic syndrome.Material and methods: This is a retrospective cross-sectional study b...

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ea0049ep647 | Obesity | ECE2017

Intima media thickness of carotid arteries and cognitive function in Georgian nondiabetic obese and overweight hypertensive subjects

Chagunava Ketevan , Lomtatidze German

Purpose: Obesity is a serious health problem that has reached very high proportions in our country; prevalence of obesity and overweight together is 56%. Obesity is strongly associated with risk factors for cardio and cerebrovascular disease, AH, type 2 diabetes and cognitive disorders. The aim of our study was to analyze the impact of AH and weight change on carotid artery intima-media thickness (IMT) and cognitive function in Georgian nondiabetic obese and overweight hyperte...

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ea0049ep648 | Obesity | ECE2017

CGI-58 gene expression profile in individuals with different body mass index

Crispim Daisy , Rheinheimer Jakeline , Moehlecke Milene , Souza Bianca de , Leitao Cristiane

Background and aim: Although chronic low-grade inflammation is observed in obese subjects, the underlying mechanisms modulating this process are still unclear. The Comparative Gene Identification-58 (CGI-58) is a lipid droplet-associated protein that has an important role in mediating intracellular fat hydrolysis by acting as a coactivator of the adipose Triglyceride Lipase (ATGL). Recent evidence suggests that CGI-58 also has a role in chronic inflammation and insulin resista...

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ea0049ep649 | Obesity | ECE2017

Fractalkinea as an inflammatory marker in obese subjects

Hamad Fatma , Khalid Mohsen , Ibrahim Asmaa , Ghanem Ayat

Background: Fractalkine (CX3CL1) is known to convey its signals through a single G-protein coupled receptor (CX3CR1). It is characterized as a structurally unique chemokine with both membrane-bound and soluble forms. Fractalkine expression has been detected in activated or stressed endothelial, smooth muscle, skeletal muscle, macrophages, neurons, hepatocytes and adipocytes. Inflammation up regulates Fractalkine particularly in adipose tissue of obese individuals.<p class=...

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ea0049ep650 | Obesity | ECE2017

The case of 36 years old obese male patient with high degree of proteinuria and a loosing weight as the major strategy of treatment

Katamadze Natia , Chochishvili Natalia , Shamanadze Anna

Introduction: Obesity-related glomerulopathy(ORG) is a secondary form of focal segmental glomerulosclerosis (FSGS) occurring in obese patients with a body mass index(BMI) higher than 30 kg/m2.ORG is typically manifested by nephrotic-range proteinuria without full nephrotic syndrome, and progressive renal insufficiency.Case presentation: Thirty-six years old male patient (BMI 59.2 kg/m2) visited endocrinologist with complains of weig...

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ea0049ep651 | Obesity | ECE2017

Mobile and wireless technology to combat obesity. Using on-line program of good nutrition and wright diet: prevention and part of the treatment of diabetes mellitus

Krylov Vadim

Introduction: It is too much easier and cheaper to combat obesity, than in the future to treat diabetes mellitus and its complications.Methods: We used an online system for patient education based on the video lessons, full of humor, pictures, and cartoons to convey the necessary information on good nutrition, necessary to do exercises and the need for exposure to the sun to our patients.Results: Watching the short movies, the pati...

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ea0049ep652 | Obesity | ECE2017

Oligonol supplementation decreases abdominal obesity and the prevalence of metabolic syndrome in a sample of overweight and obese Saudi females without dietary restriction or lifestyle modification

Bahijri Suhad , Ajabnoor Ghada , Awan Zuheir , Borai Anwar , Abdulkhaliq Altaf

Background: Obesity, and metabolic syndrome (MS) are highly prevalent in Saudi Arabia, increasing the risk for type 2 diabetes (T2DM), and cardiovascular disease (CVD). Oligonol produced from lychee fruit polyphenols (LFP) has been reported to reduce visceral obesity, and ameliorate MS in Japanese subject.Aim: To investigate the effect of oligonol supplementation on MS risk factors in overweight and obese Saudi females.Subjects and...

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ea0049ep653 | Obesity | ECE2017

Metabolic and bone effects of high fat diet on adult zebrafish

Carnovali Marta , Luzi Livio , Banfi Giuseppe , Mariotti Massimo

Obesity and type II diabetes have been linked to several health issues, including an increased risk of bone fractures. It is well known that an increase of visceral fat affects bone health causing fragility, mechanical strength reduction and increased propensity of fractures because of impaired bone matrix microstructure and aberrant bone cells function. Adult Danio rerio (zebrafish) represents a powerful model to study fat and bone metabolism. Then, the aim of this s...

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ea0049ep654 | Obesity | ECE2017

Growth hormone signaling and action in obese versus lean human subjects: evidence of increased hepatic GH sensitivity in obesity

Pedersen Morten Hogild , Bak Ann Mosegaard , Pedersen Steen Bonlokke , Jessen Niels , Moller Niels , Jorgensen Jens O.L.

Context: Obesity is accompanied by blunted GH secretion but relatively normal serum IGF-I levels, which suggests increased GH sensitivity. This, however, remains to be tested at the level of GH signaling in human subjects.Objective: To compare the effects of an acute intravenous GH bolus in obese vs normal weight subjects on GH signaling pathways in adipose and muscle tissue, substrate metabolism and insulin sensitivity.Subjects an...

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ea0049ep655 | Obesity | ECE2017

Insulin signaling is involved in the regulation of UCP-1 expression in brown adipose tissue after chronic central leptin infusion

Barrios Vicente , Frago Laura M. , Canelles Sandra , Burgos-Ramos Emma , Chowen Julie A. , Argente Jesus

Background: Brown adipose tissue (BAT) plays a pivotal role in the regulation of energy homeostasis and thermogenesis. This tissue responds to insulin, favoring the expression of uncoupling protein-1 (UCP-1), that in turn is inhibited by insulin-desensitizing cytokines. Leptin may abolish some of the effects of fasting on these parameters through its cross-talk with insulin-related signaling targets.Objectives: We hypothesized that leptin infusion preven...

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ea0049ep656 | Obesity | ECE2017

Can night eating syndrome increase basal metabolic rate?

Topsakal Senay , Yaylalı Guzin Fidan , Fenkci Semin Melahat

Introduction: Night eating syndrome (NES) is an eating disorder associated with obesity, characterized by a delayed pattern of food intake in which recurrent episodes of nocturnal eating and/or excessive food consump-tion occur after the evening meal. (1) Studies showed significant weight gain among patients with NES.However, the underlying reason is still controversial.The aim of this study is to investigate the body composition and energy metabolism in patients with NES....

