Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2017

Harrogate, UK
06 Nov 2017 - 08 Nov 2017

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SfE BES 2017 will be on the 6-8 November 2016 in Harrogate, UK.

Poster Presentations


ea0050p351 | Reproduction | SFEBES2017

Mass spectrometry-based assessment of androgen excess in 1205 consecutive patients over 5 years: PCOS most common diagnosis, but severe androgen excess indicates other ovarian and adrenal pathology

Elhassan Yasir , Idkowiak Jan , Smith Karen , Asia Miriam , Webster Rachel , Arlt Wiebke , O'Reilly Michael

Androgen excess in women is most commonly caused by polycystic ovary syndrome (PCOS), but sinister ovarian and adrenal pathology requiring immediate action needs to be excluded. Here we examined whether the severity of androgen excess indicates the likely underlying pathology in women evaluated for androgen excess.We included all women undergoing assessment of serum DHEAS, androstenedione (D4) and testosterone (T) by liquid chromatogra...

ea0050p352 | Reproduction | SFEBES2017

A comparison of Ovarian Hyperstimulation Syndrome (OHSS) parameters following different triggers of oocyte maturation during IVF Treatment

Clarke SA , Abbara A , Islam R , Jeffers L , Christopoulos G , Comninos AN , Salim R , Lavery SA , Trew GH , Dhillo WS

Background: IVF is an effective treatment for infertility, however it may be complicated by the potentially life-threatening ‘ovarian hyperstimulation syndrome’ (OHSS). OHSS is an iatrogenic condition, resultant on the mode of triggering oocyte maturation. Kisspeptin safely triggers oocyte maturation in women at high risk of OHSS, but has yet to be compared with current triggers of oocyte maturation (hCG or GnRH agonist).Meth...

ea0050p353 | Reproduction | SFEBES2017

Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes: a retrospective, observational study

Berni Thomas , Morgan Christopher , Berni Ellen , Rees Aled

Background: Polycystic ovary syndrome (PCOS) is characterised by hyperandrogenism, oligo/amenorrhoea and subfertility but the effects on mental health outcomes are unclear. Offspring neurodevelopment might also be influenced by gestational androgen exposure.Aims: To determine if (i) there is an association between PCOS and psychiatric outcomes, and (ii) rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorde...

ea0050p354 | Reproduction | SFEBES2017

Metformin improves oestrous cycle, ova count and expression of oestrogen receptors in diabetic female Sprague-Dawley rats.

Ojulari Lekan , Morakinyo Femi , Kadir E , Abdulazeez F , Adegoke Olufeyi

The female reproductive system provides several functions. These include ovulation, pregnancy and childbirth. The incidence of diabetes mellitus (DM) is increasing rapidly worldwide and it is associated with reproductive complications. Metformin is an oral hypoglycaemic drug used in the management of DM. The present study determined the effect of metformin on some reproductive function in alloxan-induced diabetic female Sprague-Dawley rats.<p class="abst...

ea0050p355 | Reproduction | SFEBES2017

RNA-Sequencing reveals a downregulation of cholesterol metabolism pathways in granulosa cells from women with PCOS

Lerner A , Caraderi T , Drong A , Makrinou E , Christopoulos G , Liyanage M , Lavery S , Hardy K , Lindgren C , Franks S

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with anovulatory infertility, menstrual disturbances and an adverse metabolic profile. Although the pathophysiology of PCOS remains unclear, dysregulation of gene expression has been previously shown in theca and granulosa cells. In this study, we used RNA-Sequencing to compare the transcriptomes of human granulosa cells from women with and without PCOS. Granulosa cells were retri...

ea0050p356 | Reproduction | SFEBES2017

Impact of delayed pubertal induction and route of estrogen administration on health parameters in adults with Turner Syndrome

Cameron-Pimblett Antoinette , Davies Melanie , Conway Gerard

Background: The Turner Syndrome Life Course Project, UCLH, has collected data on 810 women with TS, attending clinic for 20 years and has accumulated over 8000 clinic visits. We present an analysis of the effects of timing and type of exogenous oestrogen on health outcomes in adults.Methods: A cross- sectional analysis of 475 subjects with primary amenorrhoea with accurate age of pubertal induction data was performed using correlation coefficients contro...

ea0050p357 | Reproduction | SFEBES2017

Metabolic syndrome reduce gravid uterine contractility in female sprague-dawley rat

Iranloye Bolanle , Adoga Jeffery , Adejare Abdullahi , Faniru Yewande

Metabolic syndrome is a clustering of several cardiovascular risk factors including obesity, hypertension, diabetes, high triglyceride etc. Obesity has been shown to decreases key markers of uterine contractility during parturition in the rat and diabetes is associated with impairment of uterine contractility and high caesarean section rate. In this study, the effect of metabolic syndrome on gravid uterine muscle contractility in sprague-dawley rat was deter...

