Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2017

Harrogate, UK
06 Nov 2017 - 08 Nov 2017

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SfE BES 2017 will be on the 6-8 November 2016 in Harrogate, UK.

Poster Presentations

Obesity and Metabolism

ea0050p315 | Obesity and Metabolism | SFEBES2017

Advanced NAFLD is common in bariatric surgical patients, poorly staged by non-invasive NAFLD biomarkers and is associated with adverse outcome

Dempster Niall , Gerogiannis Ioannis , Franklin Rachel , Watson Michael , Rickers Lisa , Fletcher Caroline , Jenkins Eleanor , Sgromo Bruno , Gillies Richard , Cobbold Jeremy , Rosenberg William , Hodson Leanne , Tomlinson Jeremy , Ryan John

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is reported to be common in patients undergoing bariatric surgery, but the diagnostic accuracy of non-invasive NAFLD biomarkers to stage disease and track progress longitudinally has not been assessed.Methods: 274 patients undergoing bariatric surgery were included in the study. Intra-operative liver biopsies were taken from 163 patients and histologically graded using t...

ea0050p316 | Obesity and Metabolism | SFEBES2017

Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPARγ and insulin resistance

Adaikalakoteswari Antonysunil , Vatish Manu , Alam Mohammad , Ott Sascha , Kumar Sudhesh , Saravanan Ponnusamy

Background: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance (IR) and gestational diabetes (GDM). However, it is not clear whether these are causally related.Objective: B12 is a key co-factor of the DNA methylation cycle (1-carbon metabolism). We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs (miRs) during adipocyte differentiation...

ea0050p317 | Obesity and Metabolism | SFEBES2017

The use of intestinal organoids to investigate nutrient sensing

Ramgulam Anya , Gonzalez-Abuin Noemi , Frost Gary , Murphy Kevin

Intestinal nutrient sensing and transport are gaining increasing attention in the field of obesity research. To date, in vitro studies in this area have largely used two dimensional (2D) cell culture models. However, 2D cell cultures are limited by a lack of cellular heterogeneity, behaviour, and communication observed in vivo. There has consequently been growing interest for the application of three-dimensional (3D) cell culture ...

ea0050p318 | Obesity and Metabolism | SFEBES2017

5β-reductase (AKR1D1) is a potent regulator of carbohydrate and lipid metabolism and inflammation in human liver

Nikolaou Nikolaos , Gathercole Laura , Althari Sara , Green Charlotte , McNeil Catriona , Hughes Beverly , Arlt Wiebke , Hodson Leanne , Tomlinson Jeremy

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic disease. Steroid hormones and bile acids are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis. We hypothesized that AKR1D1 plays a key role in hepatic metabolic homeostasis. Genetic manipulation of AKR1D1 ...

ea0050p319 | Obesity and Metabolism | SFEBES2017

The adverse metabolic phenotype associated with obstructive sleep apnoea is not driven by activation of the hypothalamo-pituitary-adrenal axis

Hazlehurst Jonathan M , Charlton Catriona , Mantripp Diana , Hodson Leanne , Tomlinson Jeremy W

Glucocorticoid (GC) excess drives obesity, insulin resistance and type 2 diabetes. Obstructive sleep apnoea (OSA) is a prevalent condition associated with both activation of the hypothalamic-pituitary-adrenal (HPA) axis and an adverse metabolic phenotype. However, a causal link between these two features has not been established. We designed a novel human model of intermittent hypoxia (IH) aimed at replicating the systemic insulin resistance associ...

ea0050p320 | Obesity and Metabolism | SFEBES2017

Androgen excess is highly prevalent in women with idiopathic intracranial hypertension and is biochemically distinct from polycystic ovary syndromes

O'Reilly Michael , Hornby Catherine , Westgate Connar , Botfield Hannah , Markey Keira , Mitchell James , Jenkinson Carl , Gilligan Lorna , Sherlock Mark , Gibney James , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Idiopathic intracranial hypertension (IIH) is a condition of unknown aetiology characterised by raised intracranial pressure, chronic headaches and blindness. Akin to polycystic ovary syndrome (PCOS), IIH patients are almost exclusively obese females of reproductive age. A distinct androgen excess profile has been noted in PCOS. Here, we aimed to delineate androgen metabolism in IIH compared to PCOS and simple obesity.Women w...

ea0050p321 | Obesity and Metabolism | SFEBES2017

Rectal and oral administration of L-Phenylalanine supresses food intake and modulates neuronal activation in appetite-regulating brain regions in rodents

Norton Mariana , Cao Ye , Amarsi Risha , Freitas Isabel Fernandes , Alamshah Amin , Murphy Kevin G

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

ea0050p322 | Obesity and Metabolism | SFEBES2017

Cholestatic pregnancy alters the gut incretin response to diet, affecting GLP-1, PYY and FGF19 secretion, with reversal of changes associated with ursodeoxycholic acid treatment

