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Endocrine Abstracts (2017) 50 EP005 | DOI: 10.1530/endoabs.50.EP005

1Northwick Park Hospital, London, UK; 2Watford General Hospital, Watford, UK; 3Hammersmith Hospital, London, UK.

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.

A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an incidental 2.3 cm right adrenal nodule. She underwent CT and MRI of the adrenals to further characterise the lesion. These were reported as ‘indeterminate’ but likely a benign adrenal incidentaloma. Patient was then referred to our Endocrinology department. Hormone testing confirmed a non-secretory nodule. A follow up CT adrenal scan at 6 months showed an increase in the size of the tumour to 3 cm, of heterogeneous density with delayed washout of contrast with a low-enhancing centre, requiring an urgent referral for surgery. Although the pre-operative investigations suggested an adrenal tumour, at surgery the tumour was even larger and found to be invading the IVC and was clearly malignant. A planned laparoscopic procedure was changed to an open procedure and a grade 2 right peri-adrenal leiomyosarcoma was resected with resection of the lateral wall of the IVC. Interestingly, the attached adrenal gland was normal.

This case highlights the importance of appropriate radiological assessment in adrenal incidentalomas by experienced adrenal radiologists. Monitoring of patients with suspicious looking lesions even if not meeting the initial criteria for surgery should be rigorous and discussed in a dedicated multi-disciplinary team.

Volume 50

Society for Endocrinology BES 2017

Harrogate, UK
06 Nov 2017 - 08 Nov 2017

Society for Endocrinology 

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