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Endocrine Abstracts (2017) 49 GP59 | DOI: 10.1530/endoabs.49.GP59

ECE2017 Guided Posters Cardiovascular & Lipid Endocrinology (10 abstracts)

Body composition and testosterone determined VO2max in 780 young men – results from the Odense Androgen Study

Louise Lehmann Christensen , Torben Leo Nielsen , Pernille Hermann , Dorte Glintborg & Marianne Andersen

Odense University Hospital, Odense C, Denmark.

Background: Cardiorespiratory fitness is a measure for physical activity and a prognostic health indicator. However, measurement of maximal oxygen consumption (VO2max) is not possible in clinical practice.

Aim: We hypothesized that body composition and testosterone levels could be used as possible determinants of VO2max in young men.

Participants and design: The Odense Androgen Study, a population-based, observational study including 780 men aged 20–30 years. VO2max (ml/min/kg 0.73) was indirectly measured by a mechanically braked cycle ergometer. Fat mass (%) and lean body mass (%) were assessed by whole-body DXA scans. Total testosterone levels (nmol/l) were measured (RIA using extraction and chromatography). SHBG levels (nmol/l) were determined by immunoluminometric assay. Bioavailable and free testosterone were calculated.

Results: Descriptive data of the subjects were BMI 24.4 kg/m2 (22.4–26.6), waist 88 cm (82–94), percentage lean body mass 79.1% (75.6–82.5), percentage fat mass 17.2% (18.8–21.1), total testosterone 20.7 nmol/l (17.0–25.4), SHBG 27 nmol/l (21–34) and VO2max 160.3 ml/min/kg 0.73 (143.3–177.6) (median (interquartile range). In bivariate analysis, lean body mass (%) (r=0.62), SHBG (r=0.26), total testosterone (r=0.24), and free testosterone (r=0.13) were positively associated with VO2max, whereas fat mass (%) (r=−0.63) and waist (r=−0.47) were negatively associated with VO2max (all P<0.001). Fat mass (%) and lean body mass (%) were closely associated (r=−0.998, P<0.001). In multivariate regression analysis, models with VO2max as the dependent variable and lean body mass (%) or fat mass (%) as independent variables were the best predictors of VO2max (both models R2=0.47), whereas the models including testosterone (total, free or bioavailable testosterone) or SHBG as independent variables had lower R2 values (R2=0.09–0.13). All models were adjusted for age and smoking.

Conclusion: Body composition measures were the best predictors of VO2max in young men. VO2max was more closely associated with waist than testosterone or SHBG.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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