Ovadia Caroline , Chambers Jenny , Martineau Marcus , Murphy Kevin , Walters Julian , Williamson Catherine

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is characterised by maternal pruritus and raised serum bile acids, and is associated with adverse fetal outcomes (e.g. preterm birth, neonatal unit admission and stillbirth). Maternal metabolic impacts include higher rates of gestational diabetes mellitus, hypertriglyceridaemia and hypercholesterolaemia. Glucose and lipid metabolism are influenced by gut incretin release, and bile acids are ...

ea0050p323 | Obesity and Metabolism | SFEBES2017

A randomised controlled trial of vitamin D treatment on markers of liver fibrosis in obese women with Polycystic Ovary Syndrome

Javed Zeeshan , Kilpatrick Eric , Mann Vincent , Corless Lynsey , Abouda George , Rigby Alan , Atkin Stephen , Sathyapalan Thozhukat

Context: Polycystic ovary syndrome (PCOS) has been linked to non-alcoholic fatty liver disease (NAFLD) that carries an increased risk of liver cirrhosis. The Enhanced Liver Fibrosis (ELF) score comprises serum hyaluronic acid (HA), procollagen III N-terminal peptide (PIIINP) and tissue inhibitor of metalloproteinase-1 (TIMP1) that correlate with hepatic fibrosis staging.Objective: To determine the effect of vitamin D suppleme...

ea0050p324 | Obesity and Metabolism | SFEBES2017

Leptin receptors localise to β-cells in the fetal ovine pancreas, but do not appear to influence β-cell mass in utero

Harris Shelley , Raja Sharon , Blasio Miles De , Wooding FB Peter , Blache Dominique , Fowden Abigail , Forhead Alison

Babies born to mothers with diabetes during pregnancy are exposed to high circulating leptin before birth and, in turn, are at increased risk of developing diabetes in later life. In pancreatic islets isolated from fetal sheep, leptin influences β-cell proliferation in a bimodal manner. This study examined the effect of exogenous leptin infusion and leptin receptor antagonism on pancreatic β-cell mass in the sheep fetus in vivo.<...

ea0050p325 | Obesity and Metabolism | SFEBES2017

Evaluating the role of testosterone in cerebrospinal fluid secretion

Westgate Connar , Botfield Hannah , O'Reilly Michael , Hodson David , Sinclair Alexandra

Idiopathic intracranial hypertension (IIH) is a condition characterised by raised intracranial pressure (ICP) that primarily affects obese women of reproductive age. The aetiology is poorly understood but involves imbalance of cerebrospinal fluid (CSF) secretion and absorption. IIH patients share similar phenotypic characteristics to PCOS patients, a condition with a distinct androgen signature. We hypothesise that obesity and androgen excess maybe...

ea0050p326 | Obesity and Metabolism | SFEBES2017

Low vitamin B12 induces de novo lipogenesis in human hepatocytes

Boachie Joseph , Adaikalakoteswari Antonysunil , Samavat Jinus , Zammit Victor , Irshad Zehra , Saravanan Ponnusamy

Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...

ea0050p327 | Obesity and Metabolism | SFEBES2017

Male sexual dysfunction and hypogonadism improves following bariatric surgery

Ho Jan Hoong , Adam Safwaan , Azmi Shazli , Dhage Shaishav , Liu Yifen , Ferdousi Maryam , Syed Akheel , Ammori Basil , Malik Rayaz , Donn Rachelle , Soran Handrean

Background: Male sexual dysfunction is common in obesity with complex underlying mechanisms. Testosterone replacement has often been initiated in clinical practice in the presence of sexual dysfunction and male obesity-associated secondary hypogonadism. The benefits to sexual functioning, however, are not well documented. The aims of the study were to investigate the relationship between sexual function and hypogonadism in severe obesity and to understand the impact of bariatr...

ea0050p328 | Obesity and Metabolism | SFEBES2017

DNA methylation differs between lean and obese placenta and is influenced by maternal environment and fetal sex

Yang Liu , Cartier Jessy , Drake Amanda , Reynolds Rebecca

Obesity in pregnancy is associated with an increased risk of complications for mother and child. Epigenetic modifications have been proposed as an important underlying mechanism. As the placenta plays a key role in fetal nutrition and metabolism we hypothesized there would be placental DNA methylation differences between lean and obese placenta. DNA methylation array (Human Methylation 450K) was performed on placentas from n=31 obese (BMI&...

ea0050p329 | Obesity and Metabolism | SFEBES2017

Vitamin B12 deficiency triggers adipocyte dysfunction by enhancing triglyceride biosynthesis and pro-inflammatory cytokine production: a new agonist in metabolic disease?