ea0050p358 | Reproduction | SFEBES2017

Pregnancy, pre-eclampsia and vitamin D: a multi-scale mathematical approach

Beentjes Casper , Tamblyn Jennifer , Bayani Anahita , Davis Christopher , Dunster Joe , Mirams Gary , Taylor-King Jake , Jabbari Sara , Kilby Mark , Hewison Martin

Vitamin D deficiency during pregnancy has been linked to adverse pregnancy outcomes such as pre-eclampsia (PET), but continues to be defined by serum measurement of a single metabolite, 25-hydroxyvitamin (25(OH)D). To identify broader changes in vitamin D metabolism during normal and PET pregnancies we developed a mathematical model using a reduced reaction network for vitamin D metabolism that allows for complete parametrisation by multiple vitamin ...

ea0050p359 | Reproduction | SFEBES2017

Is serial urinary progesterone measured via automated chemiluminescent assay a valid alternative to pregnanediol via manual ELISA for the detection of ovulation?

Gifford Robert , Reynolds Rebecca , Anderson Richard , Woods David

Background: Urinary concentrations of the major progesterone metabolite pregnanediol glucuronide (P3G) are used clinically and in research to monitor ovulation. This ELISA is laborious and costly. If it could be replaced by the automated sensitive chemiluminescence assays routinely used for serum this would be of great value.Objective: We aimed to determine the validity of urine progesterone as measured by two widely used automated assays in comparison t...

ea0050p360 | Reproduction | SFEBES2017

Aberrant fetal development precipitated by genistein is accompanied with disruption in the Giant Trophoblast cell histomorphometry, and alteration in the serum, placenta and the amniotic fluid oxidation-reduction system

Awobajo Funmileyi , Morakinyo Ayodele , Samuel Titilola , Oyelowo Oluwakemi , Onyekwele Perpetual , Okedina Mosunmola

Genistein is an endocrine-disrupting chemical (EDC), derived from soya, with reported adverse effects on fetal development. The placenta regulates fetal environment for fidelity of organogenesis which can be compromised by several external factors including EDCs. This study examined the influence of genistein on the histomorphometry of the Giant Trophoblast Cells (GTC) of the placenta and the oxidative stress balance across the maternal serum, placenta and t...

ea0050p361 | Reproduction | SFEBES2017

Non-cardiac maternal and fetal outcomes in Turner Syndrome pregnancies.

Spain Geraldine , MacKillop Lucy , Turner Helen

Background: Despite new, albeit draft, international guidelines there remains limited data and guidance on the non-cardiac obstetric management and outcomes in women with Turner Syndrome (TS).AIMS: This retrospective single centre audit aimed to assess the maternal and fetal outcomes in a large single centre cohort.METHODS: We identified 110 women under our care with TS. Of these, 28 women had attempted to achiev...

ea0050p362 | Reproduction | SFEBES2017

Kisspeptin-leptin interplay in assisted reproductive techniques

Rehman Dr Rehana , Jamil Dr Zehra , Fatima Syeda Sadia , Khalid Aqsa , Mumtaz Aaida

Background: Leptin facilitates onset of puberty by impacting hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify their association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females.<p class="abst...

ea0050p363 | Reproduction | SFEBES2017

Effects of myoinositol and D-chiro inositol on hyperandrogenism and ovulation in women with polycystic ovary syndrome: a systematic review

Amoah-Arko Afua , Evans Meirion , Rees Aled

Background: Insulin resistance is a hallmark of Polycystic Ovary Syndrome (PCOS). Insulin sensitisers, most notably metformin, are thus used to treat the condition, but may be accompanied by gastrointestinal side-effects. The novel isomeric insulin sensitising agents D-chiro-inositol (DCI) and Myo-inositol (MI) improve insulin resistance by acting at the peripheral and ovarian level, respectively, whilst largely being devoid of adverse effects.<p class="...

ea0050p364 | Reproduction | SFEBES2017

Aortic dissection in Turner syndrome: a single centre experience

Calanchini Matilde , Myerson Saul , Turner Helen , Orchard Liz

Introduction: The risk of aortic dissection (AoD) is significantly increased (40 per 100,000/y) in women with Turner Syndrome (TS), but the clinical profile and management for those at risk are not well-established. To gain a better understanding, we present the experience of a single centre with multidisciplinary care, including dedicated cardiology, for management of TS in adulthood.Methods: Retrospective case-review of women develop...

ea0050p365 | Reproduction | SFEBES2017

Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Farooq Muhammad , Ali Shujait , Jamil Huma , Ahmad Nazir , Ashfaq Khurram

Teddy is a highly proliferative goat breed, as females of this breed are famous for high twinning rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effects of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in Teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproduc...

ea0050p366 | Reproduction | SFEBES2017

Audit of endocrine investigations undertaken in females with elevated testosterone

Frank Amy R , Jeffery Jinny , Pinkney Jon , Costelloe Sean J

Background and Aims: Clinical management of women with hyperandrogenic symptoms varies widely and UK guidelines are lacking. Dependent on presentation, differential diagnoses may include thyroid dysfunction, hyperprolactinaemia, congenital adrenal hyperplasia (CAH), hypercortisolism, acromegaly and pregnancy. Women presenting with hyperandrogenic symptoms can have a normal or elevated testosterone. This study describes hormone requesting relevant to these co...

ea0050p367 | Reproduction | SFEBES2017

Turner syndrome management. Are we going along with the new clinical guidelines?

