Aim: To investigate the possible association of the rs9939609 polymorphism in the FTO gene with obesity in the Republic of Tatarstan (RT).
Materials and methods: The study involved 63 adult patients (21 men and 42 women; 3877 years old) with overweight or obesity and 515 healthy young people (157 men and 358 women; 1635 years old) with normal weight. We assessed clinical and biochemical parameters (blood lipid profile). The analysis of the rs9939609 T/A polymorphism of the FTO gene in buccal cells was performed using Sintol kits (Russia) for RT-PCR. All the patients were tested by bioelectrical impedance analysis.
Results: The distribution of genotypes of the FTO gene polymorphism (TT 11%, TA 65% AA 24%) and alleles (T 44% A 56%) in the group of patients with overweight and obesity was significantly different from those of the control group (TT 42,9%, TA 45,4%, AA 11,7%; T 65,6%, A 34,4%; OR=2.43, P<0.0001), confirming that the A allele is a risk factor for obesity. In the group of obese patients we found an additive effect of the A allele on the increase of the average waist-hip ratio (lowest value in TT carriers, maximum value in AA carriers). We found that the number of patients with arterial hypertension and dyslipidemia was higher in the group with AA and TA genotypes compared with group with TT genotype.
Conclusion: We found a significant association of the T/A polymorphism of the FTO gene with the obesity. Obese patients with the risk allele of the rs9939609 FTO gene polymorphism have significantly higher values of absolute and relative body fat mass and BMI, total cholesterol, low-density lipoprotein, and triglycerides.
20 - 23 May 2017
European Society of Endocrinology