Endocrine Abstracts (2017) 49 EP776 | DOI: 10.1530/endoabs.49.EP776

Diagnosis of cystic fibrosis related diabetes

Ángel Rebollo-Román1, Paloma Moreno-Moreno1, Ana Barrera-Martín1, Aura-Dulcinea Herrera-Martínez1, José-Manuel Vaquero-Barrios2 & Alfonso Calañas-Continente1

1Endocrinology Service, Hospital Universitario Reina Sofía, Córdoba, Spain; 2Pneumology Service, Hospital Universitario Reina Sofía, Córdoba, Spain.

Aim: To describe the prevalence of abnormal glucose tolerance and diabetes in patients with cystic fibrosis (CF) depending on the diagnostic criteria.

Methods: Observational, cross-sectional, clinical research on patients with CF evaluated at Hospital Universitario Reina Sofía (Córdoba).

Results: Twenty-eight patients were selected for the study. Age: 31.85±8.78 years, with a CF evolution time of 21.77±9.37 years. 64% women. 55.6% of the subjects presented with the deletion of phenylalanine in position 508 (DF508), known to be a severe one. Most patients (85.2%) suffered from pancreatic insufficiency. We compared the three ADA classical diabetes diagnostic criteria. With the fasting plasma glucose 3.6% of patients were diagnosed with impaired glucose tolerance (IGT) and 3.6% with cystic fibrosis-related diabetes (CFRD). Using the glycated haemoglobin (HbA1c) 28.6% of patients had (IGT) and 3.6% CFRD. After the oral 75g-glucose test (OGTT) with intermediate blood glucose measurements, 25.1% were diagnosed with IGT and 7.1% with CFRD. We found different prevalence of abnormal glucose tolerance depending on the diagnostic criteria used. OGTT with intermediate blood glucose measurements is the most sensitive criteria for IGT and CFRD compared to fasting glucose (P=0.002) and HbA1c (P=0.289).

Conclusions: - In our series, there are statistically significant differences among the criteria used to diagnose the abnormal glucose tolerance and CFRD

- OGTT was the most sensitive test to establish the abnormal glucose tolerance and CFRD in our series, in agreement with published evidence.

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