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ea0049ep657 | Obesity | ECE2017

Association between cardiometabolic risk indicators and FGF 19 in healthy Saudi individuals of different BMI grades

Ajabnoor Ghada , Hajjar Yomna , Bahijri Suhad , Borai Anwar

Background: Fibroblast growth factor 19 (FGF19) is an enterokine derived from the ileum, and synthesized in response to release of bile acids following food ingestion. It was proposed to be an important regulator of the postprandial adaptive metabolic response. by stimulating glycogen and protein synthesis in the liver, and down regulating glucose production after a meal. There is limited research investigating the association between FG-19 and metabolic dysregulation in overw...

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ea0049ep658 | Obesity | ECE2017

The role of pioglitazone and vitamin E for the treatment of NASH with or without metabolic syndrome

Khabeishvili Nino , Barbakadze Gocha , Mikadze Ketevan , Burnadze Koba

Introduction: Obesity is a global public health problem and is associated with metabolic syndrome and dyslipidemia as well as very often with non-alcoholic steatohepatitis (NASH).Aim & methods: The aim of the present study was to evaluate the preventive and curable role of vitamin E and pioglitazone (thiazolidinedione-type) in NASH patients with or without metabolic syndrome. 51 patients with NASH were divided into two groups: 26 patients with insuli...

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ea0049ep659 | Obesity | ECE2017

MicroRNAs, associated with coronary heart disease in patients with obesity and diabetes mellitus type 2

Shvangiradze Teona , Bondarenko Irina , Troshina Ekaterina , Shestakova Marina

Introduction: Obesity and diabetes mellitus type 2 (T2DM) are considered as one of the major risk factor for coronary heart disease (CHD) development, but the mechanisms beyond this relationship still need to be clarified. miRNAs are supposed to be involved in regulatory mechanisms in this relationship.Aim: To determine miRNAs expression in patients with obesity and T2DM.Methods: MiRNAs were detected in peripheral blood of 43 patie...

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ea0049ep660 | Obesity | ECE2017

The surgical approach to obesity in numbers

Raposo Nuno Cordeiro , Ferreira Andreia Sousa , Pratas Sonia , Valadas Cristina

The prevalence of obesity has greatly increased worldwide in the last decades, particularly in Europe and Portugal. It is associated with many health problems, including cardiovascular diseases, cancer and diabetes.Methods: Revision of the clinical records of all 61 patients who underwent bariatric surgery between 2013 and 2015. Analysis of their metabolic profile prior to surgery and its evolution after the operation.Results: 61 p...

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ea0049ep661 | Obesity | ECE2017

Decreased HDL cholesterol efflux capacity in morbidly obese individuals as a surrogate marker for increased cardiovascular risk

Dotan Idit , Hafiane Anouar , Ruel Isabelle , Aggarwal Rajesh , Andalib Amin , Genest Jacques , Sherman Mark

Background: Obesity has become a worldwide epidemic and carries excess cardiovascular morbidity and mortality. HDL efflux capacity (HEC) was shown to be inversely correlated with cardiovascular risk (CVR), both in the acute and the chronic phases. Our aim was to understand if decreased HEC can serve as a surrogate marker for the increased CVR in this population.Methods: Forty patients: 10 obese diabetic (OD), 10 obese non-diabetic (OND), 10 with stable C...

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ea0049ep662 | Obesity | ECE2017

The association of anthropometric measurements and PPAR-γ gene expression among healthy adult subjects

Zarkesh Maryam , Yuzbashian Emad , Zadeh-Vakili Azita , Tabaei Kimia , Daneshafrooz Afsoon , Asghari Golaleh , Mirmiran Parvin , Hedayati Mehdi , Khalaj Alireza

Introduction: Peroxisome proliferator activated receptor-γ (PPAR-γ) is a distinguished transcription factor abundantly expressed in the adipose tissues and plays a key role in the regulation of adipocyte differentiation and development of obesity. In the current study, we aimed to investigate the association of PPAR-γ mRNA expression in omental and subcutaneous adipose tissues with anthropometric indices and blood pressure (BP) among healthy adults.<p class=...

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ea0049ep663 | Obesity | ECE2017

Results of computer-assisted intravital microscopy in overweight and obesity

Shyshko Volha , Mokhort Tatjana , Konstantinova Elena , Tsapaeva Natalia

Rationale: Obesity, prediabetes and diabetes are strongly associated with microcirculation (MC) abnormalities. It is known that pathological changes in microvessels predispose to CHD, CKD and retinopathy. Also it is widely recognized that biochemical and immunological changes accompanied with obesity and overweight lead to MC damage.ObjectiveOf the study was to assess changes in MC in patients with overweight and obesity.<p cla...

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ea0049ep664 | Obesity | ECE2017

Assessment of adipose tissue distribution in youg women with polycystic ovary syndrome

Savchanka A , Mokhort Tatjana

PCOS is characterized by abdominal obesity along with conventional diagnostic features.Objective: To assess body composition in women with PCOS and normal body weight.Materials and methods: 35 women (24±1.1 years old) with confirmed diagnosis of PCOS according to Rotterdam criteria, 27 almost healthy women (25±1.2 years old), both groups wotn normal weight. Whole Body Dual-energy X-ray Absorptiometry (DEXA Total Body) sca...

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ea0049ep665 | Obesity | ECE2017

Decreased muscle strength is associated with vitamin D and albumin levels after bariatric surgery

Yavuz Dilek Gogas , Uygur Meliha Melin

Bariatric surgery patients are at risk of decreasing in muscle mass, vitamin and protein deficiency. The aim of this study is to asses muscle strength, serum protein and vitamin levels after bariatric surgery.Methods: 264 patients underwent bariatric surgery who completed 6 th month policlinic visits were included in the study. Patients were followed appropriately supplemented protein and vitamins as suggested; all study parameters were assessed before a...

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ea0049ep666 | Obesity | ECE2017

Comparison between mathematical indexes and histopathological findings in the diagnosis of nonalcoholic fatty liver disease in mexican population

Gutierrez-Aguirre Karen-Ivette , Lazo-de-la-Vega-Monroy Maria-Luisa , Ruiz-Noa Yeniley , Ibarra-Reynoso Lorena-del-Rocio , Garcia-Ramirez Juana-Rosalba , Jordan-Perez Benjamin , Garnelo-Cabanas Serafin , Preciado-Puga Monica-del-Carmen

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico, comprising a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indices have been proposed, such as non-invasive techniques, however there are very few studies in our population.Objetive: This study aims to compare mathematical indexes and...