Samavat Jinous , Adaikalakoteswari Antonysunil , Boachie Joseph , Zammit Victor , Saravanan Ponnusamy

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...

ea0050p330 | Obesity and Metabolism | SFEBES2017

Blunt response to a stress test and higher prevalence of risk polymorphism of glucocorticoid receptor gene (NC3C1) in obese patients

de Gortari Patricia , Valdes Mariana , Camarena Beatriz , Hernandez-Munoz Sandra , Falcon Elena

Chronically exposure to stress promotes in individuals high intake of foods with high content of carbohydrates and fat and may develop obesity. Stress-induced sustained elevation of glucocorticoid serum levels may be due to impaired functioning of the hypothalamic glucocorticoid receptor GR, altering the hypothalamic-pituitary-adrenal axis regulation. As a result, chronically stressed individuals are unable to respond with higher cortisol levels wh...

ea0050p331 | Obesity and Metabolism | SFEBES2017

Alterations in concentration and characteristics of circulating extracellular vesicles in morbid obesity

Witczak Justyna , Datta Dev , James Philip , Rees Aled

Introduction: Obesity is associated with increased cardiovascular disease (CVD) risk but the underlying pathways are unclear. Extracellular vesicles (EVs) are circulating submicron particles containing proteins, enzymes and mRNA of their donor cells. They could mediate some of these risks by paracrine actions in target cells.Aims: To compare the concentration and characteristics of circulating EVs from healthy volunteers (HV)...

ea0050p332 | Obesity and Metabolism | SFEBES2017

Reverse cholesterol transport and other functions of high density lipoprotein are enhanced after bariatric surgery

Adam Safwaan , Siahmansur Tarza , Liu Yifen , Azmi Shazli , Siddals Kirk , Ho Jan Hoong , Dhage Shaishav , Malik Rayaz , Syed Akheel , Ammori Basil , Durrington Paul , Donn Rachelle , Soran Handrean

Background: Emerging evidence suggests that impaired high density lipoprotein (HDL) function is associated with cardiovascular disease (CVD). HDL is essential for removing excess circulating cholesterol by reverse cholesterol transport (RCT). Additionally HDL reduces inflammation and oxidative stress, especially through paraoxonase-1. Whereas HDL’s capacity to accept cholesterol from peripheral cells is key (i.e. cholesterol efflux capacity (CEC)), successful RCT depends ...

ea0050p333 | Obesity and Metabolism | SFEBES2017

Genes involved in zinc homeostasis are associated with metabolic syndrome and insulin resistance in Romanian and French populations

Ilie Mirela Diana , Haydar Sara , Vintila Madalina , Lautier Corinne , Normand Christophe , Gheorghiu Monica , Poiana Catalina , Badiu Corin , Grigorescu Florin

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

ea0050p334 | Obesity and Metabolism | SFEBES2017

Low iliac skinfold thickness predict mortality in a prospective cohort of white males

Loh Wann Jia , Johnston Desmond G , Godsland Ian F

Introduction: Obesity is a major risk factor for mortality from a range of causes. We investigated whether skinfold measurements predict mortality independently of variation in body mass index (BMI).Methods: A prospective analysis of mortality in 870 apparently healthy adult Caucasian men participating in an occupational health cohort was undertaken. At baseline, skinfold measurements were taken at biceps, triceps, iliac and ...

ea0050p335 | Obesity and Metabolism | SFEBES2017

Investigating the role of Annexin A1 in Adipogenesis and its ability to dampen Obesity associated Inflammation

Sajid Sehar , Renshaw Derek , Burke Bernard , Mee Christopher

Introduction: Obesity results in an imbalance of systemic adipokines as well as pro and anti-inflammatory biomarkers. The attenuation of anti-inflammatory proteins, including Annexin A1 (AnxA1) in human obesity, may be a contributing factor to the chronic inflammatory phenotype which results. However, increased AnxA1 mRNA and protein levels in mature adipocytes suggest an additional role for AnxA1 in adipose tissue biology.Ai...

ea0050p336 | Obesity and Metabolism | SFEBES2017

Metabolic phenotype of Male Obesity-associated Secondary Hypogonadism pre- and post-replacement therapy with intra-muscular Testosterone undecanoate therapy

Dimitriadis Georgios K , Randeva Harpal S , Grammatopoulos Dimitris K , Barber Thomas M

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

ea0050p337 | Obesity and Metabolism | SFEBES2017

Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obese patients with and without diabetes

Dhage Shaishav Shashikant , Adam Safwaan , Ho Jan Hoong , Yadav Rahul , Hama Salam , Schofield Jonathan , France Michael , Syed Akheel A , Siahmansur Tarza , Pemberton Philip , Aghamohammadzadeh Reza , Donn Rachelle , Malik Rayaz A , New John P , Durrington Paul , Ammori Basil A , Liu Yifen , Soran Handrean

