Endocrine Abstracts (2017) 50 P340 | DOI: 10.1530/endoabs.50.P340

Vitamin D status before and after bariatric surgery during 4 years of follow-up

Alistair Fox1,2 & Akheel Syed1,2


1Department of Endocrinology, Salford Royal NHS Foundation Trust, Salford, UK; 2Manchester Medical School, The University of Manchester, Manchester, UK.


Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.

Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.

Setting: University teaching hospital in North-West England.

Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent bariatric surgery. Patients were routinely recommended daily combined calcium and vitamin D supplementation post-surgery.

Results: We studied 480 patients with a median age of 48.8 years, weight 139.3 kg and body mass index 49.3 kg/m2 who underwent gastric bypass (277; 58.9%), sleeve gastrectomy (168; 35.7%) or other primary bariatric surgery (25 patients; 5.3%). Median vitamin D level was significantly lower at baseline and improved with supplementation post-surgery (Table 1). Whereas 52.8% had vitamin D deficiency (<30.0 nmol/l) and 25.1% insufficiency (≥30.0 <50.0 nmol/l) preoperatively, 13.3 and 23.0% had deficiency and insufficiency, respectively, at 12 months with similar trends up to 4 years of follow-up.

Conclusion: Vitamin D deficiency and insufficiency were commonly prevalent pre-surgery, which reduced significantly with routine supplementation post-surgery.

Table 1 Outcome measures after bariatric surgery
Outcome measures†0 months12 months24 months36 months48 months
Body mass index (kg/m2)4934****34****36****37****
Vitamin D (nmol/l)3057****56****50****53****
Parathyroid hormone (pmol/l)5.05.45.35.55.6
Corrected calcium (mmol/l)2.332.292.28****2.24****2.28****
Phosphate (mmol/l)1.051.14****1.091.071.10
Alkaline phosphatase (U/l)8182778378
†Median | ****P<0.0001 (compared to baseline)

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