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ea0049ep667 | Obesity | ECE2017

Obesity and infertility among Tunisian women of reproductive age: about 40 cases

Hadjkacem Faten , Rebai Mariem , Saidane Dalila , Ghorbel Dorra , Abid Mohamed

Obesity is on the increase worldwide and mainly in women of reproductive age. In turn, it is associated with various reproductive complications. To assess the detrimental effect of obesity on reproductive health and the means of its management, this retrospective cohort study of 40 obese and infertile women has been conducted in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia from 2009 to 2014. These patients have a mean age of 34 years ...

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ea0049ep668 | Obesity | ECE2017

Mindfulness-oriented weight management course in a tier 3/tier 4 obesity service

Hanson Petra , Halder Louise , Barber Thomas

Overeating contributes to obesity epidemic and has many causes. Evidence shows that problematic eating behaviours can be modified with mindfulness. In the UK the use of mindfulness in management of obesity has been studied only once before. We aimed to pilot a new weight management course that would improve patients skills and confidence in ability to lose weight, and reduce patient waiting time. The course covered mindful eating, compassion and self-esteem, managing rel...

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ea0049ep669 | Obesity | ECE2017

Menopause is a major determinant of endocannabinoid 2-arachidonoylglycerol plasma level and of its relevance as biomarker of dyslipidemia and insulin resistance in lean women

Fanelli Flaminia , Mezzullo Marco , Baccini Margherita , Casadio Elena , Gasparini Daniela Ibarra , Vicennati Valentina , Pasquali Renato , Pagotto Uberto

Context: The endocannabinoid system (ECS) hypertonicity contributes to obesity development and maintenance. Excess circulating levels of ECS mediator 2-arachidonoylglycerol (2AG) were reported in obese humans, however, unstandardized experimental settings (i.e. analytical conditions, sample size, concurrent diseases/medications, statistics, gender, body mass index (BMI) and age), clouded its role in dysmetabolism and its usefulness as biomarker. The study aimed at describing 2...

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ea0049ep670 | Obesity | ECE2017

Genetical predictors of neuroendocrine disturbances in children with severe obesity

Solntsava Anzhalika , Zagrebaeva Olga , Aksyonova Elena , Shatarnova Tatsiana , Yemelyantsava Tatsiana

Objectives: Neurogenetical predictors of psychological disturbances in children with severe obesity.Methods: We examined 254 pubertal obese children: group1 (simple obesity) 187 children, 14.3±2.0 yrs, 30.4±2.8 kg/m2; group2 (severe obesity) 67 children, 14.7±2.1, 39.1±3.8. Control 80 children, 14.4±2.0 yrs, 19.7±1.7 kg/m2. Dopamine levels were determined. Genotyping was performed on polymorphic genes C...

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ea0049ep671 | Obesity | ECE2017

Endocannabinoid 2-arachidonoylglycerol plasma level is a BMI-independent biomarker of cardiometabolic risk in adult males with higher relevance in lean and aged conditions

Fanelli Flaminia , Mezzullo Marco , Baccini Margherita , Casadio Elena , Gasparini Daniela Ibarra , Vicennati Valentina , Pasquali Renato , Pagotto Uberto

Context: Ageing and obesity are similarly characterized by metabolic impairment in terms of visceral fat, dyslipidaemia, insulin resistance and hypertension. Obesity is featured by endocannabinoid system (ECS) hyperactivation. Increased levels of endocannabinoid 2-arachidonoylglycerol (2AG) found in obesity were variously associated to dysmetabolic features, however, it is not clear whether such associations exist in normal weight conditions. Moreover, ageing contribute in mod...

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ea0049ep672 | Obesity | ECE2017

Unfavourable blood pressure and lipid levels in obese individuals from the general population

Wolffenbuttel Bruce , Slagter Sandra , van Waateringe Robert , van Vliet-Ostaptchouk Jana , van Beek Andre , van der Klauw Melanie

Background: Early diagnosis and treatment of high blood pressure (BP) and high cholesterol is important to reduce cardiovascular mortality risk.Methods: We assessed actual BP and LDL-cholesterol (LDL-C) levels in 88,029 participants (36,122 men), aged 18-80 yrs, without diabetes, from the Dutch Lifelines Cohort study. Participants were categorized according to degree of obesity (normal weight, overweight, obese) and age decade group. BP measurement was r...

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ea0049ep673 | Obesity | ECE2017

Relation of insulin resistance to neurocognitive function and electroencephalography in obese chıldren

Akın Onur , Eker İbrahim , Arslan Mutluay , Yavuz Suleyman Tolga , Akman Sevil , Taşcılar Mehmet Emre , Unay Bulent

Background: This study aimed to investigate neurocognitive functions and electroencephalography (EEG) parameters in normoglycemic obese children.Method: A total of 73 obese children (38 male and 35 female) and 42 healthy children (21 male and 21 female) were recruited. Biochemical disturbances and insulin resistance (IR) were investigated. The Wechsler Intelligence Scale for Children-Revised (WISC-R) and EEG were performed for all children. Obese partici...

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ea0049ep674 | Obesity | ECE2017

Abstract withdrawn....

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ea0049ep675 | Obesity | ECE2017

Lipid profiles and vitamin D receptor polymorphisms in overweight/obese dialysis patients

Bagci Gokhan , Huzmeli Can , Bagci Binnur , Candan Ferhan , Akkaya Lale , Kayatas Mansur

Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were carried out to investigate the association between single nucleotide polymorphisms (SNPs) in VDR gene with obesity. However, little is known about the role of VDR gene polymorphism with obesity in dialysis patients. Therefore, we aimed to investigate lipid profile and VDR gene TaqI, ApaI and FokI SNPs in overweight/obese dialysis patients.Methods: Seventy one normal weig...

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ea0049ep676 | Obesity | ECE2017

Bone mineral density and bone turnover markers after bariatric surgery

Uygur Meliha Melin , Yavuz Dilek Gogas

Although bariatric surgery has beneficial effects on obesity related complications, rapid weight loss might have negative effects on skeletal health. The objective of our study was to evaluate changes in bone mineral density (BMD) and bone biochemical markers in patients, before and 1 year after bariatric surgery.Methods: One hundred and two morbidly obese subjects (mean 43±15 years, BMI 48,5 g/cm2) performed either Roux en Y gastric bypa...

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ea0049ep677 | Obesity | ECE2017

Effects of mediterranean diet in obese patients with metabolic syndrome and depression

Dimitrijevic-Sreckovic Vesna , Janeski Hristina , Sreckovic Branko , Soldatovic Ivan , Nesovic Nevena , Vujovic Milica

Introduction: Central obesity is the source of inflammatory factors, causing endothelial dysfunction. In central nervous system, inflammatory factors mediate neurotransmitter metabolism promoting excitotoxicity and increase oxidative stress, and a major clinical symptom is depression. Mediterranean diet (MD) resulted as a good prevention method for depression.Aim: To examine the relationship of depression with abdominal obesity and metabolic syndrome (MS...

