Endocrine Abstracts

G-protein coupled receptors (GPCR) mediate the effects of multiple hormones, and consequently are fundamental for endocrine functions including glucose homeostasis, thyroid function, fertility, control of urine output, and bone remodelling. Mutations in genes encoding GPCRs result in endocrine disorders, and studies of these mutations has improved understanding of GPCR signalling and trafficking pathways, and could facilitate novel therapies. The calcium-sensing receptor (CaSR...

Heavy menstrual bleeding (HMB) is common and debilitating but it remains a taboo subject. Hence its cause remains undefined, resulting in non-specific hormone therapies with intolerable side effects.Over 70 years ago it was proposed that progesterone withdrawal caused intense vasoconstriction and a transient endometrial hypoxia that resulted in menstruation. Subsequent research confirmed that inflammation initiated menses and disputed the role of hypoxia...