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Society for Endocrinology BES 2017

Harrogate, UK
06 Nov 2017 - 08 Nov 2017

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SfE BES 2017 will be on the 6-8 November 2016 in Harrogate, UK.

Oral Communications

Obesity, Diabetes Thyroid

ea0050oc3.1 | Obesity, Diabetes Thyroid | SFEBES2017

Perchlorate exposure affects thyroid function in third trimester pregnant women from South-West England

Knight Bridget , Shields Beverley , Pearce Elizabeth , Braverman Lewis , He Xuemei , Sturley Rachel , Vaidya Bijay

Introduction: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair foetal neurological development. Perchlorate, found in some foods and everyday chemicals (e.g. fertilisers) and thiocyanate, which is found in cigarette smoke, decrease the transport of iodine from the circulation to the thyroid cells by inhibiting the sodium-iodide symporter. Environmental exposure to these substances during pregnancy may result in reduced thyroid ho...

ea0050oc3.2 | Obesity, Diabetes Thyroid | SFEBES2017

Hypothyroidism is a risk factor for acquiring diabetes in women with Turner Syndrome

Cameron-Pimblett Antoinette , King Thomas F.J. , La Rosa Clementina , Conway Gerard S.

Introduction: The adult Turner Syndrome (TS) clinic at UCLH has collected data on over 800 women, attending for up to 20 years comprising over 8000 clinic visits. Data from this cohort forms the Turner Life Course Project. This large dataset allows analysis of pathogenesis of common chronic conditions including diabetes mellitus (DM) and hypothyroidism. There is some debate about the classification of DM associated with TS, with an over representation of up to 11-fold of type ...

ea0050oc3.3 | Obesity, Diabetes Thyroid | SFEBES2017

The GLP-1R agonist exendin-4 reduces cerebrospinal fluid secretion and intracranial pressure

Botfield Hannah , Uldall Maria , Westgate Connar , Mitchell James , Hagen Snorre , Maria Gonzalez Ana , Hodson David , Jensen Rigmor , Sinclair Alexandra

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...

ea0050oc3.4 | Obesity, Diabetes Thyroid | SFEBES2017

Neutrophil elastase-mediated regulation of adipose glucocorticoid exposure through CBG cleavage

Nixon Mark , Hill Lesley , Underhill Caroline , Hammond Geoffrey , Walker Brian

Adipose exposure to glucocorticoids (GCs) results in visceral adiposity and insulin resistance. Only the unbound, free fraction of GC can diffuse into cells. Corticosteroid binding globulin (CBG) is the major GC carrier, binding 80–85% of circulating GCs with high affinity. Targeted proteolysis of CBG by neutrophil elastase (NE) significantly reduces CBG binding affinity. This suggests that neutrophil-mediated inflammation provides a regulatory mechanism for delivery of G...

ea0050oc3.5 | Obesity, Diabetes Thyroid | SFEBES2017

Increased global long interspersed nucleotide element 1 DNA methylation in type 2 diabetes mellitus individuals relates to lower blood pressure and BMI

Malipatil Nagaraj , Siddals Kirk , Moreno Gabriela , Narayanan Ram , Donn Rachelle , Lunt Mark , Heald Adrian H , Gibson J Martin

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

ea0050oc3.6 | Obesity, Diabetes Thyroid | SFEBES2017

Identification of novel sodium iodide symporter interactors which modulate iodide uptake

Fletcher Alice , Poole Vikki , Modasia Bhavika , Imruetaicharoenchoke Waraporn , Thompson Rebecca , Sharma Neil , Nieto Hannah , Baker Katie , Alshahrani Mohammed , Read Martin , Turnell Andrew , Boelaert Kristien , Smith Vicki , McCabe Christopher

By exploiting the canonical function of the sodium iodide symporter (NIS), ablative radioiodide therapy is an effective treatment for thyroid cancer. However, a subset of patients are unable to accumulate sufficient radioiodide due to decreased expression and/or plasma membrane localisation of NIS. Radioiodide therapy has been proposed as a viable treatment for breast cancer, but is hampered by low levels of NIS membrane localisation. Currently, the regulation of NIS trafficki...