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ea0049ep678 | Obesity | ECE2017

Visceral obesity in youth followed by decreased testosterone leading to erectile dysfunction and risk of early atherosclerosis

Dimitrijevic-Sreckovic Vesna , Janeski Hristina , Sreckovic Branko , Soldatovic Ivan , Pajovic Milica , Stojanovic Marko

Background: Abdominal obesity, which in fact is a metabolic syndrome (MS), is related to decreased testosterone, insulin resistance (IR), increased inflammatory factors, non-alcoholic fat liver disease (NAFLD) and risk of early atherosclerosis. Elevated inflammatory markers (CRP) may interfere with insulin signal transduction at the neuronal level inducing hypogonadotropic hypogonadism.Objective: To examine testosterone relationship with abdominal obesit...

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ea0049ep679 | Obesity | ECE2017

The prevalence of obesity and related factors: An urban survey study

Salici Ayla Gokmen , Sisman Pinar , Gul Ozen Oz , Karayel Tugce , Cander Soner , Ersoy Canan

Objectives: Obesity is a chronic and progressive disease that limits physical activity, causes psychological problems, and finally leads to social isolation of the person. Detecting the factors affecting obesity and its prevalence in the populaton are important steps in dealing with the problem. In this study, we aimed to evaluate the obesity prevalence and the factors affecting this prevalence in randomly selected volunteers from residents of the city of Bursa.<p class="a...

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ea0049ep680 | Obesity | ECE2017

Effect of Vitamin D supplementation on body composition in overweight men: A randomized controlled trial

Karefylakis Christos , Ariander Annaclara , Sarnblad Stefan , Rask Peter , Rask Eva

Introduction: The prevalence of vitamin D deficiency is higher in obese individuals but it is unclear whether vitamin D deficiency impacts body composition or if body composition impacts the vitamin D status. The research regarding vitamin D supplementation and weight loss in obese individuals is ambiguous. One hypothesis for the presumed fat reductive effect of vitamin D is that vitamin D inhibits adipocyte differentiation.Aim: To investigate if treatme...

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ea0049ep681 | Obesity | ECE2017

Intensified telematic treatment for obesity using the web platform PREDIRCAM2, descriptive basal characteristics and preliminary results

Alcantara-Aragon Valeria , Rodrigo-Cano Susana , Martinez Maria Jose , Martinez Carmen , Tapia Jose , Iniesta Jose , Lupianez Ascension , Tenes Susana , Hernando M Elena , Merino-Torres J Francisco , Leiva Alberto de , Gonzalez Cintia

Background: PREDIRCAM2 is a web platform for obesity treatment and follow-up. It contains modules for: dietary prescription and registry with nutritional analysis based on individualized and mediterranean dietary goals, physical activity prescription and tracking with individualized targets, and anthropometric tracking. An ongoing multicenter randomized clinical trial evaluates the interventions effectiveness in obesity treatment and cardio-metabolic-risk prevention....

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ea0049ep682 | Obesity | ECE2017

Suboptimal prediction of advanced fibrotic liver disease by standard non-invasive scoring systems in obese patients undergoing bariatric surgery

Dempster Niall , Watson Michael , Franklin Rachel , Juszczak Maciej , Rickers Lisa , Fletcher Caroline , Sgromo Bruno , Gillies Richard , Cobbold Jeremy , Hodson Leanne , Tomlinson Jeremy , Ryan John

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD), is present in over 90% of obese patients undergoing bariatric surgery. It is a spectrum of pathology ranging from steatosis through to inflammation (Non-Alcoholic Steatohepatitis, NASH) and fibrosis. Bariatric surgery is currently the most effective treatment for NAFLD, but post-operative hepatic decompensation can occur and therefore pre-operative stratification of liver disease severity is beneficial. Several non-invas...

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ea0049ep683 | Obesity | ECE2017

Discussion with cases: Could we achieve the goal with non-surgical treatments in morbid obese patients?

Cifci Aydin , Durmaz Senay Arikan , Gungunes Askin , Karahan Irfan , Yalcin Selim , Ozdemir Kubra

Objective: Diet, lifestyle changes, medical agents and surgical approaches are treatment options in obese patients. We reported two morbid obese patients who lost 25 and 21% of their previous weight respectively with only lifestyle changes and orlistat therapy.Case 1: Forty nine year-old woman had type 2 diabetes mellitus for 20 years. She took premix insulin twice a day. Her height was 157 cm, her weight was 120 kg, body mass index was 48.6 kg/m2</...

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ea0049ep684 | Obesity | ECE2017

Body compositions in obesity may corralete the minimal change of tyhroid functions within normal range

Urun Veysel , Ureten Kemal , Utku Ozlem Gul , Gungunes Askin , Durmaz Senay Arikan

Introduction and aim: Overt thyroid dysfunction is well recognized to affect weight, but the influence of minor perturbations of thyroid function remains unclear. There is ongoing debate regarding the influence of minor changes in thyroid hormones status within the normal range and BMI. The aim of this study was to investigate the association between thyroid function within normal ranges and obesity via BMI and body compositions analyzed by bioelectrical impedance.<p class...

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ea0049ep685 | Obesity | ECE2017

Association of Transforming growth factor β and Fibroblast growth factor 21 with cardiovascular diseases in obese patients

Shvangiradze Teona , Troshina Ekaterina , Bondarenko Irina , Shestakova Marina , Nikankina Larisa

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are associated with cardiovascular diseases (CVD). Fibrotic changes in obesity include several molecular processes, including activation of Transforming growth factor β (TGF-β). Recent data indicate the involvement of Fibroblast growth factor 21 (FGF-21) as an important metabolic regulator, and even biomarker of metabolic changes in obesity and T2DM.Aim: To determine TGF-β and FGF-2...

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ea0049ep686 | Obesity | ECE2017

The dynamics of anthropometric data in fertile age women by various types of the treatment

Abduvakhabova Maryam , Ismailov Saidganikhoja

The aim: To study efficiency of pathogenetic therapy and dynamics of anthropometric indexes for women with obesity of fertile age at different endocrinopathies to and through 6 months after treatment.Material and research methods: On the etiologic factor of patient with obesity were up-diffused on three groups: 1 g. are patients with obesity at the polycystic syndrome of ovaries (PCOS) 30 patients, 2 g. are patients with hypothalamic obesity &#150...