Kakouri Eleni , Michala Lina , Ntali Georgia

Introduction and aim: Turner Syndrome (TS) is associated with a variety of morbidities affecting nearly every body system, and necessitates multidisciplinary management. To facilitate care, the International Turner Syndrome Consensus Group have drafted Clinical Practice Guidelines that were disseminated to ESE members in April 2017. The aim of this audit was to assess whether current management of adolescent and adult TS women in our care is in accordance wi...

ea0050p368 | Reproduction | SFEBES2017

Polycystic Ovarian Syndrome (PCOS): Social situation influences Cardiometabolic Outcome

Heald Adrian H , Livingston Mark , Holland David , Moreno Gabriela Y C , Donnahey Gemma , Duff Christopher J , Shalet Shashana , Wu Pensee , Fryer Anthony A

Introduction: Previous studies have shown that PCOS (first described 1935) increases the future risk of hypertension and coronary artery disease.Aims: We investigated in women with PCOS, the link between social disadvantage and markers of cardiometabolic risk and how weight gain over time related to social disadvantage.Methods: In a primary care-based study, 1797 women were identified from patients attending one ...

ea0050p369 | Reproduction | SFEBES2017

Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care

Heald Adrian H , Livingstone Mark , Holland David , Robinson John , Moreno Gabriela Y C , Donnahey Gemma , Duff Christopher J , Wu Pensee , Fryer Anthony A

Introduction: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age. We examined the specific tests that are done in primary care to lead to the diagnosis of PCOS, and to support the diagnosis once made.Methods: 1797 women were identified from a pooled GP practice database. The search included all patients defined with PCOS or related terms. Records included demographic infor...

ea0050p370 | Reproduction | SFEBES2017

High prevalence of multimorbidity in overweight and obese women with Polycystic Ovary Syndrome (PCOS)

Mani Hamidreza , Chudasama Yogini , Bodicoat Danielle , Levy Miles , Gray Laura , Howlett Trevor , Khunti Kamlesh , Davies Melanie

Background: Multimorbidity, presence of 2 or more chronic conditions, is a growing issue for patients as well as health systems. Reported prevalence of multimorbidity in females in a UK study was 23%. Presence of an additional chronic condition adds challenges to an existing condition. The difficulties of living with polycystic ovary syndrome (PCOS) have been well described both in terms of dealing with the symptoms as well as the potential metabolic and men...

ea0050p371 | Reproduction | SFEBES2017

Standardisation of care: a quality improvement project in Polycystic Ovary Syndrome (PCOS) clinic

Mani Hamidreza , Bhake Ragini , Levy Miles , Reddy Narendra

Background: Considering the high prevalence of metabolic and mental health issues associated with PCOS, it is important to screen for these routinely in clinic. We aimed to implement a standard approach to ensure we do this in our specialist PCOS clinic.Methods: We introduced a standard ‘PCOS clinic pack’ which included the following documents and data collected for analysis1. Checklist for doctors to e...

ea0050p372 | Reproduction | SFEBES2017

A rare case of Gestational Hyperandrogenism

Bajwa Hammad , Agha Adnan

A 27 years old primigravida, with no significant past medical history, was referred to Endocrine clinic at 37 weeks gestation with hirsutism. She developed hirsute features during pregnancy and symptoms progressed with advancing gestation. Her physical examination revealed thick coarse dark hair growth in the midline of lower abdomen, between the breasts and forearms. She noted deepening of her voice but denied headaches, visual disturbance or clitromegaly.<...

ea0050p373 | Reproduction | SFEBES2017

Successful stimulation of spermatogenesis in a man with hypogonadotrophic hypogonadism, azoospermia, previous right orchidectomy and a remaining small left testicle

Oyibo Samson O

Introduction: Infertility affects 15% of couples and a male factor accounts for 50% of cases. Adequate history taking, examination of both partners, hormone testing and semen analysis are required to ascertain a cause and treatment strategy. Gonadotropin therapy with Human Chorionic Gonadotropin (HCG) and recombinant Follicle Stimulating Hormone (rFSH) is indicated for use in men with reduced spermatogenesis due to hypogonadotropic hypogonadism (HH). We pres...

ea0050p374 | Reproduction | SFEBES2017

Clinical and biochemical evaluation of a 32 year old patient with hypogonadism.

Sahar Bashar

A 32 year old emirati patient is evaluated in the endocrine clinic because of symptoms of hypogonadism in the form of reduced sexual desire and erectile dysfunction. On further history taking he confenssed that he was abusing anabolic steroids over the last 3 years but has stopped 3 months prior to his evaluation. On physical exam he appears musculinized, his BMI is 27 kg/m2. He has acne on his face. Testicular size is around 15 ml bilateral. Has ...