Background: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes.Aims: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with a...

ea0050p338 | Obesity and Metabolism | SFEBES2017

Body fat distribution by dual energy x-ray absorptiometry (DXA) and metabolic risk factors in intravenous glucose tolerance test (IVGTT)-defined high and low insulin sensitivity normoglycaemic, overweight men

Loh Wann Jia , Stevenson John C , Johnston Desmond G , Godsland Ian F

Background: Increased adiposity is associated with increased cardiovascular disease (CVD) risk but among overweight individuals clarification is needed of relationships between insulin sensitivity, fat distribution and metabolic health that might contribute to this risk.Methods: During the Heart Disease and Diabetes Research Indicators in a Screened Cohort (HDDRISC) study, 560 employment cohort normoglycaemic (FPG less than 7...

ea0050p339 | Obesity and Metabolism | SFEBES2017

The Prevalence of Obstructive Sleep Apnoea in women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

Kahal Hassan , Kyrou Ioannis , Uthman Olalekan , Brown Anna , Johnson Samantha , Wall Peter , Metcalfe Andrew , Tahrani Abd , Randeva Harpal

Background: Obesity is a common risk factor for obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS).Objective: To examine the prevalence of OSA in women with PCOS.Search sources: Electronic databases [Medline, Embase, Cinahl, PsycInfo, Scopus, Web of Science, Opengrey, and Cochrane Central Register of Controlled Trials], conference abstracts, and reference lists of relevant articles. The...

ea0050p340 | Obesity and Metabolism | SFEBES2017

Vitamin D status before and after bariatric surgery during 4 years of follow-up

Fox Alistair , Syed Akheel

Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.Setting: University teaching hospital in North-West England.Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent b...

ea0050p341 | Obesity and Metabolism | SFEBES2017

Resistant Hypertriglyceridemia in pregnancy

Kushe Manish Shrikrishna , Tabassum Fareeda , Kyaw-Tunn Julie

Case: A 34 years old lady presented to the antenatal clinic at 7 weeks gestation with unplanned pregnancy. She had background history of HTN, poorly controlled T2DM and hypercholesterolemia . She continued taking metformin, gliclazide, sitagliptin and simvastatin which were stopped at the booking appointment . Metformin continued and started on insulin. Blood tests at booking showed HbA1c 126, Cholesterol 5.2 , Triglycerides 2.7. She was started on...

ea0050p342 | Obesity and Metabolism | SFEBES2017

Anthropometric changes associated with antiretroviral therapy in nigerians infected with human immunodeficiency virus

Alalade BA , Adesina OF , Otukoya OA , Adewusi TF , Olukunle GO , Bello A

Background: Human immunodeficiency virus (HIV) infection and the Acquired Immune Deficiency Syndrome (AIDS) are health problems with infected individuals frequently manifesting some abnormalities including significant weight loss. This has been associated withtumor necrosis factor alpha and interleukin 1β production by circulating mononuclear white blood cells in patients with HIV infection andaltered metabolism due to cytokine dysregulation and metabolic demands of antir...

ea0050p343 | Obesity and Metabolism | SFEBES2017

The challenges of reducing calorie intake in everyday life- a pilot study

Joseph-Gubral Jude

One of the major risk factors for type 2 diabetes is Obesity (accounts for 80-85% of overall risk of developing type 2 diabetes). The UK is currently amid an obesity epidemic and it is recommended that the UK population reduce their daily calorie intake. As people are surrounded by food, it was acknowledged that this can be challenging to achieve on a long-term basis. This pilot study aimed to identify common social cues that encourage people to in...

ea0050p344 | Obesity and Metabolism | SFEBES2017

Metabolic profile in a semi urban community in South western Nigeria

Ojo Olubukola , Ojo Olalekan , Ilesanmi Olayinka , Amenkhienan Ibidun , Ajiboye John , Junaid Oladimeji

Introduction: The number of people with type 2 diabetes is increasing worldwide. Currently, 415 million adults have diabetes worldwide and It has been projected that this will increase to 642 million people by 2040. Several important risk factors have been linked to the development of type 2 diabetes, the most important of which is excess body weight.This study set out to determine the blood glucose levels of people in a semi...

ea0050p345 | Obesity and Metabolism | SFEBES2017

The challanges faced in managing gycogen storage disease

Bawa Fareha , Qureshi Mohammed Zubair

Glycogen storage disease, which is a metabolic disorderof glycogen storage, affecting 1 in 20000-40000 ive births. This is a case of yound adolescent female with glycogen storage disease type1b, presented with lactic acidosis and managed in ITU.18 years old femae from Honk kong, student in a college, admitted to a dgh hospital with fever, vomiting and abdominal pain for a week. examination showed severe features of dehydratio...