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ea0049ep687 | Obesity | ECE2017

Effects of IL-1β on the hypothalamic-pituitary-gonadal axis in men with obesity and metabolic syndrome – A randomized, double-blind, placebo-controlled trial

Ebrahimi Fahim , Schuetz Philipp , Mueller Beat , Urwyler Sandrine A , Donath Marc Y , Christ-Crain Mirjam

Background: Low testosterone levels in men appear to be an independent cardiovascular risk factor closely associated with the metabolic syndrome. Reciprocally, the metabolic syndrome leads to a decrease in testosterone levels, suggesting a bidirectional relationship. It has been hypothesized that increased inflammation is causative for the development of obesity-associated hypogonadism. However, clinical evidence supporting this hypothesis is lacking. The aim of the present st...

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ea0049ep688 | Obesity | ECE2017

Demographic and baseline characteristics of an obese population admitted for bariatric surgery in a secondary care centre

Gallo Daniela , Ippolito Silvia , Veronesi Giovanni , Dozio Eugenia , Frattini Francesco , Trotti Eugenia , Lai Adriana , Sassi Lorenza , Sabatino Jessica , Masiello Elvira , Premoli Paola , Bianconi Eleonora , Cusini Claudio , Rosetti Sara , Tanda Maria Laura , Dionigi Gianlorenzo , Bartalena Luigi , Piantanida Eliana

Obesity has become one of the greatest public health concerns and is known to be a major risk factor for cardiac, respiratory and metabolic diseases. Bariatric surgery is the most effective treatment for morbid obesity. According with guidelines, surgery is indicated for treatment of patients with BMI greater than 40 kg/m2 or above 35 kg/m2, with at least one obesity-related comorbid condition, such as as type 2 diabetes, hypertension, dyslipidemia, sleep...

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ea0049ep689 | Obesity | ECE2017

Clinical and metabolic markers of X-syndrome

Savasteeva Irina , Navmenova Yana , Yarets Yulia , Makhlina Alena , Kaplieva Marina , Yeudachkova Tamara , Vaschenko Elena

We identified factors that significantly influenced the development of the X-syndrome. A significant influence on the development of X-syndrome have increase the level of total cholesterol (b=0.65; P=0.036; Exp (b) =1.92 (1.04÷3.54)). Increases the risk of X-syndrome increase the level of apo-B-protein (b=4.79; P=0.014; Exp (b) =12.69 (2.68÷54.41)). The increase in linear dimension of preperitonialy fat increased ...

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ea0049ep690 | Obesity | ECE2017

Impact of weight changes on the incidence of diabetes mellitus: a Korean nationwide cohort study

Sook Kim Eun , Sun Jeong Jee , Han Kyungdo , Kyoung Kim Mee , Lee Seunghwan , Park Yong-Moon , Baek Ki-Hyun , Dae Moon Sung , Han Je-Ho , Song Ki-Ho , Kwon Hyuk-Sang

Objective: Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and future diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using prospective nationwide data.Research design and methods: A total of 51 405 non-diabetic subjects were included who had undergone health examinations in 2002 and complet...

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ea0049ep691 | Obesity | ECE2017

Metabolic profile reversal after bariatric surgery

Gallo Daniela , Ippolito Silvia , Veronesi Giovanni , Dozio Eugenia , Frattini Francesco , Trotti Eugenia , Lai Adriana , Sassi Lorenza , Sabatino Jessica , Masiello Elvira , Premoli Paola , Bianconi Eleonora , Rosetti Sara , Cusini Claudio , Laura Tanda Maria , Dionigi Gianlorenzo , Bartalena Luigi , Piantanida Eliana

Bariatric surgery is the most-effective treatment for morbid obesity, superior to medical treatment. Metabolic syndrome (MS) is a condition characterized by multiple major risk factors for coronary heart disease, diabetes, fatty liver, and several cancers; the main, diagnostic, components of MS are low HDL-cholesterol (<40 mg/dl in man, <50 mg/dl in woman), raised triglycerides (>150 mg/dl), blood pressure >130/85 mmHg, fasting plasma glucose >100 mg/dl and...

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ea0049ep692 | Obesity | ECE2017

Hydroxysteroid (17beta) dehydrogenase 13 knockout mice present with inflammation associated liver steatosis

Heikela Hanna , Adam Marion , Portius Dorothea , Maki-Jouppila Jenni , Mehmood Arfa , Adhikari Prem , Esposito Irene , Elo Laura , Zhang Fu-Ping , Ruohonen Suvi T , Strauss Leena , Foti Michelangelo , Poutanen Matti

: Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) form a group of enzymes that are characterized by their sequence similarity at the active site, and their ability to catalyze the conversion between the weak 17keto- and the highly active 17beta-hydroxysteroids. To study the physiological role of HSD17B13, a lipid droplet associated protein, we characterized the phenotype of knockout (KO) mice deficient in HSD17B13 (HSD17B13KO). The data revealed normal serum sex steroid conce...

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ea0049ep693 | Obesity | ECE2017

Visceral vs subcutaneous white adipose depots response to insulin treatments in rats

Markelic Milica , Jankovic Aleksandra , Golic Igor , Aleksic Marija , Stancic Ana , Otasevic Vesna , Masovic Sava , Marin Marija , Korac Bato , Korac Aleksandra

: White adipose tissue (WAT) has an important role in the regulation of metabolic homeostasis. It is well known that two distinct WAT depots in mammals, subcutaneous WAT (sWAT) and visceral WAT (vWAT) display different metabolic roles and it could be presumed that exert different response to various hormones. Numerous studies revealed leading role of insulin in both fat accumulation (lipogenesis) and adipocyte differentiation (adipogenesis) although it is not clear is there a ...

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ea0049ep694 | Obesity | ECE2017

Association between obesity and glomerular hyperfiltration: impact on metabolic risk factors

Sumarac-Dumanovic Mirjana , Gligic-Kuzmanovic Ana , Stamenkovic-Pejkovic Danica , Polovina Snezana , Jeremic Danka , Cvijovic Goran , Zoric Svetlana , Micic Dragan

Abstract: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease, independently of classical risk factors such as diabetes. In terms of determining the creatinine clearance has numerous drawbacks, in clinical use are predictors of glomerular filtration rate (GFR) which show varying degrees of accuracy in obese patients. The aim of our study was to determine whether it is in our group of obese patients without type 2 dia...

