Searchable abstracts of presentations at key conferences in endocrinology
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45th Meeting of the British Society for Paediatric Endocrinology and Diabetes

ea0051p001 | Thyroid | BSPED2017

Relationship between the level of trace elements and growth in school children group of 6 to 12 ages with goitre

Demir Ilknur , Orbak Zerrin , Karakelleoglu Cahit

The aim of the study was to determine level of trace elements and whether it is related to the growth in children with goitre. The study was performed in children of ages 6–12 years. Goitre staging was performed according to the WHO criteria. A total of 86 cases, 55 with goitre and 31 as control group, were included in the study. When parameters were compared in cases with and without iodine deficiency, TSH and FT3 levels were determined significantly higher in cases with...

ea0051p002 | Thyroid | BSPED2017

Radioactive Iodine therapy for the management of hyperthyroidism in children and adolescents

Wilkinson Ingrid C E Wilkinson , Meso Muriel , Rowse Victoria , Joel Emily , Morris Elizabeth , Price Leanne , Storr Helen L , Drake William M

Background: Radioactive iodine therapy (RAI) is established as a safe and effective treatment for adults with Grave’s disease. As thyrotoxicosis in children is rare, it is difficult to obtain high quality evidence about the safety and efficacy of RAI. We present data from our centre between 2007 and 2017.Methods: 20 paediatric patients with hyperthyroidism (16F), median age 15.7 years (range 10.8–19.3) had RAI in our centre either one or two do...

ea0051p003 | Thyroid | BSPED2017

Long-term follow-up of Grave’s disease in Adolescents: a 10 year study from a single UK tertiary centre

Li Judy , Giri Dinesh , Ramakrishnan Renuka , Das Urmi , Dharmaraj Poonam , Blair Jo , Didi Mohammad , Senniappan Senthil

Introduction: Anti-thyroid medications are the first line therapy for children and young people with Grave’s disease (GD). Some studies have shown remission rates up to 40–50%; however long-term follow up studies have reported much lower remission rates in children compared to adults.Aim: To review the long-term follow up and management of adolescents with Grave’s disease in a single tertiary centre in the UK.Methods...

ea0051p004 | Thyroid | BSPED2017

Double Trouble in a case of iatrogenic induced hyperthyroidism

Appleby Gayle , Lascelles Karine , Arya Ved , Ajzensztejn Michal

Background: Twin sisters with infantile epilepsy developed biochemical hyperthyroidism after commencing Topiramate, which resolved post cessation. This case-report describes the events and has found limited evidence in the literature.Case presentation: MCDA twins, 9 months of age, were admitted with seizure activity. Additionally twin 2, had neurocutaneous melanosis and a viral respiratory illness. Medications on admission were: Levetiracetam, Vigabatrin...

ea0051p005 | Thyroid | BSPED2017

Follicular thyroid carcinoma due to a heterozygous gain of function mutation in thyrotropin receptor (TSHR)

Blackburn James , Giri Dinesh , Seniappan Senthil , Didi Mohammed , Ciolka Barbara , Jones Matthew , Kokai George , Waghorn Alison , Gossan Nicole

Introduction: Activating mutations in thyrotropin receptor (TSHR) have been previously described in the context of non-autoimmune hyperthyroidism (familial or sporadic) and thyroid adenomas. We describe, for the first time, a mutation in TSHR contributing to follicular thyroid carcinoma (FTC) in an adolescent girl.Case: A 12-year-old girl presented with a right-sided neck swelling, increasing in size over the previous four weeks. Clinic...

ea0051p006 | Thyroid | BSPED2017

Routine checking of TSH-receptor Antibodies in pregnancy to reduce postnatal length of stay

Law James , Fozi Anis Mohd , Wynn-Davies Anneli

Introduction: Graves’ hyperthyroidism affects 0.2–2% of women and 1–5% of infants born to these mothers will be symptomatic. Neonatal thyrotoxicosis is a potentially life-threatening condition and infants are currently monitored in hospital till day 4 of life. Graves’ disease is caused by TSH-receptor antibodies (TRAb) which can cross from the maternal to the foetal circulation where they may stimulate the developing thyroid gland causing neonatal thyrotoxi...