Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 51 | BSPED2017 | Next issue

45th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 7

ea0051oc7.1 | Oral Communications 7 | BSPED2017

JUMP: Maternal family history of diabetes and non-white ethnicity adversely affects beta cell response in young people with Type 2 Diabetes

Dias Renuka , Aston Kayleigh , tornese gianluca , Dunger David , Wales Jerry , Hamilton-Shield Julian , Barnett Anthony , Barrett Timothy

Background: Type 2 diabetes (T2D) in children and adults continues to rise. The relative contribution of pancreatic beta cell failure is not established. We aimed to analyse beta cell function in a subgroup of the UK T2D (JUMP) cohort.Methods: Participants were recruited at 58 hospital centres across England and Wales (n=204). Patients were 5–18 years, diagnosed with T2D (ADA criteria) and a BMI SDS>+1.0. At baseline, demographics, clin...

ea0051oc7.2 | Oral Communications 7 | BSPED2017

Use of human pluripotent stem cells to model monogenic diabetes

El-Khairi Ranna , Hattersley Andrew , Vallier Ludovic

Heterozygous mutations in the transcription factor, hepatocyte nuclear factor 1b (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not fully understood due to lack of an appropriate animal model system. Human pluripotent stem cells (PSCs), which are capable of self-renewal and can differentiate into any cell type, ar...

ea0051oc7.3 | Oral Communications 7 | BSPED2017

Level of WFS1 protein expression correlates with clinical progression of optic atrophy in wolfram syndrome patients

Hu Kun , Astuti Dewi , Williams Denise , Dias Renuka , Barrett Timothy , Zatyka Malgorzata

Introduction: Wolfram Syndrome (DIDMOAD) is an autosomal recessive disease caused by mutations in WFS1 gene, resulting in childhood onset diabetes mellitus and optic atrophy. There have been limited functional assays for WFS1 genetic variants. We aimed to investigate WFS1 protein expression in patients and relate this to their genotype and phenotype.Methods: Nine patients from a regional paediatric centre consented to skin biopsies. Six patients had comp...

ea0051oc7.4 | Oral Communications 7 | BSPED2017

Effect of a reduced fluid replacement regimen on resolution of diabetic ketoacidosis in children:comparison of BSPED 2015 and 2009 guidelines

Hapuarachchi Danica Shanee , Ahmed Jaberuzzaman , Gevers Evelien , Moodambail Abdul , Thankamony Ajay

Background: A substantially reduced fluid replacement regimen was introduced in the New’ BSPED (2015) compared to ‘Old’ BSPED (2009) guideline for DKA management in children. However, effects of varying fluid replacement regimens are limited and we explored this by comparing outcomes of the two guidelines on the resolution of DKA.Methods: In a retrospective audit of consecutively admitted patients (age <18 years) to t...

ea0051oc7.5 | Oral Communications 7 | BSPED2017

Service satisfaction, mental wellbeing and clinical progression in young people with diabetes in transition from child to adult services

Gray Sue , Cheetham Tim , Parr Jeremy , Mann Kay , Pearce Mark , McConachie Helen , Colver Allan

Introduction: Transition from child to adult healthcare is a period of vulnerability for young people with diabetes. We hypothesised that patient satisfaction with services and patient wellbeing would be positively associated with a satisfactory clinical progression.Methods: We included data from 150 young people recruited in 2012 to a longitudinal study of transition ( Young people’s satisfaction with services (&...

ea0051oc7.6 | Oral Communications 7 | BSPED2017

Single-centre experience of bariatric surgery in adolescents with significant obesity

Polenok IA , Chapman SA , Kapoor RR , Prince A , Desai AP , Ford-Adams ME

Childhood obesity is a serious public health challenge. Bariatric surgery is gaining popularity as a treatment modality for severely obese adolescents.Backgrounds: To report the safety and 1 year outcome data on morbidly obese adolescents that underwent bariatric surgery at a tertiary hospital in the UK.Methods: A retrospective review of patients (mean preoperative BMI 50.4 kg/m2; mean BMI SDS +4.2) who underwent bariatr...

ea0051oc7.7 | Oral Communications 7 | BSPED2017

Role of Degludec in improving diabetes outcomes in young people - An observational study from Young Diabetes Connections (YDC) Network, London

Nambisan Aparna K R , Fredriksen Samantha , Rowland Amy , Morrow Hannah , Castro-Gonzalez Marie , Ajzensztejn Michal , Hulse Tony , Lawrence Joanna , Shamekh Ahmed , Ford-Adams Martha , Chapman Simon

Introduction: YDC is a partnership of four hospital trusts;Kings College Hospital, Princess Royal University Hospital, Lewisham University Hospital and Evelina London Children’s Hospital,caring for a total of 492 children and young people with diabetes. Most young people are on conventional long acting insulin (Levemir and Glargine), but increasingly, poorly controlled patients (HbA1C>100 mmol/mol) with high admission rates are being switched to insulin Degludec due t...

ea0051oc7.8 | Oral Communications 7 | BSPED2017

Out of hours telephone advice service improves emergency department attendances for diabetes related complications

Holloway Edward , Bailey Matthew

Introduction: We sought to the impact of an out of hours telephone advice service for children and young people with diabetes mellitus on Emergency Department attendance rates.Methods: In July 2014 we commenced a collaborative service for 240 patients with diabetes across two Paediatric diabetes centres- Croydon University Hospital (CUH) and St George’s University Hospital, London. Paediatric diabetes specialist nurses and consultants in Paediatric ...