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ea0049ep695 | Obesity | ECE2017

Characteristics of cellular immunity in men with obesity and hypogonadism

Dzantieva Elizaveta , Khripun Irina , Gusova Zalina , Vorobiev Sergey , Allakhverdieva Yanina , Kuzmenko Natalia , Petrovskaya Ekaterina

Abstract: There are few studies of the cellular immunity in men with obesity and hypogonadism. The aim was to study the parameters of cellular components of the immune system in patients with obesity and hypogonadism.Materials and methods: The study included 120 men aged 4065 years with obesity (mean BMI 35±5.6 kg/m2). Patients were divided into two groups depending on the level of total testosterone (T). The first group incl...

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ea0049ep696 | Obesity | ECE2017

GLP-1 therapy and the immune system – can we predict responders from non-responders?

O'Shea Donal , Tobin Laura , Cody Declan , Mat Arimin , Kinlen David , Hogan Andrew

Abstract: Obesity has reached epidemic proportions globally. At least 2.8 million people die each year as a result of being overweight or obese, the biggest burden being obesity-related diseases. Glucagon like peptide 1 (GLP-1) targeted therapies show the greatest potential for intervention and are approved as weight loss agents. However not all patients respond to GLP-1 therapy. Understanding the mechanisms of bodyweight regulation and their role in GLP-1 responders vs. non-r...

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ea0049ep697 | Obesity | ECE2017

An assessment of the relationship between abdominal obesity and the severity of upper extremity lymphedema

Jeon YunKyung , Shin MyungJun , Shin YongBeom , Kim InJoo , Kim BoHyen

Abstract: Obesity is one of the well-known initiating and aggravating factor of lymphedema. BMI is typically used to define obesity, but in Asian populations, health risks are elevated at lower BMI levels and abdominal fat may be a better obesity metric. Thus, we assessed the potential association between abdominal obesity and lymphedema severity in postoperative breast cancer patients. Thirty-three women with breast cancer-related lymphedema participated in this study. Arm ci...

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ea0049ep698 | Obesity | ECE2017

Associations between the dysregulation of splicing machinery components and the development of hepatic steatosis in obese women

del Rio-Moreno Mercedes , Pedraza-Arevalo Sergio , Gonzalez-Rubio Sandra , Ferrin Gustavo , Rodriguez-Peralvarez Manuel , Kineman Rhonda D , Ibanez-Costa Alejandro , de la Mata Manuel , Castano Justo P , Luque Raul M , Gahete Manuel D

: Hepatic steatosis is a common obesity-associated pathology characterized by the accumulation of fat within the liver, which can progress to liver fibrosis, cirrhosis and ultimately lead to hepatocellular carcinoma. Remarkably, obesity and cancer course with a profound dysregulation of the genetic expression patterns and, particularly, with the aberrant expression of splicing variants that could contribute to the aggressiveness and comorbidities of these pathologies. Since th...

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ea0049ep699 | Obesity | ECE2017

Irisin and cardiovascular risk

Assyov Yavor , Gateva Antoaneta , Kamenov Zdravko

Aims: Irisin is a recently discovered myokine that has been implicated in the pathogenesis of type 2 diabetes (T2D) and metabolic syndrome (MS). Its involvement with cardiovascular disease (CVD), however, has not yet been elucidated. The aim of the current study was to shed light on the potential association with irisin and cardiovascular risk.Methods: Eighty patients with obesity (BMI ≥ 30 kg/m2) and mean age 50,4±10,6 years were i...

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ea0049ep700 | Obesity | ECE2017

Circulating adipomyokines, inflammatory marker, insulin resistance, and physical fitness among severely obese Korean children and adolescents

Park Kyung Hee , Seo Young-Gyun , Lee Hye Ja , Chang Han Byul , Park Sang Ick , Kim Yoon Myung , Lim Hyun Jung

Background: Associations between obesity and adipomyokines, inflammatory marker, and level of physical fitness have not been well evaluated in severe obesity in children and adolescents.Method: Data on leptin, irisin, FGF21, hsCRP, glucose, insulin, physical fitness measured by arm curl test for upper extremity)and wall sit test for lower extremity were obtained in 266 participants who were recruited for ICAAN study, community- based multidisciplinary we...

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ea0049ep701 | Obesity | ECE2017

Genetic variants of the adiponectin gene and its association with adiponectin level in metabolic syndrome women

Gupta Abhishek , Tiwari Sunita , Agrawal Suraksha , Singh Arun Kumar , Paul Bhola Nath , Cianflone Katherine

Background: Adiponectin is an adipocyte-derived adipokine, down-regulated in obesity linked disorders. Here, we investigated the genotypic variability of adiponectin (at position; +T45G and +G276T) and its association with circulating adiponectin and metabolic syndrome in North Indian adult women.Methods: We compared metabolic syndrome (MetS; 269) women to without metabolic syndrome (wMetS; 272) women of North India. Genotype frequencies of the adiponect...

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ea0049ep702 | Obesity | ECE2017

Obesity, cardiomyopathy and anabolic hormones

Gangitano Elena , Costantini Daniela , Tozzi Rossella , De Giorgi Francesca , Poggiogalle Eleonora , Mariani Stefania , Petrangeli Elisa , Donini Lorenzo Maria , Barbaro G. , Gnessi Lucio , Lubrano Carla

Obesity is associated with hemodynamic alterations that may lead to heart failure (HF), through the development of cardiac structural abnormalities and impairment of ventricular function. Obesity-related neurohormonal and metabolic disturbances may predispose to HF, even in the absence of comorbidities. Excess adipose tissue and in particular visceral adiposity contributes to the altered production of a number of anabolic hormones also involved in the regulation of the cardiac...

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ea0049ep703 | Obesity | ECE2017

Are there any associations between vitamin D levels and insulin resistance in obese patients?

Topaloglu Omercan , Evren Bahri , Yologlu Saim , Sahin Ibrahim

Introduction: Most of the human studies suggested an association between obesity and low 25(OH)D3 0levels. It has been proposed that co-existence of vitamin D deficiency may have a role in the development of IR in obesity. We aimed to reveal whether any association was present between IR and 25(OH)D3.Materials-methods: 223 obese patients referred to our clinics were evaluated for the study. 24 patients with known diabetes mellitus were excluded. Finally,...

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ea0049ep704 | Obesity | ECE2017

Elevated serum adiponectin in Alzheimer’s disease as neuroprotective strategy

Letra Liliana , Rodrigues Tiago , Matafome Paulo , Duro Diana , Lemos Raquel , Patricio Miguel , Castelo-Branco Miguel , Baldeiras Ines , Seica Raquel , Santana Isabel

Background: Several studies have highlighted the contribution of adipose tissue dysfunction to the development and progression of Alzheimers Disease (AD), which may depend on alterations in adipokine secretion. Leptin and adiponectin are the most abundant adipokines in circulation, with recognized systemic effects, but also able to cross the blood-brain barrier and influence cognitive-related structures, such as the hippocampus.Objective: To determ...

