Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2017

Harrogate, UK
06 Nov 2017 - 08 Nov 2017

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SfE BES 2017 will be on the 6-8 November 2016 in Harrogate, UK.

Oral Communications

Clinical Highlights

ea0050oc2.1 | Clinical Highlights | SFEBES2017

Mild autonomous cortisol excess in adrenal incidentalomas – metabolic disease burden and urinary steroid metabolome in 1201 prospectively recruited patients

Prete Alessandro , Taylor Angela E , Sitch Alice J , Gilligan Lorna C , Vassiliadi Dimitra , Ambroziak Urzula , Lang Katharina , Kastelan Darko , Tabarin Antoine , Dennedy M Conall , Ueland Grethe AEstrom , Quinkler Marcus , Masjkur Jimmy Rusdian , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Beuschlein Felix , Manolopoulos Konstantinos , Tsagarakis Stylianos , Shackleton Cedric H L , Deeks Jonathan J , Bancos Irina , Arlt Wiebke

Background: Adrenal incidentalomas (AI) are found in approximately 5% of the adult population. Most AIs are benign; however, small-scale studies have indicated that 20–50% of patients harbouring a benign AI show biochemical evidence of mild autonomous cortisol excess (MACE), previously termed subclinical Cushing’s syndrome. MACE is differentiated into MACE-1 (serum cortisol after overnight suppression with 1 mg dexamethasone (1 mg-DST) 50–140 nmol/l) and MACE-2 ...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

ea0050oc2.3 | Clinical Highlights | SFEBES2017

A novel IGSF1 mutation in a large Irish kindred highlights the need for systematic familial endocrine screening in the IGSF1 deficiency syndrome

McGowan Anne , Roche Edna , Koulouri Olympia , Turgeon Marc-Olivier , Nicholas Adeline K , Heffernan Emmeline , El-Khairi Ranna , Lyons Greta , Persani Luca , Dattani Mehul T , Gurnell Mark , Bernard Daniel J , Schoenmakers Nadia

Background: Loss-of-function mutations in IGSF1 result in X-linked congenital central hypothyroidism (CeCH), occurring in isolation or in association with additional pituitary hormone deficits. Intrafamilial penetrance is highly variable and a minority of heterozygous females are also affected. We identified and characterized a novel IGSF1 mutation and investigated its associated phenotypes in a large Irish kindred.Methods: A novel, hem...

ea0050oc2.4 | Clinical Highlights | SFEBES2017

Development of endocrinopathy following treatment of metastatic melanoma with an immune checkpoint inhibitor is associated with better response

Mitsaki Stefania , Flynn Michael , Gore Martin , Larkin James , Morganstein Daniel

Background: Immune checkpoint inhibitors have revolutionized the treatment of metastatic melanoma, demonstrating durable responses, but can result in immune-related adverse events (irAEs). Endocrinopathies are amongst the more common adverse events, and thyroid dysfunction and hypophysitis being the most frequent; the latter of these has been positively correlated with oncological outcome. This study compared overall survival (OS), progression-free survival (PFS) and disease c...

ea0050oc2.5 | Clinical Highlights | SFEBES2017

Additional value of 4D-CT in patients with primary hyperparathyroidism and negative conventional imaging; a reason to change primary imaging modality in patients over 60?

Alkemade Gonnie , Sifontes-Dubon Mildred , Bhatt Dhruti , Smith David , Duguid Rebecca , Straiton Jack , Dymot Jane , Graveling Alex , Abraham Prakash

Introduction: Minimally invasive surgical treatment of primary hyperparathyroidism (PHPT) requires optimal preoperative localisation imaging. Parathyroid four-dimensional CT (4D-CT) has been reported to provide greater sensitivity than MIBI-SPECT/CT in localizing parathyroid adenomas. We analysed the additional value of 4D-CT in our cohort of PHPT patients.Materials and methods: Patients who attended our parathyroid clinic between February 2016 and April...

ea0050oc2.6 | Clinical Highlights | SFEBES2017

Reduced early GLP-1 response in gestational diabetes is associated with hyperinsulinaemia and insulin resistance: a prospective case-control study

Sukumar Nithya , Bagias Christos , Goljan Ilona , Gharanei Seley , Tan Bee , Juls Holst Jens , Sa Ponnusamy

Background: Glucagon-like peptide-1 (GLP-1) concentrations are reduced by 20–50% in type 2 diabetes but studies in women with gestational diabetes mellitus (GDM) are inconclusive. Our aim was to study the GLP-1 profile during a glucose tolerance test (GTT) at GDM diagnosis and its relationship with insulin levels.Methods: A prospective study of selectively screened women was conducted. Plasma GLP-1, insulin and glucose were measured at 30-minute int...