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ea0049ep705 | Obesity | ECE2017

Late dumping syndrome in pregnant women after ROUX-EN-Y gastric bypass (RYGB) surgery

Pacheco Lucia Vera , Garcia Maria Teresa Gallego , Del Peso Gilsanz Cristina , Redondo Lorena Rentero , Navalon Carles Iniesta , Garcia-Talavera Espin Noelia Victoria , Espin M^a Bienvenida Garcia-Talavera , Munoz Manuel Romero , Aviles Amparo Meoro

Introduction: Dumping syndromes are common after bariatric surgery and can present diagnostic and therapeutic challenges in pregnancy.Case report: A 23-year-old female who underwent a RYGB surgery because of morbid obesity in 2013. She had no medical history of diabetes nor any other comorbidity related to obesity. Two years later, her weight had reduced from 128 to 76 kg and also her body mass index (BMI) from 43.8 to 26 kg/m2. She was treate...

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ea0049ep706 | Obesity | ECE2017

Folate: a new player in metabolic syndrome?

Paredes Silvia , Alves Marta , Pereira Maria Lopes , da Costa Jose Maia , Fernandes Aline , Manso Fernando , Marques Olinda , Ribeiro Laura

Introduction: Bariatric surgery (BS) candidates display several nutritional deficiencies that can aggravate after surgery. Metabolic syndrome (MS) is a cluster of cardiovascular risk factors with several disturbed metabolic pathways. Therefore, individuals with MS submitted to BS are probably more prone to nutritional deficiencies.Objective: To evaluate the prevalence of nutritional deficiencies and eventual differences between BS candidates with and wit...

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ea0049ep707 | Obesity | ECE2017

Evolution of body composition 3 years after sleeve gastrectomy

Paredes Silvia , Alves Marta , Pereira Maria Lopes , da Costa Jose Maia , Fernandes Aline , Manso Fernando , Marques Olinda , Ribeiro Laura

Background: Sleeve gastrectomy (SG) has effective results on weight loss, which should result from fat mass loss and efforts should be made to preserve lean mass. Few studies have evaluated body composition (BC) changes after SG for periods >2 years.Objective: To investigate the impact of SG on weight and BC, comparing by gender.Materials and methods: Retrospectively, databases of patients who underwent SG between 2011 and 2013...

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ea0049ep708 | Obesity | ECE2017

Comparative study between laparoscopic gastric bypass and laparoscopic sleeve gastrectomy

Aragon-Alonso Aurora , Gomez Mercedes Ferrer , Sanchez Jose Ramon Cuenca , de Angulo Martin David Ruiz , Bernal Maria Dolores Frutos , Espallardo Maria Angeles Campillo , Luque Pedro Segura , Martinez Antonio Hernandez

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity. Laparoscopic gastric bypass (LGB) and laparoscopic sleeve gastrectomy (LSG) are the most widely used bariatric procedures today.Objectives: In this study we compared LGB and LSG in order to establish whether there is any superiority of one or the other in effectiveness and complications.Methods: We included all the patients who ...

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ea0049ep709 | Obesity | ECE2017

Prevalence of mono-ethyl-hexyl phthalate and mono-ethyl phthalate in Serbian population and their influence on leptin and thyroid function in obesity

Bajkin Ivana , Milic Natasa , Novakovic-Paro Jovanka , Icin Tijana , Prodanovic Jovana , Curic Nikola , Vukovic Bojan , Medic-Stojanoska Milica

Introduction: Phthalates are ubiquitous endocrine disruptors (EDs). EDs induce obesity. MEP and MEHP affect thyroid function.Aim: Estimation of burden of MEP and MEHP in our population, evaluation of leptin in obese MEP and MEHP positive and negative subjects and evaluation of connection between leptin, MEP, MEHP and thyroid indicators in that subgroup. Materials and methods: a cross-sectional study, with 201 subjects divided into MEP/MEHP positive and n...

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ea0049ep710 | Obesity | ECE2017

Using diaserein on the patients with glucose intolerance

Cadirci Kenan , Yildiz Kadri

Diaserein is used in the spesific and long-term treatment of degenerative joint diseases (as osteoarthritis). In vitro studies have showed that Diaserein and its active metabolyte Rheinin inhibate production and activity of interleukin-113 (IL-113), some proinflamatuar and pro-catabolic cytokines. Interleukin-113 play important role to trigger production of more pro-inflamatuar factors as cytokines, cyclo-oxygeneas, prostogalandines, nitric oxide, matrix metalloprotei...

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ea0049ep711 | Obesity | ECE2017

Bone mineral density in obese patients

Ansari Nawal El , Zaher Fatima Zahra , Elmghari Ghizlane

Background: Obesity and osteoporosis are two public health problems with an increasing prevalence and high impact on morbidity and mortality which, during the last two decades, have become major health threats worldwide. However, obesity has long been considered as a protective factor against osteoporosis. The purpose of our study was to evaluate the bone mineral density in obese patients followed at Mohammed VI university hospital.Methods: Our study has...

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ea0049ep712 | Obesity | ECE2017

Role of cognitive-behavioral therapy in the treatment of obesity

Popovic-Pejicic Snjezana

Dietary therapy, programmed physical activity and cognitive-behavioral therapy are basic measures in the treatment of obesity. Cognitive-behavioral therapy applies methods which change eating habits of obese persons, aiming to remove barriers relating dietary therapy and programmed physical activity. The goal is to try efficiency of applying cognitive-behavioral therapy in the program for the reduction of body mass of obese persons, versus the application of dietary therapy an...

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ea0049ep713 | Obesity | ECE2017

Dynapenic obesity and myosteatosis in women with and without the metabolic syndrome

Poggiogalle Eleonora , Donini Lorenzo , Gnessi Lucio , Mariani Stefania , Di Martino Michele , Ciccantelli Barbara , Mancini Cecilia , Arca Marcello , Lenzi Andrea , Lubrano Carla

Introduction: Insulin resistance is a well-known hallmark of the metabolic syndrome (MetS), and it detrimentally affects also protein metabolism, favoring to the decline of lean body mass. The aim of the present study was to explore muscle strength (as a functional consequence of sarcopenic obesity) and muscle quality (namely, myosteatosis) in women with and without the Metabolic Syndrome (MetS).Methods: Study participants were enrolled at the Sapienza U...

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ea0049ep714 | Obesity | ECE2017

Concern about body image, impulsiveness and personality traits in the morbidly obese before bariatric surgery and in patients who have undergone surgery

Mateo-Gavira Isabel , Medina-Rivero Daniel , Novalbos-Ruiz Jose Pedro , Rodriguez-Martin Amelia , Santi-Cano Maria Jose , de Castro D Ogalla , Aguilar-Diosdado Manuel

Objectives: To analyse the levels of anxiety, depression, impulsiveness, bulimic behaviour, concern about body image and the quality of life of patients included in the care process following bariatric surgery, in our field.Methods: Observational study of the patients included in the care process for bariatric surgery at University Hospital Puerta del Mar. Two cohorts were identified according to their situation before or after surgery. Studies were made...

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ea0049ep715 | Obesity | ECE2017

Lifestyle of morbidly obese patients awaiting bariatric surgery and in the cohort of patients who have undergone surgery

Mateo-Gavira Isabel , Medina-Rivero Daniel , Rodriguez-Martin Amelia , Novalbos-Ruiz Jose Pedro , Santi-Cano Maria Jose , Diaz-Yelamos A , Aguilar-Diosdado Manuel

Objectives: To determine the habits and lifestyle of the morbidly obese before and after bariatric surgery.Material and methods: Transversal study of two groups of morbidly obese patients attending the Endocrinology Unit of Puerta del Mar, Cádiz: one group before and the other after bariatric surgery. Clinical and analytical data of the patients was collected: socio-demographic and lifestyle characteristics, Bulit-R Questionnaire (Bulimia), BIS (imp...

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ea0049ep716 | Obesity | ECE2017

Thyroid hormone treatment reduces inflammatory cytokines in mesenteric adipose tissue improving insulin sensitivity of obese rats

Panveloski-Costa Ana Carolina , Serrano-Nascimento Caroline , Poyares Leonice , Viana Gabriela Souza , Bargi-Souza Paula , Nunes Maria Tereza

Thyroid hormone plays an important role on carbohydrate and lipid metabolism. In hypothyroidism is observed reduction of glucose transporter-4 expression and insulin sensitivity and in hyperthyroid states the key enzymes of gluconeogenesis and glycogenolysis are induced, and both conditions lead to glucose intolerance. It has been reported an increased prevalence of thyroid dysfunction in obese and diabetic patients. Recently we have demonstrated a hypothyroid state in alloxan...

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ea0049ep717 | Obesity | ECE2017

Predictive factors of outcome in bariatric surgery

Aragon-Alonso Aurora , Gomez Mercedes Ferrer , Sanchez Jose Ramon Cuenca , Martin David Ruiz de Angulo , Bernal Maria Dolores Frutos , Espallardo Maria Angeles Campillo , Luque Pedro Segura , Martinez Antonio Hernandez

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity, although rates of weight loss and comorbidities resolution differ among bariatric techniques and depending on preoperative factors.Objectives: In this study we analyse possible factors that influence the outcome of bariatric surgery (weight loss and improvement in metabolic comorbidities) in order to identify those patients most likely to benefit from...

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ea0049ep718 | Obesity | ECE2017

Prevalence of obesity in Algeria

Fafa Nadira , Meskine Djamila , Fedala Saida , Kedad Lamia

Introduction: The epidemiological transition has resulted in a major increase in the prévalence of obesity in our country. Obesity is closely associated with chronic diseases such as type 2 diabetes, hypertension and dyslipidemia. The aim of our study is assessing the prevalence of general obesity, central obesity (OA), associated risk factors (D2, HTA and dyslipidemia) and tries to provide information on determinants of obesity in Algerian adult.Me...

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ea0049ep719 | Obesity | ECE2017

Testosterone deficiency in obese males: is insulin resistance the one to blame?

Souteiro Pedro , Magalhaes Daniela , Pedro Jorge , Oliveira Sofia Castro , Neves Joao Sergio , Belo Sandra , Costa Maria Manuel , Bettencourt-Silva Rita , Varela Ana , Queiros Joana , Freitas Paula , Carvalho Davide , Group AMTCO

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...

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ea0049ep720 | Obesity | ECE2017

Anthropometric and metabolic effects of a milk-based intensive lifestyle intervention in severely obese adults

Ioana Iulia Andrada , Mohammed Faraz Rafey , Murphy Conor , Kilkelly Katriona , Brassil Colm , Cunningham Katie , Mcgrath Robert , Griffin Helena , O'Shea Paula , Finucane Francis M

Therapeutic options for patients with severe obesity are limited. Low energy meal replacement regimes can induce significant short-term weight loss and improvements in metabolic variables. We sought to estimate the effect size on adiposity and cardiovascular risk factors of a relatively inexpensive 24-week regime based on meal replacement with semi-skimmed milk in severely obese adults. A retrospective cohort analysis showed that of 206 patients in our hospital-based bariatric...

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ea0049ep721 | Obesity | ECE2017

Association of cortisol, DHEA-S and cortisol/DHEAS ratio with insulin resistance in overweight and obese women

Maciejewski Adam , Litwinowicz Monika , Marcinkowska Emilia , Grzymislawski Marian , Lacka Katarzyna

HPA axis that plays important controlling and modulating functions in organism is also linked with insulin resistance and weight control. The number of evidences linking cortisol secretion with obesity and other metabolic complication increase, but still there is a lack of definitive results. Therefore the aim of our study was to compare adrenal function parameters between high and normal insulin resistant overweight and obese women. This retrospective analysis was performed o...

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ea0049ep722 | Obesity | ECE2017

Obesity and fruit and vegetables consumptions in children

Sousa Bruno

Introduction: Obesity is associated with the low consumption of fruit and vegetables.Objective: Evaluate the obesity and the fruit and vegetables consumptions in children after an intervention of school food education program.Methodology: It was implemented a food education program in three classes (n=55) of 1st cycle, on school year (2016/2017) and the evaluation of this action was done comparing fruit and vegetables cons...

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ea0049ep723 | Obesity | ECE2017

Neuromedin B receptor: role in adipogenesis and a possible target for obesity treatment

Paula Gabriela , Wilieman Marianna , Souza Luana , Ribeiro Karina , Baptista Leandra , Cabanelas Carmen

Neuromedin B (NB) is a peptide highly expressed in adipose tissue (AT) but its function remains unclear. We showed that NB receptor (NB) knockout mice (NBR-KO) are resistant to diet-induced obesity compared to wild type (WT) and now we aimed to analyze NBR influence in adipocytes. Mesenchimal cells from perigonadal AT of WT and NBR-KO mice were isolated and maintained in growth medium (GM) as control group or in differentiation medium (DM) as induced group. After 2 weeks cells...

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19th European Congress of Endocrinology

BiosciAbstracts